Doppler-guided early mobilization: Individualized early mobilization after ischemic stroke, guided by hemodynamic assessment using carotid and transcranial Doppler ultrasound. The type and timing of mobilization are adjusted according to the presence of significant hemodynamic alterations.
Study summary
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.
In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients diagnosed with ischemic stroke aged 18 years or older;
* Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours;
* Informed consent obtained from the patient or legal representative.
Exclusion Criteria:
* Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4;
* Diagnosis of Transient Ischemic Attack (TIA);
* Severe hemodynamic instability, defined as:
* Systolic blood pressure \< 100 mmHg or \> 220 mmHg;
* Peripheral oxygen saturation \< 92%;
* Heart rate \< 40 or \> 112 beats per minute;
* Body temperature \> 38.5°C;
* Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale \< 10);
* Patients who underwent neurosurgical intervention within the past 30 days;
* Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer);
* Requirement for continuous monitoring or continuous intravenous drug infusion;
* Acute deep vein thrombosis/pulmonary embolism.
Primary outcome measure(s)
Functional status at 3 months after ischemic stroke — 3 months post-stroke Functional status assessment at 3 months after ischemic stroke, using the modified Rankin Scale (mRS), analyzed on an ordinal scale (0-6), to measure the degree of dependence/functional impairment.
Score ranges:
0-no residual symptoms (better outcome);
1. no significant disability;
2. slight disability;
3. moderate disability;
4. moderately severe disability;
5. severe disability;
6. death (worse outcome).
Trial sites (7)
Facility
City
Region
Status
University Hospital Rijeka
Rijeka
Croatia
Not Yet Recruiting
University Hospital Center Zagreb
Zagreb
Croatia
Not Yet Recruiting
Unidade Local de Saude de Coimbra
Coimbra
Coimbra District
Recruiting
Unidade Local de Saúde de Santa Maria
Lisbon
Lisbon District
Not Yet Recruiting
Unidade Local de Saude de Matosinhos
Porto
Matosinhos
Recruiting
Unidade Local de Saúde de São João
Porto
Porto District
Not Yet Recruiting
ULS São José
Lisbon
Portugal
Recruiting
More Unidade Local de Saúde de Coimbra, EPE trials in Portugal
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.
