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Trackers› Clinical trials› Lisbon
Clinical trial register · Portugal

Clinical Trials in Lisbon, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Portugal and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 1100 matching records held by the registry are in this view. Synced 03 Oct 2026, 03:16 UTC
1100
Studies in scope
all four open statuses
535
Recruiting now
open to new participants
284
Lead sponsors
across recruiting studies
Top sites
Lisbon 683 Porto 541 Coimbra 258 Braga 180 Vila Nova de Gaia 108
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Recruitment status
Phase
Lead sponsor
AstraZeneca33 Janssen Research & Development, LLC32 Merck Sharp & Dohme LLC28 Hoffmann-La Roche27 Novartis Pharmaceuticals27
Site location
Lisbon683 Porto541 Coimbra258 Braga180 Vila Nova de Gaia108
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Trials with a site in Lisbon

683 of 1100 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Portugal
Start
Recruiting
A Beta-only IL-2 ImmunoTherapY Study
NCT05086692Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
DrugsKeytruda·Pembrolizumab
Medicenna Therapeutics, Inc.
Phase 1/2
115
Lisbon, Porto
2021-08-27
Active, closed
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
NCT04961996Early Breast Cancer
DrugGiredestrant
Hoffmann-La Roche
Phase 3
4,170
Lisbon, Guimarães, Loures, Porto, Vila Nova de Gaia, Vila Real
2021-08-27
Active, closed
A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy
NCT04923893Multiple Myeloma
DrugsCilta-cel·Bortezomib·Lenalidomide·Fludarabine
Janssen Research & Development, LLC
Phase 3
743
Lisbon, Porto
2021-08-19
Active, closed
A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728NASH - Nonalcoholic Steatohepatitis
Inventiva Pharma
Phase 3
1,000
Braga, Guimarães, Lisbon, Porto, Senhora da Hora, Vila Real
2021-08-19
By invitation
Selatogrel Outcome Study in Suspected Acute Myocardial Infarction
NCT04957719Acute Myocardial Infarction
Viatris Innovation GmbH
Phase 3
25,000
Aveiro, Coimbra, Leiria, Lisbon
2021-08-14
Recruiting
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
NCT04924075Pheochromocytoma/Paraganglioma, Pancreatic Neuroendocrine Tumor, Von Hippel-Lindau Disease, Advanced Gastrointestinal Stromal Tumor
DrugBelzutifan
Merck Sharp & Dohme LLC
Phase 2
355
Lisbon, Porto
2021-08-12
Active, closed
A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 Administration in Participants With Multiple Sclerosis
NCT05704361Multiple Sclerosis
Hoffmann-La Roche
Phase 1
119
Braga, Lisbon, Santa Maria da Feira
2021-08-11
Active, closed
Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin or Who Refuse Cisplatin
NCT04960709Muscle Invasive Bladder Cancer
DrugsEnfortumab Vedotin·Tremelimumab·Durvalumab
AstraZeneca
Phase 3
712
Braga, Coimbra, Faro, Lisbon
2021-08-05
Active, closed
Pulmonary Embolism International THrOmbolysis Study-3
NCT04430569Pulmonary Embolism
DrugAlteplase
Assistance Publique - Hôpitaux de Paris
Phase 3
800
Almada, Lisbon, Matosinhos Municipality, Porto, Setúbal
2021-08-04
Active, closed
The CROCO Study: CROhn's Disease COhort Study
NCT05420233Crohn Disease
GLSMED Learning Health S.A.
Not applicable
533
Almada, Lisbon, Loures
2021-08-01
Recruiting
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
European Foundation for Study of Chronic Liver Failure
Observational
3,000
Lisbon
2021-07-08
Active, closed
Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)
NCT04964934ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Anastrozole·Ribociclib·Abemaciclib
AstraZeneca
Phase 3
315
Guimarães, Lisbon, Loures, Porto, Vila Nova de Gaia
2021-06-30
Recruiting
CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting
NCT05002543Cardiac Valve Disease
Corcym S.r.l
Observational
2,150
Lisbon
2021-06-29
Active, closed
Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease
NCT04915755Neoplasms, Breast
DrugNiraparib
GlaxoSmithKline
Phase 3
40
Lisbon, Loures
2021-06-28
Active, closed
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
NCT04793958Advanced Colorectal Cancer, Metastatic Colorectal Cancer
DrugsAdagrasib·Erbitux·MFOLFOX6·Folfiri
Mirati Therapeutics Inc.
Phase 3
461
Braga, Lisbon, Porto
2021-06-24
Active, closed
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
NCT04739761Breast Cancer
DrugTrastuzumab deruxtecan
AstraZeneca
Phase 3
506
Lisbon, Porto
2021-06-22
Active, closed
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
NCT04895358Breast Neoplasms
DrugsLiposomal doxorubicin·Abraxane·Xeloda·Taxol
Merck Sharp & Dohme LLC
Phase 3
342
Lisbon, Matosinhos Municipality, Porto
2021-06-18
Recruiting
Metabolic Effects of Bariatric Arterial Embolization vs Bariatric Surgery
NCT05859022Obesity, Type2diabetes, Bariatric Surgery Candidate, Metabolic Disease
Universidade Nova de Lisboa
Not applicable
30
Lisbon
2021-06-16
Active, closed
A Clinical Study on Implants With TiUltra Technology and Associated Prosthetic Components
NCT04737421Marginal Bone Level Change
Nobel Biocare
Observational
1,000
Lisbon
2021-05-26
Recruiting
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
NCT04844606Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
DrugMirikizumab
Eli Lilly and Company
Phase 3
150
Braga, Lisbon, Porto
2021-05-26
Recruiting
Deep Brain Stimulation-Induced Mania in Parkinson's Disease
NCT05444907Mania, Parkinson Disease
Albino Maia
Observational
100
Lisbon
2021-05-25
Active, closed
A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread
NCT04810078Clear Cell Renal Cell Carcinoma
DrugsNivolumab and rHuPH20·Opdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
681
Coimbra, Lisbon
2021-05-21
Active, closed
Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)
NCT04544293Autoimmune Pulmonary Alveolar Proteinosis
DrugMolgramostim
Savara Inc.
