Clinical trial register · Spain

Clinical Trials in Spain

Every study on the ClinicalTrials.gov registry that lists a site in Spain and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 5909 matching records held by the registry are in this view. Synced 13 Nov 2026, 03:19 UTC

5909

Studies in scope

all four open statuses

3100

Recruiting now

open to new participants

1129

Lead sponsors

across recruiting studies

Top sites

Barcelona 3245 Madrid 3071 Valencia 1206 Seville 1059 Málaga 762

Trials in this register

Status

Study

Lead sponsor

Phase

Enrol

Sites in Spain

Start

Active, closed

Administration of High Doses of Antiretroviral Drugs to Eliminate the Latent HIV-1 Reservoir

NCT06640192HIV-1-infection

Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal

Phase 2

Madrid

2025-05-30

Recruiting

Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

NCT06872905Aortoiliac Occlusive Disease

W.L.Gore & Associates

Observational

158

Alicante

2025-05-30

Recruiting

Comparison of the Perception of Non-technical Skills

NCT06340529Healthy

University of Valencia

Not applicable

100

Valencia

2025-05-30

Recruiting

Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

NCT06784752Somatostatin Receptor Positive (SSTR+), Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET)

DrugOctreotide LAR

Novartis Pharmaceuticals

Phase 3

240

L'Hospitalet de Llobregat, Oviedo, Barcelona, Madrid, Salamanca

2025-05-30

Active, closed

A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

NCT06961006Malignant Melanoma

DrugsIntismeran autogene·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 2

160

Barcelona, Madrid

2025-05-29

Recruiting

Encorafenib and biNimetinib Followed by CEmiplimab and FiAnLimab in Patients With BRAF Mutant melanOma and Symptomatic Brain Metastases

NCT06887088Melanoma BRAF V600E/K Mutated, Melanoma and Brain Metastases

DrugsFianlimab·Encorafenib·Binimetinib·Cemiplimab

Grupo Español Multidisciplinar de Melanoma

Phase 2

A Coruña, Barcelona, Burgos, Santander, Cáceres, Donostia / San Sebastian, Madrid, Majadahonda

2025-05-29

Recruiting

Effects of Peptamen 1.6 in Malnourished Patients (or at Risk) With Pancreatic Neoplasia Undergoing Cephalic Pancreaticoduodenectomy (CPD): A Mechanistic Study

NCT06852014Pancreatic Cancer, Adult, Cephalic Duodenopancreatectomy

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud

Not applicable

Málaga

2025-05-29

Recruiting

Medical Device Clinical Trial Without CE Marking to Evidence Safety and Performance of the INBENTUS VERSATILE Ventilator in Patients Requiring Assisted/Controlled Mechanical Ventilation and Weaning.

NCT07432191Acute Respiratory Distress Syndrome (ARDS), Pneumonia, COPD (Chronic Obstructive Pulmonary Disease), Postoperative Respiratory Distress

Iconic Solutions By Murcia SL

Not applicable

Murcia

2025-05-29

Active, closed

Study of BLU-808 in Chronic Inducible Urticaria (CIndU) and Chronic Spontaneous Urticaria (CSU)

NCT06931405Chronic Inducible Urticaria, Chronic Spontaneous Urticaria

Blueprint Medicines Corporation

Phase 2

105

Barcelona, Málaga

2025-05-28

Active, closed

A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event

NCT07000123Cardiovascular Disease

DrugAZD0780

AstraZeneca

Phase 3

3,103

A Coruña, Barcelona, Córdoba, Madrid, Santiago(A Coruña), Seville

2025-05-28

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine

NCT06682988Advanced High-Grade Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancers

DrugsMIRV·Mirvetuximab Soravtansine

AbbVie

Phase 2

110

Badalona, Jaén, El Palmar, Pamplona, Seville, Barcelona, Madrid, Valencia

2025-05-28

Recruiting

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

NCT06780098Lung Neoplasm

DrugsR-DXd·Ifinatamab Deruxtecan·Taxotere·Docetaxel

Merck Sharp & Dohme LLC

Phase 2

144

L'Hospitalet de Llobregat, Barcelona, Madrid, Seville

2025-05-28

Recruiting

A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)

NCT06782373VEXAS, VEXAS Syndrome

DrugPacritinib

Swedish Orphan Biovitrum

Phase 2

156

Barcelona, L'Hospitalet de Llobregat, Salamanca

2025-05-28

Recruiting

Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

NCT07039916Generalized Myasthenia Gravis

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 3

231

Barcelona, Córdoba, Madrid

2025-05-27

Recruiting

Multicenter Study for the Validation of an AI-based ECG Platform for Early Cardiac Amyloidosis Diagnosis

NCT06978660Transthyretin Cardiac Amyloidosis

Idoven 1903 S.L.

Observational

2,200

Palma de Mallorca, San Sebastián, Huelva

2025-05-27

Recruiting

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

NCT07012395Ulcerative Colitis, Inflammatory Bowel Diseases, Colitis, Colitis, Ulcerative

DrugsSPY001·SPY002·SPY003

Spyre Therapeutics, Inc.

Phase 2

645

Santiago de Compostela, Gijón, Lugo, Madrid, Ourense, Seville

2025-05-27

Recruiting

Patient-centered Personalized Cardiac Rehabilitation in Post Acute Coronary Syndrome (BREAK-trial)

NCT07038265Acute Coronary Syndromes (ACS), Cardiac Rehabilitation, Frailty, Women

Institut d'Investigació Biomèdica de Bellvitge

Not applicable

202

L'Hospitalet de Llobregat

2025-05-26

Recruiting

tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis

NCT06986278tDCS, Sham tDCS

University of Castilla-La Mancha

Not applicable

Toledo

2025-05-26

Recruiting

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

NCT06941272Malignant Neoplasm

DrugPatritumab deruxtecan

Merck Sharp & Dohme LLC

Phase 1/2

Esplugues de Llobregat, Barcelona, Madrid

2025-05-26

Recruiting

Intelligent Lung Support in the Intensive Care Unit

NCT06595602Mechanical Ventilation, Intensive Care Medicine

Technische Universität Dresden

Observational

530

Madrid, Sabadell

2025-05-25

Recruiting

Maternal and Postnatal Outcomes Study (MOS): A Global Observational Registry Assessing the Safety of Elfabrio® in Women With Fabry Disease and Their Infants During Pregnancy and Breastfeeding

NCT06941025Fabry Disease, Pregnancy, Pregnancy Complications

Chiesi Farmaceutici S.p.A.

Observational

Madrid

2025-05-23

Active, closed

The RECOVERY Study: Using Supersaturated Oxygen Therapy To Treat Small Vessel Blockages After a Heart Attack

NCT07000266Anterior STEMI

Fundacio Privada Mon Clinic Barcelona

Not applicable

Barcelona

2025-05-23

Recruiting

Intermittent Androgen Deprivation Therapy in the Era of AR Pathway Inhibitors

NCT05974774Prostate Cancer

European Organisation for Research and Treatment of Cancer - EORTC

Phase 3

1,600

Barcelona, Madrid, Majadahonda

2025-05-23

Recruiting

Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck Cancer

NCT05815927Oligometastatic Squamous Cell Carcinoma of the Head and Neck

DrugPembrolizumab

European Organisation for Research and Treatment of Cancer - EORTC

Phase 3

200

Badalona, Barakaldo, Barcelona, Las Palmas de Gran Canaria, Madrid, Málaga

2025-05-23

Active, closed

VITUS Post-Market Registry

NCT06832631Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease

OrbusNeich

Observational

283

Gijón, Granollers, Ourense, Toledo

2025-05-22

Recruiting

Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.

NCT06697301Advanced Melanoma

DrugsEIK1001·Keytruda·Pembrolizumab

Eikon Therapeutics

Phase 2/3

740

Santiago de Compostela, Badalona, Barcelona, Santander, Cáceres, Lugo, Girona, Madrid

2025-05-22

Recruiting

A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

NCT06901531Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

DrugsZolbetuximab·Adrucil·Capecitabine·Oxaliplatin

Astellas Pharma Global Development, Inc.

Phase 3

500

Elche, San Cugat Del Valles Barcelona, Madrid, Navarra, A Coruña, Barcelona, El Palmar, Lleida

2025-05-22

Recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

NCT06952504Endometrial Cancer

DrugsSacituzumab tirumotecan·Keytruda·Docetaxel·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

1,123

L'Hospitalet de Llobregat, Girona, Barcelona, Córdoba, Madrid, Valencia

2025-05-22

Recruiting

Study of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic Urticaria

NCT06865651Chronic Urticaria (CU): Chronic Inducible Urticaria (CINDU) and Chronic Spontaneous Urticaria (CSU)

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 2

Barcelona, Pamplona, Alicante, Madrid

2025-05-22

Active, closed

A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia

NCT06843590Idiopathic Hypersomnia

DrugALKS 2680

Alkermes, Inc.

Phase 2

126

Barcelona, Madrid

2025-05-22

Active, closed

Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa

NCT06940830Hemophilia A

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 4

252

Salamanca, A Coruña, Barcelona, Málaga, Palma de Mallorca, Zaragoza

2025-05-21

Active, closed

A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)

NCT06966479Severe Asthma

DrugVerekitug

Upstream Bio Inc.

Phase 2

396

Barcelona, Madrid

2025-05-21

Active, closed

Clinical Trial on the Use of Stratafix Symmetric vs. Resorbable Monofilament for Closure of Large Median Laparotomy in Oncological Patients

NCT07218679Incisional Hernia After Midline Laparotomy

Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

Not applicable

140

Seville

2025-05-21

Recruiting

Patient-Centric Study to Assess the Impact of Genomic Profiling on the Treatment of Patients With Metastatic Breast Cancer in Spain

NCT06991946Metastatic Breast Cancer

SOLTI Breast Cancer Research Group

Observational

300

Barcelona

2025-05-20

Not yet open

Cortical Effects of Peripheral Proprioceptive Stimulation on the Motor Evoked Potentials of the Limbs

NCT06936579Healthy Subjects

Facultat de ciencies de la Salut Universitat Ramon Llull

Not applicable

Barcelona

2025-05-20

Recruiting

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

NCT06935370Heart Failure

DrugsVicadrostat·Dapagliflozin

Boehringer Ingelheim

Phase 3

4,200

Barcelona, Madrid, Sanlúcar de Barrameda, Santiago de Compostela, Torrejón de Ardoz, Valencia, Villamartín

2025-05-20

Active, closed

A Long-term Study to Monitor the Health Status of People With Cystic Fibrosis Who Took Part in a Previous Study With BI 3720931 (Lenticlair™-ON)

NCT06962852Cystic Fibrosis

Boehringer Ingelheim

Phase 1/2

Barcelona

2025-05-20

Recruiting

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

NCT06977581Asthma

DrugTilrekimig

Pfizer

Phase 2

252

Santander, Pozuelo de Alarcón, Madrid, Málaga

2025-05-20

Recruiting

The Cooling Sensation Safe Deglution Study

NCT06936501Neuromotor Dysphagia After Acute Stroke

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud

Not applicable

Málaga

2025-05-19

By invitation

Manual Therapy Techniques for Cervical Pain: Algometric Evaluation

NCT06982456Myofascial Pain Syndromes, Massage, Stretching

Universidad de Murcia

Not applicable

105

Murcia

2025-05-19

Recruiting

Phase III Extension Study of Efficacy and Safety of Ianalumab With or Without Study Treatment Withdrawal in Participants With Lupus Nephritis (SIRIUS-LN Extension)

NCT06711887Lupus Nephritis

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

348

Barcelona

2025-05-19

Recruiting

Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation

NCT06830798Delayed Graft Function, DGF, Kidney Transplant

DrugRavulizumab

Alexion Pharmaceuticals, Inc.

Phase 3

450

Badajoz, Barakaldo, Barcelona, Cadiz, Córdoba, Granada, Madrid, Málaga

2025-05-19

Recruiting

Cardiovascular Research in EMbarazo and MAternity (EMMA). Study on Heart Rate Variability and Hemodynamic Adaptations During Pregnancy and Postpartum.

NCT07376616Pregnancy Related, Heart Rate Variation (HRV), Hemodynamics

Fundacin Biomedica Galicia Sur

Observational

242

Vigo

2025-05-19

Recruiting

Exploring Participant Preference for Screening Methods and Experience Into Colorectal Cancer Screening Programme

NCT06696534Screening for Colon Cancer, Survey and Questionnaire

ADVANCED MARKER DISCOVERY S.L.

Not applicable

1,000

Madrid

2025-05-19

Recruiting

Exercise to Fight Obesity

NCT06934681Morbid Obesity, Bariatric Surgery, Telerehabilitation

Instituto de Investigacion Sanitaria La Fe

Not applicable

Valencia

2025-05-19

Recruiting

EEG-based Neurofeedback to Improve Emotion Regulation in Major Depressive Disorder: A Randomized Clinical Trial

NCT07041073Major Depression With Comorbid Anxiety Symptoms, Major Depressive Disorder (MDD)

Corporacion Parc Tauli

Not applicable

Sabadell

2025-05-19

Recruiting

A Study of Duvelisib Versus Gemcitabine or Bendamustine in Participants With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype

NCT06522737Lymphoma

DrugsDuvelisib·Bendamustine·Gemcitabine

SecuraBio

Phase 3

124

Barcelona, Madrid, Salamanca, Seville

2025-05-19

Active, closed

Tibulizumab Skin Healing and Inflammation Evaluation for Lasting Defense

NCT06993610Hidradenitis Suppurativa (HS)

Zura Bio Inc

Phase 2

247

Córdoba, Madrid, Zaragoza

2025-05-16

Active, closed

Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC)

NCT06898957Small Cell Lung Cancer

DrugsTam-Peli·Tarlatamab·Durvalumab

Amgen

Phase 1

Barcelona, Majadahonda, Madrid

2025-05-16

Recruiting

Platform Study to Evaluate the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis

NCT06947993Atopic Dermatitis

Novartis Pharmaceuticals

Phase 2

224

Badalona, Alicante, Granada, Las Palmas GC, Madrid, Pontevedra

2025-05-16

Recruiting

Life Monitoring for Rural Older Adults

NCT06974006Aged 60 Years or Older

European University Miguel de Cervantes

Observational

Valladolid

2025-05-15

Active, closed

Effectiveness of a Prehabilitation Program for Hip or Knee Arthroplasty Surgery.

NCT06721897Prehabilitation, Knee Osteoarthritis, Hip Osteoarthritis, Physical Therapy Modalities

University of Jaén

Not applicable

Granada

2025-05-15

Recruiting

Evaluation of an Integrated Home Care Model

NCT07408882Older Adults (70 or More) Living at Home With Health and Social Complexity

Parc Sanitari Pere Virgili

Not applicable

1,000

Barcelona, Girona, Olot, Vic

2025-05-15

Recruiting

Surgical vs Transcatheter Aortic Valve Replacement in YOUNG Patients

NCT06861361Symptomatic Severe Aortic Stenosis

Ceric Sàrl

Not applicable

1,180

Oviedo, Valladolid

2025-05-15

Recruiting

Perioperative Durvalumab With Neoadjuvant ddMVAC in Patients With Muscle-Invasive Bladder Cancer (NIAGARA-2)

NCT06960577Urinary Bladder Neoplasms, Immune Checkpoint Inhibitors, Methotrexate, Vinblastine

DrugsVinblastine·Methotrexate·Doxorubicin·Durvalumab

AstraZeneca

Phase 2

150

Barcelona, Girona, Las Palmas de Gran Canaria, Lugo, Madrid, Santiago de Compostela

2025-05-15

Recruiting

Optimizing Reperfusion to Improve Outcomes and Neurologic Function

NCT06990867Acute Ischemic Stroke

Corxel Pharmaceuticals

Phase 2/3

740

A Coruña, Albacete, Barcelona, Girona, Madrid, Málaga, Seville, Valencia

2025-05-15

Recruiting

One-year Outcomes by Index Treatment in Elderly Patients With Acute Cholecystitis

NCT07006298Acute Cholecystitis

Instituto de Investigación Sanitaria y Biomédica de Alicante

Observational

376

Alicante

2025-05-15

Recruiting

EFESO: Study on Juvenile Onset Eosinophilic Fasciitis

NCT07348263Eosinophilic Fasciitis

Meyer Children's Hospital IRCCS

Observational

Barcelona

2025-05-15

Not yet open

Multicomponent FIBROWALK Therapy Plus Unified Protocol for Emotional Regulation in Individuals With Fibromyalgia

NCT06906991Fibromyalgia (FM)

Hospital Universitari Vall d'Hebron Research Institute

Not applicable

182

Barcelona

2025-05-15

Active, closed

Study of GS-0151 in Participants With Rheumatoid Arthritis

NCT06902519Rheumatoid Arthritis

Gilead Sciences

Phase 1

A Coruña, Barcelona, Madrid, Sabadell, Seville

2025-05-14

Active, closed

RADIQAL Study (Radiation Dose and Image Quality Trial)

NCT06944509Coronary Artery Disease

Philips Clinical & Medical Affairs Global

Not applicable

824

Madrid

2025-05-14

By invitation

Prevalence of Sarcopenia in Patients Admitted to ICU and Its Progression During Hospitalization.

