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Trackers› Clinical trials› Coimbra
Clinical trial register · Portugal

Clinical Trials in Coimbra, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Portugal and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 1100 matching records held by the registry are in this view. Synced 03 Oct 2026, 03:16 UTC
1100
Studies in scope
all four open statuses
535
Recruiting now
open to new participants
284
Lead sponsors
across recruiting studies
Top sites
Lisbon 683 Porto 541 Coimbra 258 Braga 180 Vila Nova de Gaia 108
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
University of Coimbra20 Novartis Pharmaceuticals16 Hoffmann-La Roche12 Boehringer Ingelheim9 Janssen Research & Development, LLC9
Site location
Lisbon683 Porto541 Coimbra258 Braga180 Vila Nova de Gaia108
All 96 locations
Target enrolment
to

Trials with a site in Coimbra

258 of 1100 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Portugal
Start
Not yet open
A Study to Understand How Nerandomilast Works in People With Active Idiopathic Inflammatory Myopathies
NCT07789015Idiopathic Inflammatory Myopathies
DrugNerandomilast
Boehringer Ingelheim
Phase 3
270
Aveiro, Coimbra, Lisbon
2026-11-09
Not yet open
The Efficacy of the iWork.COMP Among Health Care Professionals
NCT07018089Toxic Leadership Styles
University of Coimbra
Not applicable
200
Coimbra
2026-11-01
Not yet open
Primary Palliative Care - a Feasibility Cluster Trial
NCT07737899Palliative Care, Primary Palliative Care, Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD)
University of Coimbra
Not applicable
30
Coimbra
2026-10-01
Not yet open
Integrated Early-CARE for Head & Neck Cancer.
NCT07671573Head & Neck Cancer, Locally Advanced Head and Neck Cancer, Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
Portuguese Oncology Institute, Coimbra
Not applicable
64
Coimbra
2026-10-01
Recruiting
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
NCT07811193Colorectal Adenocarcinoma
DrugsVVD-133214·Pembrolizumab
Vividion Therapeutics, Inc.
Phase 2
140
Coimbra, Lisbon, Porto
2026-09-11
Active, closed
Cuidar-ME, a Web-based Psychological Intervention for (Peri)Menopausal Women: A Pilot Randomized Controlled Trial
NCT07672002Menopause, Perimenopause
University of Coimbra
Not applicable
150
Coimbra
2026-09-01
Not yet open
Sociocognitive Intervention and Rehabilitation Program in Multiple Sclerosis
NCT07734675Multiple Sclerosis
Sonia Batista
Not applicable
130
Coimbra
2026-09-01
Not yet open
COMPASS 65+ - Community-based Physical Activity Snacks for Healthy Aging in Overweight and Obese Aged Adults
NCT07289529Obesity & Overweight, Aged 65 Years or Older
University of Coimbra
Not applicable
60
Coimbra
2026-09
Not yet open
Evaluation of a Modified Bowel Preparation Regimen in Cirrhotic Patients Undergoing Colonoscopy
NCT07668778Cirrhosis, Bowel Preparation
DrugBisacodyl
Hospital do Divino Espírito Santo de Ponta Delgada
Phase 3
252
Funchal, Ponta Delgada, Coimbra, Setúbal
2026-08-01
Not yet open
F.I.R.E.- Fighters With Focus, Intention, Regulation and Engagement
NCT07484711Firefighters' Mental Health
University of Coimbra
Not applicable
53
Coimbra
2026-08
Recruiting
A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis
NCT07497087Systemic Sclerosis
Boehringer Ingelheim
Phase 3
448
Almada, Coimbra, Lisbon, Ponte de Lima, Porto
2026-07-27
Recruiting
Pridopidine Phase 3 Study in Huntington's Disease
NCT07609108Huntington Disease
DrugPridopidine
Prilenia
Phase 3
400
Coimbra, Lisbon, Porto, Torres Vedras
2026-07-01
Recruiting
Safety and Performances of the LINEA Cardiac Pacing Lead Optimized for the Implantation in Interventricular Septum
NCT07342608Bradycardia, Left Bundle Branch Area Pacing, Left Bundle Branch Pacing
MicroPort CRM
Not applicable
450
Coimbra, Lisbon
2026-06-23
Recruiting
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
NCT07192952Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)
DrugFinerenone
Bayer
Phase 3
117
Coimbra, Lisbon, Porto
2026-06-01
Recruiting
BIO|STREAM.CSP CLS
NCT07608822Sinus Node Disease, Atrioventricular Block
Biotronik SE & Co. KG
Observational
150
Coimbra
2026-05-29
Recruiting
BIO|STREAM.CSP Study
NCT07393009Cardiac Pacing, Cardiac Pacemaker, Implantable Cardioverter Defibrillator, Cardiac Resynchronization Therapy Devices
Biotronik SE & Co. KG
Observational
1,000
Coimbra, Lisbon
2026-05-25
Recruiting
A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis
NCT07387549Primary Sclerosing Cholangitis
DrugElafibranor
Ipsen
Phase 3
350
Lisbon, Porto, Coimbra
2026-05-14
Recruiting
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
NCT07517263Cardiovascular Disease and Lipoprotein(a)
DrugPelacarsen
Novartis Pharmaceuticals
Phase 3
5,700
Coimbra, Guimarães, Setúbal
2026-05-11
Recruiting
Augmented Reality-Based Binocular Therapy for Visual Rehabilitation in Adults With Amblyopia
NCT07819552Amblyopia, Anisometropic Amblyopia
Polytechnic Institute of Porto
Not applicable
60
Coimbra, Porto
2026-05-01
Not yet open
Home Monitoring in eAMD Treatment
NCT07340372Exudative Age-Related Macular Degeneration
DrugAflibercept
Association for Innovation and Biomedical Research on Light and Image
Observational
80
Coimbra, Leiria, Lisbon, Loures, Porto
2026-05
By invitation
Open-Label, Long-Term, Extension Study of Infigratinib in Children With Hypochondroplasia
NCT07393373Hypochondroplasia
DrugInfigratinib
QED Therapeutics, a BridgeBio company
Phase 2
135
Coimbra
2026-04-23
Recruiting
A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes
NCT07415954Diabetes Mellitus, Type 2
DrugsNNC0662-0419·Semaglutide
Novo Nordisk A/S
Phase 2
270
Coimbra, Ponte de Lima, Vila do Conde, Vila Nova de Gaia
2026-04-17
Recruiting
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
NCT07496567Macular Degeneration, Age-Related Macular Degeneration, Choroidal Neovascularization, Wet Macular Degeneration
DrugsTiespectus·Eylea·Aflibercept
EyeBiotech Ltd.
Phase 2/3
960
Coimbra
2026-04-15
Not yet open
Preliminary Efficacy of the AdoptMindful2Care@Web: A Web-Based Mindful Parenting Post-Adoption Intervention for Adoptive Parents
NCT07534111Parenting Stress, Positive Mental Health
University of Coimbra
Not applicable
90
Coimbra
2026-04
Recruiting
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
NCT07282574Progressive Multiple Sclerosis
DrugOcrelizumab
Hoffmann-La Roche
Phase 2
360
Braga, Coimbra, Lisbon, Santa Maria da Feira
2026-03-10
Recruiting
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
NCT07220083Focal Segmental Glomerulosclerosis
DrugApecotrep
Boehringer Ingelheim
Phase 3
286
Almada, Amadora, Braga, Coimbra, Lisbon, Loures, Porto, Setúbal
2026-02-16
Recruiting
PERFECT - Portuguese Evolut Registry Studying the Outcomes of Medtronic Evolut™ FX+ TAVI System by Evaluating an Optimal Care Pathway for TAVI
NCT07343674Severe Symptomatic Aortic Stenosis (Defined as New York Heart Association (NYHA) Class ≥ II)
Portuguese Association of Interventional Cardiology
Observational
500
Coimbra, Lisbon, Funchal, Porto, Vila Nova de Gaia, Evora
2026-01-14
Recruiting
Assessing Agreement Between Acuvera Capture and Paper-Based Methods for BCVA Data Recording in Ophthalmic Trials
NCT07613580Ophthalmopathy
OptymEdge, LLC
Observational
90
Coimbra, Porto
2026-01-12
Recruiting
A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant
NCT06932562Multiple Myeloma
DrugsLinvoseltamab·Daratumumab·Lenalidomide·Dexamethasone
European Myeloma Network B.V.