Phase 3
164
Lisbon, Porto
2021-05-19
Recruiting
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
NCT07218029Pulmonary Arterial Hypertension
DrugSotatercept
Merck Sharp & Dohme LLC
Phase 3
815
Almada, Lisbon
2021-05-12
By invitation
Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM
NCT04848506Symptomatic Hypertrophic Cardiomyopathy (HCM)
DrugAficamten
Cytokinetics
Phase 2/3
900
Aveiro, Lisbon
2021-05-06
Active, closed
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
NCT04873362Breast Cancer
DrugsTrastuzumab emtansine·Herceptin·Tecentriq·Trastuzumab
Hoffmann-La Roche
Phase 3
1,188
Lisbon, Loures, Porto
2021-05-04
Active, closed
DiamondTemp Global Registry
NCT04735016Arrhythmia
Medtronic Cardiac Ablation Solutions
Observational
545
Lisbon
2021-04-22
Active, closed
Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
NCT04700124Bladder Cancer
DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin
Merck Sharp & Dohme LLC
Phase 3
808
Coimbra, Lisbon, Porto
2021-04-21
Active, closed
A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment
NCT04576156Myelofibrosis
DrugImetelstat sodium
Geron Corporation
Phase 3
327
Lisbon
2021-04-12
Active, closed
Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)
NCT04662255Lymphoma, Mantle-Cell
DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib
Loxo Oncology, Inc.
Phase 3
500
Lisbon
2021-04-08
Active, closed
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
NCT04822181Non-alcoholic Steatohepatitis
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,205
Senhora Da Hora, Matosinhos, Almada, Aveiro, Braga, Guarda, Guimarães, Lisbon, Porto
2021-04-01
Active, closed
Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in Pediatric PID Patients (KIDCARES10)
NCT04944979Primary Immunodeficiency Disease
DrugKedrion IVIG
Kedrion S.p.A.
Phase 3
30
Lisbon, Porto
2021-03-31
Recruiting
HepatoPredict Prognostic Tool for the Decision of Liver Transplant in Hepatocellular Carcinoma
NCT04499833Hepatocellular Carcinoma, Scirrhous, Recurrence Tumor
Centro Hospitalar de Lisboa Central
Not applicable
40
Lisbon
2021-03-25
Active, closed
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
NCT04586010Relapsing Multiple Sclerosis
DrugsFenebrutinib·Teriflunomide
Hoffmann-La Roche
Phase 3
746
Braga, Coimbra, Lisbon, Porto, Santa Maria da Feira
2021-03-17
Active, closed
SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity
NCT04775082Obesity
DrugLiraglutide
Novo Nordisk A/S
Phase 3
78
Lisbon, Porto
2021-03-04
Recruiting
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
NCT04710576Chronic Graft-versus-host-disease
DrugAxatilimab
Syndax Pharmaceuticals
Phase 2
296
Lisbon, Porto
2021-03-04
Active, closed
LifeSprout Lumina™ Study in the Treatment of Nasolabial Folds
NCT04839484Nasolabial Fold
LifeSprout, Inc.
Not applicable
118
Lisbon
2021-03-02
Active, closed
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
DrugsAdagrasib·Taxotere·Docetaxel
Mirati Therapeutics Inc.
Phase 3
453
Almada, Braga, Coimbra, Guimarães, Lisbon, Loures, Porto, Santa Maria da Feira
2021-02-23
Recruiting
Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL
NCT04502394Diffuse Large B Cell Lymphoma, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma
DrugsNavtemadlin·Acalabrutinib
Kartos Therapeutics, Inc.
Phase 1/2
84
Braga, Lisbon, Porto, Vila Nova de Gaia
2021-02-23
Active, closed
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
NCT05388708Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
University of Michigan
Observational
550
Lisbon
2021-02-04
Recruiting
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
NCT03127267Amyotrophic Lateral Sclerosis
DrugsMasitinib·Riluzole
AB Science
Phase 3
495
Lisbon
2021-02-02
Active, closed
A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
NCT04711252ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Anastrozole·Palbociclib
AstraZeneca
Phase 3
1,371
Braga, Guimarães, Lisbon, Loures, Porto, Vila Nova de Gaia
2021-01-28
Active, closed
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
NCT04534205Unresectable Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
DrugPembrolizumab
BioNTech SE
Phase 2/3
358
Coimbra, Lisbon
2021-01-07
Recruiting
Secukinumab Open Label Roll-over Extension Protocol
NCT04638647Autoimmunity, Inflammation
DrugSecukinumab
Novartis Pharmaceuticals
Phase 4
1,000
Lisbon
2020-12-22
Active, closed
A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy
NCT04640623Urinary Bladder Neoplasms
DrugsTAR-200·Cetrelimab
Janssen Research & Development, LLC
Phase 2
220
Almada, Aveiro, Guimarães, Lisbon, Loures, Porto, Vila Nova de Gaia, Vila Real
2020-12-18
Active, closed
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
NCT04624204Small Cell Lung Cancer
DrugsOlaparib·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
672
Lisbon, Porto
2020-12-08
Active, closed
A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder
NCT04658862Urinary Bladder Neoplasms
DrugsTAR-200·Cetrelimab·Gemcitabine·Cisplatin
Janssen Research & Development, LLC
Phase 3
518
Almada, Coimbra, Lisbon, Porto
2020-12-07
Active, closed
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
NCT04622319HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer
DrugsTrastuzumab emtansine·Trastuzumab deruxtecan
Daiichi Sankyo
Phase 3
1,600
Guimarães, Lisbon, Loures, Matosinhos Municipality, Porto, Vila Nova de Gaia
2020-12-04
Active, closed
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
NCT04548999Multiple Sclerosis
DrugsOcrelizumab·Methylprednisolone
Hoffmann-La Roche
Phase 3
769
Braga, Lisbon, Porto
2020-12-03
Active, closed
Assessment of the Axone Micro Quadripolar Lead for Enhanced Cardiac Resynchronization Therapy
NCT04463641Heart Failure, Cardiac Resynchronization Therapy
MicroPort CRM
Not applicable
92
Lisbon, Porto
2020-12-03
Recruiting
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
NCT04613596Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
DrugsAdagrasib·Pembrolizumab
Mirati Therapeutics Inc.