NCT07303335Sarcopenia, Critical Illness, Intensive Care (ICU) Myopathy, Body Composition Measurement

Hospital Mutua de Terrassa

Observational

100

Terrassa

2025-05-14

Recruiting

Digital Solutions for bEtter cAre

NCT07416513Cancer Diagnosis

European Institute of Oncology

Not applicable

200

Barcelona

2025-05-14

Active, closed

A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone

NCT06806852Head and Neck Squamous Cell Carcinoma

DrugsBI 770371·Cetuximab·Pembrolizumab

Boehringer Ingelheim

Phase 1

Barcelona

2025-05-14

Recruiting

A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis

NCT07003425Atopic Dermatitis

DrugAPG777

Apogee Therapeutics, Inc.

Phase 2

350

Santiago de Compostela, Badalona, Las Palmas de Gran Canaria, Alicante, Madrid

2025-05-14

By invitation

The Effect of Digital Markers in the Self-management of Depressive Symptoms

NCT06919133Depression - Major Depressive Disorder, Mental Distress

Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital

Not applicable

660

Barcelona

2025-05-13

Recruiting

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

NCT06925737Prostate Cancer, Prostatic Neoplasms

DrugsIfinatamab Deruxtecan·Prednisolone·Prednisone·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

1,440

Santander, Santiago de Compostela, Majadahonda Madrid, Madrid, Barcelona, Córdoba, Lugo, Seville

2025-05-13

Active, closed

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

NCT06780085Carcinoma, Non-Small-Cell Lung

DrugsR-DXd·Ifinatamab Deruxtecan

Merck Sharp & Dohme LLC

Phase 2

L'Hospitalet de Llobregat, Madrid

2025-05-13

Recruiting

Validation of α-synuclein Modifications in Parkinson's dIsoRder Evolution

NCT06941012Parkinson Disease (PD)

Casa di Cura IGEA

Observational

1,200

Madrid

2025-05-12

Active, closed

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

NCT06925750Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

130

Palma, Santander, Barcelona, Madrid, Seville, Toledo

2025-05-12

Active, closed

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight

NCT06962280Type 1 Diabetes, Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

465

Badajoz, Badalona, Barcelona, Madrid, Seville

2025-05-12

Recruiting

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

NCT06563895Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis, Cardiomyopathies

DrugAcoramidis

Eidos Therapeutics, a BridgeBio company

Phase 3

587

A Coruña, Barcelona, Huelva, Majadahonda, Palma de Mallorca, Salamanca

2025-05-12

Recruiting

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

NCT06819891Moderately to Severely Active Crohns Disease

DrugAfimkibart

Hoffmann-La Roche

Phase 3

425

Alcorcón, Majadahonda, Madrid, Zaragoza

2025-05-12

Recruiting

FB-CT2 Includes Two Prospective, Multi-centre Studies With a Medical Device in Hospital Settings: a Randomized, Dual-arm, Open-label Pilot Study in Spain, Followed by a Single-arm, Non-randomized, Open-label International Pivotal Study

NCT06968364Threatened Preterm Labor

Ultrasound-Innovation Medtech, S.L.

Not applicable

457

A Coruña, Barcelona, Bilbao, Donostia / San Sebastian, Granada, Las Palmas de Gran Canaria, Madrid, Málaga

2025-05-10

Recruiting

A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN)

NCT06935357Immunoglobulin A Nephropathy (IgAN)

DrugFelzartamab

Biogen

Phase 3

454

Viladecans, Barcelona, A Coruña, Alcorcón, Getafe, Cáceres, Girona, Madrid

2025-05-08

Recruiting

Spontaneous Eye Blinking in Disorders of Consciousness

NCT06323031Disorders of Consciousness

Fondazione Don Carlo Gnocchi ETS

Observational

Valencia

2025-05-08

Recruiting

Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.

NCT06626022Prostate Cancer Screening

University of Alberta

Phase 3

1,284

Bilbao

2025-05-08

Recruiting

Evaluation of Clinical Outcomes of Ponto Procedures Performed in Settings Outside the Main Operating Room (i.e. Out-of-OR)

NCT06930781Hearing Loss, Bone Anchored Hearing Aids

Oticon Medical

Observational

270

Granada

2025-05-07

Active, closed

A Dose Escalation and Expansion Trial With BYON4228 Alone and in Combination in Patients With Advanced or Metastatic Solid Tumors

NCT06932952Solid Tumor

DrugsBYON4228·Pembrolizumab

Byondis B.V.

Phase 1

Madrid

2025-05-07

Recruiting

Impact of a Perioperative Physical Exercise and Respiratory Physiotherapy Program on the Patient Undergoing Bariatric Surgery

NCT06987903Bariatric Surgery and Physical Activity, Obesity/Therapy, Bariatric Surgery Complications, Bariatric Patients

Fundacin Biomedica Galicia Sur

Not applicable

132

Vigo

2025-05-07

Active, closed

FARAPULSE Workflow Assessment Registry

NCT06656884Atrial Fibrillation (AF)

Boston Scientific Corporation

Observational

524

Barcelona, El Palmar, Pamplona, Santa Cruz de Tenerife

2025-05-06

Active, closed

CEB-01 in Pediatrics With Locally Resectable Abdominal Tumors

NCT06986811Locally Resectable Pediatrics Tumors

DrugCEB-01

CEBIOTEX

Phase 2

Esplugues de Llobregat

2025-05-06

Recruiting

Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2

NCT07227246Intracerebral Hemorrhage

DrugRecombinant Factor VIIa

Joseph Broderick, MD

Phase 3

350

Badalona, Horta, L'Hospitalet de Llobregat, Barcelona, Girona, Lleida, Valladolid

2025-05-06

Recruiting

Safety of HRX215 in Patients After Minor and Major Liver Resection

NCT06638502Liver Resection, Colorectal Carcinoma Liver Metastases

HepaRegeniX GmbH

Phase 1/2

Madrid, Valencia

2025-05-06

Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

NCT06499285Myelodysplastic Syndromes

DrugElritercept

Takeda

Phase 3

225

Salamanca, Barcelona, L'Hospitalet de Llobregat, Madrid, Valencia

2025-05-06

Recruiting

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

NCT06881784NSCLC (Non-small Cell Lung Cancer), Non-Small Cell Lung Cancer, NSCLC, NSCLC (Non-small Cell Lung Carcinoma)

DrugsCetuximab·Docetaxel

Revolution Medicines, Inc.

Phase 3

590

A Coruña, Barcelona, Jerez de la Frontera, Jaén, Las Palmas de Gran Canaria, Fuencarral-El Pardo, Madrid, Majadahonda

2025-05-06

Recruiting

VitaFlow LIBERTY Europe

NCT06535659Aortic Valve Stenosis

Shanghai MicroPort CardioFlow Medtech Co., Ltd.

Observational

222

A Coruña, Madrid, Valladolid

2025-05-06

Recruiting

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

NCT06921785Hepatocellular Carcinoma

DrugsRilvegostomig·Tremelimumab·Atezolizumab·Bevacizumab

AstraZeneca

Phase 3

1,220

Barcelona, Madrid, Santander

2025-05-06

Active, closed

Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach to Treat Myasthenia Gravis

NCT06799247Myasthaenia Gravis

Cartesian Therapeutics

Phase 3

128

Barcelona, Madrid

2025-05-06

Recruiting

A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)

NCT06952699Narcolepsy Type 2

DrugTAK-360

Takeda

Phase 2

Madrid

2025-05-06

Recruiting

Ultrathin Strut Sirolimus-eluting Stent With Bioabsorbable Polymer in Patients Receiving Chronic Oral Anticoagulation

NCT06863155Coronary Artery Disease, Ischemic Heart Disease

Fundación EPIC

Observational

500

Albacete, Alicante, Badajoz, Castelló, Ciudad Real, Elche, L'Hospitalet de Llobregat, Laguna

2025-05-06

Recruiting

A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

NCT06747351Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

DrugsTAK-881·Phesgo

Takeda

Phase 3

Barcelona, Valencia

2025-05-06

Active, closed

A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity

NCT06965413Obesity, Overweight, Overweight With One Weight Related Comorbidity

DrugsRO7204239·Tirzepatide

Hoffmann-La Roche

Phase 2

285

Seville, Santander, Castilleja de la Cuesta, A Coruña, Barcelona, Málaga

2025-05-05

Not yet open

Muscle Oxygen Saturation and Functional Capacity in Breast Cancer Survivors

NCT06976593Breast Cancer Survivorship, Muscle Oxygenation, Near-infrared Spectroscopy, Exercise

University of Extremadura

Observational

Badajoz

2025-05-05

Active, closed

Multimodal Training With Immersive Virtual Reality to Improve the Cognitive Health and Emotional Well-being of Older Women Living Alone

NCT06956794Social Isolation in Older Adults, Poverty

Consorci Sanitari de Terrassa

Not applicable

Barcelona, Terrassa

2025-05-05

Recruiting

Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML

NCT06652438Acute Myeloid Leukemia, Adult

DrugRevumenib

Stichting Hemato-Oncologie voor Volwassenen Nederland

Phase 3

448

Alicante, Barcelona, Girona, Lleida, Madrid, Palma de Mallorca, Tarragona, Valencia

2025-05-05

Recruiting

Effectiveness of a Telerehabilitation Program for Improving Sexual Function and Reducing Pain in Menopausal Women

NCT06710002Menopause, Genitourinary Syndrome of Menopause, Dyspareunia

Instituto Médico Tecnológico SL

Not applicable

Barcelona

2025-05-05

Active, closed

WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)

NCT06967805Idiopathic Pulmonary Fibrosis

Mediar Therapeutics

Phase 2

168

Barcelona, Lugo, Madrid, Santander

2025-05-05

Recruiting

Effectiveness of an IVR-based Therapeutic Exercise Program With Altered Visual Feedback in Fibromyalgia Patients

NCT06948500Fibromyalgia

Cardenal Herrera University

Not applicable

Valencia

2025-05-05

Not yet open

Predictors of Physical Activity in Adult Patients With Hemophilic Arthropathy

NCT06960499Hemophilia

Universidad Católica San Antonio de Murcia

Observational

Murcia

2025-05-04

Recruiting

2024 NewAnescat Register

NCT06792773Anesthesia

Consorci Sanitari de Terrassa

Observational

13,634

Barcelona

2025-05-04

Recruiting

Spanish Validation of KOQUSS-40 Questionnaire: Assessing QoL of Gastric Cancer Patients After Gastrectomy: SPQUSS-41

NCT07504913Stomach Neoplasms, Validation Study

Parc de Salut Mar

Observational

505

Badalona, Barcelona, L'Hospitalet de Llobregat, Puerto Real, Logroño, Lleida

2025-05-03

Recruiting

Identity-Based Transdiagnostic Therapy for Young People With Anxiety and Depression

NCT06384196Depression, Anxiety

University of Barcelona

Not applicable

138

Badalona, Barcelona

2025-05-02

Not yet open

Effects of Two Strength Exercise Programs on Upper Limb Functionality in Breast Cancer

NCT06952270Breast Cancer Survivor, Breast Cancer, Breast Cancer Patients, Breast Cancer - Female

University of Vigo

Not applicable

Pontevedra

2025-05-02

By invitation

SMARTCLOTH. Design, Implementation and Study of the Effectiveness and Usability of a Digital Tablecloth for Self-management of Diet in Diabetic Patients.

NCT06623708Diabetes Mellitus Type 2, Diabetes Mellitus Type 1

Maimónides Biomedical Research Institute of Córdoba

Not applicable

Córdoba

2025-05-02

Recruiting

Treatment of Rumination

NCT06971354Rumination Syndrome

Hospital Universitari Vall d'Hebron Research Institute

Not applicable

Barcelona

2025-05-02

Recruiting

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

NCT06892548Advanced Lung Cancer

DrugsBNT324·Pumitamig

BioNTech SE

Phase 1/2

594

Barcelona, Córdoba, Málaga, Seville, Torrejón de Ardoz, Valencia

2025-05-02

Recruiting

Study of the Effect of Peripheral Somatosensory Stimulation on the Functionality of Patients With Cerebral Palsy and Reduced Mobility

NCT06951568Cerebral Palsy

Facultat de ciencies de la Salut Universitat Ramon Llull

Not applicable

Barcelona

2025-05-02

Recruiting

Effectiveness and Acceptability of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in People With Long COVID-19.

NCT06928480Long Covid-19, Emotional Disorder, Anxiety, Depression Disorders

Instituto de Investigación Sanitaria Aragón

Not applicable

Zaragoza

2025-05-01

Recruiting

Impact of a High-resolution Program for the Prevention of Suicidal Behavior in At-risk Adults: a Quasi-experimental Ambispective Cohort Study

NCT07655986Prevention of Suicidal Behavior

University of Salamanca

Not applicable

198

Salamanca

2025-05-01

Recruiting

Efficacy of Physical Therapy Treatment in Endometriosis and Its Relationship to Adherence Rates.

NCT06795243Endometriosis, Endometriosis Related Pain, Endometriosis, Pain, Endometriosis-related Pain

University of Seville

Not applicable

Seville

2025-05-01

Recruiting

HablaRÉ: Self-applied Online Training for Correcting Emotional Reasoning Biases in Public Speaking Anxiety.

NCT07051135Public Speaking Anxiety

Universitat Jaume I

Not applicable

Castellon

2025-05-01

Recruiting

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.

NCT06916806Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, Rheumatoid Arthritis

DrugAZD5492

AstraZeneca

Phase 1

Mérida, Seville, Valladolid

2025-05-01

By invitation

A Two-year Prospective, Observational Study of Wegovy in Real-world Clinical Practice

NCT07055607Obesity

DrugsWegovy·Semaglutide

Novo Nordisk A/S

Observational

1,250

Barcelona, Cartagena, Castilleja de la Cuesta, El Palmar (Murcia), Ferrol, Getafe (Madrid), La Cuesta (Santa Cruz de Tenerife), Las Palmas de Gran Canaria

2025-05-01

Not yet open

Corporal Composition and Gut Microbiome Modification Through Exclusion Dietary Intervention in Crohn's Disease

NCT06933264Crohn Disease

Hospital Universitario Virgen de la Arrixaca

Not applicable

El Palmar

2025-05-01

By invitation

ESCAPE10: Epidemiology, Risk Factors, and Outcomes of Severe Community-acquired Pneumonia in Elderly Patients Acquired Pneumonia in Elderly Patients

NCT07070284Severe Community-Acquired Pneumonia (sCAP), Elderly Infection, Community-Acquired Infections, Health Care Quality, Access, and Evaluation

Joan Sabater-Riera

Observational

500

Seville, L'Hospitalet de Llobregat, Barcelona, Sabadell, Donostia / San Sebastian

2025-05-01

Recruiting

NESA Neuromodulation Versus Transcutaneous Posterior Tibial Stimulation

NCT07019597Bladder Dysfunction

Daniel David Álamo Arce

Not applicable

Valencia

2025-05-01

Active, closed

OptimAIR: Towards Right Care in Asthma Through Point-of-care Phenotyping, Guideline-based Assessment and Management Optimalisation Using the AsthmaOptimiser in Primary Care

NCT07390669Asthma Control

General Practitioners Research Institute

Not applicable

746

Palma de Mallorca

2025-05-01

Recruiting

PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis

NCT06855329Progressive Pulmonary Fibrosis, Interstitial Lung Disease

University of Massachusetts, Worcester

Observational

500

Madrid

2025-05-01

Recruiting

Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)

NCT06961175Blood Platelet Disorders, Cardiac Surgery, Postoperative Bleeding

Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León

Observational

180

Salamanca

2025-05-01

By invitation

Validation Study of a New Digital Diagnostic and Treatment Test Based on Interactive Video Games for Alzheimer's Disease

NCT06963879Alzheimer Disease, MCI

Braingaze

Not applicable

Mataró

2025-05-01

Recruiting

Creation of Arteriovenous Fistulas for Hemodialysis Using the End-to-side Anastomotic Technique vs. Piggyback.

NCT06997042Chronic Kidney Disease Requiring Hemodialysis

Hospital Clinic of Barcelona

Not applicable

130

Barcelona

2025-05-01

Not yet open

Effects of Peripheral Somatosensory Stimulation Through Mechanical Pressure on Lower Limb Muscle Strength in Stroke Survivors

NCT06958185Stroke

Pedro Victor López Plaza

Not applicable

Barcelona

2025-05

Not yet open

Effects of Peripheral Somatosensory Stimulation Via Mechanical Pressure on Lower Limb Muscle Strength in Healthy Subjects.

