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Trackers› Clinical trials› Aachen
Clinical trial register · Germany

Clinical Trials in Aachen, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Germany and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 5051 matching records held by the registry are in this view. Synced 26 Sep 2026, 19:51 UTC
5051
Studies in scope
all four open statuses
2882
Recruiting now
open to new participants
988
Lead sponsors
across recruiting studies
Top sites
Berlin 1584 Hamburg 889 Essen 760 Dresden 707 Heidelberg 627
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca18 RWTH Aachen University14 Novartis Pharmaceuticals10 Incyte Corporation10 Janssen Research & Development, LLC7
Site location
Berlin1584 Hamburg889 Essen760 Dresden707 Heidelberg627
All 635 locations
Target enrolment
to

Trials with a site in Aachen

267 of 5051 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Germany
Start
Recruiting
A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia
NCT07623200Essential Thrombocythemia
DrugINCA033989
Incyte Corporation
Phase 3
426
Aachen, Berlin, Dresden, Freiburg im Breisgau, Halle, Hamburg, Hanover, Homburg
2026-09-08
Recruiting
A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD)
NCT07624305Renal Insufficiency, Chronic
DrugsBalcinrenone/dapagliflozin·Dapagliflozin
AstraZeneca
Phase 3
2,800
Aachen, Bad Nenndorf, Berlin, Bonn, Brandenburg an der Havel, Braunschweig, Cloppenburg, Essen
2026-09-01
Not yet open
Shortening Treatment Duration in Uncomplicated Candidemia: the CanTEN Trial
NCT07788586Candidemia, Invasive Candidiasis
Oliver Cornely, MD
Phase 4
420
Aachen, Berlin, Cologne, Dresden, Düsseldorf, Frankfurt am Main, Freiburg im Breisgau, Giessen
2026-09
Recruiting
Adjuvant Trial in Patients With Resected PDAC Randomized to Allocation of Oxaliplatin- or Gemcitabine-based Chemotherapy by Standard Clinical Criteria or by a Transcriptomic Treatment Specific Stratification Signature
NCT05314998Pancreatic Ductal Adenocarcinoma
DrugsFolinic acid·Irinotecan·Adrucil·Capecitabine
John Neoptolemos
Phase 3
394
Aachen, Augsburg, Bochum, Bonn, Deggendorf, Dresden, Erlangen, Frankfurt
2026-08-17
Recruiting
Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study
NCT07746895C3 Glomerulopathy (C3G), Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)
DrugPegcetacoplan
Swedish Orphan Biovitrum
Phase 4
150
Aachen, Berlin, Cologne, Dresden, Erlangen, Essen, Hamburg, Hanover
2026-08-05
Not yet open
Prevention Programme for Improvement of Well-being and Level of Participation in Adolescents With Enhanced Psychiatric Burden in the School Environment.
NCT06390384Blended-care Counselling, Digital and Mental Literacy Training, App STEPS
RWTH Aachen University
Not applicable
100
Aachen
2026-08-01
Recruiting
A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)
NCT07742735Short Bowel Syndrome (SBS), SBS Associated With Intestinal Failure (SBS-IF)
DrugApraglutide
VectivBio AG
Phase 3
124
Heidelberg, Erlangen, Hamburg, Bonn, Essen, Münster, Aachen, Berlin
2026-08
Recruiting
Pridopidine Phase 3 Study in Huntington's Disease
NCT07609108Huntington Disease
DrugPridopidine
Prilenia
Phase 3
400
Aachen, Bochum, Erlangen, Münster, Taufkirchen, Ulm
2026-07-01
Not yet open
Everolimus bAsed caLcineurin inhibiTor frEe immunosuppRession oNe Year AfTer lIver transplantatiON (ALTERNATION)
NCT07739914Liver Allograft, Liver Diseases, Liver Transplantation
DrugsCyclosporine·Tacrolimus·Everolimus
Hannover Medical School
Phase 3
150
Heidelberg, Tübingen, Regensburg, Würzburg, Hamburg, Hanover, Rostock, Aachen
2026-06-30
Recruiting
An Observational Study of Octreotide Subcutaneous Depot in Patients With Acromegaly
NCT07583563Acromegaly
Camurus AB
Observational
200
Aachen, Leipzig, Magdeburg, München, Würzburg
2026-06-05
Recruiting
Safety and Performance of the Novalung Ultimate Kit and Xenios 2.0 During Stationary Use in Hospital and Ground-based Transport of Patients on Extracorporeal Life Support (ECLS)
NCT07156669Cardio-Respiratory Failure, Extracorporeal Membrane Oxygenation Complication, Acute Lung Injury
Xenios AG
Observational
20
Erfurt, Aachen, Solingen
2026-05-19
Recruiting
Study of INCA036978 in Participants With Myeloproliferative Neoplasms
NCT07441694Myeloproliferative Neoplasms
Incyte Corporation
Phase 1
218
Aachen, Berlin, Freiburg im Breisgau, Halle, Mainz
2026-05-11
Recruiting
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
NCT07567001Obesity, Heart Failure
DrugNNC0487-0111
Novo Nordisk A/S
Phase 3
5,610
Aachen, Bad Friedrichshall, Bad Oeynhausen, Berlin, Bochum, Coburg, Cologne, Dresden
2026-05-11
Recruiting
Adjuvant Stereotactic Body Radiation Therapy After Trans-arterial Chemoembolization in Hepatocellular Carcinoma
NCT04996914Hepatocellular Carcinoma Non-resectable
RWTH Aachen University
Not applicable
30
Aachen
2026-05-05
Not yet open
Psychological Stress and Support Needs of Volunteer First Responders After Smartphone-based Cardiac Arrest Alerts
NCT07607808Mental Health, Stress Disorder, Post Traumatic
University Hospital, Aachen
Not applicable
75
Aachen
2026-05-01
Recruiting
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
NCT07585890End-stage Liver Disease (ESLD), Acute Liver Failure, Liver Cirrhosis, Liver Transplantation
University Medical Center Groningen
Observational
10,000
Aachen, Essen, Frankfurt, Heidelberg
2026-04-21
Recruiting
DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy
NCT07472517Small Cell Lung Cancer (SCLC), Extensive-stage Small Cell Lung Cancer (ES-SCLC)
DrugsObrixtamig·Etoposide·Atezolizumab·Carboplatin
Boehringer Ingelheim
Phase 3
670
Aachen, Berlin, Berlin-Spandau, Dresden, Essen, Frankfurt, Freiburg im Breisgau, Gauting
2026-04-13
Recruiting
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
NCT07405801Breast Cancer
DrugsInavolisib·Ribociclib·Fulvestrant
Hoffmann-La Roche
Phase 2
80
Aachen, Dessau, Essen, Heidelberg, Tübingen
2026-04-07
Recruiting
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease
NCT07326709Huntington Disease
DrugVotoplam
Novartis Pharmaceuticals
Phase 3
770
Aachen, Bochum, Münster, Tübingen, Ulm
2026-03-24
Recruiting
Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)
NCT07223814Acute Myeloid Leukemia
DrugsBleximenib·Idarubicin·Daunorubicin·Cytarabine
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
875
Aachen, Bochum, Bonn, Greifswald, Halle, Hanover, Heilbronn, Karlsruhe
2026-03-01
Not yet open
A Study on Remote Health Support for Patients With Heart Failure.
NCT07440472Heart Failure
Universitat Internacional de Catalunya
Observational
90
Aachen
2026-03
Recruiting
Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS
NCT07197944Short Bowel Syndrome
DrugGlepaglutide
Zealand Pharma
Phase 3
90
Rostock, Leipzig, Aachen, Berlin, Bonn, Hamburg
2026-02-11
Recruiting
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
NCT07215702Sepsis, Acute Kidney Injury
DrugAZD4144
AstraZeneca
Phase 2
124
Aachen, Essen, Frankfurt, Greifswald, Heidelberg, Kiel, Leipzig, Münster
2026-02-10
Recruiting
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
NCT07412756Depressive Disorder, Major
DrugBrenipatide
Eli Lilly and Company
Phase 3
1,000
Aachen, Berlin, Bielefeld, Chemnitz, Mainz, Mannheim, Schwerin, Siegen
2026-02-09
Recruiting
Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation
NCT07025824AML - Acute Myeloid Leukemia, MDS (Myelodysplastic Syndrome)
DrugsTreosulfan·Melphalan·Fludarabine
Technische Universität Dresden
Phase 2
220
Aachen, Augsburg, Berlin, Chemnitz, Cologne, Dresden, Frankfurt am Main, Greifswald
2026-01-21
Recruiting
Smoking Cessation Before Bronchoscopy or CT-guided Puncture
NCT07322796Pulmonary Nodule, Solitary, Smoking Behaviors
RWTH Aachen University
Observational
25
Aachen
2026-01-01
Recruiting
Chemotherapy De-escalation in HR +, HER2-, Intermediate-risk Early Breast Cancer Treated With Adjuvant Ribociclib
NCT07237256Breast Cancer
UNICANCER
Phase 3
3,902
Aachen, Augsburg, Bad Nauheim, Berlin, Bremen, Cottbus, Dresden, Düsseldorf
2025-12-18
Recruiting
STOP-PKD: SGLT2-inhibition to Improve Prognosis in Polycystic Kidney Disease
NCT07280585Polycystic Kidney, Autosomal Dominant
DrugDapagliflozin
University of Cologne
Phase 3
420
Stuttgart, Nuremberg, Aachen, Berlin, Cologne, Dortmund, Dresden, Düsseldorf
2025-12-16
Recruiting
Development of the PTSD-iMPACT to Measure PTSD-Related Functional Impairment in Children and Adolescents - A Validation Study in Switzerland and Germany
NCT07368166PTSD - Post Traumatic Stress Disorder, PTSD-Related Functional Impairment in Children and Adolescents
University Children's Hospital, Zurich
Observational
1,200
Aachen, Bamberg, Eichstätt, Konstanz, Marburg, Oldenburg, Ulm
2025-12-15
Recruiting
A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)
NCT07221253Biliary Tract Cancer
DrugsGemcitabine/Cisplatin·Rilvegostomig·Durvalumab
AstraZeneca
Phase 3
1,100
Aachen, Berlin, Bonn, Düsseldorf, Essen, Frankfurt, Freiburg im Breisgau, Hamburg
2025-12-04
Not yet open
Impact of a Physical Activity Intervention on Cardiometabolic Health, Mental Health, and Lifestyle Factors.