Phase 2/3
626
Coimbra, Guimarães, Lisbon, Porto, Vila Nova de Gaia
2020-12-02
Active, closed
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
NCT04544436Multiple Sclerosis
DrugsOcrelizumab·Methylprednisolone
Hoffmann-La Roche
Phase 3
864
Braga, Lisbon
2020-11-26
Recruiting
ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)
NCT04561518Transthyretin-Mediated Amyloidosis, ATTR Amyloidosis
Alnylam Pharmaceuticals
Observational
1,500
Lisbon, Porto
2020-11-23
Recruiting
Induction Chemotherapy for Locally Recurrent Rectal Cancer
NCT04389086Recurrent Rectal Cancer
DrugsFolfiri·Folfox
Catharina Ziekenhuis Eindhoven
Phase 3
364
Lisbon
2020-11-13
Active, closed
A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer
NCT04557059Prostatic Neoplasms
DrugsLhrha·Apalutamide
Janssen Pharmaceutica N.V., Belgium
Phase 3
691
Lisbon, Porto, Santa Maria da Feira
2020-11-12
Recruiting
LANDMARK Trial: a Randomised Controlled Trial of Myval THV
NCT04275726Aortic Valve Stenosis
Meril Life Sciences Pvt. Ltd.
Not applicable
988
Carnaxide, Lisbon, Porto
2020-11-04
Recruiting
The AFteR Registry - Follow-up Study to Monitor the Efficacy and Safety of the Occlutech AFR in Heart Failure Patients
NCT04405583Heart Failure
Occlutech International AB
Observational
150
Carnaxide, Lisbon
2020-10-28
Active, closed
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis
NCT04544449Multiple Sclerosis, Primary Progressive
DrugsFenebrutinib·Ocrelizumab
Hoffmann-La Roche
Phase 3
985
Braga, Lisbon, Porto
2020-10-26
By invitation
A Study Following Males With Haemophilia A on Prophylaxis With Esperoct®
NCT04574076Haemophilia A
DrugTuroctocog alfa pegol
Novo Nordisk A/S
Observational
60
Lisbon, Porto
2020-10-23
Active, closed
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
NCT04464226Cancer
DrugDarolutamide
Bayer
Phase 3
402
Almada, Lisbon, Porto
2020-10-20
Active, closed
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
NCT04446117Metastatic Prostate Cancer, Prostate Adenocarcinoma
DrugsZytiga·Xtandi·Abiraterone·Abiraterone acetate
Exelixis
Phase 3
575
Braga, Guimarães, Lisbon, Loures, Porto, Vila Real
2020-10-19
Active, closed
A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions
NCT04538664Carcinoma, Non-Small-Cell Lung
DrugsAmivantamab·Pemetrexed·Carboplatin
Janssen Research & Development, LLC
Phase 3
308
Lisbon, Porto, Vila Nova de Gaia
2020-10-13
Active, closed
A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)
NCT04546009Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
DrugsGiredestrant·Palbociclib·Letrozole
Hoffmann-La Roche
Phase 3
992
Coimbra, Lisbon, Porto
2020-10-09
Active, closed
A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)
NCT04529772Diffuse Large B-Cell Lymphoma
DrugsAcalabrutinib·Vincristine·Doxorubicin·Prednisone
Acerta Pharma BV
Phase 3
611
Braga, Lisbon, Matosinhos Municipality, Porto, Vila Nova de Gaia
2020-10-08
Active, closed
A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors
NCT04434092Paroxysmal Nocturnal Hemoglobinuria
DrugsCrovalimab·Eculizumab
Hoffmann-La Roche
Phase 3
210
Aveiro, Lisbon, Porto
2020-10-08
Active, closed
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04487080Carcinoma, Non-Small-Cell Lung
DrugsLazertinib·Amivantamab·Osimertinib
Janssen Research & Development, LLC
Phase 3
1,074
Lisbon, Porto
2020-09-30
Active, closed
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)
NCT04497844Prostatic Neoplasms
DrugsAbiraterone acetate·Prednisone
Janssen Research & Development, LLC
Phase 3
696
Almada, Coimbra, Lisbon
2020-09-23
Recruiting
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
NCT04625907Rhabdomyosarcoma
DrugsActinomycin-D·Dactinomycin·Ifosfamide·Vinorelbine
University of Birmingham
Phase 1/2
1,672
Lisbon
2020-09-17
Active, closed
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib
NCT04421963Ovarian Cancer, Breast Cancer
DrugOlaparib
AstraZeneca
Phase 3
185
Lisbon, Porto
2020-08-04
Active, closed
Personalized Therapy Study - HFRS (TriageHF) Post Approval Study
NCT04489225Heart Failure
Medtronic
Observational
2,200
Guimarães, Lisbon, Porto, Santarém
2020-08-01
Recruiting
Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program
NCT05040373Hereditary Transthyretin-mediated (hATTR) Amyloidosis, Polyneuropathy
Alnylam Pharmaceuticals
Observational
10
Lisbon
2020-08-01
Active, closed
Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)
NCT04496518Ventricular Tachycardia
Medtronic
Observational
2,200
Guimarães, Lisbon, Porto, Santarém
2020-08-01
Active, closed
Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer
NCT04494425Advanced or Metastatic Breast Cancer
DrugsTrastuzumab deruxtecan·Nab-paclitaxel·Capecitabine·Paclitaxel