NCT06936020Healthy Volunteers

Facultat de ciencies de la Salut Universitat Ramon Llull

Not applicable

Barcelona

2025-05

Not yet open

Autologous Tolerogenic Dendritic Cells (ATDC) for Highly Sensitized Kidney Transplant Recipients

NCT06852625Kidney Transplant Rejection

Fundacion Clinic per a la Recerca Biomédica

Phase 1

Badalona, Barcelona, L'Hospitalet de Llobregat, Zaragoza

2025-05

Active, closed

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

NCT06813911Atherosclerotic Cardiovascular Disease (ASCVD)

DrugsPelacarsen·Inclisiran

Novartis Pharmaceuticals

Phase 3

246

Santiago Compostela, Pamplona, Castilleja de la Cuesta, A Coruña, Barcelona, Córdoba, Huelva, Las Palmas GC

2025-04-30

Active, closed

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2

NCT06952530Hypertension

DrugOrforglipron

Eli Lilly and Company

Phase 3

487

A Coruña, Barcelona, Centelles, León, Seville

2025-04-30

Not yet open

Efficacy of the Vacucis Candida® Autovaccine

NCT05289375Oral Candidiasis, Oral Candidiasis Recurrent, Radiotherapy; Complications, Candida Albicans Infection

University of Santiago de Compostela

Not applicable

Santiago de Compostela

2025-04-30

Active, closed

Pediatric Expansion Study of the Sentio System

NCT06976086Hearing Loss, Conductive, Hearing Loss, Mixed, Single Sided Deafness

Oticon Medical

Not applicable

San Sebastián, Seville, Valencia

2025-04-30

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)

NCT06884618Neoplasms

Hoffmann-La Roche

Phase 1

405

Pamplona, Barcelona, Madrid

2025-04-30

Recruiting

Drug-Drug Intercations and Direct Acting Antiviral Agents Against HCV

NCT06928259HCV Infection

University of Seville

Observational

728

Cadiz, Córdoba, Huelva, Seville

2025-04-30

Recruiting

Analyzing the Benefits of Using SYMPTOMS-JIT for in Vivo Exposure in Anxiety Disorders

NCT06788119Anxiety Disorders, Specific Phobia, Panic Disorder, Agoraphobia

Universitat Jaume I

Not applicable

158

Castellon

2025-04-30

Active, closed

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1

NCT06948435Hypertension, Overweight or Obesity

DrugOrforglipron

Eli Lilly and Company

Phase 3

487

A Coruña, Barcelona, Centelles, León, Seville

2025-04-30

By invitation

Cities for Better Health Childhood Obesity Prevention Initiative

NCT06855563Obesity

Novo Nordisk A/S

Not applicable

36,000

Madrid

2025-04-30

Active, closed

A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)

NCT06948422Hypertension

DrugOrforglipron

Eli Lilly and Company

Phase 3

974

A Coruña, Barcelona, Centelles, León, Seville

2025-04-30

Active, closed

An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment

NCT06883240Von Willebrand Disease, Type 3

DrugsActivated Prothrombin Complex·Recombinant Factor VIIa

Hoffmann-La Roche

Observational

Madrid, Seville

2025-04-29

Active, closed

Long-term Safety and Efficacy of Leniolisib in PIDs With Immune Dysregulation

NCT06990529PIDs Linked to PI3K

DrugLeniolisib

Pharming Technologies B.V.

Phase 2

Valencia

2025-04-29

Recruiting

Skin Type Determination Using Image Artificial Intelligence

NCT07765303Skin Ageing, Skin

Region Skane

Observational

1,500

Madrid

2025-04-28

Recruiting

Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML/HR-MDS and in Combination With Azacitidine in Previously Untreated HR-MDS

NCT06533761AML, Adult, MDS

DrugsAzacitadine·Cytarabine·Azacitidine

Stelexis BioSciences

Phase 1

105

Cáceres, Valencia

2025-04-28

Active, closed

Protocol for a Natural-Based Intervention to Promote Quality of Life and Healthy Habits on Children and Adolescents.

NCT07080541Life Quality, Physical Activities, Life Style, Healthy, Life Style Modification

Universidad de Extremadura

Not applicable

728

Cáceres

2025-04-28

By invitation

A Study of Long-term Safety and Efficacy of VX-670 in Participants With Myotonic Dystrophy Type I

NCT06926621Myotonic Dystrophy Type 1 (DM1)

DrugVX-670

Vertex Pharmaceuticals Incorporated

Phase 2

Valencia

2025-04-28

Recruiting

Non-Steroidal Anti-Inflammatory Drugs in Acute Myocarditis

NCT06686862Myocarditis Acute

DrugIbuprofen

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III

Phase 3

150

Majadahonda

2025-04-28

Recruiting

Acetic Acid 2% Solution for Skin Ulcers

NCT06297967Ulcer, Skin

DrugProntosan

Consorci Sanitari de l'Alt Penedès i Garraf

Phase 3

104

Barcelona

2025-04-27

Active, closed

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

NCT06914895Type 1 Diabetes, Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

905

A Coruña, Barcelona, Ferrol, Móstoles, Santander, Seville

2025-04-25

Recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

NCT06820463Metastatic Colorectal Cancer

DrugsTelisotuzumab Adizutecan·Panitumumab·Fluorouracil·Leucovorin

AbbVie

Phase 2

390

Santander, Pamplona, Barcelona, Madrid, Valencia

2025-04-24

Recruiting

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

NCT06875310Carcinoma, Non-Small-Cell Lung

DrugsAdagrasib·Pemetrexed·Keytruda·Cisplatin

Mirati Therapeutics Inc.

Phase 3

630

A Coruña, Santiago de Compostela, Barcelona, Palma, Madrid, Majadahonda, Pontevedra, Valencia

2025-04-24

Active, closed

A Trial to Evaluate the Efficacy and Safety of Sibeprenlimab Administered Subcutaneously in Participants With Sjögren's

NCT06928142Sjogren Disease

DrugSibeprenlimab

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 2

Santander, Castelló, Madrid, Torrevieja

2025-04-23

Recruiting

Effectiveness of m-CIMT of the Upper Limb in Acute Post-stroke Patients. (m-CIMT, Modified Constraint-induced Movement Therapy)

NCT07233161Isquemic Stroke, Upper Limb Weakness Due to Central Neurologic Injury

Hospital Clinic of Barcelona

Not applicable

Barcelona

2025-04-23

By invitation

Effect on Body Weight Reduction of a Behavioral Intervention on Lifestyle Using a Digital Nutritional Program in People Living With HIV and Metabolic Dysfunction-associated Steatotic Liver Disease

NCT07456332Metabolic Dysfunction-Associated Steatotic Liver Disease, People Living With HIV, Life Style

Hospital Universitari de Bellvitge

Not applicable

116

L'Hospitalet de Llobregat

2025-04-23

Recruiting

A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer

NCT06827236Locally Advanced Breast Cancer, Unresectable Breast Carcinoma, Metastatic Breast Cancer

DrugPumitamig

BioNTech SE

Phase 1/2

380

Barcelona, Madrid, Pamplona, Pozuelo de Alarcón

2025-04-23

Recruiting

MELIORA Data Collection Campaigns

NCT07190066Breast Cancer Prevention

Harokopio University

Not applicable

300

Valencia

2025-04-22

Recruiting

EMBRACE Tremor BiFUS

NCT06974916Essential Tremor

InSightec

Not applicable

100

Badalona, Móstoles, Pamplona, Valencia

2025-04-22

Active, closed

Treatment of Patients With Neck Pain After a Commuting Accident

NCT06938828Cervical Injury Spine

Universidad Católica San Antonio de Murcia

Observational

204

Murcia

2025-04-22

Active, closed

A Study of Roginolisib (IOA-244) in Combination With Dostarlimab With or Without Docetaxel in Metastatic Non Small-cell Lung Cancer (NSCLC) Patients

NCT06879717Non-Squamous Non-Small Cell Lung Cancer (NSCLC), Advanced Non Squamous NSCLC

DrugsRoginolisib·Dostarlimab·Docetaxel

iOnctura

Phase 1/2

Barcelona, Palma, Valencia

2025-04-22

By invitation

An Interventional Study of Infigratinib in Children With Hypochondroplasia

NCT06873035Hypochondroplasia

DrugInfigratinib

QED Therapeutics, a BridgeBio company

Phase 2/3

Vitoria-Gasteiz

2025-04-22

Recruiting

Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders

NCT06450704Major Depressive Disorder, Inflammatory Response

Fundación de Investigación Biomédica - Hospital Universitario de La Princesa

Not applicable

124

Alcalá de Henares, Majadahonda, Madrid

2025-04-21

Recruiting

Is it Really Necessary Going All Over the Top in Patients With Symptomatic Lumbar Spinal Stenosis?

NCT07026305Lumbar Canal Stenosis, Lumbar Spinal Stenosis, Lumbar Spinal Stenosis (LSS)

Universidad Complutense de Madrid

Not applicable

Madrid

2025-04-21

Recruiting

Intravenous Lacosamide for the Treatment of Acute Pain in Trigeminal Neuralgia

NCT06851910Trigeminal Neuralgia

DrugLacosamide

Hospital Universitari de Bellvitge

Observational

L'Hospitalet de Llobregat

2025-04-21

Recruiting

Optimising TREATment for Severe Gram-Negative Bacterial Infections

NCT07004049Bloodstream Infection, Ventilator Associated Bacterial Pneumonia, Hospital Acquired Bacterial Pneumonia, Carbapenem Resistant Bacterial Infection

DrugsCeftolozane-tazobactam·Cefiderocol·Fosfomycin·Meropenem-Vaborbactam

National University of Singapore

Phase 4

600

Alicante, Badajoz, Barakaldo, Barcelona, Córdoba, Granada, Madrid, Málaga

2025-04-21

Recruiting

Study To Evaluate The Efficacy And Safety Of A Nutritional Supplement Based On Bergamot, Artichoke And Other Ingredients For Reducing Cholesterol Levels In Patients With Hypercholesterolemia (Metachol+)

NCT07178769Cholesterolemia

Laboratoires Arkopharma

Not applicable

207

Madrid, Cartagena, Mazarrón

2025-04-20

Recruiting

An Extension Study of Subjects Who Received an Avalyn Inhaled Antifibrotic Agent (SAIL)

NCT06951217Progressive Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis (IPF)

Avalyn Pharma Inc.

Phase 2

340

Granada, Barcelona, Santander, Madrid, Málaga

2025-04-17

Recruiting

EUS-guided Portal Pressure Gradient (PPG) Measurement: a Potential Alternative to the Traditional HVPG

NCT06863012Portal Hypertension, Chronic Liver Disease (CLD), Cirrhosis

Fundacio Privada Mon Clinic Barcelona

Not applicable

Barcelona

2025-04-16

Active, closed

Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)

NCT06814145Hypertension, Pulmonary

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

440

Marbella, Barcelona, Madrid, Seville, Toledo

2025-04-16

Recruiting

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

NCT06966401Major Depressive Disorder

DrugOsavampator

Neurocrine Biosciences

Phase 3

850

Barcelona, Madrid

2025-04-16

Recruiting

Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity.

NCT06901739Obese Patients (BMI ≥ 30 kg/m²), Anxiety, Depressive Disorder

Celia Bañuls

Not applicable

120

Valencia

2025-04-15

Recruiting

Efficacy of Remote Monitoring of Patients With Heart Failure and Reduced Ejection Fraction by Using Caaring® Software

NCT06920160Heart Failure With Reduced Ejection Fraction

Persei Vivarium

Not applicable

196

Ferrol, Palma de Mallorca

2025-04-15

Active, closed

A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis

NCT06934226Plaque Psoriasis

DrugsIcotrokinra·Ustekinumab

Janssen Research & Development, LLC

Phase 3

752

Alicante, Barakaldo, Barcelona, Granada, Madrid, Manises, Santiago Compostela, Seville

2025-04-15

Recruiting

Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

NCT06795412Advanced Solid Tumors

DrugsPYX-201·Keytruda·Pembrolizumab

Pyxis Oncology, Inc

Phase 1/2

220

Barcelona, Madrid, Valencia

2025-04-15

Recruiting

A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003).

NCT06843447Ovarian Cancer Recurrent

DrugsMK-2010·R-DXd·Zirabev·Pegylated liposomal doxorubicin

Merck Sharp & Dohme LLC

Phase 1/2

605

L'Hospitalet de Llobregat, Majadhonda, Madrid, Valencia, Barcelona, Málaga

2025-04-15

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)

NCT06858813Hepatocellular Cancer, Squamous-Cell Non-Small Cell Lung Cancer

DrugLenvatinib

AbbVie

Phase 1

232

Madrid

2025-04-14

Recruiting

Impact of IBD Activity on Frailty in Patients Over 60 Years

NCT06844318IBD

Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa

Observational

153

Vitoria-Gasteiz, Badalona, L'Hospitalet de Llobregat, Manresa, Mataró, Terrassa, Viladecans, Torrelavega

2025-04-14

Recruiting

Reproducibility of Multiparametric Renal Magnetic Resonance Imaging on 1.5T MRI Scanners

NCT06884410Multiparametric MRI

Mario Negri Institute for Pharmacological Research

Not applicable

Pamplona

2025-04-12

Recruiting

Safeguarding the Brain of Our Smallest Children-IIIv (SafeBoosC-IIIv)

NCT05907317Hypoxia, Infant, Newborn, Diseases

Copenhagen Trial Unit, Center for Clinical Intervention Research

Phase 3

1,610

Madrid

2025-04-11

Recruiting

Determining the Effectiveness of Remote Monitoring of Cancer Patients With Oral Cancer Treatment Using Caaring® Software

NCT06998888Cancer

Persei Vivarium

Not applicable

194

Boadilla del Monte, Hortaleza, Móstoles

2025-04-11

Recruiting

Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers

NCT06906341Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms, Endometrial Cancer

DrugsNab-paclitaxel /m^2·Relacorilant·Bevacizumab

Corcept Therapeutics

Phase 2

270

Badalona, Barcelona, Madrid, Valencia

2025-04-11

Recruiting

Personalized Monitoring of Non-foveal, Non-vision Compromising Atrophic Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression

NCT06351657Age-Related Macular Degeneration, Geographic Atrophy

Medical University of Vienna

Observational

200

Barcelona

2025-04-11

Active, closed

ASCEND CSP IDE Study

NCT06830746Heart Failure, Ventricular Arrythmia

Abbott Medical Devices

Not applicable

414

Granada, Valencia

2025-04-11

Recruiting

The 3D Stent Study

NCT06898021Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)

CoreAalst BV

Observational

200

Barcelona

2025-04-11

Recruiting

Effect of Partially Hydrolyzed Formula With Synbiotics on Skin Barrier Function

NCT06943469Atopic Dermatitis (AD)

Société des Produits Nestlé (SPN)

Not applicable

400

A Coruña, Almería, Barcelona, Madrid, Málaga, Seville, Tarragona, Zaragoza

2025-04-10

Recruiting

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

NCT06868277Carcinoma, Non-Small Cell Lung

DrugsRilvegostomig·Keytruda·Pembrolizumab

AstraZeneca

Phase 3

830

Badajoz, Badalona, Barcelona, Castellon, Granada, Jaén, Lugo, Madrid

2025-04-10

Recruiting

An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

NCT05066217Lennox Gastaut Syndrome

DrugClemizole HCl

Epygenix

Phase 3

260

Barcelona, Madrid, Málaga, Pamplona, Seville

2025-04-09

Active, closed

Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

NCT06822790Hypertriglyceridemia

DrugPlozasiran

Arrowhead Pharmaceuticals

Phase 3

710

A Coruña, Barcelona, Madrid, Santiago de Compostela, Seville, Valencia, Zaragoza

2025-04-09

Recruiting

A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

NCT06824467Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

DrugsSteroid mouthwash (dexamethasone·Mvasi·Acetaminophen·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

770

Girona, Madrid, Valencia, Barcelona, Córdoba

2025-04-09

By invitation

Pain Neuroscience Education, Conditioned Pain Modulation and Emotional Processes in Fibromyalgia

NCT07055971Fibromyalgia

Universidad de Granada

Not applicable

Granada

2025-04-09

Recruiting

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

NCT06790693Breast Cancer

DrugsCDK4/6i·Inavolisib·Letrozole

Hoffmann-La Roche

Phase 3

450

Elche, L'Hospitalet de Llobregat, Pamplona/iruña, Bilbao, Barcelona, Madrid, Málaga, Seville

2025-04-09

Recruiting

Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

NCT06408259Multiple Sclerosis, Relapsing-Remitting

DrugsFingolimod·Ozanimod

Bristol-Myers Squibb

Phase 3

194

Esplugues de Llobregat, Vigo, Seville, Valencia, Zaragoza

2025-04-08

Active, closed

Motivational Support for an Autonomous Exercise Program for Healthy Aging

NCT07447453Frailty at Older Adults

Hospital Universitario Getafe

Not applicable

190

Getafe, Madrid

2025-04-08

Active, closed

Emotional Intelligence Intervention to Improve Mental Well-Being of Adolescents With Emotional Distress (BEAM)

NCT06713460Emotional Distress

Consorci Sanitari de Terrassa

Not applicable

104

Terrassa

2025-04-07

Not yet open

Functionality of Lower Limbs in Patients Who Have Undergone Knee Meniscectomy

NCT06920394Meniscectomy Sequelae

Universidad Católica San Antonio de Murcia

Observational

Murcia

2025-04-05

Active, closed

A Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (DMD)

NCT06450639Duchenne Muscular Dystrophy

DrugSatralizumab

Hoffmann-La Roche

Phase 2

Esplugues de Llobregas, Asturias, Almería, Valencia

2025-04-04

Recruiting

Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

NCT06801834Extensive Stage Small Cell Lung Cancer (ES-SCLC)

DrugsAmrubicin·Lurbinectedin·Topotecan·Sacituzumab Govitecan

Gilead Sciences

Phase 3

695

A Coruña, Barcelona, Córdoba, Girona, Jaén, Las Palmas de Gran Canaria, Madrid, Málaga

2025-04-04

Recruiting

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors

NCT06726148Advanced HR+/HER2- Breast Cancer, Advanced CCNE1-amplified Solid Tumors, Extensive-stage Small Cell Lung Cancer

DrugsRibociclib·Fulvestrant

Novartis Pharmaceuticals

Phase 1/2

280

Barcelona

2025-04-03

Recruiting

Effectiveness of an Online Biopsychosocial Intervention to Improve Well-being and Mental Health During Pregnancy

NCT06871397Prenatal Anxiety, Prenatal Depression, Wellbeing, Obstetrical Complications

University Rovira i Virgili

Not applicable

228

Reus

2025-04-03

By invitation

Evaluation of a Decision Analysis Model in the DASH-Osteo Decision Aid.