NCT07237893Healthy
University of Liege
Not applicable
1,000
Aachen
2025-11-24
Recruiting
Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in Curative mIDH1 Cholangiocarcinoma
NCT07260175Cholangiocarcinoma, IDH Mutation
DrugIvosidenib
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Phase 2
40
Aachen, Bonn, Essen, Frankfurt, Giessen, Göttingen, Hamburg, Jena
2025-11-18
Recruiting
Combining Loncastuximab Tesirine and Epcoritamab in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)
NCT07197307Aggressive Diffuse Large B-cell Lymphoma, High-grade B-cell Lymphoma (HGBL), Follicular Lymphoma (FL) Grade 3B
Universität Münster
Phase 2
120
Aachen, Augsburg, Berlin, Bielefeld, Chemnitz, Düsseldorf, Erlangen, Essen
2025-10-31
Recruiting
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
NCT07213804Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis
DrugsSofe-M·MIRV·Pegylated liposomal doxorubicin·Topotecan
Eli Lilly and Company
Phase 3
1,630
Aachen, Berlin, Bonn, Cologne, Dresden, Düsseldorf, Erlangen, Essen
2025-10-22
Recruiting
A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis
NCT07196748Colitis, Ulcerative
DrugIcotrokinra
Janssen Research & Development, LLC
Phase 3
882
Aachen, Berlin, Dachau, Erlangen, Halle, Hanover, Jerichow, Kiel
2025-10-01
Not yet open
Prospective Register Study to Assess Eligibility for and Efficacy of Surgical Treatment in Patients With nEuRovascular Conflict
NCT07135024Trigeminal Neuralgia, Tic Douloureux, Facial Pain, Glossopharyngeal Neuralgia
Gerrit A Schubert
Observational
5,001
Aachen
2025-10-01
Recruiting
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
NCT06865417Ulcerative Colitis
DrugFilgotinib
Alfasigma S.p.A.
Phase 3
80
Aachen, Leipzig, Mainz, Tübingen
2025-09-29
Recruiting
Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML
NCT07007312Acute Myeloid Leukemia (AML)
DrugsZiftomenib·Venclyxto·Ara-C·Venclexta
Kura Oncology, Inc.
Phase 3
1,300
Bad Saarow, Aachen
2025-09-26
Recruiting
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
NCT07181109High Risk Cardiovascular Disease, Hypertension, High Cardiovascular Risk
DrugZilebesiran
Alnylam Pharmaceuticals
Phase 3
11,000
Aachen, Ahaus, Altenburg, Bad Homburg, Berlin, Brandenburg an der Havel, Bremen, Cologne
2025-09-22
Active, closed
A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
NCT07169578Alzheimers Disease
DrugTrontinemab
Hoffmann-La Roche
Phase 3
1,101
Aachen, Bad Homburg, Bayreuth, Bochum, Bremen, Erbach/Odenwald, Freiburg im Breisgau, Hamburg
2025-09-17
Recruiting
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
NCT07157774Elevated Lp(a), Atherosclerotic Cardiovascular Disease (ASCVD)
Eli Lilly and Company
Phase 3
10,450
Aachen, Bad Homburg, Berlin, Dresden, Essen, Frankfurt, Freiburg im Breisgau, Greifswald
2025-09-02
Recruiting
SCORE Study: Comparing Surgery and Rigid Collar Treatment for Odontoid Fractures in Adults Over 70
NCT06961578Odontoid Fracture, Elderly
Technical University of Munich
Not applicable
322
Munich, Frankfurt am Main, Berlin, Aachen, Cologne, Dresden, Essen, Göttingen
2025-08-13
Recruiting
A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy
NCT06963827Kidney Disease
DrugMezagitamab
Takeda
Phase 3
347
Aachen, Jena, Mainz
2025-07-15
Recruiting
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
NCT06976216Alzheimer's Disease
DrugsKarX-EC·KarXT
Bristol-Myers Squibb
Phase 3
586
Mannheim, Münster, Mainz, Berlin, Aachen, Bremen, Hamburg, Munich
2025-07-14
Recruiting
European Venous Registry
NCT06906250Deep Venous Disease of the Lower Limbs
IRCCS San Raffaele
Observational
100
Aachen
2025-07-05
Recruiting
Clinical Study on the Safety and Efficacy of the Minimally Invasive Ennovate® Method for Pedicle Screw Placement
NCT06960018Cervical Spine Disease, Pain, Postoperative
Aesculap AG
Not applicable
76
Aachen, Berlin, Freiburg im Breisgau
2025-06-20
Recruiting
Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Neoplasia With IDH1 (Isocitrate Dehydrogenase 1) Mutation
NCT06717958AML, MDS
DrugIvosidenib
Technische Universität Dresden
Phase 2
76
Aachen, Chemnitz, Dresden, Erlangen, Essen, Frankfurt am Main, Greifswald, Halle
2025-06-17
Recruiting
A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich's Ataxia
NCT06953583Friedreich Ataxia
DrugsOmaveloxolone·Skyclarys
Biogen
Phase 3
255
Aachen, Giessen, Hamburg
2025-06-09
Recruiting
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
NCT06872892Bronchiectasis
DrugVerducatib
Boehringer Ingelheim
Phase 3
1,755
Aachen, Ahrensburg, Bamberg, Berlin, Bochum, Bonn, Cologne, Donaustauf
2025-06-09
Active, closed
A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy
NCT06821542Chronic Graft-versus-host-disease
DrugAxatilimab
Incyte Corporation
Phase 3
9
Aachen, Berlin, Cologne, Dresden, Erlangen, Frankfurt am Main, Freiburg im Breisgau, Göttingen
2025-06-04
Recruiting
Assessing Declined Liver Grafts With Normothermic Machine Perfusion to Reduce Transplant Waiting Time
NCT06874296Liver Transplantation, Liver Diseases, Surgery
Charite University, Berlin, Germany
Not applicable
186
Hamburg, Aachen, Bonn, Münster, Berlin, Hanover, München, Regensburg
2025-06-02
Recruiting
Safety and Efficacy of Crofelemer in Adult Patients With Short Bowel Syndrome and Intestinal Failure (SBS-IF) Without Colon-in-continuity (CIC)
NCT06904872Short Bowel Syndrome, Malabsorption Syndromes, Short Gut Syndrome, Post-Op Complication
DrugCrofelemer
Napo Therapeutics, S.p.A.
Phase 2
18
Aachen, Berlin, Essen, Hamburg, Rostock
2025-05-29
Recruiting
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
NCT06952504Endometrial Cancer
DrugsSacituzumab tirumotecan·Docetaxel·Keytruda·Paclitaxel
Merck Sharp & Dohme LLC
Phase 3
1,123
Aachen, Trier, Saarbrücken, Leipzig, Jena, Berlin, Hamburg
2025-05-22
Recruiting
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
NCT06921785Hepatocellular Carcinoma
DrugsRilvegostomig·Tremelimumab·Atezolizumab·Bevacizumab
AstraZeneca
Phase 3
1,220
Aachen, Berlin, Bonn, Dortmund, Dresden, Essen, Frankfurt, Göttingen
2025-05-06
Recruiting
Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers
NCT06906341Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms, Endometrial Cancer
DrugsNab-paclitaxel /m^2·Relacorilant·Bevacizumab
Corcept Therapeutics
Phase 2
270
Aachen, Berlin, Kempten
2025-04-11
Active, closed
Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858878Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
DrugMaridebart cafraglutide
Amgen
Phase 3
1,105
Aachen, Bad Krozingen, Bad Mergentheim, Bad Oeynhausen, Berlin, Elsterwerda, Essen, Falkensee
2025-03-17
Recruiting
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
NCT06677060Heart Failure
DrugBaxdrostat/dapagliflozin
AstraZeneca
Phase 3
11,300
Aachen, Amberg, Bad Homburg, Bad Oeynhausen, Bamberg, Bechhofen, Berlin, Bochum
2025-03-14
Active, closed
Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858839Obesity
DrugMaridebart cafraglutide
Amgen
Phase 3
3,853
Aachen, Bad Homburg, Bad Krozingen, Bad Mergentheim, Bad Oeynhausen, Berlin, Dresden, Elsterwerda
2025-03-12
Active, closed
Bemarituzumab in FGFR2b+ Patients With Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction, Who Failed at Least One Prior Line of Palliative Chemotherapy
NCT06680622Metastatic Gastro-esophageal Adenocarcinoma
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Phase 2
126
Aachen, Amberg, Augsburg, Bad Saarow, Berlin, Bielefeld, Chemnitz, Dortmund
2025-03-03
Recruiting
Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib
NCT06855498Hidradenitis Suppurativa (HS)
DrugPovorcitinib
Incyte Corporation
Phase 3
600
Aachen, Bad Bentheim, Berlin, Bochum, Bonn, Buxtehude, Darmstadt, Dortmund
2025-02-28
Recruiting
IMPACT-AML: A Randomized Pragmatic Clinical Trial for Relapsed or Refractory Acute Myeloid Leukemia.