Phase 3
1,000
Coimbra, Lisbon
2025-12-23
Recruiting
A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)
NCT07107945Chronic Kidney Disease
DrugDapagliflozin
Boehringer Ingelheim
Phase 3
120
Coimbra, Lisbon, Porto
2025-12-09
Recruiting
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
NCT06937229Alzheimer Disease, Agitation
DrugsKarX-EC·KarXT
Bristol-Myers Squibb
Phase 3
650
Coimbra, Guimarães, Lisbon, Senhora da Hora, Torres Vedras
2025-12-02
By invitation
Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
NCT07256392Chronic Spontaneous Urticaria
DrugBarzolvolimab
Celldex Therapeutics
Phase 3
1,370
Aveiro, Coimbra, Lisbon, Setúbal
2025-11-25
Recruiting
Longitudinal Observational Study of Diabetic Retinopathy Progression in Type 2 Diabetes Patients
NCT07458516Diabetic Retinopathy, Diabetes Mellitus, Type 2, Diabetic Complication, Retinal Disease
Association for Innovation and Biomedical Research on Light and Image
Observational
100
Coimbra
2025-11-24
Recruiting
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
NCT07174310Parkinson's Disease
DrugPrasinezumab
Hoffmann-La Roche
Phase 3
900
Braga, Coimbra, Funchal, Guimarães, Lisbon, Matosinhos Municipality, Torres Vedras
2025-11-24
Recruiting
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
NCT07188805Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)
DrugFinerenone
Bayer
Phase 3
111
Carnaxide, Coimbra, Lisbon, Porto
2025-11-19
Recruiting
⁶⁸Ga-FAPI PET/CT for Cardiac Fibrosis in Heart Failure
NCT07296081Myocardial Fibrosis, Heart Failure
University of Coimbra
Observational
30
Coimbra
2025-11-17
Recruiting
A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Children (6 to < 12 Years Old) With Nonsegmental Vitiligo
NCT06804811NonSegmental Vitiligo
DrugRuxolitinib
Incyte Corporation
Phase 3
250
Coimbra, Lisbon, Porto
2025-11-13
Recruiting
Phase 2 Study of ADX-038 in Participants With Geographic Atrophy
NCT06990269Geographic Atrophy Secondary to Age-related Macular Degeneration
ADARx Pharmaceuticals, Inc.
Phase 2
240
Coimbra, Porto
2025-11-10
Recruiting
DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy
NCT07472517Small Cell Lung Cancer (SCLC), Extensive-stage Small Cell Lung Cancer (ES-SCLC)
DrugsObrixtamig·Etoposide·Atezolizumab·Carboplatin
Boehringer Ingelheim
Phase 3
670
Braga, Coimbra, Lisbon, Porto
2025-11-07
Recruiting
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)
NCT07007065Neovascular Age-related Macular Degeneration
DrugSurabgene Lomparvovec
AbbVie
Phase 3
561
Coimbra, Lisbon, Porto
2025-11-05
Recruiting
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
NCT07085767Breast Cancer, Locally Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer
DrugsPalazestrant·Ribociclib·Letrozole
Olema Pharmaceuticals, Inc.
Phase 3
1,000
Coimbra, Lisbon, Porto
2025-11-03
Recruiting
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
NCT06659445Geographic Atrophy (GA), Age - Related Macular Degeneration (AMD)
DrugAvacincaptad Pegol
ONL Therapeutics
Phase 2
324
Coimbra, Gaia, Porto
2025-10-28
Recruiting
A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT06405087Ulcerative Colitis, Crohn's Disease
DrugVedolizumab
Takeda
Phase 3
70
Coimbra, Lisbon, Porto
2025-10-27
Recruiting
A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS)
NCT07161258Relapsing Multiple Sclerosis
DrugFenebrutinib
Hoffmann-La Roche
Phase 2
12
Braga, Coimbra
2025-10-06
Recruiting
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
NCT06865417Ulcerative Colitis
DrugFilgotinib
Alfasigma S.p.A.
Phase 3
80
Braga, Coimbra, Viana do Castelo
2025-09-29
Recruiting
Long-Term Low-Intervention SafEty and Clinical Outcomes Clinical Study of LivmArli® in Patients With Alagille Syndrome or Progressive Familial Intrahepatic Cholestasis in the European Union (LEAP-EU)
NCT07290257Alagille Syndrome, Progressive Familial Intrahepatic Cholestasis
DrugMaralixibat
Mirum Pharmaceuticals, Inc.
Phase 4
230
Coimbra
2025-09-25
Recruiting
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
NCT07181109High Risk Cardiovascular Disease, Hypertension, High Cardiovascular Risk
DrugZilebesiran
Alnylam Pharmaceuticals
Phase 3
11,000
Almada, Baixa Da Banheira, Carnaxide, Coimbra, Creixomil, Leiria, Lisbon, Loures
2025-09-22
Recruiting
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
NCT06926868Breast Neoplasms
DrugsIza-bren·Nab-paclitaxel·Capecitabine·Gemcitabine
Bristol-Myers Squibb
Phase 2/3
600
Lisbon, Coimbra, Porto
2025-09-11
Not yet open
Learn to Act - Promoting Mental Health Literacy in Chronic Pain
NCT07040852Chronic Pain, Mental Health, Health Literacy
University of Coimbra
Not applicable
40
Coimbra
2025-09
Recruiting
Evaluation of Safety and Effectiveness of an IOL With a Virtual Aperture Optic
NCT05955846Intraocular Lens, Cataract, Presbyopia
Z Optics, Inc.
Not applicable
60
Coimbra, Lisbon
2025-08-07
Recruiting
Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO)
NCT06709339Polypoidal Choroidal Vasculopathy
DrugsVabysmo·Faricimab
Association for Innovation and Biomedical Research on Light and Image
Phase 4
120
Coimbra, Leiria, Lisbon, Loures, Porto
2025-08-06
Recruiting
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433Atherosclerotic Cardiovascular Disease, Overweight, Obesity
DrugMaridebart cafraglutide
Amgen
Phase 3
12,800
Braga, Carnaxide, Coimbra, Guimarães, Lisbon, Matosinhos Municipality, Ponte de Lima, Riachos, Torres Novas
2025-07-25
Recruiting
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
NCT06757634Breast Cancer
DrugsGedatolisib·Ribociclib·Palbociclib·Letrozole
Celcuity Inc
Phase 3
1,180
Coimbra, Lisbon, Porto
2025-07-24
Recruiting
Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
NCT07064759Neovascular Age-Related Macular Degeneration (nAMD)
DrugsEYLEA (aflibercept)·4D-150 IVT
4D Molecular Therapeutics
Phase 3
480
Coimbra
2025-07-22
Recruiting
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
NCT07064473Diabetes Mellitus, Type 2, Hypertension, Cardiovascular Diseases
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
11,800
Almada, Amadora, Aveiro, Braga, Coimbra, Guimarães, Leiria, Lisbon
2025-07-22
Recruiting
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
NCT06976203Alzheimer's Disease
DrugsKarX-EC·KarXT
Bristol-Myers Squibb
Phase 3
586
Torres Vedras, Matosinhos Municipality, Braga, Coimbra, Guimarães, Porto
2025-07-21
Recruiting
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
NCT07011732Alzheimer Disease
DrugsKarX-EC·KarXT
Bristol-Myers Squibb
Phase 3
426
Coimbra, Guimarães, Lisbon, Senhora da Hora, Torres Vedras
2025-07-10
Not yet open
Empowering Healthy Lifestyle Personalised Intervention to Prevent and Control Obesity: The HealthyW8 Project
NCT07011368Obesity Prevention, Obesity and Overweight, Obesity and Obesity-related Medical Conditions, Digital Health
Fundació d'investigació Sanitària de les Illes Balears
Not applicable
2,720
Coimbra, Evora
2025-07-01
Active, closed
Preliminary Efficacy of AdoptMindful2Care: A Mindful Parenting Post-adoption Intervention for Adoptive Parents
NCT07043660Parenting Stress
University of Coimbra
Not applicable
78
Aveiro, Coimbra, Lisbon, Porto
2025-06-30
Recruiting
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction, Obesity
DrugMaridebart cafraglutide
Amgen
Phase 3
5,056
Almada, Coimbra, Guimarães, Lisbon, Matosinhos Municipality, Porto, Vila Nova de Gaia
2025-06-25
Recruiting
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
NCT06846281Relapsing Multiple Sclerosis
DrugsRemibrutinib·Ocrelizumab
Novartis Pharmaceuticals
Phase 3
400
Braga, Coimbra, Lisbon
2025-06-23
Recruiting
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
NCT06872892Bronchiectasis
DrugVerducatib
Boehringer Ingelheim
Phase 3
1,755
Aveiro, Braga, Coimbra, Guimarães, Leiria, Lisbon, Porto
2025-06-09
Recruiting
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
NCT07232498Arterial Ischemic Stroke
Unidade Local de Saúde de Coimbra, EPE
Not applicable
1,300
Coimbra, Lisbon, Porto
2025-06-04
Recruiting
Portuguese Registry With Meril Myval THV Series - MyPORTuVal Registry
NCT06818435Aortic Valve Stenosis, TAVI(Transcatheter Aortic Valve Implantation)
Portuguese Association of Interventional Cardiology
Observational
150
Carnaxide, Coimbra, Evora, Lisbon, Porto
2025-05-13
Recruiting
Targeting Neurovascular Coupling in Cognitive Decline Via Nitrate-Based Supplementation
NCT07329647Small Vessel Cerebrovascular Disease, Diabete Mellitus
University of Coimbra
Not applicable
25
Coimbra
2025-05-09
Recruiting
A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN)
NCT06935357Immunoglobulin A Nephropathy (IgAN)
DrugFelzartamab
Biogen
Phase 3
454
Carnaxide, Vila Nova de Gaia, Aveiro, Braga, Coimbra, Leiria, Setúbal
2025-05-08
Recruiting
The REMINDER4Care Program for Older Adults Supported by Residential and Daycare Facilities
NCT06922071Dementia Risk Factors, Prevention, Cognitive Health
University of Coimbra
Not applicable
100
Coimbra
2025-05-01
Recruiting
Combining Noninvasive Brain Stimulation and Augmented Reality-based Dichoptic Therapy for Treating Amblyopic Adults
NCT07752433Amblyopia, Anisometropic Amblyopia
Polytechnic Institute of Porto
Not applicable
80
Coimbra, Porto
2025-05-01
Recruiting
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
NCT06875310Carcinoma, Non-Small-Cell Lung
DrugsAdagrasib·Pemetrexed·Keytruda·Cisplatin
Mirati Therapeutics Inc.