AstraZeneca
Phase 3
866
Lisbon
2020-07-24
Recruiting
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
NCT04307576Leukemia, Acute Lymphoblastic
DrugsInotuzumab Ozogamicin·Imatinib·Blinatumomab
Mats Heyman
Phase 3
6,430
Coimbra, Lisbon, Porto
2020-07-13
Active, closed
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
NCT04273945Pulmonary Arterial Hypertension
DrugMacitentan
Actelion
Phase 3
935
Coimbra, Lisbon
2020-06-30
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)
NCT04241185Urinary Bladder Neoplasms
DrugsMitomycin C·Fluorouracil·Adrucil·Keytruda
Merck Sharp & Dohme LLC
Phase 3
520
Loures, Coimbra, Lisbon
2020-05-19
Recruiting
In Vivo Cortical Excitability Modulation in Major Depressive Disorder
NCT05441969Major Depressive Disorder
Fundacao Champalimaud
Observational
90
Lisbon
2020-05-19
Recruiting
EORTC Metastatic Breast Cancer Module Development
NCT07806266Metastatic Beast Cancer
University of Leeds
Observational
568
Lisbon
2020-05-01
Active, closed
A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer
NCT04214288Advanced ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Fulvestrant
AstraZeneca
Phase 2
240
Almada, Lisbon
2020-04-22
Recruiting
Randomised Evaluation of COVID-19 Therapy
NCT04381936Pneumonia
DrugsConvalescent plasma·Sotrovimab·Lopinavir / Ritonavir·Molnupiravir
University of Oxford
Phase 3
70,000
Lisbon
2020-03-19
Recruiting
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT04221542Prostate Cancer
DrugsXaluritamig·Abiraterone·Enzalutamide
Amgen
Phase 1
479
Lisbon, Porto
2020-03-04
Active, closed
Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Non-small Cell Lung Cancer (NSCLC), Ovarian Cancer, or Breast Cancer
NCT03937154Chemotherapy-induced Thrombocytopenia
DrugsNplate·Romiplostim
Amgen
Phase 3
145
Lisbon, Matosinhos Municipality, Porto
2020-02-26
Active, closed
A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
NCT04191499Breast Cancer
DrugsInavolisib·Palbociclib·Fulvestrant
Hoffmann-La Roche
Phase 2/3
325
Lisbon, Porto
2020-01-29
Active, closed
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
NCT04175600Hypertension, Pulmonary
DrugSelexipag
Actelion
Phase 3
138
Lisbon, Porto
2020-01-16
Active, closed
TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations
NCT04129502Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
DrugsMobocertinib·Pemetrexed·Cisplatin·Carboplatin
Takeda
Phase 3
354
Santa Maria da Feira, Vila Nova de Gaia, Lisbon, Porto
2020-01-10
Recruiting
Terumo Aortic Global Endovascular Registry
NCT04246463Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery
Vascutek Ltd.
Observational
1,000
Lisbon, Porto
2019-12-17
Active, closed
HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
NCT04153149Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
DrugVutrisiran
Alnylam Pharmaceuticals
Phase 3
655
Lisbon, Coimbra, Faro, Guimarães, Porto
2019-11-26
Recruiting
Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs)
NCT04075084Tachycardia, Atrial Fibrillation, Syncope, Bradycardia
Biotronik SE & Co. KG
Observational
1,400
Guimarães, Lisbon
2019-10-28
Active, closed
A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis
NCT03958877Multiple Sclerosis, Relapsing-Remitting
DrugsPlegridy·Avonex
Biogen
Phase 3
152
Lisbon, Loures, Braga, Coimbra, Porto
2019-10-18
Recruiting
Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia
NCT04793919Acute Promyelocytic Leukemia
DrugsMylotarg·All-trans retinoic acid·Arsenic Trioxide·ATRA
Associazione Italiana Ematologia Oncologia Pediatrica
Phase 2
89
Coimbra, Lisbon, Porto
2019-10-09
Active, closed
SyncAV Post-Market Trial
NCT04100148Congestive Heart Failure
Abbott Medical Devices
Not applicable
1,686
Lisbon
2019-10-03
Recruiting
Reinforcement Learning and Obsessive-compulsive Disorder: Exploring the Role of the Orbitofrontal Cortex
NCT06566781Obsessive-Compulsive Disorder
Fundacao Champalimaud
Observational
230
Lisbon
2019-10-01
Active, closed
MALIBU Trial - Combination of Ibrutinib and Rituximab in Untreated Marginal Zone Lymphomas
NCT03697512Marginal Zone Lymphoma, Nodal Marginal Zone Lymphoma, Splenic Marginal Zone Lymphoma
DrugsIbrutinib·Rituximab
International Extranodal Lymphoma Study Group (IELSG)
Phase 2
175
Lisbon
2019-09-27
By invitation
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
NCT03683186PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension
United Therapeutics
Phase 3
1,000
Almada, Coimbra, Lisbon, Porto
2019-09-23
Recruiting
Stroke Thrombectomy and Aneurysm Registry
NCT04994756Stroke, Thromboses, Intracranial, Aneurysm, Brain
Medical University of South Carolina
Observational
40,000
Lisbon
2019-09-17