NCT06713837Acute Myeloid Leukemia, Relapse/Recurrence
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Phase 3
339
Aachen, Greifswald, Halle, Rostock, Zwickau
2025-02-27
Recruiting
Tasquinimod in Patients with Myelofibrosis Refractory to or Intolerant for JAK2 Inhibition
NCT06605586Myelofibrosis
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 1/2
20
Aachen
2025-02-20
Recruiting
Maintenance ElectroConvulsive Therapy in Clozapine RESISTant Schizophrenia - the MECT-RESIST Trial
NCT06456983Schizophrenia, Treatment Resistant Schizophrenia
Central Institute of Mental Health, Mannheim
Not applicable
140
Aachen, Augsburg, Göppingen, Göttingen, Hanover, Heidelberg, Ingolstadt, Mainz
2025-02-14
Recruiting
A Study of Bempedoic Acid in Combination With Ezetimibe and Either Rosuvastatin or Atorvastatin in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia
NCT06686615Primary Hypercholesterolemiia, Mixed Dyslipidemia
DrugsBempedoic acid·Ezetimibe·Rosuvastatin·Atorvastatin
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Observational
2,000
Aachen, Ahaus, Alsfed, Bad Homburg, Berlin, Burg, Chemnitz, Detmold
2025-02-12
Recruiting
A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)
NCT06858579Chronic Inflammatory Demyelinating Polyneuropathy
DrugClaseprubart
Dianthus Therapeutics
Phase 3
256
München, Sande, Aachen, Greifswald, Rüdersdorf
2025-02-10
Recruiting
LEOPARD Training and Validation Data Collection Study
NCT06675604Decompensated Liver Cirrhosis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Hepato-cellular Carcinoma
Assistance Publique - Hôpitaux de Paris
Observational
4,500
Aachen, Berlin, Hanover, Jena, Kiel, Leipzig, Münster, Tübingen
2025-02-04
Recruiting
Long-term Evaluation of the SIMEOX Device at Home in Non-cystic Fibrosis Bronchiectasis
NCT06487273Non-cystic Fibrosis Bronchiectasis
Physio-Assist
Not applicable
622
Aachen, Lübeck, München
2025-02-03
Recruiting
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
NCT06788990Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
DrugsFicerafusp alfa·Keytruda·Pembrolizumab
Bicara Therapeutics
Phase 2/3
650
Aachen, Berlin, Braunschweig, Chemnitz, Dresden, Düsseldorf, Essen, Göttingen
2025-01-28
Recruiting
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
NCT06585774Chronic Graft-versus-host-disease
DrugsAxatilimab·Prednisolone·Methylprednisolone·Prednisone
Incyte Corporation
Phase 3
240
Aachen, Berlin, Bonn, Dresden, Düsseldorf, Erlangen, Essen, Halle
2025-01-21
Recruiting
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
NCT06712316Non-small Cell Lung Cancer
DrugsPumitamig·Pemetrexed·Paclitaxel·Carboplatin
BioNTech SE
Phase 2/3
1,580
Aachen, Berlin, Chemnitz, Düsseldorf, Erlangen, Esslingen am Neckar, Gauting, Gera
2025-01-07
Active, closed
Phase 2 Study of Rapcabtagene Autoleucel in Myositis
NCT06665256Idiopathic Inflammatory Myopathies
DrugRapcabtagene autoleucel
Novartis Pharmaceuticals
Phase 2
21
Cologne, Leipzig, Jena, Aachen, Hamburg, Mainz, Nuremberg, Ulm
2024-12-17
Recruiting
A Study to Learn More About the Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Who Are Prescribed it by Their Own Doctors
NCT06623890Friedreich Ataxia
DrugsOmaveloxolone·Skyclarys
Biogen
Observational
300
Tübingen, Aachen, Munich
2024-12-12
Recruiting
Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor
NCT06472245Patients With Non-Small Cell Lung Cancer
DrugsTedopi·Docetaxel
OSE Immunotherapeutics
Phase 3
363
Heidelberg, Stuttgart, Gauting, München, Kassel, Aachen, Bonn, Essen
2024-12-03
Active, closed
A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)
NCT06465329Non-Small Cell Lung Cancer
DrugsMarlotamig·Cemiplimab
Regeneron Pharmaceuticals
Phase 2
120
Kassel, Göttingen, Leipzig, Aachen
2024-11-18
Active, closed
Multinational Point Prevalence Study on the Management of Diabesity in Hospitals
NCT06680674Diabetes Mellitus, Obesity
Medical University of Vienna
Observational
400
Aachen
2024-11-13
Recruiting
A Study of Radiation Dosimetry, Safety, and Tolerability of Extended Lutetium (177Lu) Vipivotide Tetraxetan Treatment in Chemo-naïve Adults With Metastatic Castration-resistant Prostate Cancer: RADIOpharmaceutical DOSimetry Evaluation (RADIODOSE) Study
NCT06531499Metastatic Castration-Resistant Prostate Cancer
DrugLu-PSMA
Novartis Pharmaceuticals
Phase 1
106
Cologne, Wuppertal, Aachen, Berlin, Essen, München, Rostock
2024-11-11
Recruiting
A Phase II Randomized, Open Label Non-inferiority Study of NiraParib Maintenance After 3 vs. 6 Cycles of Platinum-based Chemotherapy in completeLy debUlked Advanced HRDpositive High-grade Ovarian Cancer patientS in First Line Therapy
NCT05460000Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, Clear Cell Carcinoma
North Eastern German Society of Gynaecological Oncology
Phase 2
640
Aachen, Baden-Baden, Berlin, Bonn, Cologne, Detmold, Dortmund, Dresden
2024-10-11
Active, closed
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)
NCT06516952Prurigo Nodularis
DrugPovorcitinib
Incyte Corporation
Phase 3
349
Aachen, Bad Bentheim, Berlin, Dortmund, Halle, Hamburg, Heidelberg, Leipzig
2024-10-10
Active, closed
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN2)
NCT06516965Prurigo Nodularis
DrugPovorcitinib
Incyte Corporation
Phase 3
346
Aachen, Buxtehude, Chemnitz, Darmstadt, Dresden, Frankfurt am Main, Göttingen, Magdeburg
2024-10-10
Recruiting
Abiomed Impella RT-DAQ - Observational Study
NCT06308055Cardiogenic Shock
Abiomed Inc.
Observational
125
Aachen, Kiel
2024-10-04
Recruiting
A Study to Investigate Effects of Ocrelizumab Treatment on Neurofilament Light Chain (NfL) Levels and Participant Satisfaction in Participants With Multiple Sclerosis (MS)
NCT06780150Multiple Sclerosis
DrugOcrelizumab
Hoffmann-La Roche
Observational
842
Aachen, Amberg, Arnsdorf, Aschaffenburg, Bad Soden, Bamberg, Berg, Berlin
2024-09-26
Recruiting
A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems
NCT06512454Alpha1-Antitrypsin Deficiency
Takeda
Observational
500
Aachen
2024-09-25
Recruiting
Efficacy and Safety of Oral Controlled-Ileocolonic-Release Nicotinamide (CICR-NAM) in Patients With Mild to Moderately Active Ulcerative Colitis
NCT06488625Ulcerative Colitis, Unspecified
University Hospital Schleswig-Holstein
Phase 2/3
459
Kiel, Aachen, Augsburg, Bamberg, Berlin, Bremen, Cologne, Dachau
2024-09-12
Active, closed
Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)
NCT06564142Immunoglobulin A Nephropathy
DrugPovetacicept
Alpine Immune Sciences Inc, A Subsidiary of Vertex
Phase 3
605
Aachen, Berlin, Dresden, Leipzig
2024-08-30
Active, closed
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
NCT06531824Kidney Disease, Chronic
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
11,000
Aachen, Bad Kreuznach, Bad Nenndorf, Bad Oeynhausen, Berlin, Bonn, Braunschweig, Coburg
2024-08-30
Recruiting
Durvalumab + Intraductal Radiofrequency Ablation (ID-RFA) in Extrahepatic Cholangiocarcinoma
NCT06440993Extrahepatic Cholangiocarcinoma, Unresectable Perihilar or Ductal CCA
DrugsDurvalumab·Gemcitabine·Cisplatin
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Phase 2
42
Aachen, Bonn, Cologne, Düsseldorf, Frankfurt, Göttingen, Hanover, Lübeck
2024-08-23
Active, closed
A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With Myeloproliferative Neoplasms
NCT06313593Myeloproliferative Neoplasms
Incyte Corporation
Phase 1
37
Aachen, Essen, Halle
2024-08-08
Recruiting
Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
NCT06380751Advanced Breast Cancer
DrugsSaruparib·Camizestrant·Exemestane·Anastrozole
AstraZeneca
Phase 3
788
Aachen, Augsburg, Berlin, Cologne, Dessau, Düsseldorf, Erlangen, Göttingen
2024-08-01
Active, closed
A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease
NCT06544616Alzheimer Disease
Janssen Pharmaceutica N.V., Belgium
Phase 2
55
Aachen, Cologne, Homburg, Münster
2024-07-22
Active, closed
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
NCT06455202Chronic Spontaneous Urticaria
DrugBarzolvolimab
Celldex Therapeutics
Phase 3
976
Aachen, Bad Bentheim, Berlin, Bonn, Dresden, Düsseldorf, Essen, Hamburg
2024-07-19
Active, closed
A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD
NCT06405633Alpha-1 Antitrypsin Deficiency
Wave Life Sciences USA, Inc.
Phase 1/2
24
Aachen
2024-07-19
Active, closed
Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)
NCT06456346Essential Thrombocythemia
DrugsBomedemstat·Hydroxyurea
Merck Sharp & Dohme LLC
Phase 3
300
Landshut, Hanover, Aachen, Essen, Mainz, Halle, Jena, Berlin
2024-07-16
Recruiting
A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
NCT05895136Liver Cirrhosis, Decompensated Cirrhosis of Liver, Acute on Chronic Liver Failure (ACLF)
DrugsHuman albumin·Enoxaparin
European Foundation for Study of Chronic Liver Failure
Phase 2
90
Aachen, Münster
2024-07-01
Recruiting
Master Framework For Relapse or Refractory Acute Myeloid Leukemia
NCT06459024Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Observational
4,000
Aachen, Greifswald, Halle, Rostock
2024-06-28
Recruiting
Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
NCT06465810Transthyretin Amyloidosis, ATTR-CM, ATTRv-PN, ATTR
AstraZeneca
Observational
1,850
Würzburg, Frankfurt am Main, Hanover, Aachen, Cologne, Mainz, Homburg, Berlin
2024-06-25
Recruiting
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
NCT06424288Heart Failure
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
6,712
Aachen, Bad Friedrichshall, Berlin, Bonn, Dessau, Dresden, Erfurt, Frankfurt
2024-06-17
Recruiting
Ultra-high-caloric, Fatty Diet in ALS
NCT06280079Amyotrophic Lateral Sclerosis
University of Ulm
Not applicable
392
Aachen, Berlin, Bochum, Bonn, Dresden, Erlangen, Essen, Göttingen
2024-06-01
Active, closed
A Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative Colitis
NCT06294925Colitis, Ulcerative
DrugEtrasimod
Pfizer
Observational
360
Freiburg im Breisgau, Kassel, Aachen, Andernach, Berlin, Cologne, Dachau, Frankfurt am Main
2024-05-08
Active, closed
Real-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany
NCT06336330Heart Diseases, Cardiovascular Diseases, Heart Failure
AstraZeneca
Observational
831
Aachen, Alsfeld, Bamberg, Bechhofen, Bergisch Gladbach, Berlin, Brilon, Bruchsal
2024-04-25
Recruiting
Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML
NCT05904106Acute Myeloid Leukemia
DrugsGemtuzumab Ozogamicin·Azacitidine·Venetoclax
Technische Universität Dresden
Phase 2
146
Essen, Aachen, Augsburg, Chemnitz, Cologne, Dresden, Erlangen, Frankfurt am Main
2024-04-07
Active, closed
Iberdomide vs. Iberdomide Plus Isatuximab Maintenance Therapy Post ASCT in Newly Diagnosed Multiple Myeloma
NCT06216158Multiple Myeloma
DrugsIberdomide·Isatuximab·Dexamethasone
University of Heidelberg Medical Center
Phase 3
411
Aachen, Augsburg, Bad Saarow, Berlin, Bielefeld, Bonn, Braunschweig, Chemnitz
2024-04-05
Active, closed
Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
NCT06291376Immunoglobulin A Nephropathy, IgAN
DrugRavulizumab
Alexion Pharmaceuticals, Inc.
