Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact
Priya Life Science Clinical trial register
TrackersDrugsComparisonsAPI
Trackers› Clinical trials› Ohio
Clinical trial register · United States · industry-sponsored

Clinical Trials in Ohio, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

Download CSV
Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca36 Novartis Pharmaceuticals28 Hoffmann-La Roche25 Merck Sharp & Dohme LLC20 GlaxoSmithKline19
State
California5290 Florida4430 Illinois2481 Georgia2368 Arizona2238
All 51 states
Target enrolment
to

Trials with a site in Ohio

1263 of 9118 studies
Download
Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Recruiting
A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancer
NCT05125016Metastatic Castration-resistant Prostate Cancer
DrugsNezastomig·REGN4336
Regeneron Pharmaceuticals
Phase 1/2
228
California, Connecticut, Kentucky, Maryland, New Jersey, New York, North Carolina, Ohio
2021-11-30
Recruiting
Pediatric Post-Approval Registry
NCT04457154Obstructive Sleep Apnea
Inspire Medical Systems, Inc.
Observational
60
Colorado, Georgia, North Carolina, Ohio, Pennsylvania, Texas, Virginia
2021-11-30
Recruiting
CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
NCT05143996Relapsed/Refractory Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
DrugCLN-049
Cullinan Therapeutics Inc.
Phase 1
60
Alabama, California, Florida, Georgia, Massachusetts, New York, North Carolina, Ohio
2021-11-18
Active, closed
A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer
NCT05091567Small-Cell Lung Cancer
DrugsLurbinectedin·Tecentriq·Etoposide·Atezolizumab
Hoffmann-La Roche
Phase 3
660
Georgia, Illinois, Maine, Massachusetts, Michigan, New York, Ohio, Rhode Island
2021-11-18
Recruiting
First in Human Study of TORL-1-23 in Participants With Advanced Cancer
NCT05103683Advanced Solid Tumor, Ovarian Cancer, Endometrial Cancer, NSCLC
DrugTORL-1-23
TORL Biotherapeutics, LLC
Phase 1
90
California, Kentucky, Minnesota, New York, Ohio, Texas, Virginia
2021-11-17
Recruiting
Knee Related Subchondral Bone Lesions Treated With IOBP
NCT05314608Subchondral Cyst
Arthrex, Inc.
Observational
100
Colorado, Florida, Maryland, Ohio, Pennsylvania
2021-11-17
Recruiting
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
NCT04819841Sickle Cell Disease
Kamau Therapeutics
Phase 1/2
15
California, Missouri, New York, Ohio
2021-11-15
Active, closed
Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia
NCT04994717Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL)
DrugBlinatumomab
Amgen
Phase 3
303
California, Florida, Ohio, South Carolina, Texas
2021-11-02
Active, closed
A Study of the Safety and Tolerability in Participants With PIK3CA-related Overgrowth Spectrum or Proteus Syndrome Who Are Being Treated With Miransertib (MK-7075) in Other Studies (MK-7075-006)
NCT04980872PIK3CA-Related Overgrowth Spectrum (PROS)/Proteus Syndrome (PS)
Merck Sharp & Dohme LLC
Phase 2
60
Georgia, Massachusetts, Ohio, Texas, Washington
2021-11-02
Active, closed
Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression
NCT05163041Advanced Solid Tumor
DrugNivolumab
BicycleTx Limited
Phase 1/2
200
Iowa, New York, Ohio, Pennsylvania, Texas, Virginia
2021-11-02
Active, closed
Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy
NCT05112237Cardiomyopathy
Tenaya Therapeutics
Observational
200
Arkansas, California, Colorado, Delaware, Florida, Missouri, New York, Ohio
2021-11-01
Recruiting
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
NCT04981119Solid Tumor, Adult, Colorectal Cancer, Non Small Cell Lung Cancer, Pancreatic Cancer
A2 Biotherapeutics Inc.
Observational
500
Arizona, California, Florida, Massachusetts, Minnesota, Missouri, New York, Ohio
2021-10-29
Active, closed
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus
NCT04963296Systemic Lupus Erythematosus
DrugsAcetaminophen/paracetamol·Diphenhydramine hydrochloride·Methylprednisolone·Obinutuzumab
Hoffmann-La Roche
Phase 3
303
Alabama, Arkansas, California, Florida, Michigan, New York, North Carolina, Ohio
2021-10-26
Active, closed
Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors
NCT04337177Solid Tumors, Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma
DrugsTemodal·Temodar·Temozolomide
Valent Technologies, LLC
Phase 1
20
Arizona, California, District of Columbia, Georgia, Indiana, Missouri, North Carolina, Ohio
2021-10-25
Active, closed
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
NCT04861259Atypical Hemolytic Uremic Syndrome
DrugCrovalimab
Hoffmann-La Roche
Phase 3
83
California, Colorado, Georgia, Missouri, Ohio, Texas
2021-10-22
Active, closed
A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors
NCT04857372Mesothelioma
Novartis Pharmaceuticals
Phase 1
137
California, Illinois, Massachusetts, Ohio, Texas
2021-10-21
By invitation
Multi-Center Clinical Database of Infants for the Investigation of Early Nutrition Biomarkers
NCT05049655Infant Development
ByHeart
Observational
2,000
Alabama, Arizona, Arkansas, Idaho, Ohio, South Carolina, Tennessee, Utah
2021-10-19
Active, closed
A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)
NCT05104866Breast Cancer
DrugsEribulin·Dato-DXd·Vinorelbine·Capecitabine
AstraZeneca
Phase 3
732
California, Florida, Georgia, Massachusetts, Michigan, New York, Ohio, Oregon
2021-10-18
Active, closed
Study of Vimseltinib for Tenosynovial Giant Cell Tumor
NCT05059262Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor, Diffuse
DrugVimseltinib
Deciphera Pharmaceuticals, LLC
Phase 3
123
California, Colorado, Kansas, Massachusetts, Minnesota, New York, North Carolina, Ohio
2021-10-14
Active, closed
A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma
NCT05083169Multiple Myeloma
DrugsTeclistamab·Pomalidomide·Bortezomib·Daratumumab
Janssen Research & Development, LLC
Phase 3
587
Alabama, California, Connecticut, Georgia, Massachusetts, Michigan, Ohio, Pennsylvania
2021-10-14
Active, closed
A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
NCT04931342Ovarian Cancer
DrugsCobimetinib·Ipatasertib·Giredestrant·Inavolisib
Hoffmann-La Roche
Phase 2
176
California, Missouri, North Carolina, Ohio, Oklahoma, Texas, Virginia, Washington
2021-10-07
Active, closed
A Phase 1/2/3 Study of UX701 Gene Therapy in Adults With Wilson Disease
NCT04884815Wilson Disease
Ultragenyx Pharmaceutical Inc
Phase 1/2
82
California, Illinois, Indiana, Massachusetts, Michigan, North Carolina, Ohio, Tennessee
2021-09-27
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors
NCT04774718ALK Fusion-positive Solid or CNS Tumors
DrugAlectinib
Hoffmann-La Roche
Phase 1/2
42
California, Florida, Michigan, Minnesota, New York, Ohio, Tennessee
2021-09-14
Recruiting
Helix Research Network
NCT06057181Genetic Predisposition to Disease, Genetics Disease
Helix, Inc
Observational
2,000,000
Indiana, Minnesota, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania
2021-09-13
Recruiting
Perform Humeral System Study
NCT05067543Osteoarthritis Shoulder, Avascular Necrosis, Post-traumatic Arthrosis of Other Joints, Shoulder Region, Rotator Cuff Tear Arthropathy
Stryker Trauma and Extremities
Observational
300
Kentucky, Minnesota, Missouri, Ohio, South Dakota, Utah
2021-09-12
Recruiting
Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation
NCT04890613Advanced Solid Tumor
Senhwa Biosciences, Inc.
Phase 1
52
California, Florida, Massachusetts, New York, Ohio, Pennsylvania
2021-09-08
Recruiting
Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib
NCT04486833Carcinoma, Non-Small Cell Lung
DrugsQuaratusugene ozeplasmid·Tagrisso·Osimertinib
Genprex, Inc.
Phase 1/2
158
California, Colorado, Illinois, Kentucky, Maryland, New Jersey, Ohio, Texas
2021-09-03
Recruiting
Freedom-1 Study for Chronic Knee Pain
NCT03877653Osteoarthritic Knee Pain
Curonix LLC
Not applicable
100
California, Colorado, Florida, Georgia, Nevada, Ohio, Texas
2021-09-01
Active, closed
Clinical Study for Treatment-naïve IOPD Babies to Evaluate Efficacy and Safety of ERT With Avalglucosidase Alfa
NCT04910776Glycogen Storage Disease Type II
DrugAvalglucosidase alfa
Sanofi
Phase 3
17
California, Minnesota, New York, North Carolina, Ohio, Washington
2021-09-01
Active, closed
Promoting Healing of Nerves Through Electrical Stimulation
NCT04662320Cubital Tunnel Syndrome, Nerve Compression, Nerve Injury, Ulnar Neuropathies
Checkpoint Surgical Inc.
Not applicable
100
California, Illinois, Missouri, Ohio, Wisconsin
2021-09-01
Active, closed
Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC
NCT04919811Non Small Cell Lung Cancer
DrugTaletrectinib
Nuvation Bio Inc.