Active, closed
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
NCT03844048Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, Multiple Myeloma, Non-Hodgkin's Lymphoma
DrugsVenclexta·Venetoclax
AbbVie
Phase 3
165
Lisbon
2019-09-06
Recruiting
Spine Bone Cements Outcomes - Post Market Follow-up
NCT06367582Vertebral Fracture, Compression Fracture, Osteoporotic Fractures
Teknimed
Observational
500
Lisbon
2019-09-04
Recruiting
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma
NCT04043494Lymphoblastic Lymphoma, Childhood
DrugsVindesine·Thioguanine·PEG-Asparaginase·Mercaptopurine
University Hospital Muenster
Phase 3
683
Coimbra, Lisbon, Porto
2019-08-23
Active, closed
A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation
NCT04002297Mantle Cell Lymphoma; Non-Hodgkin Lymphoma
DrugsBendamustine·Zanubrutinib·Rituximab
BeOne Medicines
Phase 3
510
Lisbon, Porto
2019-08-20
Active, closed
Observational Evaluation of Atopic Dermatitis in Pediatric Patients
NCT03687359Dermatitis Atopic
Sanofi
Observational
1,860
Braga, Lisbon, Porto
2019-08-15
Recruiting
Pan Tumor Rollover Study
NCT03899155Cancer
DrugsRucaparib·Sunitinib·Relatlimab·Trametinib
Bristol-Myers Squibb
Phase 2
1,500
Lisbon, Porto
2019-08-09
Active, closed
Very Early PET-response Adapted Targeted Therapy for Advanced Hodgkin Lymphoma: a Single -Arm Phase II Study
NCT03517137Advanced Hodgkin Lymphoma
DrugsVinblastine·Brentuximab Vedotin·Dacarbazine·Adriamycin
European Organisation for Research and Treatment of Cancer - EORTC
Phase 2
150
Lisbon
2019-08-01
Active, closed
Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine
NCT03836040Migraine
Amgen
Phase 3
457
Coimbra, Lisbon
2019-07-19
Active, closed
Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
NCT03997123Triple Negative Breast Neoplasms
DrugsCapivasertib·Paclitaxel
AstraZeneca
Phase 3
923
Lisbon, Porto
2019-06-25
Active, closed
A Study of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Participants With Advanced Kidney Cancer
NCT03873402Renal Cell Carcinoma
DrugsYervoy·Opdivo·Ipilimumab·Nivolumab
Bristol-Myers Squibb
Phase 3
437
Lisbon
2019-06-21
Active, closed
Adjuvant Palbociclib in Elderly Patients With Breast Cancer
NCT03609047Breast Cancer Stage II, Breast Cancer Stage III
DrugsDoxorubicin/cyclophosphamide·Palbociclib·Paclitaxel
European Organisation for Research and Treatment of Cancer - EORTC
Phase 2
366
Lisbon, Porto
2019-06-14
Active, closed
Observational Study of Patients Receiving Dupixent® for Atopic Dermatitis (AD)
NCT03992417Dermatitis Atopic
DrugDupilumab
Sanofi
Observational
955
Coimbra, Lisbon, Porto, Vila Nova de Gaia
2019-06-11
Recruiting
Single-Dose Image-Guided Radiotherapy With Urethral Sparing and DIL Boost for Intermediate-Risk Prostate Cancer (PROSINT II)
NCT04035642Prostate Cancer
Fundacao Champalimaud
Not applicable
200
Lisbon
2019-06-01
Active, closed
A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants
NCT03253263Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Intraventricular Hemorrhage, Retinopathy of Prematurity (ROP)
OHB Neonatology Ltd.
Phase 2
295
Almada, Lisbon, Porto
2019-05-09
Active, closed
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
NCT03811561Diabetes Mellitus, Type 2
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,500
Senhora Da Hora, Matosinhos, Almada, Aveiro, Coimbra, Guimarães, Lisbon, Porto, Setúbal
2019-05-08
By invitation
A Study Following Males With Haemophilia B on Prophylaxis With Refixia/REBINYN
NCT03745924Haemophilia B
DrugNonacog beta pegol
Novo Nordisk A/S
Observational
60
Lisbon
2019-04-01
Active, closed
A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy
NCT03675308Psoriatic Arthritis
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
964
Vila Nova de Gaia, Ponte de Lima, Aveiro, Braga, Lisbon
2019-03-25
Active, closed
Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.
NCT03869892Metastatic Colorectal Cancer
DrugsTrifluridine/Tipiracil·Capecitabine
Institut de Recherches Internationales Servier
Phase 3
856
Almada, Coimbra, Lisbon, Loures, Porto
2019-03-21
Active, closed
Full Arch Rehabilitations Through the Contemporary All-on-4 Concept
NCT04769921Edentulous Jaw
Malo Clinic
Observational
43
Lisbon
2019-02-19
Active, closed
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer
NCT03748641Castration-Resistant Prostatic Cancer
DrugsNiraparib·Abiraterone acetate·Prednisone
Janssen Research & Development, LLC
Phase 3
765
Coimbra, Lisbon, Porto
2019-01-25
Active, closed
9-ING-41 in Patients With Advanced Cancers
NCT03678883Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer
DrugsCCNU·Lomustine·Abraxane·Adriamycin
Actuate Therapeutics Inc.