Phase 3
579
Aachen, Berlin, Erlangen, Essen, Greifswald, Hanover, Mainz, München
2024-03-29
Active, closed
A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.
NCT06268873Chronic Kidney Disease and Hypertension
DrugBaxdrostat/dapagliflozin
AstraZeneca
Phase 3
2,554
Aachen, Amberg, Bad Oeynhausen, Berlin, Bochum, Dresden, Essen, Falkensee
2024-03-29
Recruiting
A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia (CARDINAL)
NCT06163430Chronic Myeloid Leukemia, Chronic Phase, Chronic Myeloid Leukemia
Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 1/2
180
Aachen, Berlin, Frankfurt am Main, Hanover, Jena, Mannheim, München
2024-03-26
Active, closed
Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With Biktarvy
NCT06333808HIV-1-infection
DrugsBictegravir·Lenacapavir·B/F/TAF
Gilead Sciences
Phase 3
577
Aachen, Berlin, Cologne, Frankfurt, Hamburg, Munich, München
2024-03-25
Active, closed
REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study
NCT06041386Asthma
DrugMepolizumab
GlaxoSmithKline
Phase 4
336
Aachen, Bonn, Darmstadt, Frankfurt, Hohenstein-Ernsttal, Schleswig
2024-03-20
Recruiting
Multicenter, Interdisciplinary National VEXAS Registry With Accompanying Biomaterial Collection
NCT06377462VEXAS Syndrome
Technische Universität Dresden
Observational
500
Aachen, Chemnitz, Dresden, Düsseldorf, Essen, Göttingen, Hamburg, Jena
2024-03-13
Recruiting
An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
NCT05939414Oligometastatic Prostate Cancer (OMPC)
DrugsPiflufolastat·Lu-PSMA
Novartis Pharmaceuticals
Phase 3
450
Munich, Cologne, Aachen, Augsburg, Berlin, Essen, Münster, Rostock
2024-03-12
Recruiting
Post-Marketing Surveillance of Vliwazell® Prowound Dressing
NCT07316556Acute and Chronic Wounds
Lohmann & Rauscher
Observational
208
Aachen, Brüggen, Dortmund, Erlangen, Hamburg, Mönchengladbach, Waidhaus, Willich
2024-03-11
Recruiting
Tacrolimus C:D Ratio Measured in Renal Transplant Recipients Treated With Once-daily Prolonged-release Drugs
NCT06268769Immunosuppression
DrugsTacrolimus Pill·Envarsus·Tacrolimus
Edward Geissler
Phase 4
300
Aachen, Berlin, Dresden, Hamburg, Hanover, Jena, Mainz, Münster
2024-03-09
Active, closed
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
NCT06292013Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)
DrugLepodisiran
Eli Lilly and Company
Phase 3
17,300
Aachen, Bad Friedrichshall, Bad Homburg, Berlin, Bielefeld, Cologne, Dresden, Essen
2024-03-05
Recruiting
Eye Diseases "Treated" With Interoperable Medical Informatics
NCT06810011Intravitreal Injections
University Hospital Muenster
Observational
2,000
Chemnitz, Aachen, Greifswald, Leipzig, Münster, Tübingen
2024-03-01
Recruiting
Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)
NCT06165341Alpha1-Antitrypsin Deficiency
DrugFazirsiran
Takeda
Phase 3
50
Aachen, Berlin, Hanover, Tübingen
2024-03-01
Active, closed
Long-Term Safety, Tolerability and Efficacy of OMS906 in Paroxysmal Nocturnal Hemoglobinuria
NCT06298955Paroxysmal Nocturnal Hemoglobinuria
DrugOMS906 study drug
Omeros Corporation
Phase 2
25
Aachen, Ulm
2024-02-19
Active, closed
Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib
NCT06120140Carcinoma, Non-Small-Cell Lung
DrugsClobetasol·Minocycline·Chlorhexidine·Clindamycin
Janssen Research & Development, LLC
Phase 2
305
Aachen, Essen, Giessen, Heidelberg, Kassel, Kiel
2024-02-16
Active, closed
Early Genetic Identification of Obesity
NCT06239064Obesity, Childhood, Hyperphagia, Retinopathy, Syndactyly
Rolfs Consulting und Verwaltungs-GmbH (RCV)
Observational
1,000
Aachen, Augsburg, Bad Krozingen, Bielefeld, Bonn, Bückeburg, Cologne, Essen
2024-01-24
Active, closed
A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)
NCT06079879Essential Thrombocythemia
DrugsAnagrelide·Bomedemstat·Busulfan·Ruxolitinib
Merck Sharp & Dohme LLC
Phase 3
340
Aachen, Dresden, Halle
2023-12-31
Recruiting
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms
NCT06150157Neoplasms
DrugsMomelotinib·Ruxolitinib
Janssen Research & Development, LLC
Phase 1
300
Aachen, Berlin, Essen, Hanover, Heidelberg, Regensburg
2023-12-20
Recruiting
Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA)
NCT05512364ER-positive Breast Cancer, HER2-negative Breast Cancer, Stage IIB Breast Cancer, Stage III Breast Cancer
DrugsElacestrant·Tamoxifen·Exemestane·Anastrozole
European Organisation for Research and Treatment of Cancer - EORTC
Phase 3
220
Aachen, Augsburg, Bergisch Gladbach, Bottrop, Bremen, Cologne, Dresden, Hanover
2023-12-15
Active, closed
A Study to Evaluate the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythaemia Patients
NCT06514807Essential Thrombocythaemia
DrugBesremi
AOP Orphan Pharmaceuticals AG
Phase 3
117
Aachen, Halle, Hanover, Mannheim, Minden, Ulm
2023-12-04
Active, closed
A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202
NCT06062420Neoplasms, Head and Neck
DrugsRemzistotug·Nelistotug·Belrestotug·Dostarlimab
GlaxoSmithKline
Phase 2
316
Frankfurt am Main, Essen, Aachen, Berlin, Giessen, Hamburg, Regensburg, Ulm
2023-11-14
Active, closed
Trial of Efficacy and Safety of MC0518 Versus Best Available Therapy in Participants With Steroid-Refractory Acute Graft Versus Host Disease
NCT06075706Steroid-refractory Acute Graft-versus-host Disease
DrugMC0518
medac GmbH
Phase 2
49
Aachen, Essen, Frankfurt, Freiburg im Breisgau, Giessen, Hanover, Jena, Leipzig
2023-11-13
Active, closed
Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)
NCT06087835Chronic Kidney Disease With High Proteinuria
DrugDapagliflozin
AstraZeneca
Phase 3
1,835
Aachen, Bad Oeynhausen, Berlin, Dresden, Hanover, Mainz, München
2023-11-07
Active, closed
An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
NCT05952557Breast Cancer, Early Breast Cancer
DrugsCamizestrant·Tamoxifen·Exemestane·Anastrozole
AstraZeneca
Phase 3
5,511
Aachen, Berlin, Cologne, Darmstadt, Deggendorf, Dessau, Düsseldorf, Essen
2023-10-05
Active, closed
A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
NCT05936359Myeloproliferative Neoplasms
DrugsINCA033989·Ruxolitinib
Incyte Corporation
Phase 1
160
Aachen, Halle, Ulm
2023-09-25
Active, closed
A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC
NCT05884398Metastatic Castrate-sensitive Prostate Cancer
DrugApalutamide
Janssen Research & Development, LLC
Phase 3
420
Aachen, Augsburg, Cologne, Dresden, Lübeck, München, Nürtingen, Würzburg
2023-08-31
Recruiting
Adjusted High-dose Chemotherapy With Autologous Stem Cell Transplant vs. Conventional Immunochemotherapy in Elderly PCNSL Patients
NCT06830421Primary Central Nervous System Lymphoma
University Hospital Freiburg
Phase 3
340
Freiburg im Breisgau, Stuttgart, Aachen, Augsburg, Berlin, Bielefeld, Bochum, Braunschweig
2023-08-09
Active, closed
A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression
NCT05797610Primary IgA Nephropathy
Hoffmann-La Roche
Phase 3
459
Leipzig, Aachen, Berlin, Cologne, Hanover, Mainz, Stuttgart, Villingen-Schwenningen
2023-08-08
Active, closed
An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease
NCT05899673Alpha1-Antitrypsin Deficiency
DrugFazirsiran
Takeda
Phase 3
31
Aachen
2023-08-08
Recruiting
Randomized Trial in Adult de Novo Ph Positive ALL With Chemotherapy, Imatinib or Ponatinib, Blinatumomab and SCT
NCT06061094Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
DrugsPonatinib·Imatinib·Blinatumomab
Goethe University
Phase 2
220
Aachen, Aschaffenburg, Augsburg, Bad Saarow, Bayreuth, Berlin, Bielefeld, Bochum
2023-07-14
Recruiting
Diaphragmatic Function as a Biomarker
NCT05903001Dyspnea; Asthmatic, COPD, Fibrosis, Pulmonary Hypertension
RWTH Aachen University
Observational
800
Aachen
2023-07-01
Recruiting
Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study
NCT06016946Friedreich Ataxia
Friedreich's Ataxia Research Alliance
Observational
3,000
Aachen, Bonn, Munich, Tübingen
2023-06-28
Recruiting
Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAML
NCT05807932Myelodysplastic Syndromes, Secondary Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia
DrugsMycophenolate Mofetil·Ara-C·Tacrolimus·Venetoclax
Heinrich-Heine University, Duesseldorf
Phase 1/2
38
Aachen, Düsseldorf, Cologne, Frankfurt, Jena, München
2023-06-26
Recruiting
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
NCT05646862Breast Cancer
DrugsBupropion·Omeprazole·Alpelisib·Inavolisib
Hoffmann-La Roche
Phase 3
420
Aachen, Bielefeld, Essen, Freiburg im Breisgau, Georgsmarienhütte, Göttingen, Hamburg, Hanover
2023-06-07
Recruiting
PredIcting sterOid depeNdEnt livEr injuRy With Polyreactive Immunoglobulin G
NCT05810480Autoimmune Hepatitis, Autoimmune Liver Disease
Hannover Medical School
Observational
400
Aachen, Hamburg, Hanover, Heidelberg, Lübeck, Rostock
2023-06-06
Recruiting
Patient-reported, Health Economic and Psychosocial Outcomes in Friedreich Ataxia
NCT05943002Friedreich Ataxia
German Center for Neurodegenerative Diseases (DZNE)
Observational
200
Aachen, Bonn, Münich, Tübingen
2023-06-01
Active, closed
Immunogenicity of COVID-19 Vaccination in Immunocompromised Patients (Auto-COVID-VACC)
NCT05597761COVID-19, Adult, Immunocompromised Patients
Oliver Cornely, MD
Observational
49
Aachen, Cologne, Essen
2023-05-15
Recruiting
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
NCT05716100Focal Onset Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
360
Aachen, Bielefeld, Frankfurt
2023-05-09
Active, closed
IMPACT EU Post-Market Clinical Follow-Up Study
NCT05756751Left Ventricular Dysfunction
Abiomed Inc.