Phase 2
217
California, Florida, Louisiana, Minnesota, New Jersey, Ohio, Tennessee, Texas
2021-09-01
Active, closed
NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers
NCT05020678Lymphoma, Non-Hodgkin, B-cell Acute Lymphoblastic Leukemia, Large B-cell Lymphoma, Mantle Cell Lymphoma
DrugNKX019
Nkarta, Inc.
Phase 1
150
Colorado, Ohio
2021-08-20
Active, closed
Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)
NCT04938817Small Cell Lung Carcinoma
DrugsMK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab·R-DXd
Merck Sharp & Dohme LLC
Phase 1/2
110
Arizona, Georgia, Indiana, Kentucky, Maryland, Nebraska, Ohio, Pennsylvania
2021-08-19
Active, closed
STOP Persistent AF PAS
NCT05005949Persistent Atrial Fibrillation
Medtronic Cardiac Ablation Solutions
Observational
400
Connecticut, Florida, Illinois, Michigan, Ohio, Texas
2021-08-19
Active, closed
Long-Term Follow-up of Subjects Who Were Treated With ST-920
NCT05039866Fabry Disease, Fabry Disease, Cardiac Variant
Sangamo Therapeutics
Observational
32
California, Florida, Georgia, Iowa, Minnesota, New York, Ohio, Virginia
2021-08-16
Active, closed
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
NCT04624230Ulcerative Colitis
DrugTofacitinib
Pfizer
Phase 3
118
California, Connecticut, Florida, Georgia, Massachusetts, New York, Ohio, Pennsylvania
2021-08-12
Active, closed
Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects With Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)
NCT05005975EPP, XLP
Tanabe Pharma America, Inc.
Phase 3
286
California, Florida, Massachusetts, Michigan, Missouri, New York, North Carolina, Ohio
2021-08-10
By invitation
IT Matters: The Erectile Restoration Registry
NCT04200937Erectile Dysfunction
Boston Scientific Corporation
Observational
450
California, Florida, Illinois, Indiana, Louisiana, Missouri, North Carolina, Ohio
2021-08-05
Active, closed
Evaluating the Clinical Effectiveness of a Patient-specific Silicone Stent
NCT05050591Pulmonary Disease, Chronic Obstructive
VisionAir Solutions
Not applicable
20
Minnesota, Ohio
2021-08-05
Recruiting
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
NCT04913285Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma
Pierre Fabre Medicament
Phase 1
400
California, Colorado, Florida, Minnesota, New Jersey, New York, Ohio, Tennessee
2021-08-04
Active, closed
MIRACLE of LIFE Study
NCT06074601Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane
Mirvie
Observational
10,000
California, Florida, Louisiana, Massachusetts, Missouri, Ohio, Pennsylvania, Texas
2021-08-01
Active, closed
A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD
NCT04691154Pulmonary Arterial Hypertension, Pulmonary Hypertension Due to Lung Diseases
Liquidia Technologies, Inc.
Phase 3
28
Arizona, California, Florida, New York, Ohio, Oregon, Texas
2021-08-01
Active, closed
Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria
NCT04747613Paroxysmal Nocturnal Hemoglobinuria
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
208
California, Florida, Georgia, New York, Ohio, South Carolina
2021-07-27
Active, closed
EFS of the CardioMech MVRS
NCT04820764Mitral Regurgitation
CardioMech AS
Not applicable
35
California, Illinois, Kansas, Minnesota, New York, North Carolina, Ohio, Tennessee
2021-07-27
Active, closed
Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
NCT04541108Solid Tumor
DrugsAZD9592·Sabestomig·Volrustomig·Rilvegostomig
Presage Biosciences
Phase EARLY_PHASE1
15
Louisiana, New York, North Carolina, Ohio, Oregon, Pennsylvania, South Carolina, Washington
2021-07-26
Active, closed
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 6 and 17 Years With Moderate to Severe Plaque Psoriasis Treated With Subcutaneous (SC) Injection of Risankizumab Who Have Completed Participation in Study M19-977
NCT04862286Psoriasis
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
132
Alabama, California, Florida, Illinois, Nevada, Ohio, South Carolina, West Virginia
2021-07-24
Active, closed
Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas
NCT05101148Neurofibromatosis Type 1
DrugSelumetinib
AstraZeneca
Phase 1
24
Minnesota, Ohio
2021-07-21
Recruiting
Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.
NCT04775745CLL/SLL, Waldenstrom Macroglobulinemia, Follicular Lymphoma, Diffuse Large B Cell Lymphoma
DrugRocbrutinib
Newave Pharmaceutical Inc
Phase 1
60
North Carolina, Ohio, Utah
2021-07-19
Active, closed
Triathlon All-Polyethylene Tibia Outcomes Study
NCT04636190Arthropathy of Knee, Replacement, Knee Arthritis
Stryker Orthopaedics
Not applicable
204
Michigan, New York, North Carolina, Ohio, Texas
2021-07-02
Active, closed
Ovarian Suppression Evaluating Subcutaneous Leuprolide Acetate in Breast Cancer
NCT04906395Breast Cancer
DrugsTOL2506·Tamoxifen·Exemestane·Anastrozole
Tolmar Inc.
Phase 3
250
California, Colorado, Illinois, Kentucky, Maryland, Nebraska, New York, Ohio
2021-07-01
Active, closed
Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting
NCT04900844Carotid Artery Stenosis
InspireMD
Not applicable
317
Florida, Louisiana, Michigan, Missouri, New York, North Carolina, Ohio, Pennsylvania
2021-07-01
Active, closed
Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test
NCT04635384Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
CareDx
Observational
307
California, Florida, Georgia, Massachusetts, Missouri, New York, Ohio, Oregon
2021-06-30
Recruiting
CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting
NCT05002543Cardiac Valve Disease
Corcym S.r.l
Observational
2,150
Indiana, Louisiana, Maine, North Carolina, Ohio, Pennsylvania
2021-06-29
Active, closed
Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial.
NCT04925024Hypoplastic Left Heart Syndrome
Longeveron Inc.
Phase 2
40
California, Colorado, Georgia, Illinois, Massachusetts, Nebraska, Ohio, Pennsylvania
2021-06-25
Active, closed
Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea
NCT04801771Down Syndrome, Obstructive Sleep Apnea
Inspire Medical Systems, Inc.
Not applicable
57
Georgia, Massachusetts, Ohio, Pennsylvania, Texas, Virginia, Wisconsin
2021-06-24
Active, closed
MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients
NCT04651634Head and Neck Squamous Cell Carcinoma, Oral Mucositis
DrugCCRT
MitoImmune Therapeutics
Phase 2
60
Arizona, California, Kansas, New York, North Carolina, Ohio
2021-06-21
Active, closed
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
NCT04768972Amyotrophic Lateral Sclerosis
Ionis Pharmaceuticals, Inc.
Phase 3
89
California, Maryland, Massachusetts, Missouri, New York, Ohio, Utah
2021-06-14
Active, closed
A Prospective Study to Observe & Describe Clinical Outcomes of Alglucosidase Alfa Treatment in Patients ≤6 Months of Age With Infantile-onset Pompe Disease (IOPD)
NCT04848779Glycogen Storage Disease Type II
DrugAlglucosidase alfa
Sanofi
Observational
16
New York, North Carolina, Ohio, Tennessee, Washington
2021-06-10
Recruiting
A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer
NCT04872166Advanced Solid Tumor, Metastatic Breast Cancer
DrugBTX-A51
Edgewood Oncology Inc.
Phase 1
112
Florida, Ohio, Tennessee, Texas
2021-06-07
Active, closed
Selective Internal Radiation Therapy (SIRT) Using SIR-Spheres® Y-90 Resin Microspheres on DoR & ORR in Unresectable Hepatocellular Carcinoma Patients
NCT04736121Unresectable Hepatocellular Carcinoma, BCLC Stage A Hepatocellular Carcinoma, BCLC Stage B Hepatocellular Carcinoma, BCLC Stage C Hepatocellular Carcinoma
Sirtex Medical
Not applicable
100
California, Florida, Georgia, Kansas, Massachusetts, New York, North Carolina, Ohio
2021-05-28
Recruiting
A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy
NCT04570423Solid Tumors, Lymphoma
Spectrum Pharmaceuticals, Inc
Phase 2
40
New York, North Carolina, Ohio, Texas
2021-05-20
Active, closed
A Study of SmartFlow Magnetic Resonance (MR) Compatible Ventricular Cannula for Administering Eladocagene Exuparvovec to Pediatric Participants
NCT04903288AADC Deficiency
PTC Therapeutics
Phase 2
13
Massachusetts, North Carolina, Ohio, Texas
2021-05-12
Active, closed
Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
NCT04675333Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
DrugsEvorpacept·Cisplatin/Carboplatin·Fluorouracil·Keytruda
ALX Oncology Inc.
Phase 2
172
California, Florida, Illinois, Kentucky, Maryland, New York, Ohio, Oregon
2021-05-10
Recruiting
A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies
NCT04830137Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Waldenstrom Macroglobulinemia (WM), Mantle Cell Lymphoma (MCL)
Nurix Therapeutics, Inc.
Phase 1
248
California, Colorado, Florida, Illinois, Maryland, New York, Ohio, Tennessee
2021-05-05
Active, closed
ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer
NCT04662580Metastatic Prostate Cancer
DrugsARX517·Apalutamide·Abiraterone acetate·Prednisone
Janssen Research & Development, LLC
Phase 1
183
California, Georgia, Indiana, Michigan, Missouri, Nebraska, New York, Ohio
2021-05-03
Active, closed
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
NCT04660344Muscle-invasive Bladder Cancer
DrugsTecentriq·Atezolizumab
Hoffmann-La Roche
Phase 3
761
Florida, Ohio, Pennsylvania
2021-05-03
Active, closed
A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice
NCT04475926Limb-girdle Muscular Dystrophy
Sarepta Therapeutics, Inc.