Phase 2
350
Lisbon, Porto
2019-01-04
Active, closed
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
NCT03682536Myelodysplastic Syndromes
DrugsEpoetin Alfa·Luspatercept
Celgene
Phase 3
363
Beja, Braga, Lisbon, Porto, Setúbal
2019-01-02
Active, closed
Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS
NCT03650114Relapsing Multiple Sclerosis
Drugs13-valent pneumococcal conjugate vaccine·23-valent pneumococcal polysaccharide vaccine·Ofatumumab
Novartis Pharmaceuticals
Phase 3
1,882
Braga, Coimbra, Lisbon, Loures, Matosinhos Municipality, Porto, Santa Maria da Feira
2018-12-28
Active, closed
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
NCT03725059Breast Cancer
DrugsEpirubicin·Adriamycin·Cytoxan·Taxol
Merck Sharp & Dohme LLC
Phase 3
1,240
Lisboa, Lisbon, Porto
2018-12-27
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)
NCT03711032High-risk Non-muscle Invasive Bladder Cancer
DrugsKeytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,397
Braga, Coimbra, Lisbon, Porto
2018-12-24
Active, closed
Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)
NCT03765918Head and Neck Neoplasms
DrugsKeytruda·Cisplatin·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
714
Braga, Lisbon, Porto
2018-12-17
Active, closed
A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy
NCT03762850Immunoglobulin A Nephropathy
DrugsSparsentan·Irbesartan·Dapagliflozin
Travere Therapeutics, Inc.
Phase 3
406
Coimbra, Lisbon, Loures, Setúbal, Vila Nova de Gaia
2018-12-11
Active, closed
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).
NCT03653507Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
DrugsZolbetuximab·Capecitabine·Oxaliplatin
Astellas Pharma Global Development, Inc.
Phase 3
507
Braga, Coimbra, Guimarães, Lisbon, Porto, Santa Maria da Feira, Setúbal, Vila Real
2018-11-28
Active, closed
Registry of Patients With Acute/Subacute Type B Aortic Dissection Treated by Means of the STABILISE Technique (STABILISE)
NCT03707743Aortic Dissection
IRCCS San Raffaele
Observational
200
Lisbon
2018-10-30
Recruiting
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157Spinal Muscular Atrophy (SMA)
DrugZolgensma
Novartis Pharmaceuticals
Observational
700
Coimbra, Lisbon, Porto
2018-09-25
Active, closed
A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis
NCT03398135Ulcerative Colitis (UC)
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
1,242
Guimarães, Portimão, Santa Maria DA Feira, Almada, Coimbra, Lisbon, Porto, Viseu
2018-08-28
Recruiting
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
NCT03486873Solid Tumors, Hematologic Malignancies
DrugsPembrolizumab/Favezelimab·) Berahyaluronidase alfa·Olaparib·Lenvatinib
Merck Sharp & Dohme LLC
Phase 3
3,500
Lisbon, Porto
2018-08-21
Recruiting
A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS)
NCT02991469Juvenile Idiopathic Arthritis
DrugSarilumab
Sanofi
Phase 2
51
Lisbon
2018-08-09
Active, closed
Observation of Clinical Routine Care for Heart Failure Patients Implanted With BIOTRONIK CRT Devices
NCT03366545Heart Failure
Biotronik SE & Co. KG
Observational
3,030
Carnaxide, Evora, Lisbon, Porto
2018-05-14
Active, closed
A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors
NCT03530397Selected Advanced Solid Tumors
DrugsVolrustomig·Nab-paclitaxel·Pemetrexed·Paclitaxel
MedImmune LLC
Phase 1
400
Lisbon, Porto
2018-04-24
Active, closed
Pyruvate Kinase Deficiency Global Longitudinal Registry
NCT03481738Pyruvate Kinase Deficiency
Agios Pharmaceuticals, Inc.
Observational
500
Coimbra, Lisbon, Porto
2018-04-23
Active, closed
A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
NCT03105102Crohn's Disease
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
1,336
Guimarães, Portimão, Lisbon, Santa Maria DA Feira, Almada, Faro, Loures, Porto
2018-04-09
Active, closed
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations
NCT03390504Urothelial Cancer
DrugsVinflunine·Erdafitinib·Docetaxel·Pembrolizumab
Janssen Research & Development, LLC
Phase 3
629
Lisbon, Porto
2018-03-23
Active, closed
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
NCT03345823Crohn's Disease
DrugUpadacitinib
AbbVie
Phase 3
747
Guimarães, Lisbon, Almada, Ponte de Lima, Porto
2018-03-21
Active, closed
To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.