Not applicable
123
Heidelberg, Aachen, Düsseldorf, Essen, Mainz, Halle, Kiel, Berlin
2023-04-27
By invitation
An Open-label Study of XEN1101 in Epilepsy
NCT05718817Focal Epilepsy, Tonic-Clonic Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
880
Aachen, Bielefeld, Frankfurt, Freiburg im Breisgau, Marburg, München, Ulm
2023-04-25
Active, closed
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
NCT05794906Biochemically Recurrent Prostate Cancer
DrugDarolutamide
Bayer
Phase 3
985
Mannheim, Nürtingen, Stuttgart, Würzburg, Frankfurt am Main, Braunschweig, Göttingen, Aachen
2023-04-03
Recruiting
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
NCT05774951Breast Cancer, Early Breast Cancer
DrugsCamizestrant·Tamoxifen·Exemestane·Anastrozole
AstraZeneca
Phase 3
4,300
Aachen, Augsburg, Bayreuth, Berlin, Bonn, Deggendorf, Dessau, Dresden
2023-03-31
Active, closed
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
NCT05501873Atrial Fibrillation
Boston Scientific Corporation
Observational
1,173
Aachen, Dresden, Göttingen, Hamburg, Heidelberg, Karlsruhe, Münster
2023-03-24
Active, closed
Real-world Effectiveness Study of Long-term Treatment With Dupilumab in Participants ≥6 Years With Atopic Dermatitis
NCT06039241Atopic Dermatitis
Sanofi
Observational
572
Aachen, Ahaus, Andernach, Berlin, Braunschweig, Buxtehude, Chemnitz, Cologne
2023-03-07
Recruiting
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein
NCT05677971Alpha1-Antitrypsin Deficiency
DrugFazirsiran
Takeda
Phase 3
160
Aachen, Berlin, Hanover, Kiel, Tübingen
2023-03-06
Active, closed
A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE
NCT05702034Ischemic Stroke; Ischemic Attack, Transient
DrugMilvexian
Janssen Research & Development, LLC
Phase 3
12,523
Aachen, Altenburg, Bad Neustadt an der Saale, Berlin, Dortmund, Dresden, Erlangen, Essen
2023-02-15
Recruiting
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
NCT05667142Primary Generalized Tonic-Clonic Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
160
Aachen, Berlin, Bielefeld, Frankfurt, Freiburg im Breisgau, Marburg, München, Radeberg
2023-02-14
Recruiting
Treatment of Non-resectable Bile Duct Cancer with Radiofrequency Ablation or Photodynamic Therapy
NCT05551299Hilar Cholangiocarcinoma
University of Leipzig
Phase 4
258
Aachen, Augsburg, Berlin, Bonn, Frankfurt, Freiburg im Breisgau, Greifswald, Halle
2023-02-10
By invitation
A Study to Follow Patients With Adult Growth Hormone Deficiency (AGHD) Treated With Sogroya® for Long Term Safety Information
NCT05718570Adult Growth Hormone Deficiency
DrugSomapacitan
Novo Nordisk A/S
Observational
400
Aachen, Frankfurt am Main, Halle, Mainz, München, Oldenburg, Würzburg
2023-02-03
Active, closed
GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
NCT05686551Huntington Disease
Hoffmann-La Roche
Phase 2
301
Aachen, Berlin, Bochum, Bonn, Erlangen, Lübeck, Taufkirchen, Ulm
2023-02-03
Recruiting
Nivolumab in Children and Adults With Nasopharyngeal Carcinoma
NCT06019130Nasopharyngeal Carcinoma, Nasopharyngeal Cancer, Nasopharyngeal Neoplasms, Nasopharynx Cancer
DrugsAvonex·Opdivo·Adrucil·Nivolumab
German Society for Pediatric Oncology and Hematology GPOH gGmbH
Phase 2
57
Aachen, Berlin, Bielefeld, Bonn, Cologne, Cottbus, Dortmund, Dresden
2023-01-10
Active, closed
A Retrospective Analysis of Magnetic Resonance Imaging Data for Breast Cancer Screening in the Open Consortium for Decentralized Medical Artificial Intelligence
NCT05698056Breast Cancer
Technische Universität Dresden
Observational
25,000
Aachen, Dresden
2023-01-01
Active, closed
Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)
NCT05531526Alzheimer Disease
AriBio Co., Ltd.
Phase 3
1,535
Aachen, Bad Homburg, Berlin, Günzburg, Homburg, Mannheim
2022-12-23
Active, closed
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
NCT05581303Atherosclerotic Cardiovascular Disease
DrugOlpasiran
Amgen
Phase 3
7,297
Aachen, Bad Krozingen, Bad Oeynhausen, Berlin, Bremen, Cologne, Dresden, Essen
2022-12-14
Recruiting
HRS-AKI Treatment With TIPS in Patients With Cirrhosis
NCT05346393Cirrhosis, Liver, Hepatorenal Syndrome, Acute Kidney Injury, Ascites Hepatic
Jena University Hospital
Not applicable
124
Aachen, Berlin, Dresden, Essen, Freiburg im Breisgau, Halle, Hamburg, Hanover
2022-11-29
Recruiting
A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant
NCT05623020Multiple Myeloma
DrugsElranatamab·Bortezomib·Daratumumab·Lenalidomide
Pfizer
Phase 3
1,060
Freiburg im Breisgau, Tübingen, Ulm, Mainz, Aachen, Braunschweig, Chemnitz, Hamburg
2022-11-10
Recruiting
PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study)
NCT04790253Limited Stage Small Cell Lung Cancer, Extensive-stage Small-cell Lung Cancer
European Organisation for Research and Treatment of Cancer - EORTC
Not applicable
600
Aachen
2022-10-27
Active, closed
The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study
NCT05409976Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis
W.L.Gore & Associates
Not applicable
136
Aachen, Arnsberg
2022-10-25
Active, closed
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
NCT05587296Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes
Bayer
Phase 3
474
Mannheim, Tübingen, Frankfurt am Main, Hanover, Aachen, Bergisch Gladbach, Bonn, Essen
2022-10-14
Recruiting
Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
NCT05211661Diaphragm Issues, Mechanical Ventilation Complication, Respiratory Failure, Intensive Care (ICU) Myopathy
RWTH Aachen University
Observational
20
Aachen
2022-10-10
Recruiting
Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell Carcinoma Resection and Drugs-induced Osteonecrosis
NCT04098146Mandibular Reconstruction, Segmental Mandibular Defects
AO Innovation Translation Center
Observational
300
Tübingen, Aachen, Berlin, Hanover, Heidelberg, Leipzig, Munich, Ulm
2022-09-12
Recruiting
Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection
NCT05413850Prostate Cancer, Metastatic Castration-resistant Prostate Cancer, mCRPC, Urogenital Neoplasms
Blue Earth Therapeutics Ltd
Phase 1/2
82
Aachen, Augsburg, Essen, Munich
2022-07-20
Active, closed
Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis
NCT05126277Lupus Nephritis
DrugIanalumab
Novartis Pharmaceuticals
Phase 3
452
Aachen, Bochum
2022-07-14
Active, closed
(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis
NCT05186753SSM, Mastocytosis, Indolent, Mastocytosis, Systemic, Mastocytosis
DrugBezuclastinib
Cogent Biosciences, Inc.
Phase 2
237
Aachen, Berlin, Hamburg, Kiel, Mannheim
2022-06-27
Recruiting
CytOSorb TreatMent Of Critically Ill PatientS Registry
NCT05146336Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
CytoSorbents, Inc
Observational
3,000
Aachen, Bad Oeynhausen, Bochum, Essen, Göttingen, Herford, Jena, Kassel
2022-06-22
Recruiting
Effects of Pulmonary Diseases and Their Treatment on Cardiac Function
NCT05042219COPD, Bronchial Asthma, Idiopathic Pulmonary Fibrosis
Ayham Daher
Observational
120
Aachen
2022-06-01
Recruiting
A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB
NCT05183646FSGS
DrugRepagermanium
Dimerix Bioscience Pty Ltd
Phase 3
286
Aachen, Cologne, Dresden, Hamburg, Hanover, Lübeck, Mainz, Villingen-Schwenningen
2022-05-30
Recruiting
A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia
NCT05304377Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Cml
DrugELVN-001
Enliven Therapeutics
Phase 1
250
Aachen, Berlin, Frankfurt, Homburg, Jena, Mannheim, Rostock
2022-05-22
Recruiting
Sympathetic Nerve Activity Predictors in Patients With Chronic Obstructive Pulmonary Disease
NCT04849806COPD, Sympathetic Nervous System Diseases, Catecholamine; Overproduction
RWTH Aachen University
Observational
135
Aachen
2022-05-10
Active, closed
A Phase 3 Study of Rusfertide in Patients With Polycythemia Vera
NCT05210790Polycythemia Vera
DrugRusfertide
Protagonist Therapeutics, Inc.