Observational
205
Arizona, Arkansas, California, Illinois, Ohio, Oregon, Pennsylvania, Texas
2021-04-22
Active, closed
Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum
NCT04589650PIK3CA-related Overgrowth Spectrum (PROS)
DrugAlpelisib
Novartis Pharmaceuticals
Phase 2
206
California, Colorado, Missouri, New York, North Carolina, Ohio, Pennsylvania, Texas
2021-04-19
Active, closed
A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML
NCT04730258Acute Myeloid Leukemia, Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, AML
DrugsCFI-400945·Azacitidine
Treadwell Therapeutics, Inc
Phase 1/2
72
California, Kentucky, New York, Ohio, Texas
2021-04-16
Active, closed
A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura
NCT04683003Thrombotic Thrombocytopenic Purpura (TTP)
DrugTAK-755
Takeda
Phase 3
77
Georgia, New York, North Carolina, Ohio, Oklahoma
2021-04-14
Active, closed
A Study Comparing Two Doses of AGTC-501 in Male Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (SKYLINE)
NCT06333249X-Linked Retinitis Pigmentosa
DrugRAAV2tYF-GRK1-RPGR
Beacon Therapeutics
Phase 2
14
Florida, Massachusetts, Ohio, Oregon, Texas
2021-04-13
Active, closed
A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment
NCT04576156Myelofibrosis
DrugImetelstat Sodium
Geron Corporation
Phase 3
327
California, Connecticut, Florida, Kentucky, New York, North Carolina, Ohio, South Dakota
2021-04-12
Active, closed
Study to Evaluate of EXG34217 in Patients With Telomere Biology Disorders With Bone Marrow Failure
NCT04211714Telomere Shortening, Bone Marrow Failure
DrugEXG34217
Elixirgen Therapeutics, Inc.
Phase 1
12
Ohio
2021-04-08
Active, closed
Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)
NCT04816604Pulmonary Arterial Hypertension
DrugSeralutinib
Gossamer Bio USA, Inc.
Phase 2
74
California, Florida, Kansas, Kentucky, Massachusetts, Nebraska, New York, Ohio
2021-04-05
By invitation
rAAV-Olig001-ASPA Gene Therapy for Treatment of Children With Typical Canavan Disease
NCT04833907Canavan Disease
DrugsLevetiracetam·Prednisone
Myrtelle Inc.
Phase 1/2
24
Ohio
2021-04-01
Active, closed
Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in Pediatric PID Patients (KIDCARES10)
NCT04944979Primary Immunodeficiency Disease
DrugKedrion IVIG
Kedrion S.p.A.
Phase 3
30
California, Colorado, Florida, Louisiana, North Carolina, Ohio, Oklahoma
2021-03-31
Recruiting
FX Shoulder Prospective Clinical Study
NCT06078865Osteoarthritis Shoulder, Rotator Cuff Syndrome of Shoulder and Allied Disorders, Fracture, Shoulder
FX Shoulder Solutions
Observational
600
Arizona, Ohio, Rhode Island, Texas
2021-03-31
Active, closed
A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors
NCT04673942Solid Tumor, Adult, Cancer, Neoplasms, Sarcoma
EpicentRx, Inc.
Phase 2
140
California, Ohio, Texas
2021-03-29
Recruiting
Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System
NCT04634916Kidney Disease, End-Stage, End-stage Renal Disease, Arteriovenous Fistula
C. R. Bard
Not applicable
220
California, Florida, Massachusetts, New York, North Carolina, Ohio, Pennsylvania, Tennessee
2021-03-26
Active, closed
Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant Rejection
NCT04727788Kidney Transplant Rejection
Verici Dx
Observational
550
Illinois, Maryland, Michigan, Nebraska, Ohio, Pennsylvania, Tennessee, Washington
2021-03-21
Recruiting
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
NCT04555161Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
Aria CV, Inc
Not applicable
30
California, Indiana, Massachusetts, Minnesota, New York, Ohio, South Carolina, Wisconsin
2021-03-15
Active, closed
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III
DrugAutogene cevumeran
BioNTech SE
Phase 2
327
California, Indiana, Minnesota, Ohio, Rhode Island, Tennessee, Texas, Virginia
2021-03-08
Active, closed
SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity
NCT04775082Obesity
DrugLiraglutide
Novo Nordisk A/S
Phase 3
78
Arizona, Colorado, Idaho, Louisiana, Maryland, Minnesota, New York, Ohio
2021-03-04
Active, closed
A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma
NCT04594642B-cell Non Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma
DrugSurovatamig
AstraZeneca
Phase 1
226
Florida, Kentucky, New Jersey, North Carolina, Ohio, Pennsylvania, Texas, Wisconsin
2021-03-02
Recruiting
Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL
NCT04502394Diffuse Large B Cell Lymphoma, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma
DrugsNavtemadlin·Acalabrutinib
Kartos Therapeutics, Inc.
Phase 1/2
84
Indiana, Ohio, Texas
2021-02-23
Recruiting
PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
NCT04545502Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection
Vascutek Ltd.
Observational
2,000
Colorado, Florida, Indiana, North Carolina, Ohio, Pennsylvania, Virginia
2021-02-17
By invitation
Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol
NCT05304728Severe Sepsis, Severe Sepsis Without Septic Shock
Beckman Coulter, Inc.
Observational
40,000
California, Georgia, Indiana, Missouri, New Jersey, North Carolina, Ohio
2021-02-15
Active, closed
Extension Study to Evaluate the Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopathy of Prematurity in the VGFTe-ROP-1920 Study (Acronym: Butterfleye Next)
NCT04515524Retinopathy of Prematurity
Regeneron Pharmaceuticals
Observational
100
California, New York, Ohio, Rhode Island, Texas, West Virginia
2021-02-05
Active, closed
Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04612751Advanced or Metastatic NSCLC
DrugsSabestomig·Volrustomig·Rilvegostomig·Dato-DXd
AstraZeneca
Phase 1
155
California, Missouri, New Jersey, Ohio, Pennsylvania, Texas, Virginia
2021-02-02
Recruiting
Isatuximab in Combination With Novel Agents in RRMM - Master Protocol
NCT04643002Plasma Cell Myeloma Refractory
DrugsEvorpacept·Belumosudil·Belantamab mafodotin·Isatuximab
Sanofi
Phase 1/2
258
Georgia, Illinois, Michigan, New York, Ohio
2021-01-25
Active, closed
Trial of ERapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance
NCT04230499Familial Adenomatous Polyposis
DrugERapa
Rapamycin Holdings Inc.
Phase 2
30
Michigan, Ohio, Texas
2021-01-18
Active, closed
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
NCT04657991Melanoma
DrugsBinimetinib·Encorafenib·Keytruda·Pembrolizumab
Pfizer
Phase 3
257
Florida, Kansas, Massachusetts, Ohio, Tennessee
2021-01-15
Active, closed
Growth Trial: Study of the Renata Minima Stent
NCT05086016Coarctation of the Aorta, Pulmonary Artery Stenosis
Renata Medical
Not applicable
42
California, Massachusetts, Ohio, Tennessee, Washington
2021-01-14
Active, closed
A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)
NCT04628494Diffuse Large B-cell Lymphoma
DrugEpcoritamab
Genmab
Phase 3
483
Indiana, Kentucky, Michigan, Minnesota, New Jersey, North Carolina, Ohio, Texas
2021-01-13
Recruiting
A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment
NCT04635111Hepatotoxicity, Tenosynovial Giant Cell Tumor
DrugTuralio
Daiichi Sankyo
Observational
30
California, Massachusetts, New York, Ohio, Texas
2021-01-07
Active, closed
MYLUNG Consortium Study Protocol 2
NCT05644808Carcinoma, Non-Small-Cell Lung
US Oncology Research
Observational
1,002
Alabama, Colorado, Florida, Illinois, Maryland, Minnesota, New York, Ohio
2020-12-29
Active, closed
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
NCT04538742Metastatic Breast Cancer
DrugsTucatinib·Pertuzumab·Trastuzumab deruxtecan·Durvalumab
AstraZeneca
Phase 1/2
245
Florida, New York, Ohio, Tennessee, Texas, Virginia
2020-12-28
Recruiting
Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry
NCT04669548Intraabdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury, Cardiovascular Surgery
Potrero Medical
Observational
2,500
California, District of Columbia, Florida, Kentucky, North Carolina, Ohio
2020-12-21
Active, closed
Study to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations
NCT04641442NLRC4-GOF, AIFEC (Autoinflammation With Infantile Enterocolitis), XIAP Deficiency, CDC42 Mutations
DrugArumakimig
Novartis Pharmaceuticals
Phase 2
17
Ohio, Pennsylvania, Texas, Washington
2020-12-18
Active, closed
A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)
NCT04471727Small-Cell Lung Cancer, Neuroendocrine Carcinoma
DrugsGocatamig·Ifinatamab Deruxtecan·Atezolizumab
Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 1/2
232
California, Colorado, Massachusetts, Michigan, New York, Ohio, Oregon, Tennessee
2020-12-14
Active, closed
Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
NCT04652882Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
DrugTasimelteon
Vanda Pharmaceuticals
Phase 3
70
California, Colorado, Massachusetts, Missouri, New York, Ohio, South Carolina, Texas
2020-12-09
Recruiting
A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab
NCT04590326Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Endometrial Cancer
DrugsUbamatamab·Sarilumab·Cemiplimab
Regeneron Pharmaceuticals
Phase 1/2
612
California, Florida, Illinois, Massachusetts, Michigan, New York, Ohio, Pennsylvania
2020-12-08
Recruiting
The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study
NCT04343313Mitral Valve Insufficiency
Half Moon Medical
Not applicable
30
New York, Ohio, Oregon, Pennsylvania
2020-12-08
By invitation
Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C Reduction
NCT04798430Cardiovascular Disease With Mention of Arteriosclerosis, Elevated Cholesterol, Familial Hypercholesterolemia
DrugLerodalcibep
LIB Therapeutics LLC
Phase 3
2,000
Illinois, Ohio
2020-12-03
Active, closed
A Study Evaluating the Efficacy and Safety of Giredestrant Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (acelERA Breast Cancer)
NCT04576455Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
DrugsGiredestrant·Fulvestrant
Hoffmann-La Roche
Phase 2
303
Georgia, Ohio, Oregon
2020-11-27
Recruiting
A Gene Transfer Therapy Study to Evaluate the Safety of and Expression From Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD) - Non-Ambulatory Cohort
NCT04626674Duchenne Muscular Dystrophy
Sarepta Therapeutics, Inc.