Phase 3
630
Lisbon, Coimbra, Porto
2025-04-24
By invitation
An Interventional Study of Infigratinib in Children With Hypochondroplasia
NCT06873035Hypochondroplasia
DrugInfigratinib
QED Therapeutics, a BridgeBio company
Phase 2/3
24
Coimbra
2025-04-22
Recruiting
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
NCT06868277Carcinoma, Non-Small Cell Lung
DrugsRilvegostomig·Keytruda·Pembrolizumab
AstraZeneca
Phase 3
830
Alcabideche, Braga, Coimbra, Lisbon, Loures, Matosinhos Municipality, Porto
2025-04-10
Recruiting
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
NCT06408259Multiple Sclerosis, Relapsing-Remitting
DrugsFingolimod·Ozanimod
Bristol-Myers Squibb
Phase 3
194
Braga, Coimbra, Lisbon, Porto
2025-04-08
Recruiting
Empower Your Mind to Embrace Your Life: an Online ACT Intervention for Young-Onset Parkinson's Disease
NCT07310147Parkinson's Disease (PD)
University of Coimbra
Not applicable
20
Coimbra
2025-04-01
Recruiting
Real-World Study to Assess Subcutaneous Epcoritamab in Adult Participants With Diffuse Large B-Cell and Follicular Lymphoma
NCT06830759Diffuse Large B-cell Lymphoma, Follicular Lymphoma
AbbVie
Observational
700
Coimbra, Vila Real
2025-03-28
Recruiting
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
NCT06890598Carcinoma, Non-Small-Cell Lung
DrugsOlomorasib·Durvalumab·Pembrolizumab
Eli Lilly and Company
Phase 3
700
Coimbra, Lisbon, Porto
2025-03-27
Active, closed
A Study of Navenibart in Participants With Hereditary Angioedema
NCT06842823Hereditary Angioedema (HAE)
DrugNavenibart
Astria Therapeutics, Inc.
Phase 3
157
Coimbra, Lisbon
2025-03-20
Active, closed
One-day Mind Programme for Women With Breast Cancer
NCT06852833Breast Cancer Females
University of Coimbra
Not applicable
40
Coimbra
2025-03-19
Recruiting
Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake
NCT06571149Ischemic Stroke
DrugsAlteplase·Tenecteplase
Insel Gruppe AG, University Hospital Bern
Phase 4
906
Amadora, Coimbra, Funchal, Lisbon, Matosinhos Municipality, Porto
2025-03-14
Recruiting
To Evaluate the Best Metric for Inspection Time During a Diagnostic and/or Surveillance Upper Gastrointestinal Endoscopy (Age ≥ 18 Years, Informed Consent), Between Total Inspection Time Versus Withdrawal Time, for the Identification of Malignant Lesions
NCT06696209Premalignant Conditions, Malignant Lesions, Gastric, Esophageal
Portuguese Oncology Institute, Coimbra
Not applicable
1,290
Coimbra
2025-03-07
Recruiting
A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines
NCT06671483Psoriatic Arthritis
DrugZasocitinib
Takeda
Phase 3
1,088
Coimbra, Ponte de Lima, Vila Nova de Gaia, Almada, Lisbon
2025-03-03
Recruiting
BCI Training for Social Cognition and Error Monitoring in ASD
NCT06829303Autism Spectrum Disorder (ASD)
University of Coimbra
Not applicable
28
Coimbra
2025-03-01
Recruiting
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
NCT06767514Non-Small Cell Lung Cancer
DrugsIvonescimab·Pembrolizumab
Summit Therapeutics
Phase 3
780
Braga, Lisbon, Porto, Coimbra, Faro
2025-02-27
Recruiting
A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
NCT06810505Chronic Migraine
DrugAtogepant
AbbVie
Phase 3
420
Lisbon, Almada, Coimbra, Porto
2025-02-13
By invitation
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
NCT06908226Developmental and Epileptic Encephalopathy
DrugBexicaserin
Longboard Pharmaceuticals
Phase 3
324
Coimbra, Lisbon, Porto
2025-02-12
Active, closed
A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)
NCT06680817Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
DrugsVabysmo·Faricimab
Hoffmann-La Roche
Observational
875
Coimbra, Lisbon, Porto
2025-02-05
Recruiting
A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum
NCT06624670Pyoderma Gangrenosum
DrugsSpesolimab·Prednisolone·Prednisone
LEO Pharma
Phase 3
90
Coimbra, Lisbon, Porto
2025-02-05
Not yet open
Knowledge of Vascular Age Contributes to Improve the Collaboration Between Community Pharmacies and Primary Health Care Physicians in Reducing Blood Pressure in Hypertensive Patients.
