Wound Healing and Patient-Reported Outcomes After Gingival Graft Harvesting From the Palate

Condition(s) studied

Investigational drug(s) / intervention(s)

Suture: Hemostatic sutures at the palatal donor site; 5-0 non-resorbable suspensory mattress sutures will be anchored to the soft tissues apical to the palatal wound area (5-0 Polypropylene, Prolene, Ethicon, Johnson and Johnson, New Brunswick, NJ, USA).

Cyanoacrylate bioadhesive: Several drops of a high-viscosity cyanoacrylate bioadhesive will be applied (Cuantum Oral Adhesive, Cuantum Medical Cosmetics S.L., Spain) to create a uniform adhesive layer.

Study summary

The goal of this clinical trial is to evaluate whether two different techniques for treating palatal wounds-sutures and cyanoacrylate bioadhesive-can influence postoperative morbidity, clinical healing, and soft tissue dimensional changes in patients undergoing epithelialized gingival graft harvesting from the palate. The main questions it aims to answer are:

Does the use of cyanoacrylate bioadhesive reduce postoperative morbidity compared to sutures? Does the choice of wound treatment technique affect clinical healing and three-dimensional changes in soft tissues? Researchers will compare the sutures (control group) to the cyanoacrylate bioadhesive (test group) to determine if the bioadhesive leads to improved postoperative outcomes.

Participants will:

Undergo epithelialized gingival graft harvesting from the palate. Receive either sutures or cyanoacrylate bioadhesive for wound closure. Be monitored for postoperative morbidity, clinical healing, and soft tissue dimensional changes.

Eligibility

Primary outcome measure(s)

• Postoperative pain — 1 day, 3 days, 1 week, 2 weeks, 3 weeks, and 4 weeks
  Minimum and maximum values \[0-100\] Higher scores mean worse outcome (more pain) A questionnaire will be prepared and handed to patients on the day of the surgery. Patients will be instructed to answer the questions at the same time of the day and refer only to the palatal wound. Postoperative pain will be assessed using a Visual Analog Score (VAS) at 1 day, 3 days, 1 week, 2 weeks, 3 weeks, and 4 weeks postoperatively.

Trial sites (1)

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