Cemiplimab: Intravenous (IV) infusion administration
Platinum-based chemotherapy: IV infusion
REGN7075: IV infusion
This study will enroll adult participants with early-stage (stage II-IIIB) non-small cell lung cancer for whom surgery is planned.
The aim is to find out whether an investigational treatment (consisting of the immunotherapy drug cemiplimab plus chemotherapy plus a third drug) works better than cemiplimab plus chemotherapy without the additional drug.
The study is also looking at several other research questions, including:
* What are the side effects associated with the investigational treatments in comparison to the control treatment?
* Do the investigational treatments or the control treatment have an effect on the type of surgery that is performed?
* How much of the study drug(s) are in the blood at a given time?
* Does the body make antibodies against the study drug(s) (which could make the drug(s) less effective or could lead to side effects)?
| Facility | City | Region | Status |
|---|---|---|---|
| University of California Irvine | Orange | California | |
| Orchard Healthcare Research Inc. | Skokie | Illinois | |
| Karmanos Cancer Institute | Detroit | Michigan | |
| Detroit Clinical Research Center | Farmington Hills | Michigan | |
| Oncology Hematology Care Clinical Trials LLC | Cincinnati | Ohio | |
| Providence Portland Medical Center | Portland | Oregon | |
| University Of Nebraska Medical Center | Portland | Oregon | |
| Lifespan Cancer Institute | Providence | Rhode Island | |
| Prairie Lakes Healthcare System | Watertown | South Dakota | |
| University of Tennessee Medical Center | Knoxville | Tennessee | |
| Sarah Cannon Research Institute (SCRI) Oncology Partners | Nashville | Tennessee | |
| BRCC/Oncology & Hematology Associates of SW Virginia | Blacksburg | Virginia | |
| Oncology Clinical Research Center | Cachoeiro de Itapemirim | Espírito Santo | |
| Instituto Mario Penna | Belo Horizonte | Minas Gerais | |
| Instituto Sul Mineiro De Oncologia LTDA | Pouso Alegre | Minas Gerais | |
| Instituto de Medicina Integral Professor Fernando Figueira | Recife | Pernambuco | |
| Liga Norte Riograndense Contra o Cancer | Natal | Rio Grande do Norte | |
| Hospital Mae de Deus Integrated Oncology Center | Porto Alegre | Rio Grande do Sul | |
| Hospital Sao Lucas da PUCRS | Porto Alegre | Rio Grande do Sul | |
| Ynova Pesquisa Clinica | Florianópolis | Santa Catarina | |
| Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto | São José do Rio Preto | São Paulo | |
| Unimed Sorocaba | Sorocaba | São Paulo | |
| Hospital Alemao Oswaldo Cruz | São Paulo | Brazil | |
| CHU Rennes | Rennes | Brittany Region | |
| Centre Hospitalier Intercommunal Toulon - CHITS | Toulon | Var | |
| Centre Hospitalier de la Cote Basque | Bayonne | France | |
| Clinique Belharra | Bayonne | France | |
| CHU Grenoble Alpes | Grenoble | France | |
| Montpellier Academic Hospital | Montpellier | France | |
| Institut Curie | Paris | Île-de-France Region | |
| Klinikum Kassel GmbH, Hauttumorzentrum | Kassel | Hesse | |
| University Medicine Gottingen | Göttingen | Lower Saxony | |
| University of Leipzig | Leipzig | Saxony | |
| University Hospital RWTH Aachen | Aachen | Germany | |
| Catalan Instituye of Oncology Badalona | Badalona | Barcelona | |
| Hospital Valdecilla | Santander | Cantabria | |
| Hospital Universitario Insular de Gran Canaria | Las Palmas de Gran Canaria | Las Palmas | |
| Clinica Universidad de Navarra | Pamplona | Navarre | |
| MD Anderson Cancer Center | Madrid | Spain | |
| Hospital Universitario Clinico San Carlos | Madrid | Spain |
+ 7 more sites — see the full list on the official registry below.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06465329 on ClinicalTrials.gov ↗ ← All trials in Germany