Multicenter, Interdisciplinary National VEXAS Registry With Accompanying Biomaterial Collection

NCT06377462 · tracked via the Priya Life Science Germany tracker

Sponsor

Technische Universität Dresden

Phase

Observational

Started

2024-03-13

Last updated

2026-05-15

Condition(s) studied

VEXAS Syndrome

Study summary

The aim is rapid collection of real-life data on the epidemiology, treatment and disease course in patients with VEXAS syndrome during routine clinical practice and collect biomaterials to evaluate genotype-phenotype associations, determine optimal treatment schedule, identify diagnostic features and biomarkers

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients with established or suspected (clinical and hematological criteria) VEXAS Syndrome * Age ≥18 years * Signed informed consent form Exclusion Criteria: * patients who are not in a position to understand the nature and scope of participation in this register

Primary outcome measure(s)

Collection of epidemiological data on VEXAS — enrollment
incidence, age and sex distribution in adults in Germany
Collection and monitoring of initial disease manifestations — 5 years
* spectrum and frequency of inflammatory manifestations * Association with hematological (pre)malignancies (MDS, Myeloma, MGUS, CHIP) * Monitor cardiovascular risk/thromboembolic events
Documentation of the treatment approaches and therapy sequences — 5 years
Documentation of the treatment approaches and therapy sequences
Analysis of clinical-relevant clinical endpoints — 5 years
complete remission (CR), hematological and clinical remission, molecular remissions, treatment-free remission (TFR)

Trial sites (17)

Facility	City	Region	Status
Universitätsklinikum Aachen	Aachen	Germany	Recruiting
Klinikum Chemnitz gGmbH	Chemnitz	Germany	Recruiting
Universitätsklinikum Carl Gustav Carus	Dresden	Germany	Recruiting
Universitätsklinikum Düsseldorf	Düsseldorf	Germany	Recruiting
Evang. Kliniken Essen-Mitte	Essen	Germany	Recruiting
Universitätsmedizin Göttingen	Göttingen	Germany	Recruiting
Universitätsklinikum Hamburg-Eppendorf	Hamburg	Germany	Recruiting
Universitätsklinikum Jena	Jena	Germany	Recruiting
Universitätsklinikum Leipzig AöR	Leipzig	Germany	Recruiting
Universitätsmedizin Mannheim	Mannheim	Germany	Recruiting
Klinikum rechts der Isar TUM	München	Germany	Recruiting
Klinikum Nürnberg, Campus Nord	Nuremberg	Germany	Recruiting
Klinikum Osnabrück GmbH	Osnabrück	Germany	Recruiting
Helios Kliniken Schwerin GmbH	Schwerin	Germany	Recruiting
Robert Bosch Gesellschaft für Medizinische Forschung mb	Stuttgart	Germany	Recruiting
Krankenhaus der Barmherzigen Brüder	Trier	Germany	Recruiting
Universitätsklinikum Tübingen	Tübingen	Germany	Recruiting

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Other trials for the same condition

A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS) Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06377462 on ClinicalTrials.gov ↗ ← All trials in Germany