Clinical trial register · European Union · CTIS

EU Clinical Trials Tracker

Name: EU clinical trials authorised under CTIS
Creator: Priya Life Science
License: https://www.ema.europa.eu/en/about-us/legal-notice

The most recently authorised trials on the EU Clinical Trials Information System (CTIS), the single register for every trial run under the EU Clinical Trials Regulation (536/2014). CTIS holds a far larger historical archive than any one list can usefully show — this register states both numbers rather than picking one.

Download CSV

Source: EMA Clinical Trials Information System (CTIS). Showing the 2557 most recently authorised of 12788 total CTIS records — a stated recency window, not the full historical archive. Synced 07 Nov 2026, 03:17 UTC

2557

Shown in this register

most recently authorised

12,788

Total on CTIS

full historical archive

789

Phase III

within the shown window

Top member states

Spain 1074 France 933 Germany 893 Italy 777 Poland 614 Netherlands 544

Narrow the registerReset

Search within results

Phase

Lead sponsor

Member state

All 28 states

Trials in this register

Phase

Study

Lead sponsor

Area

Member states

Decision

Phase IV

A Single Arm, Multicenter Open-Label Interventional Collaborative Study to Evaluate the Efficacy of Upadacitinib re-induction therapy in patients with Ulcerative Colitis who lost response to 30 mg maintenance dose - Re-induCtiOn with UPadacitinib (ReCOUP Study)

2026-526174-16-00Ulcerative Colitis

DrugUpadacitinib

i-GETAID

Digestive System Diseases

France

06/11/2026

Phase IV

Preparation with N-ACETYLCYSTEINE plus SIMETHICONE prior to a high-quality upper gastrointestinal endoscopy to improve gastric mucosal visibility and increase diagnostic accuracy. GASTROprep

2026-526469-42-00Upper Endoscopy with Chromoendoscopy

Fundacion Para El Fomento De La Investigacion Sanitaria Y Biomedica De La Comunitat Valenciana

Diagnosis

Spain

06/11/2026

Phase IV

The Swedish study of shortened antibiotic treatment after surgery for Pediatric Acute Perforated Appendicitis; a randomized controlled non-inferiority study (RCT) comparing 3 versus 5 days of postoperative antibiotics.

2026-525977-38-00Paediatric Acute Perforated Appendicitis - postoperative tr…

DrugsClindamycin·Ciprofloxacin

Vaestra Goetalandsregionen

Digestive System Diseases

Sweden

03/11/2026

Phase IV

Effect of Inclisiran on LDL-C Levels and Coronary Plaque Burden Assessed by Ultra-High Resolution Photon-Counting CT Angiography

2026-526046-28-00Chronic coronary syndrome (CCS)/ history of myocardial infa…

DrugInclisiran

Policlinico San Donato S.p.A.

Cardiovascular Diseases

Italy

02/11/2026

Phase IV

Evaluation of the efficacy of sublingual sufentanil (Dzuveo®, prescribed as rescue analgesia for acute postoperative pain) on the quality of health recovery after surgery: a randomized, controlled, multicenter, open-label trial against an active comparator (SUBLIME)

2026-527137-64-00Operated on in a surgical department for a procedure whose …

DrugSufentanil

Les Hopitaux Universitaires De Strasbourg

Not possible to specify

France

02/11/2026

Phase IV

A feasibility randomised controlled trial of a weight management programme for women living with obesity and infertility

2026-526869-19-00obesity, infertility

DrugTirzepatide

University College Dublin

Nutritional and Metabolic Diseases

Ireland

30/10/2026

Phase IV

ONCE: Once daily eliglustat in stable CYP2D6 intermediate and extensive metabolizers with Gaucher disease type 1

2026-527117-33-00Gaucher Disease Type 1

Amsterdam UMC Stichting

Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Netherlands

22/10/2026

Phase IV

Phase IV, randomized, open-label study comparing the use of Grafalon® versus Thymoglobulin® in non-sensitized patients who have received a kidney transplant at high risk of delayed graft function

2026-526938-23-00Chronic Kidney Disease, Kidney transplantation

Fundacion Para El Fomento De La Investigacion Sanitaria Y Biomedica De La Comunitat Valenciana

Not possible to specify

Spain

19/10/2026

Phase IV

A Single-Blind, Randomized, Placebo-Controlled Trial Evaluating the Impact of Clesrovimab on Nasopharyngeal Shedding of RSV and Other Viral and Bacterial Respiratory Pathogens in Infants: The RSV-SHIELD Trial

2026-526874-18-00Respiratory Syncytial Virus (RSV) prophylaxis (vaccination)

University Of Crete

Respiratory Tract Diseases

Greece

19/10/2026

Phase IV

A study on stopping versus continuing beta-blockers in patients with hypertrophic cardiomyopathy treated with mavacamten

2026-526612-36-00Obstructive Hypertrophic Cardiomyopathy.