NCT07120854Osteoporosis, Postmenopausal, Osteoporotic Fractures, Diphosphonates, Fracture Risk Assessment

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Not applicable

114

Barcelona

2025-04-03

Recruiting

Clinical Trial With MBK-01, Intestinal Microbiota Capsules, for the Treatment of Patients With Recurrent Diverticulitis

NCT06687382Diverticulitis, Diverticulitis of Sigmoid

Mikrobiomik Healthcare Company S.L.

Phase 2

Madrid

2025-04-03

Recruiting

Efficacy and Safety of SLIT in Patients With Rhinitis/RC With/Without Mild-moderate Asthma, Due to Dpt and/or Df

NCT07348302Rhinitis, Rhinoconjunctivitis

Inmunotek S.L.

Phase 3

736

Benidorm, Alicante

2025-04-02

Recruiting

Evaluation of the Gambling Habits of Adolescents and Young Adults Post-COVID-19 and Implementation of a Digital Escape Room Intervention for Preventing Gambling in High School Students

NCT06904794Mental Health

Hospital Miguel Servet

Not applicable

240

Zaragoza

2025-04-02

Not yet open

Obesity Prevention in Children and Young People Treated for Acute Lymphoblastic Leukaemia with ALLTogether

NCT06846294Diet Intervention, Physical Activity Intervention, Standard Care Control

University of Exeter

Not applicable

Madrid

2025-04-01

Active, closed

A Study of Raludotatug Deruxtecan (R-DXd) in People With Gastrointestinal Cancers (MK-5909-005)

NCT06864169Gastrointestinal Cancer

DrugR-DXd

Merck Sharp & Dohme LLC

Phase 2

160

Badalona, Santander, Barcelona, Madrid

2025-04-01

Recruiting

A Study of 2 Doses of Ritlecitinib in People 12 Years of Age and Older With Alopecia Areata

NCT06873945Alopecia Areata

DrugsLitfulo·Ritlecitinib

Pfizer

Phase 3

674

Santiago de Compostela, Córdoba, Madrid, Zaragoza

2025-04-01

Active, closed

Manual Therapy and Physical-sport Performance

NCT06871202Healthy, Musculoskeletal Disorders

University of La Laguna

Not applicable

San Cristóbal de La Laguna

2025-04-01

Recruiting

Home-based Graded Repetitive Arm Supplementary Program for Quality of Life and Functional Upper Limb Recovery

NCT07146789Stroke With Hemiparesis

Universidad Miguel Hernandez de Elche

Not applicable

Valencia

2025-04-01

Active, closed

A Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe Atopic Dermatitis

NCT06863961Atopic Dermatitis

DrugAfimkibart

Hoffmann-La Roche

Phase 2

162

Santiago de Compostela, Pamplona, Córdoba, Madrid

2025-04-01

Recruiting

Laparoscopic Ultrasound Versus Fluorescence Cholangiography in Technically Challenging Laparoscopic Cholecystectomy

NCT07400237Cholecystectomy

Consorci Sanitari Integral

Not applicable

Sant Joan Despí

2025-04-01

Recruiting

Troubled-Desire & Therapeutic Chat for Reduction of CSAM Use (TD-CHAT)

NCT06852443Prevention, Well Being, Sexual Behavior, Behavior Change

Charite University, Berlin, Germany

Not applicable

180

Barcelona

2025-04-01

Recruiting

Protocol to Improve the Representation of the Reproductive Process in Spanish Fiction.

NCT06842004Sexual Health, Community Participation, Social Norms

Universitat de Lleida

Not applicable

Lleida

2025-04-01

Not yet open

Effect of a Specific Hand Intervention in Women With Arthralgia Secondary to Hormone Therapy Following Breast Cancer.

NCT06746376Arthralgia

Universidad Europea de Madrid

Not applicable

Villaviciosa de Odón

2025-04-01

Recruiting

Preventing Suicide With Digital Phenotyping and Pharmacogenetics-Based Interventions

NCT07422090Suicide Attempt

Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz

Observational

5,000

Madrid

2025-04-01

Active, closed

European Multicenter Validation of PCaVision: A Head-to-Head Diagnostic Accuracy Study Comparing Multiparametric Transrectal Ultrasound to MRI for Clinically Significant Prostate Cancer Detection

NCT06935487Prostate Cancer

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Not applicable

806

Barcelona

2025-04-01

Recruiting

Evaluation of BRUDYGLAUCO (DHA + Citicoline) in Patients With Glaucoma

NCT07322965Glaucoma, Primary Open Angle Glaucoma (POAG), Neuroprotection

Institut Catala de Retina

Not applicable

108

Barcelona

2025-04-01

By invitation

Long-term Safety and Efficacy Study of Riliprubart in Participants With CIDP

NCT06859099Polyneuropathy, Inflammatory Demyelinating, Chronic

DrugRiliprubart

Sanofi

Phase 3

300

Barcelona, Majadahonda, Pamplona, Málaga, Valencia

2025-04-01

Recruiting

BOne Metastases REgistry for Patients Undergoing cryoAbLation With curatIve purpoSe

NCT06480955Bone Metastases

Cardiovascular and Interventional Radiological Society of Europe

Observational

Valencia

2025-04-01

Recruiting

Comparison Between Bipolar Transurethral Resection of the Prostate and Moses Assisted Holmium Laser Enucleation of the Prostate

NCT06649357Prostate Hyperplasia, Surgery, Endoscopic Anatomical Enucleation of the Prostate (EEAP)

Fundacio Puigvert

Not applicable

130

Santiago de Compostela, Barcelona, L'Hospitalet de Llobregat, Santander, Gijón, Valladolid

2025-04-01

Not yet open

Study to Evaluate the Safety and Efficacy of ARI0002h, for the Initial Treatment of Patients With Primary Plasma Cell Leukaemia

NCT06830733Leukemia, Plasma Cell

Fundacion Clinic per a la Recerca Biomédica

Phase 2

Santander, Madrid, Murcia, Pamplona, Salamanca, Barcelona

2025-04

Not yet open

Effectiveness of Therapeutic Exercise Combined With Respiratory Muscle Training in Patients With Subacute Stroke

NCT06949839Stroke

Ana Lista Paz

Not applicable

A Coruña

2025-04

Not yet open

Effects of a Prehabilitation Program in Patients Undergoing Lumbar Radiculopathy Surgery

NCT06145620Lumbar Radiculopathy

Cardenal Herrera University

Not applicable

100

Valencia

2025-04

Not yet open

Oscillometry in the COPD Exacerbator Phenotype With Triple Inhaled Therapy Study

NCT06931899COPD (Chronic Obstructive Pulmonary Disease)

Hospital Universitari de Bellvitge

Observational

L'Hospitalet de Llobregat

2025-04

Recruiting

Prospective Study on Antimicrobial RESIstance in Chronic Pulmonary DiseasE

NCT07874139Chronic Lung Diseases

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Observational

683

Barcelona, Getafe, Madrid, Málaga, Valladolid

2025-03-31

Recruiting

A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

NCT06898450Advanced Solid Tumors Cancer, MSI-H Cancer

Nimbus Wadjet, Inc.

Phase 1/2

134

Barcelona, Madrid

2025-03-31

Recruiting

Footwear Difference in Sports Use in Runners With Functional Equinus

NCT06930287Sport Injury

Universidad Católica de Ávila

Observational

Salamanca

2025-03-31

Recruiting

Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell Malignancies

NCT06980116Relapsed or Refractory B-cell Malignancies, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Follicular Lymphoma (FL), Marginal Zone Lymphoma (MZL)

Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

Phase 1

Madrid, Pamplona

2025-03-31

Not yet open

Physical Activity in Patients With Systemic Lupus Erythematosus

NCT06919250Lupus Erythematosus, Systemic

University of Oviedo

Observational

Oviedo

2025-03-31

Recruiting

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

NCT06731907Non-small Cell Lung Cancer

DrugsPatritumab deruxtecan·Abraxane·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 2

L'Hospitalet de Llobregat, Barcelona, Madrid

2025-03-30

Recruiting

Real-World Study to Assess Subcutaneous Epcoritamab in Adult Participants With Diffuse Large B-Cell and Follicular Lymphoma

NCT06830759Diffuse Large B-cell Lymphoma, Follicular Lymphoma

AbbVie

Observational

700

A Coruña, Badalona, Sabadell, Córdoba, Marbella, Pamplona, Seville, Manises

2025-03-28

Recruiting

Effects of Education and Exercise on Pain, Psychosocial Factors, and Upper Limb Function in Non-specific Neck Pain.

NCT06889389Neck Pain, Patient Education, Exercise Therapy, Fear

Universidad Miguel Hernandez de Elche

Not applicable

Elche

2025-03-28

Recruiting

Comparison of the Effectiveness of Classical Perineal Massage Therapy Versus the Use of an Intravaginal Device to Reduce Postpartum Perineal Pain

NCT06921174Pelvic Pain

Instituto Sexológico Murciano

Phase 2

140

Murcia

2025-03-27

Recruiting

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

NCT06989112Endometrial Cancer

DrugsRilvegostomig·Taxotere·Paraplatin·Trastuzumab deruxtecan

AstraZeneca

Phase 3

600

A Coruña, Córdoba, Donostia / San Sebastian, El Palmar, L'Hospitalet de Llobregat, Madrid, Palma de Mallorca, Valencia

2025-03-27

Recruiting

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

NCT06644781Esophageal Squamous Cell Carcinoma

DrugsIfinatamab Deruxtecan·Irinotecan·Docetaxel·Paclitaxel

Daiichi Sankyo

Phase 3

510

Barcelona, Burgos, Elche, L'Hospitalet de Llobregat, Madrid, Málaga, Ourense, Oviedo

2025-03-27

Recruiting

First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours

NCT06795022Hepatocellular Carcinoma

AstraZeneca

Phase 1/2

304

Barcelona, Pamplona

2025-03-27

Recruiting

Thrombectomy Using Pulsed Aspiration for Reperfusion of Brain Occlusions

NCT06029491Acute Ischemic Stroke

RapidPulse, Inc

Not applicable

170

Alicante, Badalona, Barcelona, Girona, Madrid

2025-03-27

Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

NCT06890598Carcinoma, Non-Small-Cell Lung

DrugsOlomorasib·Durvalumab·Pembrolizumab

Eli Lilly and Company

Phase 3

700

Badajoz, Barcelona, Hospitalet, Jerez de la Frontera, Las Palmas de Gran Canaria, Madrid, Málaga, Palma

2025-03-27

Recruiting

Desarda Tissue Technique vs Lichtenstein Technique for Primary Inguinal Hernia Repair

NCT06650878Inguinal Hernia Unilateral, Complications of Surgical Procedures or Medical Care

Consorci Sanitari de l'Alt Penedès i Garraf

Not applicable

478

Sant Pere de Ribes

2025-03-26

Recruiting

Dietary Strategy to Tackle Cognitive and Locomotor Abilities in Early Elderly Subjects

NCT06871384Cognitive Disorders, Muscular Disorders, Atrophic

University Rovira i Virgili

Not applicable

Logroño, Reus

2025-03-26

Recruiting

Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids

NCT06932263Asthma

DrugTozorakimab

AstraZeneca

Phase 2

540

Barcelona, Madrid, Málaga, Mérida, Patraix, Santander

2025-03-26

Recruiting

Mathematical Analysis of Signals and Clinical Parameters Provided by Non-invasive Home Ventilation Devices

NCT07267104COPD (Chronic Obstructive Pulmonary Disease)

Corporacion Parc Tauli

Observational

Sabadell

2025-03-25

Recruiting

A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)

NCT06818643Advanced Solid Tumors, Malignant Neoplasm

DrugMK-3120

Merck Sharp & Dohme LLC

Phase 1/2

270

L'Hospitalet de Llobregat, Barcelona, Madrid, Málaga

2025-03-25

Recruiting

Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal Fusions

NCT06368245Spinal Fusion

AO Foundation, AO Spine

Observational

1,244

Barcelona

2025-03-24

Recruiting

A Study to Evaluate the Mass Balance, Metabolism, Elimination, and Drug Levels of [14C]-BMS-986504 (MRTX1719) in Participants With Advanced Solid Tumors With Homozygous Methylthioadenosine Phosphorylase Deletion

NCT06672523Advanced Solid Tumors With Homozygous MTAP Deletion

DrugNavlimetostat

Bristol-Myers Squibb

Phase 1

Logroño, Madrid

2025-03-24

Recruiting

Keep On Keep Up Bladder Health: Co-creating and Testing a Self-management Technological Solution for Ageing Well

NCT06583733Urinary Incontinence in Old Age

University of Vic - Central University of Catalonia

Not applicable

120

Lleida, Vic

2025-03-24

Recruiting

A Study of ATTR-01 in Participants With Select Epithelial Solid Tumours

NCT06977737Solid Tumor, Adult

Accession Therapeutics Limited

Phase 1/2

Barcelona, Madrid, Rioja

2025-03-21

Recruiting

Study of the Effects of Time-Restricted Feeding on the Immune Function of Individuals With Obesity

NCT06858683Obesity and Obesity-related Medical Conditions

Hospital Universitari Vall d'Hebron Research Institute

Not applicable

Barcelona

2025-03-21

Active, closed

A Study of JNJ-90189892 for Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Neoplasms

NCT06651229Leukemia, Myeloid, Acute, Myelodysplastic Neoplasms

DrugsAzacitadine·Venetoclax

Janssen Research & Development, LLC

Phase 1

Madrid, Pamplona, Seville

2025-03-21

Active, closed

Study of Eftilagimod Alfa (Efti) in Combination With Pembrolizumab and Chemotherapy Versus Placebo in Combination With Pembrolizumab and Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) (TACTI-004)

NCT06726265Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

DrugsEfti·Pemetrexed·Keytruda·Paclitaxel

Immutep S.A.S.

Phase 3

756

Badalona, Barcelona, Córdoba, Madrid, Málaga, Oviedo, Sabadell, Seville

2025-03-21

Recruiting

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

NCT06914128MTAP-deleted Solid Tumors

Bayer

Phase 1/2

450

Barcelona, Pamplona, Logroño, Madrid, Pozuelo de Alarcón, Málaga, Valencia

2025-03-21

Recruiting

Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

NCT06797635Breast Neoplasms, Breast Cancer

DrugsPatritumab deruxtecan·Doxorubicin Hydrochloride·Epirubicin·Adriamycin

Merck Sharp & Dohme LLC

Phase 2

372

Badalona, Madrid, Córdoba

2025-03-20

Active, closed

Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)

NCT06788912Lung Neoplasm Malignant

DrugsSteroid mouthwash (dexamethasone·Acetaminophen·Ribociclib·Paraplatin

Merck Sharp & Dohme LLC

Phase 2

Barcelona

2025-03-20

Active, closed

A Study of Navenibart in Participants With Hereditary Angioedema

NCT06842823Hereditary Angioedema (HAE)

DrugNavenibart

Astria Therapeutics, Inc.

Phase 3

157

Barcelona, Madrid, Santa Cruz de Tenerife, Seville, Valencia

2025-03-20

Recruiting

Predictive Model for Mortality in Older People With Critical Illness

NCT06727903Critical Illness

Consorci Sanitari de l'Alt Penedès i Garraf

Observational

450

Badalona, Sant Pere de Ribes, Barcelona, Girona

2025-03-20

Active, closed

A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa

NCT06840392Hidradenitis Suppurativa

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

565

Granada, Palma, Barcelona, Granollers, Las Palmas GC, Madrid, Pontevedra, Seville

2025-03-20

Recruiting

Fissios© and Postoperative Complications (FPoC Trial)

NCT06732193Surgical Procedure, Unspecified, Non Small Cell Lung Cancer, Surgery Scheduled, Thoracic Surgery

Carlos Alfredo Fraile Olivero, MD, PhD.