Phase 3
293
Aachen, Berlin, Dresden, Greifswald, Hamburg, Koblenz, Mainz
2022-04-01
Active, closed
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
NCT05239728Carcinoma, Renal Cell
DrugsBelzutifan·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,800
Singen, Tübingen, Munich, Aachen, Bonn, Düsseldorf, Essen, Münster
2022-03-15
Active, closed
GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG
NCT05153226Graft Vs Host Disease, Peripheral Blood Stem Cell Transplantation, AML, MDS
DrugCyclophosphamide
DKMS gemeinnützige GmbH
Phase 3
640
Aachen, Augsburg, Chemnitz, Cologne, Dortmund, Dresden, Düsseldorf, Essen
2022-03-02
Active, closed
EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke
NCT05029414Acute Ischemic Stroke
University Hospital, Basel, Switzerland
Not applicable
543
Aachen, Berlin, Bremen, Dresden, Erfurt, Frankfurt, Göttingen, Hamburg
2021-12-09
Recruiting
A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures
NCT05077904Stereotypical Prolonged Seizures
DrugStaccato alprazolam
UCB Biopharma SRL
Phase 3
350
Aachen, Berlin, Bielefeld, Erlangen, Frankfurt am Main, Kehl-kork, Marburg, München
2021-12-07
Recruiting
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT04910685Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis
Blueprint Medicines Corporation
Phase 2/3
534
Aachen, Berlin, Erlangen, Hamburg, Mannheim, Munich
2021-11-30
Recruiting
ITP Registry and Accompanying Biospecimen Collection
NCT05152238Immune Thrombocytopenia
Jena University Hospital
Observational
1,100
Aachen, Altenburg, Aschaffenburg, Bad Homburg, Bad Liebenwerda, Berlin, Biberach, Bochum
2021-11-29
Recruiting
(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
NCT04996875Advanced Systemic Mastocytosis (AdvSM), SM With an Associated Hematologic Neoplasm (SM-AHN), Mast Cell Leukemia (MCL), Aggressive Systemic Mastocytosis (ASM)
DrugBezuclastinib
Cogent Biosciences, Inc.
Phase 2
140
Aachen, Freiburg im Breisgau, Lübeck, Mannheim
2021-11-09
Active, closed
A Long-term Extension Study of Ustekinumab in Pediatric Participants
NCT05092269Crohn Disease, Colitis, Ulcerative, Arthritis, Psoriatic
DrugUstekinumab
Janssen Research & Development, LLC
Phase 3
159
Aachen, Berlin
2021-10-18
Active, closed
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP
NCT04971226Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive
DrugsBosutinib·Asciminib·ABL001·Nilotinib
Novartis Pharmaceuticals
Phase 3
405
Mannheim, Frankfurt am Main, Jena, Aachen, Berlin, Lübeck
2021-10-06
Recruiting
Translational Investigation of the Glutamatergic and GABAergic System in Schizophrenia
NCT04655235Schizophrenia
RWTH Aachen University
Observational
600
Aachen, Gangelt
2021-10-01
Active, closed
A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy
NCT04557462Primary IgA Nephropathy
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
448
Freiburg im Breisgau, Stuttgart, Aachen, Berlin, Essen, Hanover, Kiel, Magdeburg
2021-09-20
Recruiting
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma
NCT04973605Relapsed/Refractory Multiple Myeloma
DrugsSonrotoclax·Carfilzomib·Pomalidomide·Daratumumab
BeOne Medicines
Phase 1/2
246
Aachen, Dresden, Hamburg, Würzburg
2021-09-16
Recruiting
Non-invasive Differentiation of Supraventricular Tachyarrhythmia
NCT06061120Supraventricular Arrhythmia, Atrial Fibrillation
RWTH Aachen University
Observational
1,250
Aachen
2021-09-01
Recruiting
European Disease Registry on Retinopathy of Prematurity (ROP)
NCT04939571Retinopathy of Prematurity
University Medicine Greifswald
Observational
3,000
Aachen, Berlin, Bonn, Braunschweig, Chemnitz, Cologne, Cottbus, Düsseldorf
2021-08-06
Active, closed
Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
NCT04790370Pulmonary Embolism
DrugsLMWH·Heparin
Boston Scientific Corporation
Phase 4
544
Aachen, Bielefeld, Bonn, Chemnitz, Freiburg im Breisgau, Immenstädt, Lübeck, Mainz
2021-08-02
Recruiting
Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
NCT04817618C3G
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
98
Cologne, Aachen, Erlangen, Essen, Hamburg, Hanover, Heidelberg, Mainz
2021-07-28
Active, closed
Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria
NCT04747613Paroxysmal Nocturnal Hemoglobinuria
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
208
Dresden, Aachen, Essen, Hamburg, Riesa, Ulm
2021-07-27
Recruiting
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
European Foundation for Study of Chronic Liver Failure
Observational
3,000
Regensburg, Kiel, Aachen, Berlin, Frankfurt, Hamburg, Hanover, Heidelberg
2021-07-08
Recruiting
The ABC-HCC Trial: Atezolizumab Plus Bevacizumab vs. Transarterial Chemoembolization (TACE) in Intermediate-stage HepatoCellular Carcinoma
NCT04803994Hepatocellular Carcinoma
DrugsTecentriq·Avastin·Atezolizumab·Bevacizumab
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Phase 3
434
Aachen, Amberg, Berlin, Bochum, Cologne, Dresden, Düsseldorf, Erlangen
2021-07-06
Recruiting
A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD
NCT04201210HbS Disease, Hemoglobin S Disease, Sickle Cell Anemia, Sickle Cell Disorders
University of Regensburg
Phase 2
212
Aachen, Berlin, Düsseldorf, Frankfurt, Heidelberg, Regensburg, Tübingen, Würzburg
2021-06-30
Recruiting
Postcapillary Blood Gas Analysis in Wedge Position (Wedge-BGA)
NCT04993612Pulmonary Hypertension
Ayham Daher
Observational
100
Aachen
2021-06-25
Active, closed
Non-interventional Study to Collect Real-world Clinical and Patient-reported Outcomes in Ovarian Cancer
NCT04830709Ovarian Cancer
AstraZeneca
Observational
752
Böblingen, Göttingen, Nürtingen, Osnabrück, Rotenburg (Wümme), Aachen, Amberg, Aschaffenburg
2021-06-15
Recruiting
ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES
NCT04503395Aortic Aneurysm, Abdominal
FCRE (Foundation for Cardiovascular Research and Education)
Not applicable
204
Aachen, Leipzig, München, Münster
2021-05-21
Active, closed
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
NCT04824092Diffuse Large B-cell Lymphoma
DrugsTafasitamab·Vincristine·Doxorubicin·Prednisone
Incyte Corporation
Phase 3
899
Aachen, Augsburg, Berlin, Bonn, Chemnitz, Cottbus, Göttingen, Halle
2021-05-11
Active, closed
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
NCT04763200Left Ventricular Dysfunction, Coronary Artery Disease
Abiomed Inc.
Not applicable
1,252
Erlangen, Munich, Karlsburg, Düsseldorf, Trier, Aachen, Bad Krozingen, Berlin
2021-04-13
Recruiting
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
NCT07717437Liver Cancer, Liver Metastases
Maastricht University Medical Center
Observational
350
Aachen, Saarbrücken, Halle
2021-03-16
Active, closed
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
NCT04717414Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis
DrugLuspatercept
Celgene
Phase 3
313
Aachen, Baden-Warttemberg, Düsseldorf, Halle, Hamburg, Jena, Leipzig, Mannheim
2021-02-25
Active, closed
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
NCT04586231Carcinoma, Renal Cell
DrugsBelzutifan·Cabozantinib·Lenvatinib
Merck Sharp & Dohme LLC
Phase 3
747
Freiburg im Breisgau, Heidelberg, Nuremberg, Frankfurt am Main, Aachen, Homburg/ Saar, Halle, Erfurt
2021-02-25
Active, closed
A Natural History Study to TRACK Brain and Spinal Cord Changes in Individuals with Friedreich Ataxia (TRACK-FA)
NCT04349514Friedreich Ataxia
Monash University
Observational
300
Aachen
2021-02-10
Active, closed
Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia
NCT04579367Hypercholesterolemia, Mixed Dyslipidemia
DrugBempedoic acid
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Observational
5,000
Aachen, Amberg, Aue, Bad Elster, Bad Friedrichshall, Bad Homburg, Bad Krozingen, Bad Segeberg
2021-01-15
Active, closed
A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)
NCT04204616Prurigo Nodularis
DrugNemolizumab
Galderma R&D
Phase 3
500
Aachen, Augsburg, Bad Bentheim, Berlin, Bonn, Darmstadt, Dresden, Düsseldorf
2021-01-11
Active, closed
Bioavailability and Practicability of Envarsus Versus Advagraf in Liver Transplant Recipients
NCT04720326Prophylaxis Against Liver Transplant Rejection
DrugsTacrolimus Pill·Envarsus·Tacrolimus
Edward Geissler
Phase 4
268
Aachen, Berlin, Essen, Frankfurt, Hamburg, Hanover, Heidelberg, Jena
2020-12-23
Active, closed
Efficacy and Safety of Standard of Care Plus Durvalumab in Patients With Limited Disease Small Cell Lung Cancer (DOLPHIN)
NCT04602533Small Cell Lung Cancer Limited Stage
DrugDurvalumab
Michael Hopp
Phase 2
105
Immenstadt im Allgäu, München Gauting, Potsdam, Giessen, Kassel, Offenbach, Rostock, Aachen
2020-12-21
Recruiting
HIPEC + FLOT vs. FLOT Alone in Patients With Gastric Cancer and GEJ (PREVENT)
NCT04447352Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
DrugsCalciumfolinat·Leucovorin·Adrucil·Docetaxel
Krankenhaus Nordwest
Phase 3
200
Aachen, Dresden, Frankfurt, Halle, Leipzig, Ludwigsburg, Lübeck, Magdeburg
2020-12-17
Active, closed
Restoration of Central Vision With the PRIMA System in Patients With Atrophic AMD
NCT04676854Geographic Atrophy
Science Corporation
Not applicable
38
Aachen, Bonn, Hamburg, Ludwigshafen am Rhein, Lübeck, Munich, Münster, Sulzbach
2020-11-24
Active, closed
CARdiomyopathy in Type 2 DIAbetes Mellitus
NCT04303364Cardiomyopathy, Diabetic
Institut National de la Santé Et de la Recherche Médicale, France
Observational
1,256
Aachen, Heidelberg
2020-10-02
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors
NCT04432584Paroxysmal Nocturnal Hemoglobinuria
DrugsCrovalimab·Eculizumab
Hoffmann-La Roche
Phase 3
190
Aachen, Riesa
2020-09-30
Active, closed
BGP+ Stent as Bridging Stent in BEVAR
NCT03982940Thoracoabdominal Aortic Aneurysm, Without Mention of Rupture
Marc Bosiers, MD
Not applicable
118
Heidelberg, Kiel, Aachen, Hamburg, Leipzig, Munich, Münster, Nuremberg
2020-09-09
Recruiting
Combination of Midostaurin and Gemtuzumab Ozogamicin in First-line Standard Therapy for Acute Myeloid Leukemia (MOSAIC)
NCT04385290Acute Myeloid Leukemia
DrugsMidostaurin·Daunorubicin
Technische Universität Dresden
Phase 1/2
214
München, Essen, Aachen, Augsburg, Chemnitz, Dresden, Frankfurt am Main, Halle
2020-09-04
Active, closed
rTMS Add on Value for Amelioration of Negative Symptoms of Schizophrenia
NCT04318977Negative Symptoms With Primary Psychotic Disorder, Schizophrenia
University of Regensburg
Not applicable
62
Aachen, Regensburg
2020-02-01
Recruiting
Medtronic SYMBIOSIS Post-Market Registry for Patients Undergoing Cardiac Surgery
NCT04241328Cardiovascular Diseases
Medtronic Cardiac Surgery
Observational
5,000
Aachen, Bad Oeynhausen, Munich
2020-01-09
Active, closed
Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis
NCT03989206Moderate-to-Severe Atopic Dermatitis
DrugNemolizumab
Galderma R&D
Phase 3
1,700
Aachen, Augsburg, Bad Bentheim, Berlin, Bielefeld, Bonn, Buxtehude, Darmstadt
2019-12-30
Active, closed
SAVR: IMPACT of Pre-existing Comorbidities on Patient Outcomes and Prosthetic Valve Performance in a Real-world Setting.