NCT03330847Metastatic Triple Negative Breast Cancer
DrugCeralasertib
AstraZeneca
Phase 2
273
Lisbon, Loures, Porto, Vila Nova de Gaia
2018-03-07
Active, closed
AMPLATZER PFO Occluder Post Approval Study
NCT03309332Stroke, Patent Foramen Ovale
Abbott Medical Devices
Not applicable
1,214
Lisbon
2018-01-31
Active, closed
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC
NCT03395197mCRPC
Pfizer
Phase 3
1,054
Braga, Coimbra, Lisbon, Porto
2017-12-18
Active, closed
A Study to Investigate the Clinical Benefit of Isatuximab in Combination With Bortezomib, Lenalidomide and Dexamethasone in Adults With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
NCT03319667Plasma Cell Myeloma
DrugsVelcade·Isatuximab·Bortezomib·Lenalidomide
Sanofi
Phase 3
475
Braga, Coimbra, Lisbon, Porto
2017-12-07
Active, closed
Endurant CHevAr New Indication Trial: ENCHANT
NCT03320252AAA - Abdominal Aortic Aneurysm
Medtronic Cardiovascular
Observational
150
Lisbon
2017-10-26
Active, closed
A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
NCT03148418Cancer
DrugsTecentriq·Avastin·Atezolizumab·Bevacizumab
Hoffmann-La Roche
Phase 3
382
Lisbon, Porto
2017-09-20
Recruiting
Registry for Patients With X-Linked Hypophosphatemia
NCT03193476X-Linked Hypophosphatemia
Kyowa Kirin Pharmaceutical Development Ltd
Observational
1,489
Coimbra, Lisbon, Porto
2017-09-12
Recruiting
International Study for Treatment of High Risk Childhood Relapsed ALL 2010
NCT03590171Acute Lymphoblastic Leukemia (ALL)
DrugBortezomib
Charite University, Berlin, Germany
Phase 2
250
Lisbon
2017-09-01
Active, closed
Personalized Therapy Study - Attain Stability Quad Post-Approval Study
NCT04024943Heart Failure
Medtronic
Observational
1,092
Guimarães, Lisbon, Porto, Santarém
2017-08-21
Active, closed
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
NCT03155997Breast Cancer
DrugAbemaciclib
Eli Lilly and Company
Phase 3
5,637
Coimbra, Lisbon, Porto
2017-07-12
Active, closed
Chemotherapy-free Trastuzumab and Pertuzumab in HER2-positive Breast Cancer: FDG-PET Response-adapted Strategy.
NCT03161353Breast Cancer
DrugsPerjeta·Herceptin·Tamoxifen·Pertuzumab
MedSIR
Phase 2
377
Guimarães, Lisbon, Porto, Vila Real
2017-06-26
Active, closed
Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer
NCT02947685HER-2 Positive Breast Cancer, Estrogen Receptor Positive Breast Cancer
DrugsPerjeta·Herceptin·Exemestane·Anastrozole
Alliance Foundation Trials, LLC.
Phase 3
518
Lisbon, Loures, Porto
2017-06-21
Recruiting
SPECTA: Screening Cancer Patients for Efficient Clinical Trial Access
NCT02834884All Tumor Types
European Organisation for Research and Treatment of Cancer - EORTC
Observational
4,975
Coimbra, Lisbon, Porto, Vila Nova de Gaia
2017-05-03
Active, closed
A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)
NCT03006068Ulcerative Colitis (UC)
DrugUpadacitinib
AbbVie
Phase 3
950
Guimarães, Santa Maria DA Feira, Almada, Braga, Lisbon, Porto, Viana do Castelo
2017-01-31
Recruiting
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
NCT02855476Huntington's Disease
University College, London
Observational
2,500
Lisbon
2017-01-01
Active, closed
A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy
NCT02677922Leukemia, Myeloid, Acute
DrugsEnasidenib·Ivosidenib·Azacitidine
Celgene
Phase 1/2
130
Lisbon
2016-06-03
Recruiting
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
NCT02735707Community-acquired Pneumonia, Influenza, COVID-19
DrugsConvalescent plasma·Repagermanium·Telmisartan·Captopril
UMC Utrecht
Phase 3
20,000
Abrantes, Lisbon
2016-04-11
Active, closed
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
NCT02629159Rheumatoid Arthritis
DrugsHumira·Adalimumab·Upadacitinib
AbbVie
Phase 3
1,629
Lisbon, Vila Nova de Gaia, Braga, Porto, Viana do Castelo
2015-12-01
Active, closed
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
NCT02542293Non Small Cell Lung Carcinoma NSCLC
DrugsTremelimumab·Durvalumab·Pemetrexed·Gemcitabine
AstraZeneca
Phase 3
953
Amadora, Lisbon, Porto
2015-11-03
Active, closed
Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer
NCT02516241Urothelial Cancer
DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin
AstraZeneca
Phase 3
1,126
Lisbon, Loures, Porto
2015-11-02
Active, closed
PALbociclib CoLlaborative Adjuvant Study
NCT02513394Breast Cancer
DrugPalbociclib
Alliance Foundation Trials, LLC.
Phase 3
5,796
Lisbon, Porto
2015-08
Active, closed
Micra Transcatheter Pacing System Post-Approval Registry
NCT02536118Bradycardia
Medtronic
Observational
3,100
Lisbon
2015-07
Recruiting
The European NAFLD Registry
NCT04442334NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver
Newcastle University
Observational
10,000
Lisbon
2015-05-01
Recruiting
Surgery for Recurrent Glioblastoma
NCT02394626Glioblastoma
Insel Gruppe AG, University Hospital Bern
Phase 2
120
Lisbon
2015-05-01
Active, closed
CINC424A2X01B Rollover Protocol
NCT02386800Primary Myelofibrosis, Polycythemia Vera, Graft Versus Host Disease, Acute Myeloid Leukemia
DrugsJakavi·Ruxolitinib
Novartis Pharmaceuticals
Phase 4
279
Lisbon
2015-03-05
Active, closed
Attachment Inhibitor Comparison in Heavily Treatment Experienced Patients
NCT02362503HIV Infections
ViiV Healthcare
Phase 3
371
Lisbon
2015-02-23
Active, closed
A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial
NCT02320435Solid Tumors
DrugsPerjeta·Pertuzumab·Trastuzumab
Hoffmann-La Roche
Phase 3
154
Coimbra, Lisbon, Porto
2015-02-02
Active, closed
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer
NCT02308085Early Breast Cancer
ETOP IBCSG Partners Foundation
Not applicable
518
Lisbon
2014-12-04
Active, closed
Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer
NCT02032823Breast Cancer
DrugOlaparib
AstraZeneca
Phase 3
1,837
Lisbon, Loures, Porto
2014-04-22
Recruiting
AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer.