Phase 1
83
Arkansas, California, Florida, Illinois, Missouri, North Carolina, Ohio, Texas
2020-11-23
Active, closed
A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer
NCT04557059Prostatic Neoplasms
DrugsLhrha·Apalutamide
Janssen Pharmaceutica N.V., Belgium
Phase 3
691
Arizona, Arkansas, Colorado, Florida, Indiana, Michigan, New York, Ohio
2020-11-12
Active, closed
Safety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With Myelofibrosis
NCT04454658Myelofibrosis (MF)
DrugsNavitoclax·Ruxolitinib
AbbVie
Phase 1
21
California, New Hampshire, New York, Ohio, Oklahoma, Oregon, Texas, Washington
2020-11-11
Recruiting
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
NCT04329728Lymphoid Malignancies
AVM Biotechnology Inc
Phase 1/2
144
California, Florida, Illinois, Kentucky, Nebraska, Ohio, Tennessee, Texas
2020-11-06
Recruiting
Phase 2 Clinical Trial of CartiLife® in the United States
NCT04744402Articular Cartilage Defect, Articular Cartilage Degeneration
Biosolution Co., Ltd.
Phase 2
25
California, Louisiana, Ohio
2020-10-28
Recruiting
Abbott Vascular Medical Device Registry
NCT04573660Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism
Abbott Medical Devices
Observational
3,784
Alabama, Arkansas, California, Illinois, Nebraska, Ohio, Tennessee
2020-10-25
Active, closed
Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers
NCT04404595Gastric Cancer, Pancreatic Cancer
CARsgen Therapeutics Co., Ltd.
Phase 1/2
110
California, Florida, Kansas, Michigan, Minnesota, New York, Ohio, Texas
2020-10-23
Active, closed
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
NCT04440189Osteoarthritis, Knee
GID BIO, Inc.
Phase 3
114
California, Florida, Louisiana, New Jersey, North Carolina, Ohio, Pennsylvania, Texas
2020-10-15
Active, closed
Myasthenia Gravis Inebilizumab Trial
NCT04524273Myasthenia Gravis
DrugInebilizumab
Amgen
Phase 3
238
California, Connecticut, District of Columbia, Florida, Kansas, North Carolina, Ohio, Pennsylvania
2020-10-15
Active, closed
Dual-sided Hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea (DREAM)
NCT03868618Obstructive Sleep Apnea
Nyxoah S.A.
Not applicable
115
Alabama, Florida, Georgia, Indiana, Iowa, Massachusetts, New York, Ohio
2020-10-14
Active, closed
CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC
NCT04495153Non Small Cell Lung Cancer
DrugAglatimagene besadenovec
Candel Therapeutics, Inc.
Phase 2
90
Arizona, Connecticut, Illinois, Maryland, Minnesota, New York, Ohio, Pennsylvania
2020-10-13
Active, closed
A Study Evaluating DS-1055a in Participants With Relapsed or Refractory Locally Advanced or Metastatic Solid Tumors
NCT04419532Solid Tumor, Advanced Cancer, Metastatic Solid Tumor
Daiichi Sankyo
Phase 1
40
New York, Ohio
2020-10-09
Active, closed
Impella ECP Early Feasibility Study
NCT04477603High-risk Percutaneous Coronary Intervention
Abiomed Inc.
Not applicable
100
Massachusetts, Michigan, New Jersey, Ohio
2020-10-09
By invitation
Lumbar Interbody Implant Study
NCT04418830Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis, Spinal Stenosis
NuVasive
Observational
1,050
California, Connecticut, Florida, Illinois, Michigan, Missouri, North Carolina, Ohio
2020-10-01
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors
NCT04432584Paroxysmal Nocturnal Hemoglobinuria
DrugsCrovalimab·Eculizumab
Hoffmann-La Roche
Phase 3
190
North Carolina, Ohio
2020-09-30
By invitation
Follow-up Study of AAV-Mediated Gene Transfer (UX111; Previously Known as ABO-102) for MPS Type IIIA
NCT04360265Mucopolysaccharidosis IIIA, MPS IIIA, Sanfilippo Syndrome, Sanfilippo A
Ultragenyx Pharmaceutical Inc
Phase 3
41
Ohio
2020-09-28
Active, closed
NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS
NCT04623944Relapsed/Refractory AML, AML, Adult, MDS, Refractory Myelodysplastic Syndromes
DrugsDecitabine·Fludarabine·Cyclophosphamide
Nkarta, Inc.
Phase 1
61
Colorado, Florida, Georgia, Illinois, Ohio, Tennessee, Texas
2020-09-21
Active, closed
Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers
NCT04430738Colorectal Carcinoma, Gastric Adenocarcinoma, GEJ Adenocarcinoma, Esophageal Adenocarcinoma
DrugsTucatinib·Fluorouracil·Leucovorin·Trastuzumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 2
40
Arizona, Colorado, District of Columbia, Missouri, New Mexico, North Carolina, Ohio, Washington
2020-09-15
Active, closed
A Unique Micro Water Jet Technology Device Versus Standard Debridement in the Treatment of Diabetic Foot
NCT04564443Diabetic Foot Ulcer, Diabetic Foot
Medaxis, LLC
Not applicable
222
California, Florida, Maryland, North Carolina, Ohio, Virginia
2020-09-11
Recruiting
Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)
NCT04098744CIN 2/3, HPV Infection, Pre-Cancerous Dysplasia, Cervical Dysplasia
DrugArtesunate
Frantz Viral Therapeutics, LLC
Phase 2
78
Florida, Michigan, Ohio, Texas
2020-09-09
Active, closed
Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL
NCT04404283Diffuse Large B-cell Lymphoma
DrugsBrentuximab Vedotin·Lenalidomide·Rituximab
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
239
Alabama, California, Florida, Kansas, Maryland, Michigan, Missouri, Ohio
2020-08-20
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma
NCT04246086Follicular Lymphoma
DrugsMosunetuzumab·Tocilizumab·Lenalidomide
Hoffmann-La Roche
Phase 1/2
237
California, Florida, Kentucky, Louisiana, Michigan, North Carolina, Ohio, Rhode Island
2020-08-12
Active, closed
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
NCT04221477Lupus Nephritis
DrugsDiphenhydramine·Acetaminophen·Methylprednisolone·Obinutuzumab
Hoffmann-La Roche
Phase 3
271
Alabama, California, Colorado, Connecticut, Florida, Georgia, New York, Ohio
2020-08-10
Active, closed
Open-label Extension of the HOPE-2 Trial
NCT04428476Duchenne Muscular Dystrophy
DrugDeramiocel
Capricor Inc.
Phase 2
13
California, Colorado, Missouri, Ohio, Wisconsin
2020-08-05
Active, closed
A Study to Evaluate MEDI5752 and Axitinib in Subjects With Advanced Renal Cell Carcinoma
NCT04522323Advanced Renal Cell Carcinoma
DrugsVolrustomig·Axitinib·Lenvatinib
MedImmune LLC
Phase 1
67
District of Columbia, Florida, Missouri, New York, Ohio, Pennsylvania, Tennessee
2020-08-05
Active, closed
A Phase III Study to Evaluate the Efficacy and Safety of Benralizumab in Patients With Hypereosinophilic Syndrome (HES)
NCT04191304Hypereosinophilic Syndrome
DrugBenralizumab
AstraZeneca
Phase 3
134
California, Georgia, Maryland, Michigan, North Carolina, Ohio, Utah
2020-07-20
Active, closed
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies
NCT04561362Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms, Hormone Receptor Positive, HER2-negative Neoplasms, Hormone Receptor Positive, HER2-low Neoplasms
DrugsZelenectide pevedotin·Keytruda·Pembrolizumab
BicycleTx Limited
Phase 1/2
329
Colorado, Florida, New York, Ohio, Pennsylvania, Tennessee, Texas
2020-07-17
Active, closed
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:
NCT02616484Pyruvate Dehydrogenase Complex Deficiency
Saol Therapeutics Inc
Phase 3
34
California, District of Columbia, Florida, Ohio, Pennsylvania, Texas, Utah, Washington
2020-07-14
By invitation
Cervical Interbody Implant Study
NCT04689854Degenerative Disc Disease, Cervical Spinal Instability
NuVasive
Observational
150
California, Connecticut, Massachusetts, Missouri, North Carolina, Ohio, Virginia
2020-07-07
Active, closed
Bilateral Treatment of Medication Refractory Essential Tremor
NCT04112381Essential Tremor
InSightec
Not applicable
51
California, Maryland, New York, Ohio, Pennsylvania, Virginia, West Virginia
2020-06-30
Active, closed
Episealer® Knee System IDE Clinical Study
NCT04000659Degenerative Lesion of Articular Cartilage of Knee
Episurf Medical Inc.