NCT06761235Hypertension and Cardiovascular Risk Factors
Enrique Rodilla
Not applicable
1,246
Coimbra
2025-02-01
Active, closed
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)
NCT06799000Hidradenitis Suppurativa
DrugRemibrutinib
Novartis Pharmaceuticals
Phase 3
588
Almada, Braga, Coimbra, Lisbon, Porto
2025-01-31
Recruiting
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
NCT06788990Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
DrugsFicerafusp alfa·Keytruda·Pembrolizumab
Bicara Therapeutics
Phase 2/3
650
Braga, Coimbra, Lisbon, Portimão, Porto, Senhora da Hora, Vila Nova de Gaia
2025-01-28
Recruiting
A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
NCT06100289Ulcerative Colitis, Crohn's Disease
DrugVedolizumab
Takeda
Phase 3
70
Coimbra, Lisbon, Porto
2025-01-22
Recruiting
Effect of a Structured Physical Exercise Program on Arteriovenous Fistula Maturation for Hemodialysis in Chronic Kidney Disease Patients
NCT06960304Chronic Kidney Disease Requiring Hemodialysis
Unidade Local de Saúde de Coimbra, EPE
Not applicable
128
Coimbra
2025-01-16
Active, closed
A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome
NCT06684847Primary Sjogrens Disease
DrugEfgartigimod PH20
argenx
Phase 3
631
Coimbra, Lisbon, Ponte de Lima, Vila Nova de Gaia
2025-01-15
Recruiting
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
NCT06227910Crohn's Disease
DrugsVedolizumab·Upadacitinib
Takeda
Phase 3
396
Coimbra, Lisbon
2025-01-02
Recruiting
Phase III Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents
NCT06745557Burns
DrugsDenovoSkin·Ehsg-Kf
CUTISS AG
Phase 3
70
Coimbra
2024-12-13
Recruiting
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
NCT06597019Familial Hypercholesterolemia - Heterozygous
DrugInclisiran
Novartis Pharmaceuticals
Phase 3
60
Coimbra, Lisbon, Porto
2024-12-09
Recruiting
Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor
NCT06472245Patients With Non-Small Cell Lung Cancer
DrugsTedopi·Docetaxel
OSE Immunotherapeutics
Phase 3
363
Coimbra, Lisbon, Porto, Vila Nova de Gaia
2024-12-03
Not yet open
Yoga Impact in Fibromyalgia, Primary Health Care
NCT06646796Fibromyalgia
University of Coimbra
Not applicable
20
Coimbra
2024-12-01
Active, closed
Observational Study of Oral Atogepant to Evaluate Real-World Effectiveness in Adult Participants With Migraine
NCT06543914Migraine
AbbVie
Observational
1,314
Guimarães, Lisbon, Loures, Sintra, Torres Vedras, Coimbra, Porto
2024-11-26
Active, closed
Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)
NCT06635824PD-L1-positive, Locally Advanced (Unresectable Stage IIIB/C) or Metastatic NSCLC
DrugsDocetaxel·Pembrolizumab
Genmab
Phase 3
191
Coimbra, Matosinhos Municipality, Porto, Setúbal
2024-11-25
Active, closed
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)
NCT06719141Developmental and Epileptic Encephalopathy
DrugBexicaserin
Longboard Pharmaceuticals
Phase 3
367
Coimbra, Lisbon, Porto
2024-11-11
Recruiting
A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis
NCT06470048Diffuse Cutaneous Systemic Sclerosis
DrugIanalumab
Novartis Pharmaceuticals
Phase 2
200
Coimbra, Lisbon, Vila Nova de Gaia
2024-10-09
Recruiting
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
NCT06561386Non-small Cell Lung Cancer
DrugsRelatlimab·Pemetrexed·Nivolumab·Cisplatin
Bristol-Myers Squibb
Phase 3
1,000
Lisbon, Coimbra, Porto
2024-10-07
Recruiting
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
NCT06492616Breast Cancer
DrugsElacestrant·Tamoxifen·Exemestane·Anastrozole
Stemline Therapeutics, Inc.
Phase 3
4,220
Loures, Vila Franca de Xira, Porto, Vila Nova de Gaia, Coimbra, Faro, Lisbon, Setúbal
2024-09-27
Active, closed
A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)
NCT06660394Dravet Syndrome
DrugBexicaserin
Longboard Pharmaceuticals
Phase 3
96
Coimbra, Lisbon, Porto
2024-09-25
Active, closed
A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)
NCT06525220Head and Neck Squamous Cell Carcinoma
DrugsPetosemtamab·Pembrolizumab
Merus B.V.
Phase 3
699
Coimbra, Lisbon, Portimão, Porto, Vila Real
2024-09-25
Active, closed
A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer
NCT06497556Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer
DrugsDivarasib·Adagrasib·Sotorasib
Hoffmann-La Roche
Phase 3
338
Braga, Coimbra, Lisbon, Porto
2024-09-23
Recruiting
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
NCT06635148Geographic Atrophy, Macular Degeneration
Janssen Research & Development, LLC
Phase 2/3
274
Coimbra, Porto
2024-09-19
Recruiting
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
NCT06548542Crohn's Disease
DrugsABBV-8736·Trosunilimab·Lutikizumab·Risankizumab
AbbVie
Phase 2
590
Guimarães, Lisbon, Braga, Coimbra, Viana do Castelo
2024-09-04
Active, closed
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
NCT06531824Kidney Disease, Chronic
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
11,000
Aveiro, Braga, Carnaxide, Castelo Branco, Coimbra, Faro, Funchal, Lisbon
2024-08-30
Recruiting
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
NCT06452277Advanced Non-small Cell Lung Cancer, HER2 Mutation
DrugsSevabertinib·Pemetrexed·Cisplatin·Carboplatin
Bayer
Phase 3
555
Matosinhos Municipality, Coimbra, Lisbon, Porto
2024-08-28
Recruiting
A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
NCT06290141Chronic Inflammatory Demyelinating Polyneuropathy
DrugsRiliprubart·IVIG
Sanofi
Phase 3
160
Braga, Coimbra, Lisbon
2024-08-21
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis
NCT06461897Atopic Dermatitis
DrugsUpadacitinib·Dupilumab
AbbVie
Phase 3
675
Coimbra, Porto
2024-08-19
Active, closed
A Study to Evaluate the Efficacy and Safety of 2 Doses of EYE103 Compared With Ranibizumab (0.5 mg) in Participants With DME
NCT06571045Diabetic Macular Edema (DME)
DrugsRestoret·Lucentis·Ranibizumab
EyeBiotech Ltd.
Phase 2/3
984
Coimbra, Porto
2024-08-07
Recruiting
Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
NCT06380751Advanced Breast Cancer
DrugsSaruparib·Camizestrant·Exemestane·Anastrozole
AstraZeneca
Phase 3
788
Coimbra, Lisbon, Matosinhos Municipality, Porto, Vila Real
2024-08-01
By invitation
Long-term Safety and Tolerability of BHV-7000
NCT06443463Focal Epilepsy
DrugOpakalim
Biohaven Therapeutics Ltd.
Phase 2
660
Santa Maria da Feira, Senhora da Hora, Braga, Coimbra, Lisbon
2024-07-30
Recruiting
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
NCT06282575Biliary Tract Cancer
DrugsZanidatamab·Durvalumab·Gemcitabine·Cisplatin
Jazz Pharmaceuticals
Phase 3
286
Almada, Coimbra, Lisbon, Porto
2024-07-19
Recruiting
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
NCT06252649Metastatic Colorectal Cancer
DrugsBevacizumab-awwb·Sotorasib·Panitumumab·Mvasi
Amgen
Phase 3
450
Almada, Coimbra, Lisbon, Matosinhos Municipality, Santa Maria da Feira
2024-07-17
Active, closed
A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) for Which the Usual Treatments do Not Work
NCT06290128Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Polyneuropathy, Inflammatory Demyelinating, Chronic
DrugRiliprubart
Sanofi
Phase 3
109
Coimbra, Lisbon, Matosinhos Municipality
2024-07-12
Active, closed
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
NCT06445023Chronic Spontaneous Urticaria
DrugBarzolvolimab
Celldex Therapeutics
Phase 3
963
Aveiro, Braga, Coimbra, Lisbon, Matosinhos Municipality, Porto, Setúbal, Vila Nova de Gaia
2024-07-11
Active, closed
A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)
NCT06496178Head and Neck Squamous Cell Carcinoma
DrugPetosemtamab
Merus B.V.
Phase 3
621
Coimbra, Lisbon, Porto
2024-06-25
Recruiting
A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections
NCT06056297Neutropenia
X4 Pharmaceuticals
Phase 3
176
Aveiro, Coimbra, Lisbon
2024-06-06
Recruiting
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
NCT06112314Advanced Melanoma
DrugsBrenetafusp·Relatlimab·Opdivo·Nivolumab
Immunocore Ltd
Phase 3
680
Coimbra, Lisbon
2024-06-05
Recruiting
Prospective Clinical Assessment Study in Children With Hypochondroplasia
NCT06410976Hypochondroplasia
QED Therapeutics, a BridgeBio company
Observational
150
Coimbra
2024-06-05
Recruiting
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
NCT06203210Small Cell Lung Cancer
DrugsAmrubicin·Ifinatamab Deruxtecan·Lurbinectedin·Topotecan
Daiichi Sankyo
Phase 3
540
Coimbra, Guimarães, Lisbon, Porto
2024-05-21
Recruiting
VE303 for Prevention of Recurrent Clostridioides Difficile Infection
NCT06237452Clostridium Difficile, Clostridium Difficile Infections, Clostridium Difficile Infection Recurrence, Clostridioides Difficile Infection
Vedanta Biosciences, Inc.
Phase 3
852
Guimarães, Coimbra, Almada, Braga, Guarda, Porto, Vila Nova de Gaia
2024-05-20
Active, closed
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
NCT06238622Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
DrugNerandomilast
Boehringer Ingelheim
Phase 3
1,666
Braga, Coimbra, Lisbon, Matosinhos Municipality, Vila Nova de Gaia
2024-05-06
By invitation
A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)
NCT06431893Homocystinuria
DrugPegtibatinase
Travere Therapeutics, Inc.