NCT04053088Cardiovascular Diseases
Institut für Pharmakologie und Präventive Medizin
Observational
500
Nuremberg, Passau, Würzburg, Frankfurt am Main, Oldenburg, Aachen, Bad Rothenfelde, Bochum
2019-12-12
Active, closed
Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia
NCT03930121Aphasia, Post-stroke
University Medicine Greifswald
Not applicable
130
Aachen, Allensbach, Bad Aibling, Bad Homburg, Bad Klosterlausnitz, Bad Sülze, Berlin, Gailingen
2019-12-06
Active, closed
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
NCT03992404Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
DrugXeomin
Merz Pharmaceuticals GmbH
Phase 3
603
Aachen, Berlin, Bonn, Düsseldorf, Hamburg, Wiesbaden, Würzburg
2019-09-16
Recruiting
Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry
NCT04310644Autonomic Neuropathy, Ehlers-Danlos Syndrome Hypermobility Type, Small Fiber Neuropathy, Postural Tachycardia Syndrome
RWTH Aachen University
Observational
200
Aachen
2019-09-15
Recruiting
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma
NCT04043494Lymphoblastic Lymphoma, Childhood
DrugsVindesine·Thioguanine·PEG-Asparaginase·Mercaptopurine
University Hospital Muenster
Phase 3
683
Aachen, Augsburg, Berlin, Bielefeld, Bonn, Braunschweig, Bremen, Chemnitz
2019-08-23
Active, closed
Frontline Asciminib Combination in Chronic Phase CML
NCT03906292Chronic Myeloid Leukemia
DrugsAsciminib·Nilotinib·Dasatinib·Imatinib
University of Jena
Phase 2
125
Aachen, Berlin, Bonn, Bremen, Chemnitz, Dresden, Erlangen, Essen
2019-08-19
Recruiting
Pan Tumor Rollover Study
NCT03899155Cancer
DrugsRucaparib·Sunitinib·Relatlimab·Trametinib
Bristol-Myers Squibb
Phase 2
1,500
Löwenstein, Munich, Nuremberg, Essen, Aachen, Berlin, Buxtehude, Cologne
2019-08-09
Recruiting
Evaluating the Treatment in the MZEB Aachen
NCT04781452Intellectual Disability, Disability Physical
RWTH Aachen University
Observational
2,000
Aachen
2019-07-01
Recruiting
E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe
NCT03818503Cancer
European Organisation for Research and Treatment of Cancer - EORTC
Observational
2,000
Aachen, Bayreuth, Dresden, Mönchengladbach, München
2019-06-24
Active, closed
A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
NCT03767244Prostatic Neoplasms
DrugApalutamide
Janssen Research & Development, LLC
Phase 3
2,517
Aachen, Braunschweig, Cologne, Eisleben Lutherstadt, Essen, Frankfurt am Main, Gronau, Hamburg
2019-06-11
Active, closed
(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT03731260Indolent Systemic Mastocytosis
DrugAvapritinib
Blueprint Medicines Corporation
Phase 2
251
Aachen, Berlin, Hamburg, Lübeck, Mainz, Mannheim, Munich
2019-04-16
Active, closed
KRT-232 Compared to Ruxolitinib in Patients With Phlebotomy-Dependent Polycythemia Vera
NCT03669965Polycythemia Vera
DrugsNavtemadlin·Ruxolitinib
Kartos Therapeutics, Inc.
Phase 2
20
Aachen, Dresden, Mutlangen
2019-01-15
Active, closed
A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy
NCT03762850Immunoglobulin A Nephropathy
DrugsSparsentan·Irbesartan·Dapagliflozin
Travere Therapeutics, Inc.
Phase 3
406
Villingen-Schwenningen, Hanover, Aachen, Düsseldorf, Kaiserslautern, Trier, Kiel, Jena
2018-12-11
Active, closed
Trial on the Effect of Isatuximab to Lenalidomide/Bortezomib/Dexamethasone (RVd) Induction and Lenalidomide Maintenance in Patients With Newly Diagnosed Myeloma (GMMG HD7)
NCT03617731Multiple Myeloma
DrugsVelcade·Isatuximab·Bortezomib·Lenalidomide
University of Heidelberg Medical Center
Phase 3
662
Aachen, Bad Saarow, Berlin, Bielefeld, Bochum, Bonn, Braunschweig, Chemnitz
2018-10-18
Active, closed
A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
NCT03690388Differentiated Thyroid Cancer
DrugCabozantinib
Exelixis
Phase 3
187
Tübingen, Würzburg, Marburg, Hanover, Dresden, Magdeburg, Aachen, Bonn
2018-10-05
Active, closed
Study of Cabozantinib as Monotherapy or in Combination With Nivolumab in Patients With Advanced or Metastatic Renal Cell Carcinoma Under Real-life Clinical Setting in 1st Line Treatment.
NCT03647878Advanced Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma
Ipsen
Observational
224
Aachen, Aschaffenburg, Augsburg, Bad Homburg, Bad Liebenwerda, Bad Schlema, Bamberg, Bergisch Gladbach
2018-09-24
Recruiting
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017
NCT03643276Acute Lymphoblastic Leukemia, Pediatric
DrugsBlinatumomab·Daunorubicin·Bortezomib·Cytarabine
Martin Schrappe
Phase 3
5,000
Aachen, Augsburg, Berlin, Braunschweig, Chemnitz, Cologne, Cottbus, Datteln
2018-07-15
Active, closed
Breast Cancer Screening: Digital Breast Tomosynthesis Versus Digital 2D Mammography
NCT03377036Breast Cancer Screening
University Hospital Muenster
Not applicable
99,689
Hanover, Lüneburg, Stade, Vechta, Wilhelmshaven, Aachen, Ahlen, Bergisch Gladbach
2018-07-05
Active, closed
Extended Access of Momelotinib in Adults With Myelofibrosis
NCT03441113Neoplasms, Post-polycythemia Vera Myelofibrosis (Post-PV MF), Primary Myelofibrosis (PMF), Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)
GlaxoSmithKline
Phase 2
237
Aachen, Cologne, Dresden, Halle, Leipzig, Lübeck, Mainz
2018-05-03
Active, closed
A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
NCT03383458Hepatocellular Carcinoma, Liver Cancer
DrugsOpdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
545
Aachen, Berlin, Bonn, Cologne, Essen, Frankfurt am Main, Hanover, Homburg
2018-04-18
Recruiting
The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry)
NCT03949972Glomerulosclerosis, Focal Segmental, Minimal Change Disease, Idiopathic Nephrotic Syndrome
Prof. Dr. Paul Brinkkoetter
Observational
500
Cologne, Aachen, Berlin, Bonn, Dachau, Erlangen, Essen, Heidelberg
2018-04-01
Recruiting
BIO-2-HEART: Identification of Biomarkers in T2DM and Heart Failure
NCT03323216Heart Failure, Diabetes Mellitus, Type 2
RWTH Aachen University
Observational
400
Aachen
2018-04-01
Recruiting
Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis
NCT03334006Peritonitis, Sepsis, Septic Shock
RWTH Aachen University
Phase 2
200
Tübingen, Regensburg, Essen, Berlin, Aachen, Bochum, Dortmund, Dresden
2017-11-20
Active, closed
Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma
NCT03298451Hepatocellular Carcinoma
DrugsSorafenib·Tremelimumab·Durvalumab
AstraZeneca
Phase 3
1,324
Aachen, Cologne, Essen, Hanover, Heidelberg, Leipzig, Mainz, München
2017-10-11
Active, closed
Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents
NCT03206671Mature B-cell Non-Hodgkin Lymphoma
DrugsIfosfamide·Doxorubicin Hydrochloride·Prednisolone·Vincristine
University Hospital Muenster
Phase 3
650
Aachen, Augsburg, Berg, Berlin, Bielefeld, Bonn, Braunschweig, Bremen
2017-08-03
By invitation
The CINCH-FMR Post-Market Registry: Percutaneous Repair in Functional Mitral Regurgitation
NCT05677568Functional Mitral Regurgitation, Mitral Regurgitation
Cardiac Dimensions, Inc.