NCT02102165Metastatic Breast Cancer
Jules Bordet Institute
Not applicable
1,000
Lisbon
2014-04
Recruiting
Monolithic Zirconia Full-Mouth Implant Supported Rehabilitation Behavior
NCT01974362Endosseous Dental Implant Failure, Accident Caused by Broken Ceramic
Implantology Institute
Observational
90
Lisbon
2014-01
Active, closed
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome
NCT01934725Brain Infarction, Ischemic Stroke, Thrombosis, Foramen Ovale, Patent
SECRETO Study Consortium
Observational
1,200
Lisbon
2013-11
Active, closed
Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC
NCT01933932Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV
DrugsPegylated G-CSF·Pegfilgrastim·Selumetinib·Docetaxel
AstraZeneca
Phase 3
510
Amadora, Coimbra, Lisbon, Porto, Vila Nova de Gaia
2013-09-25
Active, closed
A Long-term Extension Study of PCI-32765 (Ibrutinib)
NCT01804686Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma
DrugIbrutinib
Janssen Research & Development, LLC
Phase 3
539
Lisbon, Porto
2013-09-09
Recruiting
Lysosomal Acid Lipase (LAL) Deficiency Registry
NCT01633489Lysosomal Acid Lipase Deficiency, Cholesterol Ester Storage Disease, Wolman Disease, Acid Cholesteryl Ester Hydrolase Deficiency, Type 2
Alexion Pharmaceuticals, Inc.
Observational
300
Guimarães, Lisbon
2013-05-30
Active, closed
An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis
NCT01357668Juvenile Idiopathic Arthritis
Bristol-Myers Squibb
Observational
800
Lisbon
2013-01-30
Active, closed
Randomized, Open-label, Two-arms, Phase III Comparative Study Assessing the Role of Involved Mediastinal Radiotherapy After Rituximab Containing Chemotherapy Regimens to Patients With Newly Diagnosed Primary Mediastinal Large B-Cell Lymphoma
NCT01599559Primary Mediastinal B-cell Lymphoma
International Extranodal Lymphoma Study Group (IELSG)
Not applicable
540
Lisbon
2012-10
Recruiting
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053Huntington's Disease
CHDI Foundation, Inc.
Observational
35,000
Amadora, Coimbra, Lisbon, Porto
2012-07
Recruiting
Product Surveillance Registry
NCT01524276Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders
Medtronic
Observational
100,000
Carnaxide, Creixomil, Lisbon, Porto, Santarém
2012-01
Active, closed
Male Breast Cancer: Understanding the Biology for Improved Patient Care
NCT01101425Breast Cancer
European Organisation for Research and Treatment of Cancer - EORTC
Observational
200
Lisbon, Porto
2010-12
Active, closed
Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy
NCT01223248Melanoma, Ovarian Cancer, Sarcoma, Bone
Memorial Sloan Kettering Cancer Center
Phase 3
220
Lisbon
2010-10
Active, closed
A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies
NCT00781612Neoplasm Metastasis
DrugsPerjeta·Trastuzumab emtansine·Herceptin·Tecentriq
Genentech, Inc.
Phase 2
378
Lisbon, Porto
2008-10-16
Active, closed
Psoriasis Longitudinal Assessment and Registry
NCT00508547Psoriasis
Janssen Scientific Affairs, LLC
Observational
20,167
Braga, Lisbon, Porto, Vila Nova de Gaia
2007-06-21
Recruiting
Pompe Disease Registry Protocol
NCT00231400Glycogen Storage Disease Type II, Pompe Disease
Genzyme, a Sanofi Company
Observational
2,000
Coimbra, Lisbon
2004-09-15
Recruiting
Fabry Disease Registry & Pregnancy Sub-registry
NCT00196742Fabry Disease
Genzyme, a Sanofi Company
Observational
9,000
Lisbon, Porto
2001-07-31
By invitation
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
NCT02699736HIV, Hepatitis B, Hepatitis C, AIDS
Copenhagen University Hospital, Rigshospitalet
Observational
23,000
Lisbon
1994-01
Recruiting
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
NCT00358943Gaucher Disease, Cerebroside Lipidosis Syndrome, Glucocerebrosidase Deficiency Disease, Glucosylceramide Beta-Glucosidase Deficiency Disease
Genzyme, a Sanofi Company
Observational
12,000
Coimbra, Lisbon, Ponta Delgada
1991-04-01
Active, closed
RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease
NCT00002462Lymphoma
DrugsProcarbazine hydrochloride·Vinblastine Sulfate·Bleomycin·Doxorubicin Hydrochloride
European Organisation for Research and Treatment of Cancer - EORTC
Phase 3
615
Coimbra, Lisbon, Porto
1989-09
Recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
NCT00271180Arrhythmia, Bradycardia, Heart Failure, Sinus Tachycardia
Medtronic
Observational
20,000
Carnaxide, Creixomil, Lisbon, Porto, Santarém
1983-01
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Portuguese investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 3 October 2026. https://priyalifescience.com/clinical-trials-portugal/city/lisbon?page=2

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Portugal and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 1,100 studies in total at the last sync on 03 Oct 2026, 03:16 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 683 of those studies with a site in Lisbon.

How many clinical trials are recruiting in Lisbon?

331 of the 683 studies on this page are recruiting new participants as of the 03 Oct 2026, 03:16 UTC sync. A further 29 have not yet opened recruitment, 303 are active but closed to new participants, and 20 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.