Phase 3
100
Coimbra, Lisbon, Porto
2024-04-30
Active, closed
A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.
NCT06372145Relapsing Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Progressive Relapsing Multiple Sclerosis
DrugTeriflunomide
Sanofi
Phase 3
2,500
Braga, Coimbra, Lisbon, Matosinhos Municipality, Santa Maria da Feira
2024-04-16
Recruiting
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
NCT06312137Non Small Cell Lung Cancer
DrugsSacituzumab tirumotecan·Pemetrexed·Gemcitabine·Paclitaxel
Merck Sharp & Dohme LLC
Phase 3
780
Lisbon, Matosinhos Municipality, Coimbra, Porto
2024-04-03
Recruiting
Safe-Infusion Study
NCT06727240Intravenous Access, Medical Device
Interlinked AB
Not applicable
548
Coimbra
2024-03-25
Recruiting
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
NCT06256588Neoplasms, Head and Neck
DrugDostarlimab
GlaxoSmithKline
Phase 3
864
Coimbra, Faro, Lisbon, Matosinhos Municipality, Porto, Vila Nova de Gaia
2024-03-21
Recruiting
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
NCT05646381Aortic Stenosis
DrugPelacarsen
Novartis Pharmaceuticals
Phase 2
502
Alcabideche, Braga, Coimbra, Vila Nova de Gaia
2024-03-07
Recruiting
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
NCT05827081Early Breast Cancer
DrugsLeuprolide·Goserelin·Exemestane·Ribociclib
Novartis Pharmaceuticals
Phase 3
1,400
Coimbra, Lisbon, Porto
2024-02-28
Recruiting
Immunomodulation During Pregnancy
NCT06882850Aspirin, Pregnancy Complications, Immunology
Unidade Local de Saúde de Coimbra, EPE
Observational
30
Coimbra
2024-02-01
Recruiting
A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Infants (0 to <2 Years of Age) With Achondroplasia
NCT06079398Achondroplasia
DrugNavepegritide
Ascendis Pharma A/S
Phase 2
72
Coimbra
2024-01-23
Recruiting
Efficacy of Repetitive Transcranial Magnetic Stimulation in Temporomandibular Disorders.
NCT06813040Temporomandibular Joint Disorders
University of Coimbra
Not applicable
40
Coimbra
2024-01-01
Recruiting
Pegtibatinase as a Treatment for Participants With Classical Homocystinuria (HCU) Receiving Standard of Care Treatment
NCT06247085Homocystinuria
DrugPegtibatinase
Travere Therapeutics, Inc.
Phase 3
70
Coimbra, Lisbon, Porto
2023-12-28
Recruiting
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
NCT06119581Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
DrugsOlomorasib·Pemetrexed·Cisplatin·Carboplatin
Eli Lilly and Company
Phase 3
1,264
Coimbra, Lisbon, Porto
2023-12-21
Active, closed
A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With Vitiligo
NCT06118411Vitiligo
DrugUpadacitinib
AbbVie
Phase 3
614
Coimbra, Leiria, Lisbon, Porto
2023-12-19
Active, closed
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
NCT06141473Multiple Sclerosis
DrugsCholestyramine·Activated Charcoal·Teriflunomide·Frexalimab
Sanofi
Phase 3
1,655
Braga, Coimbra, Guimarães, Lisbon, Matosinhos Municipality
2023-12-13
Active, closed
A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)
NCT06065748Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer
DrugsGiredestrant·Ribociclib·Abemaciclib·Palbociclib
Hoffmann-La Roche
Phase 3
1,050
Coimbra, Lisbon, Porto, Vila Nova de Gaia
2023-12-11
Recruiting
Validation of the C-mo System - Cough Monitoring
NCT05989698Cough, Asthma, Chronic Obstructive Pulmonary Disease, Gastro Esophageal Reflux
Cough Monitoring Medical Solutions
Not applicable
300
Alfena, Amadora, Aveiro, Coimbra, Lisbon, Porto
2023-12-11
Active, closed
A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines
NCT05976243Chronic Inducible Urticaria
DrugRemibrutinib
Novartis Pharmaceuticals
Phase 3
362
Coimbra, Lisbon, Vila Nova de Gaia
2023-12-07
Active, closed
OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
NCT06016738Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer
DrugsPalazestrant·Exemestane·Anastrozole·Letrozole
Olema Pharmaceuticals, Inc.
Phase 3
510
Coimbra, Lisbon, Porto, Senhora da Hora
2023-11-16
By invitation
A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
NCT06044337Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
DrugLitifilimab
Biogen
Phase 3
306
Coimbra
2023-10-03
Recruiting
Promotion of Mental Health in Adolescents: A School-Based Preventive Version of the Unified Protocol (UP-A Kind)
NCT07021001The Focus is the Prevention and Promotion of Mental Well-being and is a Universal Delivery Intervention
University of Coimbra
Not applicable
300
Coimbra
2023-10-01
Active, closed
Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)
NCT06088290Leiomyosarcoma
DrugsLurbinectedin·Doxorubicin
PharmaMar
Phase 3
469
Lisbon, Coimbra, Porto
2023-09-21
Recruiting
ACTsocially: The (Dis)Similarities of ACT for Changing Internalizing and Externalizing Symptomatology in Adolescence
NCT07456631Social Anxiety Disorder (SAD), Oppositional Defiant Disorder
University of Coimbra
Not applicable
54
Coimbra
2023-09-01
Recruiting
A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis
NCT06016842Primary Biliary Cholangitis (PBC)
DrugElafibranor
Ipsen
Phase 3
276
Coimbra, Funchal, Vila Real
2023-08-31
Active, closed
Pediatric Patients Aged 1 to 6 Years With APDS
NCT05693129APDS
DrugLeniolisib
Pharming Technologies B.V.
Phase 3
16
Coimbra
2023-08-30
Active, closed
Cladribine Tablets Level of Response Predictors in Clinical Practice (CLODINA)
NCT05797740Multiple Sclerosis
DrugsMavenclad·Cladribine
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Observational
366
Coimbra, Lisbon, Porto
2023-08-03
Recruiting
Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
NCT05855200Colonic Neoplasms, Neoplasms, Colon
DrugsCapeox·Dostarlimab·Folfox
GlaxoSmithKline
Phase 3
892
Almada, Coimbra, Lisbon
2023-08-01
Not yet open
Comparison of Two GIC's in the Restoration of Posterior Class II Lesions in the Primary Dentition
NCT05965297Dental Caries
DMG Dental Material Gesellschaft mbH
Not applicable
140
Coimbra
2023-08
Active, closed
Can the Risk for AMD be Modulated?
NCT05735730Age-Related Macular Degeneration (ARMD)
Association for Innovation and Biomedical Research on Light and Image
Not applicable
1,800
Coimbra
2023-06-26
Active, closed
A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
NCT05827016Multiple Myeloma
DrugsIberdomide·Lenalidomide
Bristol-Myers Squibb
Phase 3
1,230
Braga, Coimbra, Porto
2023-06-22
By invitation
A Clinical Trial to Investigate Long-term Safety, Tolerability, and Efficacy of Weekly Subcutaneous Doses With TransCon CNP in Children and Adolescents With Achondroplasia
NCT05929807Achondroplasia
Ascendis Pharma Growth Disorders A/S
Phase 2/3
140
Coimbra
2023-06-21
Active, closed
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Epidermolysis Bullosa (Phase III, Cross-over)
NCT05464381Epidermolysis Bullosa
DrugAllo-APZ2-OTS
RHEACELL GmbH & Co. KG
Phase 3
91
Coimbra
2023-06-13
Recruiting
A Study of Eptinezumab in Pediatric Participants With Episodic Migraine
NCT05897320Episodic Migraine
DrugEptinezumab
H. Lundbeck A/S
Phase 3
315
Braga, Coimbra, Lisbon, Porto
2023-06-08
Recruiting
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
NCT05716100Focal Onset Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
360
Coimbra, Guimarães, Lisbon, Porto, Santa Maria da Feira, Vila Real
2023-05-09
Active, closed
Urine Extracellular Vesicles: Non-invasive Biomarkers of Β-cell Function and Novel Therapeutic Agents in Diabetes
NCT06832215Diabetes Mellitus, Type 1, Diabetes Mellitus
Unidade Local de Saúde de Coimbra, EPE
Observational
120
Coimbra
2023-05-06
By invitation
An Open-label Study of XEN1101 in Epilepsy
NCT05718817Focal Epilepsy, Tonic-Clonic Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
880
Coimbra, Guimarães, Lisbon, Porto, Santa Maria da Feira
2023-04-25
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NCT04124120Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting
Weill Medical College of Cornell University
Not applicable
2,300
Coimbra, Lisbon, Porto
2023-04-17
Active, closed
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
NCT05757869Atrial Fibrillation
DrugsMilvexian·Apixaban
Janssen Research & Development, LLC
Phase 3
20,284
Coimbra, Covilha, Figueira da Foz Municipality, Lisbon, Santa Maria da Feira, Torres Novas, Vila Nova de Gaia, Vila Real
2023-04-11
Active, closed
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
NCT05794906Biochemically Recurrent Prostate Cancer
DrugDarolutamide
Bayer
Phase 3
985
Coimbra, Lisbon
2023-04-03
Active, closed
The PORTuguese Registry of Supera Supported Femoral-Fopliteal Revascularization (SupPORT Registry)
NCT06416644Lower Limb Ischemia, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia, Chronic Limb Ischemia
Hospital do Divino Espírito Santo de Ponta Delgada
Not applicable
100
Faro, Ponta Delgada, Almada, Penafiel, Vila Nova de Gaia, Angra do Heroísmo, Coimbra, Guimarães
2023-04-01
Active, closed
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
NCT05819359Parkinson's Disease
Bial R&D Investments, S.A.