Not applicable

560

Madrid

2025-03-20

Recruiting

Evaluation of the Nutritional Status of Omega-3 Fatty Acids and the Possible Influences of Dietary Patterns and Different Socioeconomic Factors, in a Spanish Population Over 60 Years of Age

NCT06916455Fatty Acids, Omega-3

Universidad de Granada

Observational

800

Granada

2025-03-19

Recruiting

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

NCT06819007Ovarian Cancer

DrugsTrastuzumab deruxtecan·Bevacizumab

Daiichi Sankyo

Phase 3

582

A Coruña, Barcelona, Córdoba, Donostia / San Sebastian, El Palmar, Girona, Madrid, Palma

2025-03-19

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

NCT06883305Chronic Obstructive Pulmonary Disease (COPD)

DrugTezepelumab

AstraZeneca

Phase 3

990

Barakaldo, Barcelona, Granada, Madrid, Málaga, Palma de Mallorca, Pamplona, Seville

2025-03-18

Recruiting

Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

NCT06376162Relapsed/Refractory KMT2A-r Acute Leukemia, Relapsed/Refractory NUP98-r Acute Leukemia, Relapsed/Refractory NPM1-m Acute Leukemia

DrugsZiftomenib·Cytarabine·Fludarabine

PedAL BCU, LLC

Phase 1

Barcelona, Madrid

2025-03-18

Recruiting

Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT07032662Chronic Inflammatory Demyelinating Polyneuropathy

Immunovant Sciences GmbH

Phase 2

162

Barcelona, Bilbao, Córdoba, Santiago de Compostela, Valencia

2025-03-18

Active, closed

A Pivotal Study of N-Acetyl-L-Leucine on Ataxia-Telangiectasia (A-T)

NCT06673056Ataxia-Telangiectasia, Ataxia-Telangiectasia (A-T)

DrugN-Acetyl-L-Leucine

IntraBio Inc

Phase 3

Madrid

2025-03-18

Recruiting

Promoting Safe Medication Practices in the Classroom

NCT07389538Self Medication

Universidad de Granada

Not applicable

202

Granada

2025-03-17

Recruiting

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

NCT06819878Moderately to Severely Active Crohns Disease

DrugAfimkibart

Hoffmann-La Roche

Phase 3

600

Santander, Galdacao, Madrid, Murcia, Valencia, Valladolid

2025-03-17

Active, closed

A Phase 1 Trial to Evaluate the Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of VIS171 in Participants With Autoimmune Disease(s)

NCT06799520Systemic Lupus Erythematosus (SLE), Alopecia Areata (AA), Immune-mediated Focal Segmental Glomerulosclerosis (FSGS)

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 1

Barcelona, Granada

2025-03-17

Recruiting

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

NCT06841354Triple Negative Breast Neoplasms

DrugsAbraxane·Paraplatin·Sacituzumab tirumotecan·Taxol

Merck Sharp & Dohme LLC

Phase 3

1,000

Seville, L'Hospitalet de Llobregat, Madrid, Valencia, Barcelona

2025-03-16

Not yet open

Efficacy of Shock Wave Therapy in Post-Stroke Muscle Spasticity Management

NCT06815328Stroke, Spasticity, Post-stroke, Muscle Hypertonia

University of Oviedo

Not applicable

Oviedo

2025-03-15

Active, closed

Opioid-Free Anesthesia in Colorectal Surgery, 2025 (OFA-CRC-2025)

NCT07771049Pain Management, Colorectal Surgery, Opioid Free Anesthesia, Postoperative Complications

DrugOpioid-Free Anesthesia

Hospital Universitario La Fe

Phase 1/2

200

Arrecife, Zaragoza

2025-03-15

Active, closed

A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

NCT06795048Neovascular Age-related Macular Degeneration (nAMD)

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Phase 4

274

Sant Cugat de Valles, Majadahonda, Burjassot, Valencia(España), Madrid, Seville

2025-03-14

Recruiting

Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake

NCT06571149Ischemic Stroke

DrugsAlteplase·Tenecteplase

Insel Gruppe AG, University Hospital Bern

Phase 4

906

A Coruña, Barcelona, Girona, Madrid, Seville, Valladolid, Zaragoza

2025-03-14

Active, closed

EucaLimus Post-Market Registry

NCT06621524Coronary Arterioscleroses

OrbusNeich

Observational

251

L'Hospitalet de Llobregat, Barcelona, Córdoba, Lugo, San Cristóbal de La Laguna, Tarragona

2025-03-14

Recruiting

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

NCT06677060Heart Failure

DrugBaxdrostat/dapagliflozin

AstraZeneca

Phase 3

11,300

A Coruña, Barcelona, Córdoba, L'Hospitalet de Llobregat, Madrid, Málaga, Sant Joan Despí, Santiago(A Coruña)

2025-03-14

Recruiting

Results of the Use of Two Stentrievers Simultaneosly Compared With One as a Primary Treatment in Acute Ischemic Stroke

NCT05930145Stroke, Thrombectomy, Arterial Occlusive Diseases

Fundación EPIC

Not applicable

200

Barakaldo, Oviedo, Valladolid

2025-03-14

Active, closed

A Study to Assess a New Medicine Called IPN01195 When Administered Alone in Adults With Advanced Solid Tumours

NCT06833008Advanced Solid Tumor

Ipsen

Phase 1/2

Barcelona, Madrid

2025-03-14

Recruiting

AI-assisted Transcranial Duplex Sonography for Early Detection of Intracerebral Haemorrhage: HYPER-AI-SCAN

NCT07319013Stroke, Intracerebral Hemorrhage, Intracerebral Hemorrhage Basal Ganglia, Intracerebral Haemorrhage

Hospital Universitari Vall d'Hebron Research Institute

Observational

500

Barcelona

2025-03-14

Active, closed

A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

NCT06764485Metastatic Castration-resistant Prostate Cancer

DrugsAbiraterone·Enzalutamide·Docetaxel

Celgene

Phase 3

960

Córdoba, Barcelona, Sabadell, Barakaldo, Santander, Lugo, Madrid, Majadahonda

2025-03-13

Recruiting

A Study to Evaluate the Drug Levels, Efficacy, and Safety of Deucravacitinib (BMS-986165) in Pediatric Participants With Juvenile Psoriatic Arthritis

NCT06869551Juvenile Psoriatic Arthritis

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

Barcelona, Madrid, Valencia

2025-03-13

Recruiting

Study to Analyse the Use of a Digital Platform for the Preparation and Follow-up of Patients With Scheduled Outpatients Colonoscopy

NCT06916052Outpatient Colonoscopy

Persei Vivarium

Observational

225

Barcelona

2025-03-13

Active, closed

Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

NCT06858839Obesity

DrugMaridebart cafraglutide

Amgen

Phase 3

3,853

Almería, Castilleja de la Cuesta, Huelva, Sanlúcar de Barrameda, Seville, A Coruña, Pozuelo de Alarcón, Pamplona

2025-03-12

Active, closed

Blood Flow Restriction in Older Adults

NCT06906523Older Patients

Universidad Católica San Antonio de Murcia

Not applicable

Murcia

2025-03-12

Recruiting

Advanced Invasive Diagnosis Strategy for Post-PCI Patients With Stable Coronary Syndromes Undergoing Coronary Angiography

NCT07638137Angina (Stable), Percutaneous Coronary Intervention (PCI), INOCA (Ischemia With Non Obstructive Coronary Artery Disease), Chronic Coronary Syndrome

Fundacion Investigacion Interhospitalaria Cardiovascular

Observational

246

Leganés, Madrid, Valencia

2025-03-12

Recruiting

Video Classification of Intubation in Spain (VCI) (Pediatrics)

NCT06881576Difficult Intubation

Clinica Universidad de Navarra, Universidad de Navarra

Observational

1,500

Madrid

2025-03-12

Recruiting

Treatment of Lateral Epicondylalgia With Shock Waves

NCT06587412Epicondylitis of the Elbow, Epicondylitis, Lateral

University of Alcala

Not applicable

Alcalá de Henares

2025-03-12

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

NCT06615479Relapsed or Refractory Multiple Myeloma (RRMM)

DrugsArlo-cel·Carfilzomib·Pomalidomide·Daratumumab

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 3

440

Santiago de Compostela, Palma, Badalona, Pamplona, Granada, Salamanca

2025-03-12

Active, closed

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

NCT06792695Metastatic Colorectal Cancer

DrugsFOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan)·Volrustomig·Bevacizumab

AstraZeneca

Phase 2

Barcelona, Madrid, Málaga, Pamplona, Santander, Valencia

2025-03-12

Recruiting

L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

NCT06788756Acute Myeloid Leukaemia (AML)

DrugCytarabine

Moleculin Biotech, Inc.

Phase 2/3

312

Barcelona, Oviedo, Madrid, Valencia

2025-03-12

Recruiting

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

NCT06641466Menstrual Migraine

DrugRimegepant

Pfizer

Phase 3

723

Barcelona, Santander, Chiclana de la Frontera, Madrid, Seville, Valladolid, Zaragoza

2025-03-11

Recruiting

An Open-label Study to Evaluate the Pharmacokinetics and Safety of Bimekizumab in Pediatric Study Participants With Active Juvenile Idiopathic Arthritis Subtypes Enthesitis-related Arthritis (Including Juvenile-onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis

NCT06668181Enthesitis-related Arthritis, Juvenile Psoriatic Arthritis

DrugBimekizumab

UCB Biopharma SRL

Phase 3

Esplugues de Llobregat, Madrid, Valencia

2025-03-11

Recruiting

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

NCT06833073Urinary Bladder Neoplasms, Non-Muscle Invasive Bladder Neoplasms, Carcinoma in Situ

DrugIntismeran autogene

Merck Sharp & Dohme LLC

Phase 2

308

Sabadell, Las Palmas de Gran Canaria, Madrid, Seville

2025-03-11

Recruiting

CD8 PET Imaging in Metastatic Solid Tumours

NCT06534190Locally Advanced Solid Tumor

DrugsCetrelimab·Nivolumab

University Medical Center Groningen

Phase 2

Barcelona

2025-03-11

Recruiting

177Lu-DOTATATE for Recurrent Meningioma

NCT06326190Recurrent Meningioma

DrugsLuTate·Lutathera

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

136

Barcelona, Madrid

2025-03-10

Recruiting

Evaluation of a Digital School-Based Intervention for the Primary Prevention of Eating Disorders in Pre-Adolescents (PRETA Program)

NCT06792981Eating Disorders in Adolescence, Food Addiction

Servicio Canario de Salud

Not applicable

1,068

Santa Cruz de Tenerife

2025-03-10

Recruiting

The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure

NCT07008365Acute Heart Failure, Congestive Heart Failure, Intraabdominal Hypertension, Cardio-Renal Syndrome

Instituto de Investigación Sanitaria Aragón

Phase 3

168

Zaragoza

2025-03-10

Recruiting

Alleviant ALLAY-HFrEF Study

NCT06812533Heart Failure

Alleviant Medical, Inc.

Not applicable

350

A Coruña, Barcelona, Madrid, Salamanca, Valencia

2025-03-10

Active, closed

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines

NCT06671496Psoriatic Arthritis

DrugZasocitinib

Takeda

Phase 3

601

Vitoria-Gasteiz, Santander, Alcobendas, Madrid, Santa Cruz de Tenerife, Seville

2025-03-10

Not yet open

Evaluating the Feasibility of a Web-App for Pelvic Floor Health in Pregnant Women in the Ferrol Health Area: the WaPRUIN Study

NCT06797323Pregnancy, Pelvic Floor Disorder

Universidad de Oviedo

Observational

212

Ferrol

2025-03-10

Recruiting

A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

NCT06925542SLE (Systemic Lupus), Lupus Erythematosus, Systemic, Lupus Nephritis, Systemic Sclerosis

DrugZugo-cel

CRISPR Therapeutics

Phase 1

Córdoba, Pamplona, Seville, Valencia

2025-03-10

Active, closed

Phase 2 Study of ALXN2030 in Patients With Antibody-Mediated Rejection After Kidney Transplantation

NCT06744647Antibody-Mediated Rejection, Kidney Transplantation, Biopsy-proven Histologic Scores, AMR

DrugALXN2030

Alexion Pharmaceuticals, Inc.

Phase 2

Barcelona, Zaragoza

2025-03-07

Active, closed

A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

NCT06521567Melanoma, Hodgkin Lymphoma, High and Low Grade Glioma, Glioblastoma Multiforme (GBM)

DrugsCobolimab·Dostarlimab

GlaxoSmithKline

Phase 1/2

Barcelona, Madrid, Valencia

2025-03-06

Active, closed

Study to Provide Continued Access to Treatment for Patients Completing a Previous Trial With Efanesoctocog Alfa

NCT06716814Haemophilia A (Moderate or Severe)

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 3

A Coruña, Zaragoza

2025-03-06

Recruiting

Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations

NCT06772623Non Small Cell Lung Carcinoma, c-MET

DrugsBudigalimab·Telisotuzumab Adizutecan·Pemetrexed·Cisplatin

AbbVie

Phase 1/2

252

Santander, Seville, A Coruña, Alicante, Barcelona, Málaga

2025-03-06

Recruiting

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

NCT06742996Mantle Cell Lymphoma, B Cell Lymphoma

DrugsSonrotoclax·Zanubrutinib

BeOne Medicines

Phase 3

300

Barcelona, Madrid, Majadahonda

2025-03-05

Active, closed

An Ophthalmic Safety Study in Patients With Breast Cancer

NCT06767462Ophthalmic Safety in Patients With Breast Cancer

AstraZeneca

Observational

160

Badalona, Barcelona, Girona, L'Hospitalet de Llobregat, Leganés, Madrid, Majadahonda, Salamanca

2025-03-05

Recruiting

A Study of TYRA-300 in Children With Achondroplasia: BEACH301

NCT06842355Achondroplasia

DrugTYRA-300

Tyra Biosciences, Inc

Phase 2

Vitoria-Gasteiz, Madrid

2025-03-04

Active, closed

Exer-WAPA Project: Physical Exercise on Women's Affective and Physical HeAlth

NCT07466979Psychological Distress, Anxiety Symptoms, Depression Symptoms

Universidad de Granada

Not applicable

100

Granada

2025-03-04

Recruiting

A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)

NCT06796907Tumours, Gynecological

DrugsMo-Rez·Dostarlimab·Bevacizumab

GlaxoSmithKline

Phase 1/2

305

A Coruña, Barcelona, Madrid, Málaga, Valencia, Zaragoza

2025-03-04

Recruiting

Effect of Neuromodulation and Therapeutic Exercise in Urinary Incontinence

NCT06783374Urge Urinary Incontinence, Overactive Bladder (OAB)

Fundación Universidad Católica de Valencia San Vicente Mártir

Not applicable

Valencia

2025-03-04

Active, closed

Long Acting Cabotegravir Plus Rilpivirine in People Living With HIV-1 Aged ≥ 60 Years for 24 Months.

NCT06646562HIV-1 Infected Adults With Controlled Viremia

Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia

Phase 4

120

Elche, Villajoyosa, Cartagena, Lorca, Murcia, Pozo-Aledo

2025-03-03

Active, closed

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

NCT06671483Psoriatic Arthritis

DrugZasocitinib

Takeda

Phase 3

1,583

Mérida, Sabadell, Santiago de Compostela, Málaga, Seville, Valencia

2025-03-03

Active, closed

Study of Zelenectide Pevedotin in Participants With Advanced Breast Cancer

NCT06840483Breast Cancer

DrugZelenectide pevedotin

BicycleTx Limited

Phase 2

Barcelona, Madrid

2025-03-03

Recruiting

A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

NCT06742723Chronic Kidney Disease and Hypertension

DrugBaxdrostat/dapagliflozin

AstraZeneca

Phase 3

5,000

A Coruña, Almería, Badalona, L'Hospitalet de Llobregat, Majadahonda, Málaga, Palma deMallorca, Pamplona

2025-03-03

Recruiting

Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment

NCT06841055Non-small Cell Lung Cancer

DrugsPumitamig·Docetaxel

BioNTech SE

Phase 2

Barcelona, Madrid, Seville, Valencia

2025-03-03

By invitation

Relationship Between Eating Patterns, Body Composition and the Detection of Fatty Liver in Children and Adolescents With Trisomy 21: LiverTy Project

NCT06888570Obesity Prevention, Pediatric Obesity, Trisomy 21, Down Syndrome (Trisomy 21)

IMDEA Food

Observational

Madrid

2025-03-01

Recruiting

Exercise and Physical Activity in Children With Pediatric Acquired Brain Injury

NCT06804486Acquired Brain Injury

Universidade da Coruña

Not applicable

Madrid

2025-03-01

By invitation

Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0

NCT06823115Acute Kidney Injury, Fluid Overload, Prematurity Complications, Risk Factors

Indiana University

Observational

8,000

Cadiz

2025-03-01

Recruiting

Efficacy of Direct Selective Laser Trabeculoplasty in Clinical Practice in Patients with Glaucoma

NCT06808633Glaucoma

Clínica Rementería

Observational

Madrid

2025-03-01

Recruiting

Utility of ROTEM® for Risk Stratification of Post-Invasive Procedure Hemorrhage in Patients With Cirrhosis (CIR-ROTEM)

NCT06908785Cirrhosis, Liver

Instituto de Investigación Marqués de Valdecilla

Observational

330

Santander, Alicante, Barcelona, Bilbao, Burgos, Madrid, Oviedo, Toledo

2025-03-01

Active, closed

External Iliac Artery Endofibrosis in Cycling

NCT07194330Iliac Artery Occlusive Disease, Blood Flow Velocity, Performance, Cycling

Jesus Torres

Observational

Estella-Lizarra

2025-03-01

Active, closed

Evaluation of Physical Capacity and Energy Requirements in Patients With Hypoxemic Acute Respiratory Failure

NCT07178483Acute Hypoxemic Respiratory Failure, Non Invasive Ventilation (NIV), Bioimpedance Measurement Capacity, Calorimetry, Indirect

Hospital Universitari de Bellvitge

Observational

500

L'Hospitalet de Llobregat

2025-03-01

Recruiting

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

NCT06764875HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma

DrugsRilvegostomig·Trastuzumab deruxtecan·Trastuzumab·Adrucil

AstraZeneca

Phase 3

840

Badalona, Barcelona, Madrid, Ourense, Santander, Seville, Valencia

2025-03-01

Recruiting

First Trimester Prediction of Gestational Diabetes Mellitus by Continuous Glucose Monitoring.

