The goal of this observational study is to learn about the effects of low dose aspirin in immunity Pregnant women taking aspirin for other reasons (preeclampsia prevention) will be studied. The main question it aims to answer is: evaluate the effect of LDA on the modulation of innate immunity cells (NK cells, monocytes, γδ T cells) and/or acquired immunity (B and T lymphocytes, Treg cells, Th cells).
Participants already taking intervention A as part of their regular medical care for RA will answer online survey questions about their joint pain for 5 years.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: - Singleton pregnancy
* Patients attending prenatal consultations at the Obstetrics Service A of CHUC, with the first consultation occurring before 14 weeks of gestation
* Gestational age determined by first-trimester ultrasound
* Study group: Women classified as high risk for PE according to clinical/historical criteria and the Fetal Medicine Foundation algorithm. LDA-naïve.
Exclusion Criteria: Multiple pregnancy
* Autoimmune diseases
* Prior use of LDA or other immunomodulatory medication before potential recruitment
* History of spontaneous miscarriages and/or medical termination of pregnancy
* Fetal malformation
Primary outcome measure(s)
Evaluate the effect of Low dose aspirin (LDA) on the modulation of immunity cells — 30 weeks innate immunity cells and/or acquired immunity
Th1, Th2, Treg, Th17, and Th1/17 — 30 weeks Absolute and relative frequencies in total lymphocytes (LY, x10⁹/L; %)
Trial sites (1)
Facility
City
Region
Status
Unidade Local de Saúde de Coimbra, E.P.E.
Coimbra
Coimbra District
Recruiting
More Unidade Local de Saúde de Coimbra, EPE trials in Portugal
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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