Phase 2
237
Coimbra, Guimarães, Porto, Torres Vedras
2023-03-31
Active, closed
A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)
NCT05714202Bladder Cancer
DrugsTAR-200·Cetrelimab
Janssen Research & Development, LLC
Phase 3
1,135
Coimbra, Lisbon, Vila Nova de Gaia
2023-03-23
Active, closed
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
NCT05739383Primary Prevention of Atherosclerotic Cardiovascular Disease
DrugInclisiran
Novartis Pharmaceuticals
Phase 3
14,012
Almada, Carnaxide, Coimbra, Lisbon, Matosinhos Municipality, Porto, Santa Maria da Feira, Setúbal
2023-03-09
Active, closed
A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE
NCT05702034Ischemic Stroke; Ischemic Attack, Transient
DrugMilvexian
Janssen Research & Development, LLC
Phase 3
12,523
Braga, Coimbra, Covilha, Guimarães, Lisbon, Porto, Pragal, Santa Maria da Feira
2023-02-15
Recruiting
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
NCT05667142Primary Generalized Tonic-Clonic Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
160
Coimbra, Guimarães, Lisbon, Matosinhos Municipality, Porto, Santa Maria da Feira
2023-02-14
Active, closed
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
NCT05685238Haemophilia A, Haemophilia A With Inhibitors
Novo Nordisk A/S
Phase 3
451
Coimbra, Lisbon, Porto
2023-02-13
Active, closed
NarraTivAS - Narrative Family Therapy in Autism Spectrum
NCT07246395Autism Spectrum Disorder
University of Coimbra
Not applicable
63
Coimbra
2023-02-08
Recruiting
European Myeloma Network (EMN) Sample Project
NCT06237803Multiple Myeloma, Smoldering Multiple Myeloma, Plasma Cell Leukemia, Extramedullary Myeloma
European Myeloma Network B.V.
Observational
6,000
Coimbra, Lisbon, Porto
2022-12-21
Active, closed
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
NCT05581303Atherosclerotic Cardiovascular Disease
DrugOlpasiran
Amgen
Phase 3
7,297
Almada, Amadora, Aveiro, Braga, Carnaxide, Cascais, Coimbra, Guimarães
2022-12-14
Active, closed
Prediction of Progression of Retinal Ischemia in Diabetes
NCT05581225Diabetic Retinopathy
Association for Innovation and Biomedical Research on Light and Image
Observational
62
Coimbra
2022-12-02
Recruiting
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
NCT05457283Chronic Kidney Disease, Proteinuria, Children
DrugFinerenone
Bayer
Phase 3
100
Braga, Coimbra, Porto
2022-11-08
Active, closed
A Study to Evaluate Migalastat in Fabry Subjects With Amenable GLA Variant and Renal Disease
NCT04020055Fabry Disease
DrugMigalastat HCl
Amicus Therapeutics
Phase 3
14
Coimbra
2022-10-31
Active, closed
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
NCT05587296Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes
Bayer
Phase 3
474
Loures, Braga, Coimbra, Lisbon, Porto
2022-10-14
Active, closed
Improvement of Immunologic and Molecular Techniques for the Diagnosis and Follow-up of Patients With Thrombotic Thrombocytopenic Purpura
NCT05046717Acquired Thrombotic Thrombocytopenic Purpura
Fundación Española de Hematología y Hemoterapía
Observational
500
Coimbra
2022-10-13
Recruiting
Study of the Role of Genetic Modifiers in Hemoglobinopathies
NCT05799118Sickle Cell Disease, Thalassemia, Beta, Thalassemia Alpha, Hemoglobinopathies
Cyprus Institute of Neurology and Genetics
Observational
30,000
Coimbra
2022-10-01
Active, closed
A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
NCT05531565Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
DrugLitifilimab
Biogen
Phase 2/3
450
Coimbra, Lisbon, Porto, Viana do Castelo
2022-09-13
Recruiting
EPOS Discoid Meniscus (DiMe) Project
NCT05580315Discoid Meniscus of Knee
University of Milano Bicocca
Observational
500
Coimbra, Lisbon
2022-09-08
Active, closed
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
NCT05425940Colorectal Cancer
DrugsZanzalintinib·Regorafenib·Tecentriq·Atezolizumab
Exelixis
Phase 3
901
Almada, Coimbra, Guimarães, Lisbon
2022-09-07
Recruiting
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
NCT05268289Lupus Nephritis
DrugIptacopan
Novartis Pharmaceuticals
Phase 2
240
Carnaxide, Coimbra, Lisbon, Porto, Vila Nova de Gaia
2022-08-10
Active, closed
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
NCT05296798Locally Advanced or Metastatic Breast Cancer
DrugsGiredestrant·Phesgo·Pertuzumab·Trastuzumab
Hoffmann-La Roche
Phase 3
922
Coimbra, Lisbon, Loures, Porto
2022-07-18
Active, closed
Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.
NCT05267613Erosive Esophagitis
DrugNexium
AstraZeneca
Phase 3
53
Coimbra, Lisbon, Porto, Viana do Castelo
2022-07-01
Active, closed
Merit WRAPSODY™ Endoprosthesis for Treatment of Stenosis or Occlusion (WRAP)
NCT05062291Venous Stenosis, Venous Occlusion
Merit Medical Systems, Inc.
Observational
500
Coimbra
2022-06-23
Active, closed
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT04975997Multiple Myeloma
DrugsIberdomide·Bortezomib·Daratumumab·Dexamethasone
Celgene
Phase 3
939
Coimbra, Lisbon, Porto
2022-06-23
Recruiting
CytOSorb TreatMent Of Critically Ill PatientS Registry
NCT05146336Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
CytoSorbents, Inc
Observational
3,000
Coimbra, Lisbon
2022-06-22
Active, closed
A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS)
NCT05123703Relapsing-remitting Multiple Sclerosis
DrugsFingolimod·Ocrelizumab
Hoffmann-La Roche
Phase 3
188
Braga, Coimbra, Lisbon
2022-05-19
Active, closed
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
NCT05269004Multiple Sclerosis
DrugOcrelizumab
Hoffmann-La Roche
Phase 3
1,300
Braga, Coimbra, Lisbon, Pragal
2022-05-03
Recruiting
Validation of the REMINDER Dementia Risk Reduction Program
NCT05296980Healthy Aging, Risk Reduction, Old Age; Dementia
University of Coimbra
Not applicable
400
Coimbra
2022-04-01
Active, closed
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria
NCT05196035Chronic Kidney Disease, Proteinuria
DrugFinerenone
Bayer
Phase 3
219
Coimbra, Porto
2022-03-28
Active, closed
A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
NCT05132582HER2 Positive Breast Cancer
DrugsPerjeta·Tucatinib·Herceptin·Pertuzumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
654
Braga, Lisbon, Coimbra
2022-03-07
Active, closed
A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Disease (MOGAD)
NCT05063162Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD)
DrugRozanolixizumab
UCB Biopharma SRL
Phase 3
113
Coimbra, Porto
2022-02-02
Active, closed
Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-positive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.