Not applicable
13
Arizona, California, Louisiana, New Jersey, New York, Ohio, Tennessee, Texas
2020-06-18
Active, closed
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
NCT04106219Neuroblastoma
DrugsTopotecan·Cyclophosphamide
Eli Lilly and Company
Phase 1
71
California, Colorado, Illinois, Massachusetts, Ohio, Pennsylvania, Texas
2020-06-11
Active, closed
A Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 Study
NCT04215146Breast Cancer Metastatic
DrugsPelareorep·Avelumab·Paclitaxel
Oncolytics Biotech
Phase 2
48
Florida, Illinois, Indiana, Louisiana, Missouri, New Jersey, New York, Ohio
2020-06-10
Recruiting
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
NCT04429542Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of Anal Canal, Colorectal Cancer, Squamous Cell Carcinoma of the Lung
DrugPembrolizumab
Bicara Therapeutics
Phase 1
292
California, Florida, Massachusetts, New York, North Carolina, Ohio, Pennsylvania, Rhode Island
2020-06-01
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)
NCT04241185Urinary Bladder Neoplasms
DrugsMitomycin C·Fluorouracil·Adrucil·Keytruda
Merck Sharp & Dohme LLC
Phase 3
520
District of Columbia, Florida, Kentucky, Maryland, Missouri, New Jersey, New York, Ohio
2020-05-19
Active, closed
Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma
NCT04246047Multiple Myeloma
DrugsBelantamab mafodotin·Bortezomib·Daratumumab·Dexamethasone
GlaxoSmithKline
Phase 3
494
Arizona, Colorado, Kansas, Ohio, Texas
2020-05-07
Active, closed
Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients
NCT04291105Melanoma, Head and Neck Squamous Cell Carcinoma, Colo-rectal Cancer
DrugsVSV-IFNβ-NIS·Cemiplimab
Vyriad, Inc.
Phase 2
87
California, Connecticut, Florida, Louisiana, Minnesota, Montana, New York, Ohio
2020-04-24
Active, closed
A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer
NCT04214288Advanced ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Fulvestrant
AstraZeneca
Phase 2
240
Alabama, California, Florida, Nebraska, Ohio, Tennessee, Wisconsin
2020-04-22
Active, closed
Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
NCT04162210Multiple Myeloma
DrugsBelantamab mafodotin·Dexamethasone
GlaxoSmithKline
Phase 3
325
Arizona, Colorado, Michigan, Nebraska, New York, Ohio, Oregon, Texas
2020-04-02
Active, closed
GDNF Gene Therapy for Parkinson's Disease
NCT04167540Parkinson's Disease
Brain Neurotherapy Bio, Inc.
Phase 1
11
California, Ohio
2020-04-01
Recruiting
CERAMENT™| Bone Void Filler Device Registry
NCT04244942Orthopedic Disorder
BONESUPPORT AB
Observational
300
Arizona, Florida, Indiana, Kentucky, Massachusetts, New York, North Carolina, Ohio
2020-03-30
By invitation
Stronger Together Global Registry
NCT04364295Spinal Disease
SeaSpine, Inc.
Observational
2,285
Colorado, Ohio
2020-03-20
Recruiting
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
NCT04215809CLL/SLL
DrugLisaftoclax
Ascentage Pharma Group Inc.
Phase 1
144
California, Florida, Massachusetts, North Carolina, Ohio, Washington
2020-03-02
Active, closed
FemBloc® Permanent Contraception - Confirmation Feasibility Trial
NCT04273594Contraception
Femasys Inc.
Not applicable
45
Arizona, Georgia, Indiana, Michigan, Ohio
2020-02-27
Active, closed
ZIP Study-OL Study of Safety, PK, Efficacy, PD, Immunogenicity of ATB200/AT2221 in Pediatrics Aged 0 to < 18 y.o. w/LOPD
NCT03911505Pompe Disease (Late-onset)
DrugsCipaglucosidase alfa·Miglustat
Amicus Therapeutics
Phase 3
21
Florida, Georgia, Missouri, North Carolina, Ohio, Pennsylvania, Utah, Virginia
2020-02-13
Active, closed
A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer
NCT04211337Medullary Thyroid Cancer
DrugsVandetanib·Selpercatinib·Cabozantinib
Loxo Oncology, Inc.
Phase 3
291
Alabama, California, Georgia, Illinois, Massachusetts, Michigan, New York, Ohio
2020-02-11
Active, closed
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
NCT04175600Hypertension, Pulmonary
DrugSelexipag
Actelion
Phase 3
138
Arizona, California, Colorado, District of Columbia, Florida, Indiana, Michigan, Ohio
2020-01-16
Recruiting
Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL
NCT04260022Leukemia, Myeloid, Chronic, Myeloid Leukemia, Chronic Myeloid Leukemia, Philadelphia Positive Acute Lymphoblastic Leukemia
DrugBlinatumomab
Ascentage Pharma Group Inc.
Phase 1
242
Alabama, California, Georgia, Maryland, Ohio, Texas, Washington
2020-01-09
Active, closed
A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis
NCT04075266Multiple Sclerosis
DrugOcrelizumab
Hoffmann-La Roche
Phase 2
23
Colorado, District of Columbia, Massachusetts, Missouri, Ohio
2020-01-09
Recruiting
Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System
NCT04065438Focal Segmental Glomerulosclerosis
Kaneka Medical America LLC
Not applicable
35
California, Delaware, Michigan, New York, North Carolina, Ohio, South Carolina, Virginia
2020-01-01
Recruiting
Medtronic Cardiac Surgery PMCF Registry
NCT04073420Valve Disease, Heart
Medtronic Cardiac Surgery
Observational
2,700
Georgia, Michigan, New York, North Carolina, Ohio, Pennsylvania, Texas, Virginia
2019-12-02
Active, closed
Study of Subcutaneous (SC) Belimumab in Pediatric Participants With Systemic Lupus Erythematosus (SLE)
NCT04179032Systemic Lupus Erythematosus
GlaxoSmithKline
Phase 2
25
Ohio
2019-11-28
Active, closed
A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma
NCT04047251Advanced Solid Tumors, Merkel Cell Carcinoma
Fujifilm Pharmaceuticals U.S.A., Inc.
Phase 1
96
Arizona, Colorado, Massachusetts, New York, Ohio, Texas, Wisconsin
2019-11-14
Active, closed
Phase 1/1b/2 Study of Oral PMD-026 in Patients With Metastatic Breast Cancer
NCT04115306Metastatic Breast Cancer
DrugFulvestrant
Phoenix Molecular Designs
Phase 1/2
61
Arizona, California, Florida, Illinois, Massachusetts, Michigan, Ohio, Texas
2019-11-14
Recruiting
APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study
NCT05119842Paralysis, Unilateral, Vocal Cord
APrevent Biotech GmbH
Not applicable
30
Arizona, Maryland, Ohio, Texas
2019-11-13
Active, closed
A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm
NCT04041050Myeloproliferative Neoplasm
DrugsNavitoclax·Celebrex·Celecoxib·Ruxolitinib
AbbVie
Phase 1
85
California, Illinois, Kentucky, Michigan, Nebraska, North Carolina, Ohio, Pennsylvania
2019-11-08
Active, closed
A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer
NCT04025879Carcinoma, Non-Small-Cell Lung
DrugsOpdivo·Pemetrexed·Docetaxel·Nivolumab
Bristol-Myers Squibb
Phase 3
461
Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan, New Hampshire, Ohio
2019-11-05
Active, closed
A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer
NCT04036682Non Small Cell Lung Cancer, EGFR Exon 20 Mutation
DrugZipalertinib
Cullinan Therapeutics Inc.
Phase 1/2
284
California, Florida, Massachusetts, Michigan, New Jersey, New York, Ohio, Oregon
2019-10-31
Active, closed
An All Comers Registry For Normothermic Ex Vivo Lung Perfusion (EVLP) as Assessment of Donor Lungs for Transplant
NCT05101460Lung Transplant
XVIVO Perfusion
Observational
315
Ohio
2019-10-29
Active, closed
SJM Masters HP 15mm Rotatable Mechanical Heart Valve as Aortic Valve Replacement Therapy
NCT03924661Aortic Valve Disease
Abbott Medical Devices
Observational
20
California, Florida, Georgia, Mississippi, Ohio, Texas
2019-10-24
Active, closed
Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer
NCT04050436Cutaneous Squamous Cell Carcinoma, Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
DrugsVusolimogene Oderparepvec·Cemiplimab
Replimune, Inc.
Phase 2
231
California, Colorado, Florida, Georgia, New Jersey, New York, North Carolina, Ohio
2019-10-08
Active, closed
Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy
NCT04083339Diabetic Cardiomyopathies
Applied Therapeutics, Inc.