NCT06874907Gestational Diabetes Mellitus in Pregnancy

Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia

Observational

1,000

El Palmar

2025-03-01

Active, closed

Efficacy and Usability of the EXPLORER Exoskeleton in Children With Neurodevelopmental Disorders in Natural Environments

NCT06765070Neuromuscular Disorders, Neurodevelopmental Disorders

MarsiBionics

Not applicable

Alcorcón, Madrid

2025-03-01

Recruiting

Blood Flow Restriction for Upper Limb Rehabilitation in People With Multiple Sclerosis. A Randomized Controlled Trial (BFRT-EM)

NCT06795230Multiple Sclerosis

Universidad Rey Juan Carlos

Not applicable

Leganés

2025-03-01

Recruiting

Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).

NCT07247669Chest Pain, Stroke Acute, Respiratory Failure, Cardiac Arrest (CA)

Centro de Emergencias Sanitarias 061 Andalucía

Observational

5,000,000

Málaga

2025-03-01

Recruiting

Double-blind Pilot Study on the Effect of Anionic Exposome Enrichment (Biow) on Recovery and Sleep Quality in Postoperative Patients

NCT06968000Inflammatory Response After Surgery, Postoperative Recovery

Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz

Phase 1/2

150

Madrid

2025-03-01

Recruiting

Immersive Virtual Reality Training for Improving Cognition in Adults With Metabolic Syndrome

NCT07040748Metabolic Syndrome

Consorci Sanitari de Terrassa

Not applicable

Terrassa

2025-03-01

Not yet open

Implementation of the International Classification of Functioning, Disability and Health Model in Paediatric Cochlear Implant Recipients

NCT06841900Cochlear Impant Children

University Hospital, Antwerp

Observational

120

Madrid

2025-03

Not yet open

Effects of a Hip Flexor and Extensor Muscle Training Program in Individuals with Chronic Mechanical Low Back Pain

NCT06787209Chronic Low-back Pain (cLBP)

Lucía Pilar Vicente Pina

Not applicable

Zaragoza

2025-03

Recruiting

Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

NCT06855498Hidradenitis Suppurativa (HS)

DrugPovorcitinib

Incyte Corporation

Phase 3

600

Alcorcón, Alicante, Badalona, Barcelona, Córdoba, Granada, Las Palmas de Gran Canaria, Madrid

2025-02-28

Active, closed

A Phase 2 in Adult Subjects With Hereditary Angioedema

NCT06846398Hereditary Angioedema (HAE)

DrugBW-20805

Shanghai Argo Biopharmaceutical Co., Ltd.

Phase 2

Seville

2025-02-28

Recruiting

A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer

NCT06764316Hepatocellular Carcinoma

Bayer

Phase 1

148

Barcelona, Madrid, Pamplona

2025-02-28

Recruiting

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

NCT06517875Primary Myelofibrosis, Myelofibrosis; Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

DrugsMomelotinib·Reblozyl·Luspatercept

GlaxoSmithKline

Phase 2

Badalona, Barcelona, Las Palmas, Madrid, Málaga, Valencia

2025-02-28

Recruiting

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

NCT06767514Non-Small Cell Lung Cancer

DrugsIvonescimab·Pembrolizumab

Summit Therapeutics

Phase 3

780

Barakaldo, Santander, Badajoz, Las Palmas, Madrid, Sevilla, Marbella, Seville

2025-02-27

Recruiting

IMPACT-AML: A Randomized Pragmatic Clinical Trial for Relapsed or Refractory Acute Myeloid Leukemia.

NCT06713837Acute Myeloid Leukemia, Relapse/Recurrence

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Phase 3

339

Albacete, Alicante, Barcelona, Valencia

2025-02-27

Recruiting

A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

NCT06722235Immune Thrombocytopenic Purpura (ITP)

DrugMezagitamab

Takeda

Phase 3

171

Alcorcón, Madrid, Salamanca, Seville

2025-02-27

Recruiting

A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

NCT06780137Small Cell Lung Cancer

DrugsGocatamig·Ifinatamab Deruxtecan·Durvalumab

Merck Sharp & Dohme LLC

Phase 1/2

327

Eixample, L'Hospitalet de Llobregat, Madrid, Barcelona, Málaga

2025-02-27

Recruiting

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

NCT06731478Gastric Cancer, Gastroesophageal Junction Cancer

DrugsTrastuzumab deruxtecan·Trastuzumab·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 3

726

Badalona, Barcelona, Córdoba, Elche, L'Hospitalet de Llobregat, Madrid, Málaga, Murcia

2025-02-27

Active, closed

A Randomised Phase II Study of Roginolisib in Patients With Advanced/Metastatic Uveal Melanoma

NCT06717126Uveal Melanoma, Ocular Melanoma

DrugRoginolisib

iOnctura

Phase 2

Barcelona, Madrid, Santiago de Compostela, Seville, Valencia

2025-02-27

Recruiting

Physical Activity in Bed Rest Hospitalized High-Risk Pregnant Women

NCT06713083Bed Rest, Pregnancy, Pregnancy Complications

Montse Palacio

Not applicable

Barcelona

2025-02-26

Recruiting

A Phase 1 Study of IM-1021 in Participants With Advanced Cancer

NCT06823167Solid Malignancies, Hematologic Malignancies

Immunome, Inc.

Phase 1

190

Madrid

2025-02-26

Active, closed

A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in Subjects With SCLC

NCT06745323Small Cell Lung Cancer (SCLC)

DrugTarlatamab

Amgen

Phase 2

252

Las Palmas de Gran Canaria, Barcelona, A Coruña, Madrid

2025-02-26

Recruiting

Personalised Monitoring of Early and Intermediate Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression

NCT06351670Age-Related Macular Degeneration

Medical University of Vienna

Observational

500

Barcelona

2025-02-25

Recruiting

A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)

NCT06747949Sjögren's Syndrome

DrugDazodalibep

Amgen

Phase 3

844

Santa Coloma de Gramenet, Córdoba, Bilbao, Madrid, Seville

2025-02-25

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

NCT06646276Extensive-Stage Small Cell Lung Cancer

DrugsEtoposide·Atezolizumab·Nivolumab·Carboplatin

Bristol-Myers Squibb

Phase 3

530

Santiago de Compostela, Barcelona, Jaén, Madrid, Majadahonda, Valencia, Seville

2025-02-25

Recruiting

The Use of Combined Motor Imagery and Action Observation to Evaluate the Influence on Functional Parameters Such as Strength, Range of Motion, Pain or Fear of Movement Among Others, in Females Breast Cancer Survivors.

NCT07067710Breast Cancer Survivor

Fundacion Miguel Servet

Not applicable

108

Pamplona

2025-02-25

Not yet open

Evaluating Combined Electromagnetic Stimulation for Enhanced Physical and Psychological Recovery in Athletes with DOMS

NCT06855316Recovery, Psychological, Transcranial Magnetic Stimulation

Sierra Varona SL

Not applicable

Toledo

2025-02-24

Active, closed

An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB323 in Relapsing Multiple Sclerosis

NCT06617793Relapsing Multiple Sclerosis

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 1/2

Barcelona, Córdoba, Madrid, Valencia

2025-02-24

Recruiting

Evaluation of the WARIFA App and Its Impact on Healthy Lifestyle

NCT06918444Lifestyle Intervention, Non Communicable Chronic Diseases, Type 1 Diabetes (T1D)

Instituto Universitario de Investigaciones Biomédicas y Sanitarias (iUIBS) de la Universidad de Las

Not applicable

104

Las Palmas de Gran Canaria

2025-02-24

Recruiting

Effectiveness of a multicOmpoNent Behavioural intervenTion to Reduce endocrINe disrUptor Exposure During pErinatal Period (CONTINUE)

NCT07142447Pregnancy, Children

Fundació Institut Germans Trias i Pujol

Not applicable

810

Badalona

2025-02-24

Active, closed

Post-Marketing Study to Assess the Safety & Efficacy of RenalGuard® Therapy for Prevention CSA-AKI

NCT06811805AKI - Acute Kidney Injury, Cardiac Surgery Associated - Acute Kidney Injury

CardioRenal Systems, Inc.

Not applicable

300

Barcelona, Madrid

2025-02-23

Active, closed

A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis

NCT06878404Arthritis, Psoriatic

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

552

A Coruña, Barcelona, Córdoba, Madrid, Málaga, Sabadell, Santander, Seville

2025-02-21

Recruiting

A Double-blind Non Inferiority Clinical Trial to Compare the Nephroprotection of Cilastatn Versus Thiosulfate in Patients Undergoing Debulking Surgery With Intraoperative Hyperthermic Intraperitoneal Chemotherapy With Cisplatin.

NCT07229040Debulking Surgery for Ovarian Cancer, Acute Kidney Injury

Hospital General Universitario Gregorio Marañon

Phase 2

Madrid

2025-02-21

Recruiting

Personalised Health Motor and Cognitive Assistance System for RehAbilitation (PHRASE)

NCT06885502Stroke, Stroke Rehabilitation, Chronic Stroke Patients, Post Stroke Recovery

Eodyne Systems SL

Not applicable

Tarragona

2025-02-21

By invitation

Evaluation of the Efficacy of Transcranial Direct Current Stimulation in Reducing Fatigue and Improving Quality of Life in Patients With Multiple Sclerosis: A Randomized Clinical Trial

NCT06873464Multiple Sclerosis, MS

European University of Madrid

Not applicable

Madrid

2025-02-20

Recruiting

High Intensity Interval Training in the Treatment of Familial Hypercholesterolemia (UPPA-FH)

NCT06833944Familiar Hypercholesterolemia

Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental

Not applicable

Granada

2025-02-20

Active, closed

Post Market Registry for GORE® TAG® Thoracic Branch Endoprosthesis

NCT06507865Aneurysm, Dissection, Aortic, TAA Thoracoabdominal Aortic Aneurysm, Thoracic Aortic Aneurysm

W.L.Gore & Associates

Observational

155

Zaragoza

2025-02-20

Active, closed

A Study to Assess the Safety, Tolerability, and Efficacy of IMVT-1402 in Participants With Cutaneous Lupus Erythematosus (CLE)

NCT06980805Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

Badalona, Pamplona, Burjassot, Madrid, Málaga

2025-02-19

Recruiting

A Study to Assess How Vaborem® is Taking up in the Body and Tolerated in Paediatric Patients With Gram Negative Infections, Including But Not Restricted to Complicated Urinary Tract Infections

NCT06828848Gram Negative Infections

DrugMeropenem

Menarini Group

Phase 2

Barcelona, Cadiz, Girona, Madrid, Málaga, Santiago de Compostela

2025-02-18

Active, closed

Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold System in the Treatment of Subjects With Long de Novo Lesions

NCT07091682Coronary Artery Disease, Atherosclerosis of Coronary Artery, Myocardial Ischemia, Ischemic Heart Disease

Biotronik AG

Not applicable

100

Barcelona, Madrid, Valladolid

2025-02-18

Active, closed

Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01

NCT06727565Head and Neck Squamous Cell Carcinoma

DrugsDomvanalimab·Zimberelimab·Paclitaxel·Carboplatin

Gilead Sciences

Phase 2

Seville

2025-02-18

Active, closed

Intergenerational Mealtime at a Shared Site: A Small-scale Trial

NCT06996418Healthy Nutrition, Intergenerational Relations, Well-being, Relational Care

Universidad de Granada

Not applicable

Albolote

2025-02-18

Recruiting

A Study of Neoadjuvant Dostarlimab Plus Capecitabine Plus Oxaliplatin (CAPEOX) Vs CAPEOX With Previously Untreated T4N0 or Stage III Mismatch Repair Proficient (MMRp)/Microsatellite Stable (MSS) Colon Cancer

NCT06567782Neoplasms, Colon

DrugsCapeox·Dostarlimab

GlaxoSmithKline

Phase 2

120

Barcelona, Madrid, Oviedo, Valencia

2025-02-18

By invitation

Effectiveness of a Session of Analgesic Electrostimulation (Invasive and Non-invasive) Applied to the Quadriceps Muscle in Patients After Knee Surgery.

NCT06910150Anterior Cruciate Ligament Reconstruction Rehabilitation

Universidad de Murcia

Not applicable

Madrid

2025-02-18

Recruiting

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

NCT06612268Sickle Cell Disease

DrugEtavopivat

Novo Nordisk A/S

Phase 3

510

Barcelona, Madrid, Seville

2025-02-17

Recruiting

Safety and Usability of the ATLAS 2030 Exoskeleton in Pediatric Patients With Spinal Cord Injury

NCT06772077Spinal Cord Injury (SCI)

MarsiBionics

Not applicable

Toledo

2025-02-17

Recruiting

A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

NCT06697197Advanced Solid Tumors

DrugPumitamig

Bristol-Myers Squibb

Phase 1/2

286

Barcelona, Pamplona, Madrid

2025-02-17

Active, closed

Assessment of Postural Control and Balance in the Older Adult

NCT06844578Older Adult, Balance Assessment, Older Adults, Balance, Postural Balance

University of Extremadura

Not applicable

Cáceres

2025-02-17

By invitation

Development of an International Remote Digital Care System for Accessible, Inclusive and Sustainable Pregnancy Care

NCT07191236Telemedicine, Digital Health, Pregnancy Complications

UMC Utrecht

Observational

450

Barcelona

2025-02-17

Active, closed

Cardiometabolic Properties of Omega-3 Functionalized With Hydroxytyrosol

NCT06992323Hypertriglyceridemia, Normal

National Research Council, Spain

Not applicable

Madrid

2025-02-17

Not yet open

A Reminder App to Optimize Bladder Filling in Patients with Prostate Cancer Receiving HYPO-fractionated Radiotherapy

NCT06784115Prostate Cancer Patients Treated by Radiotherapy

University Hospital Schleswig-Holstein

Not applicable

Barakaldo

2025-02-15

Recruiting

Early Discharge With Hospital-at-Home After Bariatric Surgery and Economic Evaluation.

NCT07782281Severe Obesity, Morbid Obesity Requiring Bariatric Surgery

Corporacion Parc Tauli

Observational

300

Sabadell

2025-02-15

Recruiting

Exercise-Induced Hypoalgesia Differences Between Upper and Lower Limbs Resistance Training Interventions

NCT06765486Local Hypoalgesia, Distal Hypoalgesia, Resistance Training, Pressure Pain Thresholds

Centro Universitario La Salle

Not applicable

Madrid

2025-02-15

Recruiting

Accuracy of Static Guided Implant Surgery: 3D-printed vs Milled Surgical Guides

NCT06819995Dental Implant, Guided Surgery Accuracy

Universidad Complutense de Madrid

Not applicable

Madrid

2025-02-15

Recruiting

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

NCT06760819Advanced Solid Tumors, HER2 Mutation

DrugSevabertinib

Bayer

Phase 2

111

L'Hospitalet de Llobregat, Barcelona, Madrid

2025-02-13

Active, closed

Observational Study to Evaluate Fertility in Women Between 32 and 38 Years Old Treated With the Ovosicare® Fertility

NCT07083999Fertility

Procare Health Iberia S.L.

Observational

300

Sitges, Getafe, Benalmádena, Estella-Lizarra, A Coruña, Alicante, Almería, Barcelona

2025-02-13

Recruiting

The Efficacy and Safety of Once Daily Mexiletine PR in Patients With Myotonic Dystrophy Type 1 and Type 2

NCT06523400Myotonic Dystrophy

DrugMexiletine

Lupin Ltd.