Observational
250
Aachen, Ahaus, Berlin, Bremen, Darmstadt, Dresden, Frankfurt, Fritzlar
2017-06-24
Active, closed
Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Low to Intermediate Risk of Mortality
NCT03112980Aortic Valve Stenosis
Universitätsklinikum Hamburg-Eppendorf
Not applicable
1,414
Hamburg, Aachen, Bad Krozingen, Bad Nauheim, Bad Neustadt an der Saale, Bad Oeynhausen, Berlin, Bernau
2017-05-10
Active, closed
Enhancing Recovery in Early Schizophrenia
NCT02926859Schizophrenia
Central Institute of Mental Health, Mannheim
Phase 2
180
Mannheim, Munich, Berlin, Aachen, Cologne, Hamburg
2017-04-08
Active, closed
Durvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy in Untreated Extensive-Stage Small Cell Lung Cancer (CASPIAN)
NCT03043872Small Cell Lung Carcinoma Extensive Disease
DrugsTremelimumab·Etoposide·Durvalumab·Cisplatin
AstraZeneca
Phase 3
987
Aachen, Berlin, Gauting, Gera, Hamburg, Heidelberg, Mainz, Regensburg
2017-03-27
Recruiting
Development of a Biological Database in the Field of Operative Intensive Care
NCT03014427Intensive Care in General
RWTH Aachen University
Observational
99,999,999
Aachen
2017-03-01
Active, closed
Abbreviated Breast MRI and Digital Tomosynthesis Mammography in Screening Women With Dense Breasts
NCT02933489Asymptomatic
ECOG-ACRIN Cancer Research Group
Not applicable
1,516
Aachen
2016-12-27
Active, closed
Ruxolitinib vs Allogeneic SCT for Patients With Myelofibrosis According to Donor Availability
NCT03333187Bone Marrow Fibrosis
DrugJakavi
Universitätsklinikum Hamburg-Eppendorf
Phase 2
87
Aachen, Berlin, Bonn, Düsseldorf, Halle, Hamburg, Jena, Mainz
2016-12-21
Active, closed
A Longitudinal Observational Study of the Natural History and Management of Patients With HCC
NCT02954094Hepatocellular Cancer
Target PharmaSolutions, Inc.
Observational
10,000
Aachen, Berlin, Düsseldorf, Frankfurt, Hanover, Leipzig, Magdeburg, Mainz
2016-12
Active, closed
2nd or 3rd TKI-stop After 2 Years Nilotinib Pre-treatment in CML-patients
NCT02917720Chronic Myeloid Leukemia
DrugNilotinib
European LeukemiaNet
Phase 2
75
Freiburg im Breisgau, Mannheim, München, Hannover, Aachen, Bayreuth, Chemnitz, Esslingen am Neckar
2016-09
Active, closed
A Study of Niraparib (GSK3985771) Maintenance Treatment in Participants With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy
NCT02655016Ovarian Neoplasms
DrugNiraparib
Tesaro, Inc.
Phase 3
733
Aachen, Berlin, Essen, Fürth, Göttingen, Heidelberg, Hildesheim, Mannheim
2016-07-11
Active, closed
AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy.
NCT02511106Stage IB-IIIA Non-small Cell Lung Carcinoma
DrugOsimertinib
AstraZeneca
Phase 3
682
Aachen, Berlin, Cologne, Coswig, Gauting, Gerlingen, Großhansdorf, Halle
2015-10-21
Active, closed
PALbociclib CoLlaborative Adjuvant Study
NCT02513394Breast Cancer
DrugPalbociclib
Alliance Foundation Trials, LLC.
Phase 3
5,796
Aachen, Berlin, Bottrop, Braunschweig, Ebersberg, Eggenfelden, Erlangen, Frankfurt
2015-08
Active, closed
Phase III Open Label First Line Therapy Study of MEDI 4736 (Durvalumab) With or Without Tremelimumab Versus SOC in Non Small-Cell Lung Cancer (NSCLC)
NCT02453282Non-Small-Cell Lung Carcinoma NSCLC
DrugsTremelimumab·Durvalumab·Pemetrexed·Gemcitabine
AstraZeneca
Phase 3
1,118
Aachen, Bad Berka, Berlin, Freiburg im Breisgau, Gauting, Hamburg, Heidelberg, Hemer
2015-07-21
Active, closed
Micra Transcatheter Pacing System Post-Approval Registry
NCT02536118Bradycardia
Medtronic
Observational
3,100
Aachen, Berlin, Cologne, Dresden, Düsseldorf, Frankfurt, Hamburg, Hanover
2015-07
Recruiting
The European NAFLD Registry
NCT04442334NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver
Newcastle University
Observational
10,000
Aachen, Berlin, Freiburg im Breisgau, Mainz, Würzburg
2015-05-01
Active, closed
CINC424A2X01B Rollover Protocol
NCT02386800Primary Myelofibrosis, Polycythemia Vera, Graft Versus Host Disease, Acute Myeloid Leukemia
DrugsJakavi·Ruxolitinib
Novartis Pharmaceuticals
Phase 4
279
Dresden, Jena, Aachen, Hamburg, Magdeburg, Mainz, Ulm
2015-03-05
Recruiting
International HIT-MED Registry (I-HIT-MED)
NCT02417324Childhood Brain Tumor
Universitätsklinikum Hamburg-Eppendorf
Observational
500
Aachen, Augsburg, Berlin, Bielefeld, Braunschweig, Bremen, Chemnitz, Cologne
2015-01
Active, closed
Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
NCT02227251Diffuse Large B-cell Lymphoma
DrugSelinexor
Karyopharm Therapeutics Inc
Phase 2
244
Aachen, Bad Saarow, Berlin, Bremen, Cologne, Dresden, Halle, Hanover
2014-11
Active, closed
A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD)
NCT02130362Crohn's Disease
AbbVie
Observational
1,446
Ulm, Erlangen, Munster, Osnabrück, Aachen, Dresden, Forchheim, Freiburg im Breisgau
2014-08-28
Active, closed
International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma
NCT02066220Brain Tumors
Universitätsklinikum Hamburg-Eppendorf
Phase 2/3
360
Aachen, Augsburg, Berlin, Bielefeld, Bonn, Braunschweig, Bremen, Chemnitz
2014-06
Active, closed
Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer
NCT02032823Breast Cancer
DrugOlaparib
AstraZeneca
Phase 3
1,837
Aachen, Augsburg, Baden-Baden, Berlin, Bonn, Bottrop, Brandenburg, Bremen
2014-04-22
Active, closed
Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Biliary Tract Cancer
NCT02170090Cholangiocarcinoma, Gall Bladder Carcinoma
DrugsCapecitabine·Gemcitabine·Cisplatin
Universitätsklinikum Hamburg-Eppendorf
Phase 3
789
Hamburg, Aachen, Berlin, Dresden, Essen, Esslingen am Neckar, Frankfurt, Freiburg im Breisgau
2014-04
Active, closed
A Study of Apalutamide (ARN-509) in Men With Non-Metastatic Castration-Resistant Prostate Cancer
NCT01946204Prostatic Neoplasms
DrugApalutamide
Aragon Pharmaceuticals, Inc.
Phase 3
1,207
Aachen, Bergisch Gladbach, Berlin, Braunschweig, Cologne, Duisburg, Emmendingen, Frankfurt am Main
2013-10-14
Recruiting
Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia
NCT01949129Acute Lymphoblastic Leukaemia
DrugsGrafalon·Treosulfan·Thiotepa·Busulfan
St. Anna Kinderkrebsforschung
Phase 2/3
1,800
Giessen, Aachen, Berlin, Bonn, Düsseldorf, Erlangen, Essen, Frankfurt am Main
2013-04
Recruiting
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053Huntington's Disease
CHDI Foundation, Inc.
Observational
35,000
Aachen, Berlin, Bochum, Dresden, Erlangen, Freiburg im Breisgau, Kassel, Lübeck
2012-07
Recruiting
Product Surveillance Registry
NCT01524276Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders
Medtronic
Observational
100,000
Aachen, Arnsberg, Bad Oeynhausen, Berlin, Bielefeld, Bochum, Bremen, Cologne
2012-01
Recruiting
Database of Tissue Samples to Understand the Inflammatory Response After Cardiac Surgery
NCT02488876Heart Diseases
RWTH Aachen University
Observational
1,000
Aachen
2009-04
Recruiting
GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial
NCT02872987Acute Lymphoblastic Leukemia, Leukemia, Non-Hodgkin's Lymphoma
Goethe University
Observational
10,000
Frankfurt am Main, Aachen, Altenburg, Altötting, Aschaffenburg, Augsburg, Bad Saarow, Bamberg
2009-02
Active, closed
Panther: A Study Comparing Biweekly and Tailored EC-T Versus Three Weekly FEC-T in Breast Cancer Patients
NCT00798070Breast Cancer
DrugsFEC→T·Taxotere·Epirubicin·Fluorouracil
Karolinska University Hospital
Phase 3
2,017
Aachen, Bamberg, Bayreuth, Berlin, Bietigheim, Bonn, Böblingen, Celle
2007-02
Recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
NCT00271180Arrhythmia, Bradycardia, Heart Failure, Sinus Tachycardia
Medtronic
Observational
20,000
Aachen, Bad Oeynhausen, Bielefeld, Bremen, Cologne, Dresden, Düsseldorf, Essen
1983-01
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Priya Life Science (2026). Clinical trial register: studies with a German investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 1 October 2026. https://priyalifescience.com/clinical-trials-germany/city/aachen

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Germany and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 5,051 studies in total at the last sync on 26 Sep 2026, 19:51 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 267 of those studies with a site in Aachen.

How many clinical trials are recruiting in Aachen?

144 of the 267 studies on this page are recruiting new participants as of the 26 Sep 2026, 19:51 UTC sync. A further 7 have not yet opened recruitment, 113 are active but closed to new participants, and 3 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Aachen), 267 studies
PhaseStudiesRecruitingShare
Phase 31115141.6%
Observational684725.5%
Phase 2371813.9%
Not applicable24109%
Phase 4833%
Phase 1/2762.6%
Phase 1642.2%
Phase 2/3652.2%

Most active sponsors

Lead sponsors with the most studies (Aachen)
Lead sponsorStudiesRecruiting
AstraZeneca188
RWTH Aachen University1413
Incyte Corporation104
Novartis Pharmaceuticals104
Hoffmann-La Roche73
Janssen Research & Development, LLC72
Technische Universität Dresden65
Merck Sharp & Dohme LLC51
Takeda54
Universitätsklinikum Hamburg-Eppendorf51
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.