Phase 3
675
California, Florida, Illinois, Massachusetts, Mississippi, Missouri, New York, Ohio
2019-09-20
Active, closed
COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC
NCT04068610Metastatic Microsatellite-stable Colorectal Cancer
DrugsOleclumab·Folfox·Durvalumab·Bevacizumab
MedImmune LLC
Phase 1/2
61
California, Michigan, Nevada, New York, Ohio, Rhode Island, Tennessee, Texas
2019-09-13
Active, closed
Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease
NCT04120493Huntington's Disease
UniQure Biopharma B.V.
Phase 1/2
43
Alabama, Arizona, California, Colorado, Illinois, Maryland, Michigan, Ohio
2019-09-06
Active, closed
Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET
NCT03993873Advanced Solid Tumor, Metastatic Solid Tumors, MET Gene Alterations
Turning Point Therapeutics, Inc.
Phase 1
95
California, Colorado, Illinois, Massachusetts, Michigan, Missouri, Ohio, Texas
2019-09-05
Recruiting
Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients
NCT03945162Non-Muscle Invasive Bladder Cancer ("NMIBC") Unresponsive/Intolerant to BCG
Theralase® Technologies Inc.
Phase 2
90
Illinois, Indiana, New York, Ohio, Pennsylvania, South Carolina, Tennessee, Texas
2019-08-30
Recruiting
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
NCT04064060Myelodysplastic Syndromes (MDS), Beta-thalassemia, Myeloproliferative Neoplasm(MPN)-Associated Myelofibrosis
DrugLuspatercept
Celgene
Phase 3
665
California, Florida, Illinois, Massachusetts, Michigan, New York, Ohio, Pennsylvania
2019-08-12
Active, closed
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis
NCT04035005Multiple Sclerosis, Primary Progressive
DrugOcrelizumab
Hoffmann-La Roche
Phase 3
1,013
District of Columbia, Florida, Kansas, Ohio, Pennsylvania
2019-08-12
Active, closed
MDR - Biomet Cannulated Screws
NCT04002518Fractures, Bone, Fracture Multiple
Zimmer Biomet
Observational
51
Indiana, Ohio, Virginia
2019-08-07
Active, closed
Omega3 Wound Fish Skin Graft in the Treatment of DFUs
NCT04133493Diabetic Foot Ulcer
Kerecis Ltd.
Not applicable
100
Florida, Georgia, Indiana, Ohio, Pennsylvania
2019-07-31
Active, closed
Cancer Stem Cell Assay Directed Chemotherapy in Recurrent Platinum Resistant Ovarian Cancer
NCT03949283Recurrent Ovarian Carcinoma, Platinum-resistant Ovarian Cancer
Cordgenics, LLC
Phase 3
150
California, Florida, Louisiana, Ohio, Oklahoma, Pennsylvania, West Virginia
2019-07-26
Active, closed
Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)
NCT03974022Non-Small Cell Lung Cancer
DrugSunvozertinib
Dizal Pharmaceuticals
Phase 1/2
315
California, Colorado, Florida, Massachusetts, Michigan, New York, Ohio, Virginia
2019-07-09
Active, closed
A Research Study in Children Born Small and Who Stayed Small. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a Day
NCT03878446Short Stature Children Born Small for Gestational Age (SGA)
DrugsNorditropin·Somapacitan
Novo Nordisk A/S
Phase 2
62
Alabama, California, Idaho, Minnesota, New Jersey, New York, Ohio, Oklahoma
2019-07-04
Active, closed
A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)
NCT04035486Non-Small Cell Lung Cancer
DrugsPemetrexed/Cisplatin·Pemetrexed/Carboplatin·Osimertinib
AstraZeneca
Phase 3
587
California, Florida, Kansas, Kentucky, Massachusetts, Nevada, New York, Ohio
2019-07-02
Recruiting
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
NCT03947385Metastatic Uveal Melanoma, Cutaneous Melanoma, Colorectal Cancer, Other Solid Tumors
DrugsDarovasertib·Binimetinib·Crizotinib
IDEAYA Biosciences
Phase 1/2
336
California, Colorado, Iowa, Michigan, New York, North Carolina, Ohio, Pennsylvania
2019-06-28
Active, closed
Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
NCT03997123Triple Negative Breast Neoplasms
DrugsCapivasertib·Paclitaxel
AstraZeneca
Phase 3
923
California, Florida, Illinois, Kansas, Maryland, Michigan, New York, Ohio
2019-06-25
Active, closed
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Upadacitinib in Pediatric Subjects With Polyarticular Course Juvenile Idiopathic Arthritis
NCT03725007Juvenile Idiopathic Arthritis (JIA)
DrugUpadacitinib
AbbVie
Phase 1
124
Illinois, Kentucky, Massachusetts, Ohio, Oregon, Pennsylvania, Washington
2019-06-24
Active, closed
Early Feasibility Study for the Foldax Tria Aortic Heart Valve
NCT03851068Aortic Valve Disease, Aortic Valve Stenosis
Foldax, Inc
Not applicable
40
Indiana, Kansas, Michigan, Ohio
2019-06-18
Active, closed
A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors
NCT03899792Medullary Thyroid Cancer, Infantile Myofibromatosis, Infantile Fibrosarcoma, Papillary Thyroid Cancer
DrugSelpercatinib
Eli Lilly and Company
Phase 1/2
36
California, Colorado, Florida, Massachusetts, Minnesota, New York, Ohio, Pennsylvania
2019-06-13
Active, closed
An Extension Study to Evaluate Safety and Efficacy of BMN 111 in Children With Achondroplasia
NCT03989947Achondroplasia
BioMarin Pharmaceutical
Phase 2
73
California, Delaware, Georgia, Illinois, Ohio, Tennessee, Texas, Wisconsin
2019-06-12
Recruiting
Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia
NCT03817502Schizophrenia
DrugCariprazine
Gedeon Richter Plc.
Phase 3
330
California, Georgia, Michigan, Mississippi, New York, Ohio, Texas
2019-06-06
Active, closed
A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy
NCT04015141Pediatric Epileptic Syndrome, Partial-onset Seizures
DrugPerampanel
Eisai Inc.
Phase 2
100
California, Colorado, Florida, Georgia, Michigan, New Jersey, North Carolina, Ohio
2019-05-31
Recruiting
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
NCT03686124Refractory Cancer, Recurrent Cancer, Solid Tumor, Adult, Cancer
DrugsAnzu-cel·Opdivo·Nivolumab
Immatics US, Inc.
Phase 1/2
375
California, Colorado, Florida, Illinois, Massachusetts, New York, Ohio, Pennsylvania
2019-05-14
Active, closed
A Dose Escalation Study Evaluating CPI-818 in Relapsed/Refractory T-Cell Lymphoma
NCT03952078T-cell Lymphoma
DrugSoquelitinib
Corvus Pharmaceuticals, Inc.
Phase 1
151
California, Michigan, Missouri, New Jersey, Ohio, Pennsylvania
2019-05-03
Active, closed
Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas
NCT03478462Pediatric Solid Tumor, Pediatric Lymphoma, Pediatric Brain Tumor, DIPG
DrugCLR 131
Cellectar Biosciences, Inc.
Phase 1
30
California, New York, North Carolina, Ohio, Texas, Wisconsin
2019-04-30
Recruiting
A Trial of Etelcalcetide in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis
NCT03633708Secondary Hyperparathyroidism, Chronic Kidney Disease
DrugEtelcalcetide
Amgen
Phase 3
56
California, Colorado, Missouri, New York, Ohio, Oklahoma, Pennsylvania, Texas
2019-04-29
Active, closed
Ph I/II Trial of Systemic VSV-IFNβ-NIS in Combination With Checkpoint Inhibitor Therapy in Patients With Select Solid Tumors
NCT03647163Solid Tumor, Non Small Cell Lung Cancer, Neuroendocrine Carcinoma, Renal Cell Carcinoma (RCC)
DrugsVSV-IFNβ-NIS·Ipilimumab·Nivolumab·Pembrolizumab
Vyriad, Inc.
Phase 1/2
33
Minnesota, Ohio
2019-04-09
Recruiting
A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
NCT03802695Acute Myeloid Leukemia, Myelodysplastic Syndromes, Mixed Phenotype Acute Leukemia, Acute Lymphoblastic Leukemia
Orca Biosystems, Inc.
Phase 1
300
California, Florida, Georgia, Kansas, New Jersey, New York, Ohio, Texas
2019-04-08
Active, closed
Prospective Evaluation of ProChondrix CR for Repair of Articular Cartilage Defects on Femoral Condyle and Patella
NCT03873545Cartilage Injury, Cartilage Damage
AlloSource
Observational
34
Illinois, Kentucky, Ohio
2019-03-18
Recruiting
Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia
NCT03850574Leukemia, Myeloid, Acute, Refractory AML, Relapsed Adult AML, Myelodysplastic Syndrome With Excess Blasts-2
DrugsAzacitidine·Venetoclax
Aptose Biosciences Inc.