Phase 3

176

Madrid

2025-02-13

Active, closed

A Study of Bempedoic Acid in Combination With Ezetimibe and Either Rosuvastatin or Atorvastatin in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia

NCT06686615Primary Hypercholesterolemiia, Mixed Dyslipidemia

DrugsBempedoic acid·Ezetimibe·Rosuvastatin·Atorvastatin

Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Observational

2,000

Albacete, Alicante, Barakaldo, Burgos, Cadiz, Cantabria, Córdoba, Donostia / San Sebastian

2025-02-12

By invitation

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)

NCT06908226Developmental and Epileptic Encephalopathy

DrugBexicaserin

Longboard Pharmaceuticals

Phase 3

324

Esplugues de Llobregat, Pamplona, Barcelona, Madrid, Málaga, Valencia

2025-02-12

Active, closed

Efficacy of a Dog Assisted Group Intervention in Elderly with Unwanted Loneliness

NCT06860412Loneliness, Elderly (people Aged 65 or More), Animal Assisted Therapy

Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina

Not applicable

Lleida

2025-02-12

Recruiting

Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels

NCT06334575Chronic Obstructive Pulmonary Disease

DrugBudesonide

Maria Joyera Rodríguez

Phase 4

135

Barcelona, Palma de Mallorca

2025-02-12

Recruiting

Colchicine in Chronic Kidney Disease Patients

NCT06998862Chronic Kidney Disease, Cardiovascular Events

Hospital General Universitario Gregorio Marañon

Phase 3

744

Madrid

2025-02-12

Active, closed

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

NCT06834347Chronic Rhinosinusitis With Nasal Polyps

DrugsItepekimab·Mometasone furoate

Sanofi

Phase 3

231

Santiago de Compostela, Barcelona, Jerez de la Frontera, Majadahonda, Seville, Sabadell, Zaragoza

2025-02-12

Recruiting

Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants

NCT06823466Ischemic Stroke, Oral Anticoagulation, Atrial Fibrillation (AF), Outcome Assessment

University of L'Aquila

Observational

200

Madrid, Valladolid

2025-02-12

Recruiting

The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

NCT05973786Bipolar Depression

DrugsLithium·Venlafaxine·Bupropion·Quetiapine

Dr. Inge Winter

Phase 3

418

Barcelona

2025-02-11

Recruiting

A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)

NCT06858579Chronic Inflammatory Demyelinating Polyneuropathy

DrugClaseprubart

Dianthus Therapeutics

Phase 3

256

Barcelona, Alicante, Bilbao

2025-02-10

Recruiting

Gene and Molecular Pathways of Ozone Treatment Response in Gynecological Tumor Patients With Chronic Pelvic Pain Secondary to Cancer Treatment

NCT06816095Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder, Radiotherapy Side Effects, Side Effect of Chemotherapy

Bernardino Clavo, MD, PhD

Observational

Las Palmas

2025-02-10

Active, closed

Study of Oral Atogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

NCT06806293Menstrual Migraine (MM)

DrugAtogepant

AbbVie

Phase 3

468

Barcelona, Madrid, Valladolid

2025-02-10

Active, closed

A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma

NCT06748053Asthma

DrugGSK5784283

GlaxoSmithKline

Phase 2

307

Alcorcon Madrid, Barcelona, Benalmádena, Jerez de la Frontera, Madrid, Málaga, Santander, Seville

2025-02-10

Recruiting

Influence of Suture Type on Emergency Midline Laparotomy Closure

NCT06865807Linea Alba Hernia, Evisceration; Operation Wound, Suture; Complications, Mechanical

Hospital San Juan de Dios Tenerife

Not applicable

100

Santa Cruz de Tenerife

2025-02-10

Active, closed

Impact of a Tele-rehabilitation Program on People With Multiple Sclerosis

NCT07178834Multiple Sclerosis

Multiple Sclerosis Center of Catalonia

Not applicable

Barcelona

2025-02-10

Recruiting

SMASH: Study to Evaluate the Clinical Efficacy of an Extensively Hydrolysed Infant Formula With Synbiotics and a Human Milk Oligosaccharide (HMO) in Infants With Cow's Milk Protein Allergy (CMPA)

NCT07342621Cow's Milk Protein Allergy (CMPA), Food Hypersensitivity, Infant Nutrition Disorders, Gut Microbiota

Outcomes'10

Observational

Valencia

2025-02-07

Active, closed

Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer

NCT06619236Platinum-resistant Ovarian Cancer

DrugsRina-S·Pegylated liposomal doxorubicin·Topotecan·Gemcitabine

Genmab

Phase 3

584

A Coruña, Donostia / San Sebastian, El Palmar, Madrid, Seville, Valencia, Zaragoza

2025-02-07

Recruiting

Ozone Treatment in Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy

NCT06706544Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling

DrugOzone

Bernardino Clavo, MD, PhD

Phase 2/3

Las Palmas

2025-02-07

Recruiting

A Study of TAK-360 in Adults With Idiopathic Hypersomnia

NCT06812078Idiopathic Hypersomnia

DrugTAK-360

Takeda

Phase 2

Vitoria-Gasteiz, Madrid

2025-02-07

Recruiting

Gut Microbiome Profiles in Patients With Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544).

NCT06799351Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling

DrugOzone

Bernardino Clavo, MD, PhD

Phase 2/3

Las Palmas

2025-02-07

Active, closed

A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

NCT06744920Generalized Myasthenia Gravis

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

180

Barcelona, Lleida, Madrid, Málaga, Valencia

2025-02-07

Recruiting

RELIEF: Multimodal Prehabilitation to Treat Fatigue in Patients With Primary Biliary Cholangitis

NCT07161245Primary Biliary Cholangitis (PBC)

Hospital Clinic of Barcelona

Not applicable

Barcelona

2025-02-06

Active, closed

Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)

NCT06843239Systemic Sclerosis (SSc), Scleroderma

Zura Bio Inc

Phase 2

Barcelona, Seville

2025-02-06

Active, closed

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

NCT06834360Chronic Rhinosinusitis With Nasal Polyps

DrugsItepekimab·Mometasone furoate

Sanofi

Phase 3

216

Barcelona, Santander, L'Hospitalet de Llobregat, Pamplona, Madrid

2025-02-06

Recruiting

Robotic Rehabilitation of the Upper Limb in Subacute Stroke

NCT06839482Stroke

IRCCS San Raffaele Roma

Not applicable

130

Madrid

2025-02-06

Recruiting

A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

NCT06624670Pyoderma Gangrenosum

DrugsSpesolimab·Prednisolone·Prednisone

LEO Pharma

Phase 3

Barcelona, Madrid, Málaga

2025-02-05

By invitation

A Multicenter, International, Prospective and Retrospective, Follow-up Registry to Monitor the Efficacy and Safety of the Occlutech Paravalvular Leak Device (PLD) in Patients With Mitral or Aortic Paravalvular Leaks

NCT07037446Paravalvular Leak

Occlutech International AB

Observational

200

Barcelona

2025-02-05

Recruiting

Manual Therapy in Hemophilic Arthropathy of the Ankle

NCT06816056Hemophilia A

Investigación en Hemofilia y Fisioterapia

Not applicable

Murcia

2025-02-05

By invitation

Effectiveness of 5-week Digital Respiratory Practice in Children With Duchenne and Becker Muscular Dystrophies.

NCT06363526Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Muscular Dystrophy

University of Malaga

Not applicable

Málaga

2025-02-05

Recruiting

Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free.

NCT06431633Lung Diseases, Carcinoma, Non-Small-Cell Lung, Resectable Lung Non-Small Cell Carcinoma

DrugsZimberelimab·Sacituzumab Govitecan·Paraplatin·Cisplatin

Fundación GECP

Phase 3

129

Alicante, Elche, Badalona, Barcelona, L'Hospitalet de Llobregat, Bilbao, Jerez de la Frontera, A Coruña

2025-02-04

Recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

NCT06618287Lung Cancer, Breast Cancer

DrugsPumitamig·Iza-bren·Osimertinib·Opdivo

Bristol-Myers Squibb

Phase 1/2

416

Santiago de Compostela, Barcelona, Hospitalet, Madrid, Majadahonda, Valencia, Málaga, Seville

2025-02-04

Recruiting

LEOPARD Training and Validation Data Collection Study

NCT06675604Decompensated Liver Cirrhosis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Hepato-cellular Carcinoma

Assistance Publique - Hôpitaux de Paris

Observational

4,500

Murcia, Seville, Valencia

2025-02-04

Recruiting

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

NCT06651970Chronic Lymphocytic Leukaemia, Moderate to Severe Cardiac Impairment

DrugAcalabrutinib

AstraZeneca

Phase 4

Barcelona, Madrid, Seville

2025-02-04

Recruiting

Detection of Health Risk Situations in the Anesthesia Consultation.

NCT06724380Surgical Procedures, Operative

Consorci Sanitari de l'Alt Penedès i Garraf

Observational

218

Vilafranca Del Penedés

2025-02-04

Active, closed

Quantification Tools for a Novel Tau PET Marker in a Rare Neurological Disease: 18F-PI-2620 in Progressive Supranuclear Palsy

NCT07105384Parkinson Disease

Fundacion Clinic per a la Recerca Biomédica

Phase 2

Barcelona

2025-02-04

Active, closed

Retrieval of Economic Incentives and Information on Quality-of-care Indicators in Primary Care

NCT06829589Hypertension, Diabetes, Atrium; Fibrillation, Asthma

Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina

Not applicable

1,614

Artés, Berga, Calaf, Canet de Mar, Capellades, Cardona, Castellterçol, Cubelles

2025-02-03

Recruiting

Wound Healing and Patient-Reported Outcomes After Gingival Graft Harvesting From the Palate

NCT06806111Palatal Wound

Universitat Internacional de Catalunya

Not applicable

Barcelona

2025-02-03

Active, closed

The engAGE Project: Immersive Intergenerational Intervention to Improve Movement in Older Adults

NCT07112638Frailty at Older Adults

University Ramon Llull

Not applicable

240

Barcelona

2025-02-03

Active, closed

A Safety and Tolerability Study of VRDN-003 in Participants With Thyroid Eye Disease (TED)

NCT06812325Thyroid Eye Disease (TED)

DrugVRDN-003

Viridian Therapeutics, Inc.

Phase 3

320

A Coruña, Barcelona, Córdoba, Madrid, Navarrés, Seville, Zaragoza

2025-02-03

Recruiting

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

NCT06712355Extensive-stage Small-cell Lung Cancer

DrugsPumitamig·Etoposide·Atezolizumab·Carboplatin

BioNTech SE

Phase 3

621

Badajoz, Barcelona, Castellon, León, Madrid, Málaga, Seville, Torrejón de Ardoz

2025-02-03

Recruiting

Efficacy and Safety of Zelpultide Alfa in Preterm Neonates at High Risk of Developing Bronchopulmonary Dysplasia (BPD)

NCT06897839Bronchopulmonary Dysplasia

Airway Therapeutics, Inc.

Phase 2/3

366

Alicante, Barcelona, Bilbao, Cadiz, Lleida, Madrid, Málaga, Santiago de Compostela

2025-02-03

Active, closed

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

NCT06556563Glioblastoma

DrugsTemozolomide·Keytruda·Pembrolizumab

NovoCure GmbH

Phase 3

741

Madrid, Barcelona, Córdoba, Granada, Seville, Valencia

2025-02-03

Recruiting

Effects of a Multidisciplinary Intervention on Fall Risk and Urinary Incontinence in Older Women

NCT06839040Urinary Incontinence, Frailty, Balance Impairment

Fundación Universidad Católica de Valencia San Vicente Mártir

Not applicable

120

Valencia

2025-02-03

Recruiting

Comparision of Hydrodilatation Results at Different Volumes in Adhesive Capsulitis by Phases.

NCT06939530Capsulitis of Shoulder, Hydrodilatation

Javier Muñoz Paz

Not applicable

Córdoba

2025-02-02

Recruiting

Multi-scale Spatio-Temporal Analysis of Research Data

NCT07189312Colorectal Cancer

Universidad de Granada

Observational

Granada

2025-02-02

Not yet open

EFFECTIVENESS OF A TRIPLE NUTRITIONAL INTERVENTION AND PHYSICAL IN PREDIABETIC PATIENRS

NCT06820775Diabetes

Bioaraba Health Research Institute

Not applicable

Vitoria-Gasteiz

2025-02-02

Recruiting

Endoscopy/Robotic Assisted Nipple Skin Sparing Mastectomy

NCT06823414Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Cancer Non-invasive Breast Cancer, High Risk Breast Carcinoma

Alejandra García-Novoa

Observational

126

A Coruña

2025-02-01

Recruiting

Multicomponent Exercise to Prevent Hospitalization-Associated Disability

NCT07707310Clinical Deterioration

Fundacion Miguel Servet

Not applicable

300

Pamplona

2025-02-01

By invitation

Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE

NCT06679881Hereditary Angioedema (HAE)

DrugDeucrictibant

Pharvaris Netherlands B.V.

Phase 3

170

Barcelona

2025-02-01

Recruiting

Comparison of Two Surgical Techniques for Treatment of Type III Obesity (BMI 40-50 kg/m2): Single Anastomosis Duodenoileal Bypass With Sleeve Gastrectomy and Roux-en-Y Gastric Bypass.

NCT06789965Obesity

Hospital Clinic of Barcelona

Not applicable

450

Barcelona

2025-02-01

Recruiting

Impact of the Presence of the Corpus Luteum on Pregnancies Obtained Through Frozen Embryo Transfer(FET)

NCT06896617Infertilities, Embryo Transfer

DrugsEstradiol·Progesterone

Fundacion Clinic per a la Recerca Biomédica

Phase 4

334

Barcelona

2025-02-01

Not yet open

Knowledge of Vascular Age Contributes to Improve the Collaboration Between Community Pharmacies and Primary Health Care Physicians in Reducing Blood Pressure in Hypertensive Patients.

NCT06761235Hypertension and Cardiovascular Risk Factors

Enrique Rodilla

Not applicable

1,246

Sagunto (valencia), Madrid, Salamanca

2025-02-01

Not yet open

Dietary Supplements for Reduction of Intestinal Permeability Levels

NCT06760377Intestinal Permeability, Leaky Gut Syndrome, Zonulin

Universidad Complutense de Madrid

Not applicable

Madrid

2025-02-01

By invitation

Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs.

NCT07234851Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant, Major Depressive Disorder (MDD), Bipolar Disorder (BD)

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Observational

150

Barcelona

2025-02-01

Recruiting

Resistance Exercise in Patients With Ocular Melanoma

NCT06970236Ocular Melanoma

University of Valencia

Not applicable

Valencia

2025-02-01

Not yet open

Parental Stress and Attachment in Preterm Infants

NCT06813560Premature Birth, Psychological Stress, Physiological Stress

Cardenal Herrera University

Observational

Elche

2025-02-01

Recruiting

Study to Assess the Safety and Effectiveness of Beltaven® in Patients With Allergy to Apis Mellifera, Polistes Dominula or Vespula Spp.

NCT07309822Allergy

Probelte Pharma S.L.U.

Observational

Barcelona, Castellon, Ciudad Real, Córdoba, Girona, Lleida, Madrid, Orihuela

2025-02-01

Recruiting

Follow-up of Spanish Prospective Asthma and Nasal Polyposis Registry

NCT06163807Chronic Asthma

Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz

Observational

1,200

Santiago de Compostela, Badalona, Barcelona, A Coruña, Madrid, Pamplona

2025-02-01

Active, closed

Exploring Eye Vergence Markers ADHD) and ASD

NCT06885060Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD)

Elizabeth Kilbey

Observational

200

Barcelona

2025-02-01

Recruiting

Effects of GPR with K-Stretch Hammock on Posture and Musculoskeletal Discomfort

NCT06820073Cervical and Lumbar Musculoskeletal Discomfort

Universidad San Jorge

Not applicable

Zaragoza

2025-02-01

Recruiting

Impact of Virtual Reality Physiotherapy on Multiple Sclerosis Patients

NCT06735053Multiple Sclerosis

European University of Madrid

Not applicable

Móstoles, Madrid

2025-02

Not yet open

Transcranial Magnetic Stimulation in Patients with Dual Disorders

NCT06765824Major Depression, Tobacco Addiction

Cardenal Herrera University

Phase 3

Castellon

2025-02

Recruiting

Optimising Hip Mobility, Hamstring Flexibility and Performance Using Lightback

NCT06811883Injury;Sports

Universidad Católica de Ávila

Not applicable

Salamanca

2025-01-31

Active, closed

A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)

NCT06799000Hidradenitis Suppurativa

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

588

Cadiz, Badalona, Sabadell, Barcelona, Manises, Valencia, Madrid

2025-01-31

Recruiting

Effects of Functional Exercise Program With Strength Load and Resistance in Children and Adolescents With Cerebral Palsy

NCT06820398Cerebral Palsy

University of Valencia

Not applicable

Valencia

2025-01-31

Recruiting

An Ex-US Study to Assess Treatment Persistence With Risankizumab in Adult Participants With Psoriatic Arthritis

NCT06764693Psoriatic Arthritis

AbbVie

Observational

1,200

Málaga, Lorca, Vigo, Seville, Granada, Huelva, Madrid, Murcia

2025-01-31

Recruiting

Radiofrequency and Exercise-based Rehabilitation on Symptoms Associated With Pelvic Floor Dysfunctions in Breast Cancer

NCT06694519Breast Cancer, Genitourinary Syndrome, Radiofrequency, Physical Exercise

SERGIO MONTERO NAVARRO

Not applicable

117

Elche

2025-01-30

Active, closed

VRAS (Velys Robot-Assisted Solution) Operational Excellence Study

NCT06563843Total Knee Arthroplasty (TKA)

DEO NV

Observational

Madrid

2025-01-30

Recruiting

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

NCT06564038Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Mantle-cell Lymphoma, Large B-cell Lymphoma

DrugsSurovatamig·Acalabrutinib·Vincristine·Doxorubicin

AstraZeneca

Phase 1/2

408

Barcelona, Madrid, Palma de Mallorca, Santiago de Compostela, Valencia

2025-01-30

Active, closed

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)

NCT06710132Solid Tumors, Gastric Cancer, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Cancer

DrugM9140

EMD Serono Research & Development Institute, Inc.