NCT05038735Breast Cancer
DrugsAlpelisib·Fulvestrant
Novartis Pharmaceuticals
Phase 3
210
Coimbra, Lisbon, Porto
2021-12-17
Active, closed
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)
NCT05156281Relapsing Multiple Sclerosis
DrugsTeriflunomide·Remibrutinib
Novartis Pharmaceuticals
Phase 3
1,007
Braga, Coimbra, Leiria, Lisbon, Matosinhos Municipality, Santa Maria da Feira
2021-12-13
Active, closed
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
NCT05152147Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma
DrugsZanidatamab·Herceptin·Trastuzumab·Adrucil
Jazz Pharmaceuticals
Phase 3
920
Almada, Coimbra, Guimarães, Lisbon, Matosinhos Municipality, Porto
2021-12-02
Recruiting
A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
NCT05164172Migraine
DrugEptinezumab
H. Lundbeck A/S
Phase 3
600
Almada, Porto Covo, Braga, Coimbra, Porto
2021-12-01
Active, closed
Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease
NCT05030428Atherosclerotic Cardiovascular Disease
DrugInclisiran sodium
Novartis Pharmaceuticals
Phase 3
17,004
Alcabideche, Almada, Carnaxide, Coimbra, Guimarães, Leiria, Lisbon, Matosinhos Municipality
2021-11-23
Recruiting
A Study of Real-Life Current Standards of Care in Participants With Relapsed and/or Refractory Multiple Myeloma
NCT05160584Relapsed/Refractory Multiple Myeloma
Janssen Pharmaceutica N.V., Belgium
Observational
300
Chaves, Coimbra, Porto
2021-11-18
Active, closed
Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT05089734Non-Small Cell Lung Cancer
DrugsSacituzumab Govitecan·Docetaxel
Gilead Sciences
Phase 3
603
Coimbra, Lisbon, Matosinhos Municipality, Porto
2021-11-17
Active, closed
Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia
NCT04994717Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL)
DrugBlinatumomab
Amgen
Phase 3
303
Coimbra, Lisbon, Porto
2021-11-02
Active, closed
Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis
NCT04926818Multiple Sclerosis (MS)
DrugsSiponimod·Fingolimod·Ofatumumab
Novartis Pharmaceuticals
Phase 3
129
Coimbra, Lisbon
2021-10-05
Active, closed
A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes
NCT04747431Frontotemporal Dementia, FTD, FTD-GRN, Dementia Frontotemporal
Passage Bio, Inc.
Phase 1/2
30
Coimbra
2021-09-14
By invitation
Selatogrel Outcome Study in Suspected Acute Myocardial Infarction
NCT04957719Acute Myocardial Infarction
Viatris Innovation GmbH
Phase 3
25,000
Aveiro, Coimbra, Leiria, Lisbon
2021-08-14
Active, closed
Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin or Who Refuse Cisplatin
NCT04960709Muscle Invasive Bladder Cancer
DrugsEnfortumab Vedotin·Tremelimumab·Durvalumab
AstraZeneca
Phase 3
712
Braga, Coimbra, Faro, Lisbon
2021-08-05
Recruiting
A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine
NCT04965675Chronic Migraine in Children
DrugEptinezumab
H. Lundbeck A/S
Phase 3
285
Almada, Coimbra, Porto
2021-06-30
Active, closed
A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread
NCT04810078Clear Cell Renal Cell Carcinoma
DrugsNivolumab and rHuPH20·Opdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
681
Coimbra, Lisbon
2021-05-21
Active, closed
Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
NCT04700124Bladder Cancer
DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin
Merck Sharp & Dohme LLC
Phase 3
808
Coimbra, Lisbon, Porto
2021-04-21
Recruiting
COVID-19 Vaccines Safety Tracking (CoVaST)
NCT04834869Adverse Reaction to Vaccine, COVID19 Vaccine
DrugsEfluelda (TIV-HD) and Spikevax·Comirnaty
Masaryk University
Observational
30,000
Coimbra
2021-04-01
Active, closed
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
NCT04586010Relapsing Multiple Sclerosis
DrugsFenebrutinib·Teriflunomide
Hoffmann-La Roche
Phase 3
746
Braga, Coimbra, Lisbon, Porto, Santa Maria da Feira
2021-03-17
Active, closed
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
DrugsAdagrasib·Taxotere·Docetaxel
Mirati Therapeutics Inc.
Phase 3
453
Almada, Braga, Coimbra, Guimarães, Lisbon, Loures, Porto, Santa Maria da Feira
2021-02-23
Active, closed
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
NCT04534205Unresectable Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
DrugPembrolizumab
BioNTech SE
Phase 2/3
358
Coimbra, Lisbon
2021-01-07
Active, closed
A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder
NCT04658862Urinary Bladder Neoplasms
DrugsTAR-200·Cetrelimab·Gemcitabine·Cisplatin
Janssen Research & Development, LLC
Phase 3
518
Almada, Coimbra, Lisbon, Porto
2020-12-07
Recruiting
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
NCT04613596Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
DrugsAdagrasib·Pembrolizumab
Mirati Therapeutics Inc.
Phase 2/3
626
Coimbra, Guimarães, Lisbon, Porto, Vila Nova de Gaia
2020-12-02
Active, closed
A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)
NCT04546009Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
DrugsGiredestrant·Palbociclib·Letrozole
Hoffmann-La Roche
Phase 3
992
Coimbra, Lisbon, Porto
2020-10-09
Active, closed
Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
NCT04590963Squamous Cell Carcinoma of the Head and Neck
DrugsMonalizumab·Erbitux·Cetuximab
AstraZeneca
Phase 3
370
Coimbra, Porto, Vila Nova de Gaia
2020-10-02
Active, closed
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)
NCT04497844Prostatic Neoplasms
DrugsAbiraterone acetate·Prednisone
Janssen Research & Development, LLC
Phase 3
696
Almada, Coimbra, Lisbon
2020-09-23
Recruiting
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
NCT04307576Leukemia, Acute Lymphoblastic
DrugsInotuzumab Ozogamicin·Imatinib·Blinatumomab
Mats Heyman
Phase 3
6,430
Coimbra, Lisbon, Porto
2020-07-13
Active, closed
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
NCT04273945Pulmonary Arterial Hypertension
DrugMacitentan
Actelion
Phase 3
935
Coimbra, Lisbon
2020-06-30
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)
NCT04241185Urinary Bladder Neoplasms
DrugsMitomycin C·Fluorouracil·Adrucil·Keytruda
Merck Sharp & Dohme LLC
Phase 3
520
Loures, Coimbra, Lisbon
2020-05-19
Active, closed
HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
NCT04153149Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
DrugVutrisiran
Alnylam Pharmaceuticals
Phase 3
655
Lisbon, Coimbra, Faro, Guimarães, Porto
2019-11-26
Active, closed
Surveillance AFter Extremity Tumor surgerY
NCT03944798Soft Tissue Sarcoma, Lung Metastases
McMaster University
Not applicable
310
Coimbra
2019-11-19
Active, closed
A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis
NCT03958877Multiple Sclerosis, Relapsing-Remitting
DrugsPlegridy·Avonex
Biogen
Phase 3
152
Lisbon, Loures, Braga, Coimbra, Porto
2019-10-18
Recruiting
Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia
NCT04793919Acute Promyelocytic Leukemia
DrugsMylotarg·All-trans retinoic acid·Arsenic Trioxide·ATRA
Associazione Italiana Ematologia Oncologia Pediatrica
Phase 2
89
Coimbra, Lisbon, Porto
2019-10-09
Active, closed
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04033445Ulcerative Colitis
DrugGuselkumab
Janssen Research & Development, LLC
Phase 2/3
1,064
Coimbra, Porto, Santa Maria da Feira, Viseu
2019-09-26
By invitation
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
NCT03683186PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension
United Therapeutics
Phase 3
1,000
Almada, Coimbra, Lisbon, Porto
2019-09-23
Active, closed
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
NCT03950232Ulcerative Colitis
DrugEtrasimod
Pfizer
Phase 3
896
Vila Nova de Gaia, Coimbra, Guimarães, Porto
2019-09-05
Recruiting
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma
NCT04043494Lymphoblastic Lymphoma, Childhood
DrugsVindesine·Thioguanine·PEG-Asparaginase·Mercaptopurine
University Hospital Muenster
Phase 3
683
Coimbra, Lisbon, Porto
2019-08-23
Active, closed
Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine
NCT03836040Migraine
Amgen
Phase 3
457
Coimbra, Lisbon
2019-07-19
Active, closed
Observational Study of Patients Receiving Dupixent® for Atopic Dermatitis (AD)
NCT03992417Dermatitis Atopic
DrugDupilumab
Sanofi
Observational
955
Coimbra, Lisbon, Porto, Vila Nova de Gaia
2019-06-11
Active, closed
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
NCT03811561Diabetes Mellitus, Type 2
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,500
Senhora Da Hora, Matosinhos, Almada, Aveiro, Coimbra, Guimarães, Lisbon, Porto, Setúbal
2019-05-08
Active, closed
Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.