Phase 1/2
240
Alabama, California, Connecticut, Florida, Georgia, Massachusetts, North Carolina, Ohio
2019-03-11
Recruiting
Two Dose Levels of Privigen in Pediatric CIDP
NCT03684018Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
DrugImmunoglobulins
CSL Behring
Phase 4
30
Arizona, California, Iowa, Ohio, Pennsylvania, Tennessee, Texas, Virginia
2019-02-28
Active, closed
The CONFORMAL Early Feasibility Study
NCT03616028Non-valvular Atrial Fibrillation
Conformal Medical, Inc
Not applicable
64
Arkansas, California, New Hampshire, New York, Ohio, Pennsylvania, Tennessee, Texas
2019-02-22
Recruiting
A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System
NCT05653102Knee Arthroplasty, Total
Exactech
Observational
1,000
Colorado, Florida, Nevada, Ohio, South Carolina
2019-01-23
Recruiting
Phase 1/2 Study of Linvoseltamab in Adult Patients With Relapsed or Refractory Multiple Myeloma
NCT03761108Multiple Myeloma
DrugLinvoseltamab
Regeneron Pharmaceuticals
Phase 1/2
387
Florida, Georgia, Indiana, Kentucky, Michigan, New Jersey, New York, Ohio
2019-01-23
Active, closed
KRT-232 Compared to Ruxolitinib in Patients With Phlebotomy-Dependent Polycythemia Vera
NCT03669965Polycythemia Vera
DrugsNavtemadlin·Ruxolitinib
Kartos Therapeutics, Inc.
Phase 2
20
Alabama, California, Missouri, Ohio
2019-01-15
Active, closed
NOVOCART 3D Treatment Following Microfracture Failure
NCT03219307Articular Cartilage Defect
Aesculap Biologics, LLC
Phase 3
30
Illinois, Ohio, Utah
2018-11-30
Active, closed
Post-Authorization Long-Term Safety Study of LUTATHERA
NCT03691064Neuroendocrine Tumors
DrugLutathera
Advanced Accelerator Applications
Observational
1,014
Arizona, Ohio, Oregon, Washington
2018-11-28
Recruiting
Medtronic Terminate AF Study
NCT03546374Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Medtronic Cardiac Surgery
Not applicable
160
California, Connecticut, Indiana, Massachusetts, Michigan, Missouri, Ohio, Pennsylvania
2018-11-15
Active, closed
Gene Therapy for Children With CLN3 Batten Disease
NCT03770572CLN3, Batten Disease
Neela Therapeutics
Phase 1/2
7
Ohio
2018-11-13
Recruiting
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
NCT03588975Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
Vericel Corporation
Phase 3
45
California, Louisiana, Maryland, Michigan, New York, Ohio, Pennsylvania, Texas
2018-10-24
Recruiting
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
NCT03715933Ewing Sarcoma, Colorectal Adenocarcinoma
DrugsINBRX-109·Temozolomide·Fluorouracil·Leucovorin
Inhibrx Biosciences, Inc
Phase 1
411
Arizona, California, Colorado, Georgia, Illinois, Michigan, New York, Ohio
2018-10-08
Recruiting
ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease
NCT03671889Alzheimer Disease
InSightec
Not applicable
50
Florida, New York, Ohio, Texas, West Virginia
2018-09-28
Active, closed
Long Term Follow Up to Evaluate DTX301 in Adults With Late-Onset OTC Deficiency
NCT03636438Ornithine Transcarbamylase (OTC) Deficiency
Ultragenyx Pharmaceutical Inc
Observational
11
Colorado, Massachusetts, New York, Ohio
2018-08-30
Active, closed
Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood
NCT03793478Acute Myeloid Leukemia
DrugsQuizartinib·Cytarabine·Etoposide·Fludarabine
Daiichi Sankyo
Phase 1/2
65
California, Colorado, Delaware, District of Columbia, Georgia, Minnesota, Ohio, Pennsylvania
2018-08-15
Recruiting
A Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD)
NCT03619850Chronic Kidney Disease; Iron Deficiency Anemia
DrugsIron sucrose·Ferumoxytol
AMAG Pharmaceuticals, Inc.
Phase 3
129
Florida, Michigan, Missouri, New York, Ohio, West Virginia
2018-08-13
Recruiting
A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)
NCT03592472Renal Cell Carcinoma
DrugsAbexinostat·Pazopanib
Xynomic Pharmaceuticals, Inc.
Phase 3
413
Arizona, California, Kentucky, Louisiana, Nebraska, New York, Ohio, Oregon
2018-07-17
Active, closed
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Participants
NCT03451851Psoriasis
DrugsEtanercept·Guselkumab
Janssen Research & Development, LLC
Phase 3
120
California, Georgia, Illinois, New Jersey, New York, Ohio, Texas
2018-07-11
Recruiting
A Study to Evaluate the Efficacy and Safety of Nanosomal Docetaxel Lipid Suspension in Triple Negative Breast Cancer Patients
NCT03671044Triple Negative Breast Cancer
DrugTaxotere
Jina Pharmaceuticals Inc.
Phase 3
657
Georgia, Missouri, Ohio
2018-07-10
Recruiting
A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves
NCT05110989Post Operative Pain
AtriCure, Inc.
Observational
5,000
Florida, Maryland, Missouri, New Hampshire, Ohio, Texas
2018-06-29
Recruiting
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
NCT03556228Head and Neck Carcinoma, Adenoid Cystic Carcinoma, Lung Cancer, Non-Small Cell Lung Cancer
VM Oncology, LLC
Phase 1/2
242
California, Connecticut, District of Columbia, Florida, New Jersey, New Mexico, New York, Ohio
2018-06-08
Active, closed
Evaluation of the GORE PV1 Device in Patients With Pulmonary Valve Dysfunction
NCT03441971Heart Defects, Congenital, Tetralogy of Fallot, Pulmonary Valve Insufficiency, Pulmonary Valve Stenosis
W.L.Gore & Associates
Not applicable
15
Illinois, Massachusetts, Ohio
2018-06-07
Active, closed
A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis
NCT03523858Progressive Multiple Sclerosis (PMS)
DrugOcrelizumab
Hoffmann-La Roche
Phase 3
927
California, Florida, Illinois, Massachusetts, Michigan, Missouri, New York, Ohio
2018-05-28
Recruiting
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
NCT03564340Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Primary Peritoneal Cancer, Recurrent Endometrial Cancer
DrugsUbamatamab·Sarilumab·Cemiplimab·Tocilizumab
Regeneron Pharmaceuticals
Phase 1/2
890
Alabama, Massachusetts, Minnesota, New York, Ohio, Oklahoma, Tennessee, Texas
2018-05-21
Active, closed
Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations
NCT03316560X-Linked Retinitis Pigmentosa
DrugRAAV2tYF-GRK1-RPGR
Beacon Therapeutics
Phase 1/2
29
North Carolina, Ohio, Oregon, Texas
2018-04-16
Active, closed
A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer
NCT03473743Urothelial Carcinoma
DrugsErdafitinib·Cetrelimab·Cisplatin·Carboplatin
Janssen Research & Development, LLC
Phase 1/2
125
Colorado, Kentucky, Maryland, New Jersey, New York, North Carolina, Ohio, Pennsylvania
2018-04-05
Active, closed
A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and Granulocyte Colony Stimulating Factor (G-CSF) as Compared to Placebo and G-CSF for the Mobilization of Hematopoietic Stem Cells for Autologous Transplantation in Subjects With Multiple Myeloma (MM)
NCT03246529Multiple Myeloma
DrugsMotixafortide·G-Csf
BioLineRx, Ltd.
Phase 3
180
California, Florida, Illinois, Maryland, Minnesota, Missouri, Ohio, Texas
2018-03-23
Active, closed
ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease
NCT03319485Parkinson Disease
InSightec
Not applicable
92
California, Florida, Maryland, Massachusetts, Minnesota, New York, Ohio, Pennsylvania
2018-02-09
Recruiting
Dabrafenib and/or Trametinib Rollover Study
NCT03340506Melanoma, Non Small Cell Lung Cancer, Solid Tumor, Rare Cancers
DrugsDabrafenib·Trametinib
Novartis Pharmaceuticals
Phase 4
100
Arizona, Maryland, Ohio, Texas
2018-01-26
Active, closed
An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia
NCT03424018Achondroplasia
DrugVosoritide
BioMarin Pharmaceutical
Phase 3
119
California, Delaware, Georgia, Illinois, Maryland, Missouri, Ohio, Texas
2017-12-12
Active, closed
U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer
NCT03260491Non-Small Cell Lung Cancer (NSCLC)
DrugPatritumab deruxtecan
Daiichi Sankyo
Phase 1
312
California, Georgia, Massachusetts, Michigan, New York, Ohio, Pennsylvania, Tennessee
2017-10-30
Active, closed
Long-Term Follow-up Study for Patients From AVXS-101-CL-101
NCT03421977Spinal Muscular Atrophy 1
DrugsOnasemnogene Abeparvovec-xioi·Zolgensma
Novartis Gene Therapies
Observational
13
Ohio
2017-09-21
Active, closed
A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma
NCT02979522Hodgkin Disease
DrugsVinblastine·Brentuximab Vedotin·Dacarbazine·Adriamycin
Takeda
Phase 1/2
59
Colorado, Ohio
2017-09-06
Active, closed
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
NCT02962414Tuberous Sclerosis Complex
DrugEverolimus
Novartis Pharmaceuticals
Phase 3
206
Arizona, California, Colorado, Connecticut, Illinois, Minnesota, New Jersey, Ohio
2017-08-23
Active, closed
ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
NCT03130777Pulmonary Disease, Transcatheter Pulmonary Valve Replacement (TPVR), Tetralogy of Fallot, Congenital Heart Disease
Edwards Lifesciences
Not applicable
86
California, Colorado, Georgia, Missouri, New York, Ohio, Pennsylvania, Texas
2017-08-22
Active, closed
Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors
NCT03313778Solid Tumors
DrugsIntismeran autogene·Pembrolizumab
ModernaTX, Inc.
Phase 1
161
California, District of Columbia, Florida, Massachusetts, New York, Ohio, Pennsylvania, Texas
2017-08-14
Active, closed
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma
NCT02704858Glioblastoma Multiforme
DrugPerillyl alcohol
Neonc Technologies, Inc.
