Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry

Condition(s) studied

Investigational drug(s) / intervention(s)

No intervention planned, but all patients get our standart treatment: Patients are selected from clinical Routine and get our standart Treatment based on their disease

Study summary

We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.

Eligibility

Primary outcome measure(s)

• Blood pressure — baseline, 3 months and 18 months
  Change in systolic and diastolic blood pressure over time
• Heart frequency — baseline, 3 months and 18 months
  Change in heart frequency over time
• Skin biopsy — baseline
  intraepithelial nerve fiber density between groups
• Composite autonomic severity Score — baseline, 3 months and 18 months
  Change of the Score over time, the results are interpreted as normal (score=0), mild (score=1-3), moderate (score=4-6) or severe (score=7-10)

Trial sites (1)

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