Phase 1/2

184

Córdoba, Badalona, Barcelona, L'Hospitalet de Llobregat, Madrid, Pozuelo de Alarcón, Seville, Valencia

2025-01-29

Recruiting

NORA-HOME: An Ambulatory Multimodal Monitoring Model In Patients With Minor Stroke And Transient Ischemic Attacks

NCT07500116Stroke (CVA) or TIA, Stroke Recurrence

Hospital Universitari Vall d'Hebron Research Institute

Not applicable

250

Barcelona

2025-01-29

Recruiting

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

NCT06788990Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma

DrugsFicerafusp alfa·Keytruda·Pembrolizumab

Bicara Therapeutics

Phase 2/3

650

Badalona, Barcelona, Madrid, Pamplona, Santander, Valencia

2025-01-28

Recruiting

Effect of Cardiorespiratory Changes on Carotid Flow Time During Lung Resection Surgery

NCT07808749Hemodynamic Monitoring

University of Valencia

Observational

Valencia

2025-01-27

Recruiting

A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia

NCT06767683Narcolepsy Type 1, Narcolepsy Type 2, Idiopathic Hypersomnia

DrugALKS 2680

Alkermes, Inc.

Phase 2/3

786

Madrid, Barcelona

2025-01-27

Recruiting

Airway Coach Project: Prediction of Videolaryngoscopy Strategy With Clinical and Ultrasound Parameters (Multicentric)

NCT06881589Difficult Videolaryngoscopy

Clinica Universidad de Navarra, Universidad de Navarra

Observational

210

Madrid

2025-01-27

Recruiting

Effect of Oxygen Administration in the Non-dependent Lung on Postoperative Complications After Lung Surgery

NCT07461779Lung Resection Surgery, Anesthesia General

Francisco Andres de la Gala

Phase 4

177

Madrid

2025-01-27

Recruiting

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

NCT06717347Diffuse Large B-Cell Lymphoma

DrugsRituximab Biosimilar·Zilovertamab vedotin·Riabni·Ruxience

Merck Sharp & Dohme LLC

Phase 3

1,046

Seville, L'Hospitalet de Llobregat, Barakaldo, Las Palmas de Gran Canaria, Majadahonda, Gijón, Alicante, Barcelona

2025-01-27

Active, closed

Adaptation of Human Brown Adipose Tissue to Calorie Restriction

NCT06878989Obesity and Overweight

Universidad de Granada

Not applicable

Granada

2025-01-25

Recruiting

Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy

NCT06425666Cataract Surgery, Cataract and Fuchs Endothelial Corneal Dystrophy

University of Cologne

Not applicable

120

Barcelona

2025-01-24

Recruiting

Performance and Safety of Lyoplant® in Guided Bone Regeneration (GBR) in Oral Surgery

NCT06732167Bone Regeneration

Aesculap AG

Not applicable

Barcelona, Sant Cugat Del Vallés

2025-01-24

Recruiting

PRGF-ENDORET® Infiltrations in the Treatment of Low Back Pain.

NCT06715085Diseases [C] - Musculoskeletal Diseases [C05

DrugPlasma Rich in Growth Factors

Biotechnology Institute IMASD

Phase 4

Vitoria-Gasteiz

2025-01-23

Recruiting

DECIDE Just Culture: Conceptualization of Clinical Error

NCT06835517Error Disclosure

Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

Not applicable

1,255

Alicante

2025-01-23

Active, closed

Shoulder School: A Multicenter Prospective Randomized Controlled Study

NCT06778551Subacromial Impingement Syndrome

Sandra Jiménez-del-Barrio

Not applicable

Soria

2025-01-23

Active, closed

Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma

NCT06478212IDH1-mutant Glioma, IDH2-mutant Glioma

DrugsVorasidenib·Temozolomide

Institut de Recherches Internationales Servier

Phase 1/2

Barcelona, Madrid

2025-01-22

Recruiting

A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease

NCT06100289Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

Ferrol, Madrid, Seville, Valencia

2025-01-22

Recruiting

Influence of Preoperative Fear on Pain and Postoperative Outcomes

NCT06785389Fear, Pain Management, Anxiety, Complications of Surgical Procedures or Medical Care

Hospital Universitario de Gran Canaria Doctor Negrín

Observational

138

Las Palmas de Gran Canaria

2025-01-22

Recruiting

Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).

NCT06641414Higher-risk Myelodysplastic Syndrome

DrugsLisaftoclax·Azacitidine

Ascentage Pharma Group Inc.

Phase 3

490

Badalona, Barcelona, Cáceres, Girona, Madrid, Málaga, Ourense, Oviedo

2025-01-22

Recruiting

A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

NCT06585774Chronic Graft-versus-host-disease

DrugsAxatilimab·Prednisolone·Methylprednisolone·Prednisone

Incyte Corporation

Phase 3

240

Barcelona, Donostia / San Sebastian, L'Hospitalet de Llobregat, Las Palmas de Gran Canaria, Madrid, Majadahonda, Salamanca, Seville

2025-01-21

Recruiting

Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia

NCT04084795Fibromyalgia, Psychological Trauma, Depressive Symptoms, Anxiety

Parc de Salut Mar

Not applicable

Barcelona

2025-01-21

Recruiting

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus

NCT06613360SLE, SLE (Systemic Lupus)

DrugCLN-978

Cullinan Therapeutics Inc.

Phase 1

Seville

2025-01-21

Recruiting

Ablation of Human Cardiac Fibrillation Based on Models of Hierarchical Organization of Tissue Excitation

NCT07390175Atrial Fibrillation (AF), Ablation Treatment, TerFib_Hyerarchy

Hospital San Carlos, Madrid

Not applicable

Madrid

2025-01-20

Active, closed

PeRioperative Immunotherapy Combined With Sacituzumab Govitecan in Muscle Invasive blAdder Cancer

NCT06133517Urothelial Bladder Carcinoma

DrugsDomvanalimab·Zimberelimab·Sacituzumab Govitecan

Fundación para el Progreso de la Oncología en Cantabria

Phase 2

L'Hospitalet de Llobregat, Santander, Madrid, Pamplona, Toledo, Valladolid

2025-01-20

Active, closed

Study to Evaluate Adverse Events and Change in Disease Activity When Intravenously (IV) Infused Livmoniplimab is Used in Combination With IV Infused Budigalimab in Adult Participants With Urothelial Carcinoma (UC)

NCT06632951Urothelial Carcinoma

DrugsLivmoniplimab·Budigalimab·Docetaxel·Gemcitabine

AbbVie

Phase 2

150

Barcelona, Madrid, Seville

2025-01-20

By invitation

Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study

NCT07251361Heart Failure With Preserved Ejection Fraction (HFPEF)

Universidad Pública de Navarra

Not applicable

150

Pamplona

2025-01-20

Recruiting

Intraoperative Ultrasound in Bowel Deep Endometriosis

NCT06876376Deep Infiltrating Endometriosis With or Without Bowel Involvement

Fundacion Dexeus

Observational

200

Barcelona

2025-01-20

Recruiting

A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

NCT06680830Parkinson Disease, Parkinson, Idiopathic Parkinson Disease, Early Parkinson Disease (Early PD)

Neuron23 Inc.

Phase 2

150

San Sebastián, Barakaldo, Barcelona, Madrid, Móstoles, Seville

2025-01-17

Active, closed

Clinical Study to Evaluate Debio0123 + Sacituzumab Govitecan Combination in TNBC or HR+/HER2- Advanced Breast Cancer

NCT06612203Advanced Breast Cancer

DrugSacituzumab Govitecan

MedSIR

Phase 1/2

Barcelona, Granada, Madrid, Málaga, Valencia

2025-01-17

Recruiting

Validity - Reliability of Berg Balance Scale in Albanian Population

NCT06834048Balance Assessment, Balance Control in Elderly, Balance Changes, Geriatric Assessment

Universidad Católica San Antonio de Murcia

Observational

200

Murcia

2025-01-17

Recruiting

A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)

NCT06555419Muscular Atrophy, Spinal

DrugNusinersen

Biogen

Phase 1

Madrid, Valencia

2025-01-16

Recruiting

Therapeutic Exercise Through Exergames on Mobile Devices for Cervical Rehabilitation

NCT06794528Neck Pain

Universitat de les Illes Balears

Not applicable

Palma de Mallorca

2025-01-16

Recruiting

ChatGPT-4 for Surgical Site Infection Detection From Electronic Health Records After Colorectal Surgery.

NCT06626399Surgical Site Infection

Hospital de Granollers

Observational

1,100

Granollers

2025-01-15

Recruiting

AI Algorithm for Surveillance of Deep Surgical Site Infections After Elective Colorectal Surgery.

NCT07130656Surgical Site Infection

Hospital de Granollers

Observational

1,200

Granollers

2025-01-15

Recruiting

Cirtuvivint in Selected Advanced Soft-Tissue Sarcomas

NCT07032285Soft Tissue Sarcoma (STS)

Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas

Phase 2

Madrid

2025-01-15

Recruiting

Antidiabetic Effect of Olive Pomace Oil

NCT06723886Type 2 Diabetes Mellitus, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetic State, Diabetes

Instituto de Ciencia y Tecnología de Alimentos y Nutrición

Not applicable

Madrid

2025-01-15

Recruiting

Music Therapy in Post-Stroke Patients: A Clinical Trial

NCT07899034CVA (Cerebrovascular Accident), Ictus, Stroke Acute, Insomnia

Universidad de Granada

Not applicable

Granada

2025-01-15

Recruiting

Evaluation of the Family Intervention Program (PIF)

NCT07106775Parenting, Children/Adolescent Adjustment, Family Functioning

University of Seville

Not applicable

Santander

2025-01-15

Active, closed

A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome

NCT06684847Primary Sjogrens Disease

DrugEfgartigimod PH20

argenx

Phase 3

631

Vitoria-Gasteiz, Badajoz, Barcelona, Santiago de Compostela, Madrid, A Coruña, Seville, Valencia

2025-01-15

Recruiting

Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery

NCT07202208Hip Fracture, Delirium - Postoperative

Cardenal Herrera University

Not applicable

112

Manises, Valencia

2025-01-15

Recruiting

Evaluation of a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer (PragmaTIL)

NCT06630611Melanoma, Non Small Cell Lung Cancer, Cervical Cancer

DrugAldesleukin

Vall d'Hebron Institute of Oncology

Phase 2

Barcelona

2025-01-15

By invitation

Implementation of the Intravitreal Injection Administered by Nurses

NCT06511700Macular Edema, Macular Degeneration, Diabetic Macular Edema

Corporacion Parc Tauli

Observational

200

Sabadell

2025-01-15

Active, closed

Immunotherapy Consolidation After Radical Treatment of Synchronous Oligo-metastatic NSCLC

NCT06219317NSCLC Stage IV

DrugCemiplimab

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

136

Barcelona, Seville

2025-01-14

Recruiting

Effectiveness of a Multidisciplinary Treatment for Patients With Chronic Low Back Pain

NCT06679205Chronic Low-back Pain (cLBP), Chronic Low-back Pain, Back Pain

University of Barcelona

Not applicable

Barcelona

2025-01-14

Recruiting

Evaluation of PreveCol's Efficiency As a Second Line Method for the Early Colorectal Cancer Detection

NCT06703632Screening for Colon Cancer, Blood Samples, Survey and Questionnaire, Colorectal Carcinoma

ADVANCED MARKER DISCOVERY S.L.

Not applicable

4,538

Madrid

2025-01-14

Recruiting

Efficacy and Safety of a New Sperm Capacitation Method

NCT06742437Reproductive Issues, Male Infertility, Asthenozoospermia, Oligozoospermia

Fecundis Lab SL

Observational

300

Barcelona

2025-01-14

Recruiting

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

NCT06695845Breast Cancer, Gastric Cancer, Esophageal Cancer, Gastroesophageal Cancer

DrugZanidatamab

Jazz Pharmaceuticals

Phase 2

200

Las Palmas, Pamplona, Barcelona, Madrid, Málaga, Valencia

2025-01-14

Recruiting

Multimodal Prehabilitation Program That Combines Physical Exercise, Psychological Intervention and Nutritional Support to Improve the Response to Neoadjuvant Chemoterhapy in Early Breast Cancer Patients

NCT07107594Breast Cancer Early Stage Breast Cancer (Stage 1-3), Prehabilitation

Hospital Clinic of Barcelona

Not applicable

214

Barcelona

2025-01-14

Recruiting

A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants

NCT06757543Intubation, Intubation Complications, Infant, Newborn, Infant Respiratory Distress Syndrome

University College Dublin

Not applicable

840

Valencia

2025-01-13

Recruiting

Pectin Intervention Study and Long-term Follow-up in Lipid Transfer Proteins Allergic Patients

NCT06558526Food Allergy

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud

Not applicable

Málaga

2025-01-13

Recruiting

A Prospective Observational Study of Video Laryngoscopy Versus Direct Laryngoscopy for Insertion of a Thin Endotracheal Catheter for Surfactant Administration in Newborn Infants

NCT06758492Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Video Laryngoscopy, Surfactant

University College Dublin

Observational

600

Valencia

2025-01-13

Recruiting

Reforça't: A Community, Social, and Healthcare Program for Patients With Cardiorespiratory Conditions Upon Hospital Discharge

NCT06897410Chronic Obstructive Lung Disease (COLD), Heart Failure

Corporació de Salut del Maresme i la Selva

Not applicable

200

Calella

2025-01-13

Active, closed

Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)

NCT06700343Relapsing-remitting Multiple Sclerosis (RRMS)

DrugOcrelizumab

Amgen

Phase 3

152

2025-01-13

Not yet open

Non-Surgical Treatment of Peri-implantitis with Systemic Azithromycin or Placebo

NCT06715150Peri-implantitis

DrugAzithromcyin

University of Santiago de Compostela

Phase 4

Santiago de Compostela

2025-01-10

Recruiting

An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures

NCT06908356Focal Onset Seizure, Primary Generalized Epilepsy

Praxis Precision Medicines

Phase 2

Madrid

2025-01-10

Active, closed

A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis

NCT06754462Rheumatoid Arthritis

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

120

Barcelona, Bilbao, Málaga, Seville

2025-01-10

Not yet open

SHARE Study: Social Chronic Heart Failure Person-centred cARE Intervention

NCT06701916Heart Failure

Clinica Universidad de Navarra, Universidad de Navarra

Not applicable

374

Pamplona

2025-01-10

Recruiting

A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

NCT06609226Sickle Cell Disease, Thalassemia

Novo Nordisk A/S

Phase 3

480

Barakaldo, Barcelona, Madrid

2025-01-10

Recruiting

An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors

NCT06589596Advanced Solid Tumor

DrugBGB-58067

BeOne Medicines

Phase 1

695

Barcelona, Madrid

2025-01-10

Recruiting

Influence of Menstrual Cycle Phases on the Glycemic Control of Aerobic or HIIT Exercise in Adult Women With Type 1 Diabetes

NCT06729242Diabetes Mellitus, Type I, Menstruation

University of Valencia

Not applicable

Valencia

2025-01-10

Active, closed

A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

NCT06807424Arthritis, Psoriatic

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

813

A Coruña, Córdoba, L'Hospitalet de Llobregat, Madrid, Málaga, Santander, Santiago de Compostela, Seville

2025-01-09

Active, closed

Pre-Symptomatic Detection of Impending Decompensation in Heart Failure Through Voice Data

NCT07443969Heart Failure, Chronic Heart Failure, Chronic Heart Disease

Noah Labs

Observational

123

Barcelona

2025-01-09

Active, closed

Long-term Safety and Efficacy of ESK-001 in Moderate to Severe Plaque Psoriasis

NCT06846541Plaque Psoriasis, Psoriasis (PsO), Psoriasis, Moderate Psoriasis

Alumis Inc

Phase 3

1,680

Alicante, Barcelona, Madrid, A Coruña, Manises

2025-01-08

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Spanish investigative site. Derived from ClinicalTrials.gov. Retrieved 13 November 2026. https://priyalifescience.com/clinical-trials-spain?page=5

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Spain and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 5,909 studies in total at the last sync on 13 Nov 2026, 03:19 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

How many clinical trials are recruiting in Spain?

3,100 of the 5,909 studies in this register are recruiting new participants as of the 13 Nov 2026, 03:19 UTC sync. A further 509 have not yet opened recruitment, 2,083 are active but closed to new participants, and 217 are enrolling by invitation only. Eligibility for any study is decided by its study team.

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Browse trials by condition

Breast Cancer (112) Multiple Myeloma (79) Obesity (59) Heart Failure (57) Non-small Cell Lung Cancer (45) Colorectal Cancer (45) Carcinoma, Non-Small-Cell Lung (45) Prostate Cancer (44) Advanced Solid Tumor (42) Non-Small Cell Lung Cancer (41) Ovarian Cancer (39) Coronary Artery Disease (39) Advanced Solid Tumors (36) Multiple Sclerosis (36) Stroke (35)

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Browse trials by site location

Barcelona (3245) Madrid (3071) Valencia (1206) Seville (1059) Málaga (762) Pamplona (612) Badalona (565) A Coruña (490) Córdoba (449) L'Hospitalet de Llobregat (448) Santander (405) Santiago de Compostela (390) Salamanca (363) Granada (321) Alicante (275)

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.