Phase 1/2
49
California, Georgia, Louisiana, New Jersey, New York, North Carolina, Ohio, Texas
2017-08-01
Active, closed
The Chocolate Touch Study
NCT02924857Peripheral Artery Disease (PAD), Ischemia, Intermittent Claudication
TriReme Medical, LLC
Not applicable
333
Florida, Georgia, Louisiana, Michigan, Mississippi, Missouri, New York, Ohio
2017-07-26
Active, closed
A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)
NCT03162536Lymphoma, B-Cell, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia
DrugNemtabrutinib
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Phase 1/2
190
Arizona, California, Colorado, Michigan, Minnesota, North Carolina, Ohio, Tennessee
2017-06-26
Active, closed
Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).
NCT03164616Non Small Cell Lung Cancer NSCLC
DrugsTremelimumab·Abraxane·Durvalumab·Pemetrexed
AstraZeneca
Phase 3
1,186
Arizona, California, Florida, Kentucky, Missouri, Ohio, Pennsylvania, Tennessee
2017-06-01
Active, closed
MAGE-A4ᶜ¹º³²T for Multi-Tumor
NCT03132922Urinary Bladder Cancer, Melanoma, Head and Neck Cancer, Ovarian Cancer
USWM CT, LLC
Phase 1
71
Florida, Missouri, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2017-05-15
Active, closed
Xeltis Bioabsorbable Pulmonary Valved Conduit Pivotal Study
NCT03022708Heart Defect, Congenital
Xeltis
Not applicable
6
California, Colorado, Florida, New York, Ohio, Pennsylvania, Texas
2017-05-08
Active, closed
The Medtronic Harmony™ Transcatheter Pulmonary Valve Clinical Study
NCT02979587Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
Medtronic Heart Valves
Not applicable
86
California, Connecticut, Minnesota, Ohio, Pennsylvania, Texas, Utah, Washington
2017-01
Active, closed
Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer
NCT02546661Muscle Invasive Bladder Cancer
DrugsDanvatirsen·Fexagratinib·Vistusertib·Adavosertib
AstraZeneca
Phase 1
117
California, Connecticut, Florida, New York, Ohio, Tennessee
2016-12-28
Active, closed
An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis
NCT02808780Ulcerative Colitis
Janssen Biotech, Inc.
Observational
535
California, Florida, Georgia, Illinois, Ohio, Pennsylvania, Texas, Virginia
2016-12-16
Active, closed
Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection
NCT02932150Chronic Hepatitis B
Gilead Sciences
Phase 2
150
California, Colorado, Indiana, Maryland, Missouri, New York, Ohio, Tennessee
2016-11
Recruiting
Phase I/II/III Gene Transfer Clinical Trial of scAAV9.U1a.hSGSH
NCT02716246MPS IIIA, Sanfilippo Syndrome, Sanfilippo A, Mucopolysaccharidosis III
Ultragenyx Pharmaceutical Inc
Phase 2/3
36
Ohio, Pennsylvania
2016-04-25
Active, closed
A Study of Acalabrutinib in Combination With Rituximab + (Bendamustine or Venetoclax) in Subjects With MCL
NCT02717624Mantle Cell Lymphoma (MCL)
DrugAcalabrutinib
Acerta Pharma BV
Phase 1
72
Kentucky, Michigan, New Jersey, New York, Ohio, Tennessee, Texas, Washington
2016-04-20
Active, closed
DS-3201b in Participants With Lymphomas
NCT02732275Lymphoma, Malignant, Non-hodgkin Lymphoma
DrugValemetostat Tosylate
Daiichi Sankyo Co., Ltd.
Phase 1
100
California, Connecticut, Georgia, Massachusetts, New Jersey, New York, North Carolina, Ohio
2016-03-31
Active, closed
A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.
NCT02734004Ovarian, Breast, SCLC, Gastric Cancers
DrugsAvastin·Olaparib·Durvalumab·Bevacizumab
AstraZeneca
Phase 1/2
264
Georgia, Maryland, Massachusetts, Michigan, Missouri, Ohio, Pennsylvania
2016-03-17
Active, closed
A Study of ACP-196 (Acalabrutinib) in Subjects With Relapsed/Refractory CLL and Intolerant of Ibrutinib Therapy
NCT02717611Chronic Lymphocytic Leukemia
DrugAcalabrutinib
Acerta Pharma BV
Phase 2
60
Arizona, California, District of Columbia, Illinois, New York, Ohio, Tennessee, Texas
2016-03-08
Active, closed
Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System
NCT02514525Barrett Esophagus
Pentax Medical
Not applicable
150
California, Florida, Illinois, Maryland, Minnesota, New York, North Carolina, Ohio
2016-03
Active, closed
A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children
NCT02637687Solid Tumors Harboring NTRK Fusion
DrugLarotrectinib
Bayer
Phase 1/2
154
California, Florida, Massachusetts, New York, Ohio, Pennsylvania, Tennessee, Texas
2015-12-16
Active, closed
On-X Aortic Prosthetic Heart Valve Low Dose Warfarin Post Approval Clinical Registry Study
NCT02677974Thrombotic and Bleeding Events
On-X Life Technologies, Inc.
Observational
510
Arizona, Connecticut, Indiana, Maine, North Dakota, Ohio, Oregon, Texas
2015-11-10
Active, closed
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
NCT02542293Non Small Cell Lung Carcinoma NSCLC
DrugsTremelimumab·Durvalumab·Pemetrexed·Gemcitabine
AstraZeneca
Phase 3
953
California, Kentucky, New Jersey, New Mexico, New York, Ohio, Pennsylvania, Texas
2015-11-03
Active, closed
JOURNEY™ II CR Total Knee System
NCT02440672Osteoarthritis, Knee
Smith & Nephew, Inc.
Observational
170
Arizona, Illinois, Maryland, New York, North Carolina, Ohio
2015-09
Recruiting
Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children
NCT02235857Focal Segmental Glomerulosclerosis
Kaneka Medical America LLC
Not applicable
35
California, Delaware, Florida, Michigan, Minnesota, New York, North Carolina, Ohio
2015-05-03
Active, closed
Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration
NCT02286089Age-Related Macular Degeneration
DrugOpRegen
Hoffmann-La Roche
Phase 1/2
24
California, Ohio, Pennsylvania
2015-04-01
Active, closed
Edwards EVOQUE Eos MISCEND Study
NCT02718001Mitral Valve Regurgitation (Degenerative or Functional)
Edwards Lifesciences
Not applicable
123
California, Georgia, Illinois, Indiana, Massachusetts, New Jersey, New York, Ohio
2015-02-06
Active, closed
Acalabrutinib in Combination With ACP-319, for Treatment of Chronic Lymphocytic Leukemia
NCT02157324Chronic Lymphocytic Leukemia
DrugAcalabrutinib
Acerta Pharma BV
Phase 1
12
Ohio, Tennessee, Texas
2014-08-18
Active, closed
Persona Total Knee Arthroplasty Outcomes Study
NCT02255383Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
737
Colorado, Illinois, Indiana, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2014-07
Recruiting
Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer
NCT01954992Metastatic Pancreatic Adenocarcinoma
DrugsFluorouracil·Adrucil
Eleison Pharmaceuticals LLC.
Phase 3
480
California, Florida, Ohio
2014-04
Active, closed
ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia
NCT02029443Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Richter's Syndrome, Prolymphocytic Leukemia
DrugAcalabrutinib
Acerta Pharma BV
Phase 1/2
306
Massachusetts, New York, Ohio, Texas, Utah, Washington
2014-01-30
Active, closed
Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant
NCT01744223Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Lymphoma, Myelodysplastic Syndromes
DrugRimiducid
Bellicum Pharmaceuticals
Phase 1/2
36
Georgia, New York, Ohio, Oregon, Texas, Washington
2013-03
Active, closed
Survivorship of Attune Primary Total Knee Prosthesis
NCT01754363Noninflammatory Degenerative Joint Disease
DePuy International
Not applicable
1,542
Arizona, California, Florida, Indiana, Iowa, Ohio, Pennsylvania, Texas
2013-02-01
Active, closed
An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis
NCT01357668Juvenile Idiopathic Arthritis
Bristol-Myers Squibb
Observational
800
Arkansas, New Jersey, Ohio
2013-01-30
Active, closed
Study to Evaluate the Antiviral Efficacy, Safety and Tolerability of Tenofovir Disoproxil Fumarate Versus Placebo in Pediatric Participants With Chronic Hepatitis B Infection
NCT01651403Chronic Hepatitis B
DrugTenofovir DF
Gilead Sciences
Phase 3
90
Arizona, California, Colorado, Ohio, Texas
2012-12-06
By invitation
Comprehensive Reverse Shoulder Data Collection
NCT03404778Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects
Zimmer Biomet
Observational
175
Maryland, Michigan, Minnesota, Ohio
2010-03-07
Recruiting
Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).
NCT00903110IGF1 Deficiency
Esteve Pharmaceuticals, S.A.
Observational
500
California, Florida, Ohio, Texas
2008-12-09
Rows per page Showing 1001–1263 of 1263
Previous 1 2 3
Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/ohio?page=3

Query this register directly
GET /api/trials?country=usa&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,263 of those studies with a site in Ohio.

How many clinical trials are recruiting in Ohio?

737 of the 1,263 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 32 have not yet opened recruitment, 450 are active but closed to new participants, and 44 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.