NCT03869892Metastatic Colorectal Cancer
DrugsTrifluridine/Tipiracil·Capecitabine
Institut de Recherches Internationales Servier
Phase 3
856
Almada, Coimbra, Lisbon, Loures, Porto
2019-03-21
Active, closed
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer
NCT03748641Castration-Resistant Prostatic Cancer
DrugsNiraparib·Abiraterone acetate·Prednisone
Janssen Research & Development, LLC
Phase 3
765
Coimbra, Lisbon, Porto
2019-01-25
Active, closed
Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS
NCT03650114Relapsing Multiple Sclerosis
Drugs13-valent pneumococcal conjugate vaccine·23-valent pneumococcal polysaccharide vaccine·Ofatumumab
Novartis Pharmaceuticals
Phase 3
1,882
Braga, Coimbra, Lisbon, Loures, Matosinhos Municipality, Porto, Santa Maria da Feira
2018-12-28
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)
NCT03711032High-risk Non-muscle Invasive Bladder Cancer
DrugsKeytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,397
Braga, Coimbra, Lisbon, Porto
2018-12-24
Active, closed
A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy
NCT03762850Immunoglobulin A Nephropathy
DrugsSparsentan·Irbesartan·Dapagliflozin
Travere Therapeutics, Inc.
Phase 3
406
Coimbra, Lisbon, Loures, Setúbal, Vila Nova de Gaia
2018-12-11
Active, closed
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).
NCT03653507Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
DrugsZolbetuximab·Capecitabine·Oxaliplatin
Astellas Pharma Global Development, Inc.
Phase 3
507
Braga, Coimbra, Guimarães, Lisbon, Porto, Santa Maria da Feira, Setúbal, Vila Real
2018-11-28
Active, closed
Post-Authorization Long-Term Safety Study of LUTATHERA
NCT03691064Neuroendocrine Tumors
DrugLutathera
Advanced Accelerator Applications
Observational
1,014
Coimbra
2018-11-28
Recruiting
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157Spinal Muscular Atrophy (SMA)
DrugZolgensma
Novartis Pharmaceuticals
Observational
700
Coimbra, Lisbon, Porto
2018-09-25
Active, closed
A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis
NCT03398135Ulcerative Colitis (UC)
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
1,242
Guimarães, Portimão, Santa Maria DA Feira, Almada, Coimbra, Lisbon, Porto, Viseu
2018-08-28
Active, closed
Pyruvate Kinase Deficiency Global Longitudinal Registry
NCT03481738Pyruvate Kinase Deficiency
Agios Pharmaceuticals, Inc.
Observational
500
Coimbra, Lisbon, Porto
2018-04-23
Active, closed
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
NCT03466411Crohn's Disease
DrugsGuselkumab 1·Guselkumab 2·Guselkumab 3·Ustekinumab
Janssen Research & Development, LLC
Phase 2/3
1,409
Braga, Coimbra, Guimarães, Portimão, Porto, Santa Maria da Feira
2018-04-13
Active, closed
Development of Novel Clinical Endpoints in Intermediate AMD
NCT03349801Age Related Macular Degeneration (AMD)
Frank G. Holz
Observational
718
Coimbra, Porto
2018-03-26
Recruiting
Randomization of Single vs Multiple Arterial Grafts
NCT03217006Coronary Artery Disease, Heart Diseases
Weill Medical College of Cornell University
Not applicable
4,300
Capuchos, Coimbra, Porto
2018-01-07
Active, closed
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC
NCT03395197mCRPC
Pfizer
Phase 3
1,054
Braga, Coimbra, Lisbon, Porto
2017-12-18
Active, closed
A Study to Investigate the Clinical Benefit of Isatuximab in Combination With Bortezomib, Lenalidomide and Dexamethasone in Adults With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
NCT03319667Plasma Cell Myeloma
DrugsVelcade·Isatuximab·Bortezomib·Lenalidomide
Sanofi
Phase 3
475
Braga, Coimbra, Lisbon, Porto
2017-12-07
Recruiting
Registry for Patients With X-Linked Hypophosphatemia
NCT03193476X-Linked Hypophosphatemia
Kyowa Kirin Pharmaceutical Development Ltd
Observational
1,489
Coimbra, Lisbon, Porto
2017-09-12
Active, closed
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
NCT03155997Breast Cancer
DrugAbemaciclib
Eli Lilly and Company
Phase 3
5,637
Coimbra, Lisbon, Porto
2017-07-12
Recruiting
SPECTA: Screening Cancer Patients for Efficient Clinical Trial Access
NCT02834884All Tumor Types
European Organisation for Research and Treatment of Cancer - EORTC
Observational
4,975
Coimbra, Lisbon, Porto, Vila Nova de Gaia
2017-05-03
Active, closed
Characterization of Potential Biomarkers of Eye Disease and Vision
NCT02500862Eye Disease
Association for Innovation and Biomedical Research on Light and Image
Observational
100
Coimbra
2015-09
Active, closed
A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial
NCT02320435Solid Tumors
DrugsPerjeta·Pertuzumab·Trastuzumab
Hoffmann-La Roche
Phase 3
154
Coimbra, Lisbon, Porto
2015-02-02
Active, closed
Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC
NCT01933932Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV
DrugsPegylated G-CSF·Pegfilgrastim·Selumetinib·Docetaxel
AstraZeneca
Phase 3
510
Amadora, Coimbra, Lisbon, Porto, Vila Nova de Gaia
2013-09-25
Recruiting
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053Huntington's Disease
CHDI Foundation, Inc.
Observational
35,000
Amadora, Coimbra, Lisbon, Porto
2012-07
Recruiting
Pompe Disease Registry Protocol
NCT00231400Glycogen Storage Disease Type II, Pompe Disease
Genzyme, a Sanofi Company
Observational
2,000
Coimbra, Lisbon
2004-09-15
Recruiting
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
NCT00358943Gaucher Disease, Cerebroside Lipidosis Syndrome, Glucocerebrosidase Deficiency Disease, Glucosylceramide Beta-Glucosidase Deficiency Disease
Genzyme, a Sanofi Company
Observational
12,000
Coimbra, Lisbon, Ponta Delgada
1991-04-01
Active, closed
RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease
NCT00002462Lymphoma
DrugsProcarbazine hydrochloride·Vinblastine Sulfate·Bleomycin·Doxorubicin Hydrochloride
European Organisation for Research and Treatment of Cancer - EORTC
Phase 3
615
Coimbra, Lisbon, Porto
1989-09
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Portuguese investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 3 October 2026. https://priyalifescience.com/clinical-trials-portugal/city/coimbra

Query this register directly
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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Portugal and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 1,100 studies in total at the last sync on 03 Oct 2026, 03:16 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 258 of those studies with a site in Coimbra.

How many clinical trials are recruiting in Coimbra?

129 of the 258 studies on this page are recruiting new participants as of the 03 Oct 2026, 03:16 UTC sync. A further 15 have not yet opened recruitment, 103 are active but closed to new participants, and 11 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Coimbra), 258 studies
PhaseStudiesRecruitingShare
Phase 31546859.7%
Not applicable381914.7%
Observational352213.6%
Phase 215125.8%
Phase 2/31254.7%
Phase 4331.2%
Phase 1/2100.4%

Most active sponsors

Lead sponsors with the most studies (Coimbra)
Lead sponsorStudiesRecruiting
University of Coimbra209
Novartis Pharmaceuticals168
Hoffmann-La Roche123
Boehringer Ingelheim96
Janssen Research & Development, LLC91
AbbVie85
Bristol-Myers Squibb86
Bayer74
Amgen63
Association for Innovation and Biomedical Research on Light and Image62
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.