Ziekenhuis Oost Limburg

Cardiovascular Diseases

Belgium

13/10/2026

Phase IV

Evaluation of Thrombin Generation and Thrombosis Risk in Women on Hormonal Contraceptives with a Focus on Modifiable Risk Factors

2026-527084-15-00Venous Thromboembolism Risk associated with Hormonal Contra…

DrugsLevonorgestrel·Drospirenone·Estradiol

University Of Debrecen

Cardiovascular Diseases

Hungary

07/10/2026

Phase IV

ctDNA-guided Enfortumab Vedotin plus Pembrolizumab in Untreated Patients with Advanced Urothelial Carcinoma. The FUTURE Study

2026-527171-28-00unresectable, previously untreated locally advanced or meta…

DrugsEnfortumab Vedotin·Pembrolizumab

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Neoplasms

Italy

07/10/2026

Phase IV

An exploratory double-blind randomized placebo-controlled trial to evaluate the effect of ARTENSIUM® cream in the relief of pain in patients with knee osteoarthritis

2026-527647-18-00Knee osteoarthritis is a chronic degenerative joint disease…

Boiron

Musculoskeletal Diseases

France

06/10/2026

Phase IV

Proof-of-Concept Evaluation of Immunological Assays Using Human Blood and Urine Samples after Vaccination with StroVac

2026-527508-25-00Urinary Tract Infection

Strathmann GmbH & Co. KG

Diagnosis

Germany

05/10/2026

Phase IV

Tapering optimisation with placebo-based mechanisms in rheumatoid arthritis: the TOP-RA trial

2025-524593-42-00Rheumatoid Arthritis

DrugsCertolizumab Pegol·Abatacept·Sarilumab·Etanercept

Universiteit Leiden

Musculoskeletal Diseases

Netherlands

05/10/2026

Phase IV

OPTIMIZING THE TREATMENT WITH MEROPENEM FOR FOREIGN-BODY BONE AND JOINT INFECTIONS: PLASMA/BONE PHARMACOKINETICS WITH CONTINUOUS VS INTERMITTENT INFUSION

2026-527210-22-00BONE AND JOINT INFECTIONS

DrugMeropenem

Consorci Mar Parc De Salut De Barcelona

Bacterial Infections and Mycoses

Spain

02/10/2026

Phase IV

PRIMO : Precision immunosuppressive drug monitoring in liver transplantation: a randomized control trial

2025-523563-38-00Immunosuppressive treatment in the context of liver transpl…

DrugTacrolimus

Centre Hospitalier Universitaire De Rennes

Digestive System Diseases

France

01/10/2026

Phase IV

A long-term prospective monitoring study of all patients with Pompe Disease. Evaluating natural history, treatment response, disease markers and novel outcome measures.

2024-520365-31-01Pompe disease / glycogenosis type II / acid maltase deficie…

DrugsAlglucosidase alfa·Cipaglucosidase alfa·Miglustat·Avalglucosidase alfa

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

Nutritional and Metabolic Diseases

Netherlands

01/10/2026

Phase IV

Crohn’s disease Longitudinal Evaluation of Anti-fibrotic Response to UPadacitinib

2025-523038-16-00Crohn’s disease with ileal stricturing complication

DrugUpadacitinib

UZ Leuven

Investigative Techniques

Spain, Germany, Belgium

01/10/2026

Phase IV

Pharmacokinetic study of pembrolizumab and its impact on immunity and the tumor microenvironment, which may explain the efficacy of post-immunotherapy chemotherapy - CPI

2026-526866-26-00Non-small cell lung cancer (NSCLC) and Head and neck squamo…

DrugsCetuximab·Gemcitabine·Paclitaxel·Bevacizumab

Centre Antoine Lacassagne

Neoplasms

France

30/09/2026

Phase IV

Using GLP-1 to prevent Post-Transplantation Diabetes Mellitus

2026-525910-77-00Post-transplantation Diabetes Mellitus

DrugsGlucagon·Semaglutide

Radboud universitair medisch centrum Stichting

Hormonal diseases

Netherlands

28/09/2026

Phase IV

A phase IV randomised, parallel-group, double-blinded, placebo-controlled, trial evaluating the efficacy of the tree SLIT-tablet in adolescents (12-17 years of age) with allergic rhinitis/allergic rhinoconjunctivitis induced by birch pollen using an environmental exposure unit.

2026-526861-88-00Moderate to severe allergic rhinitis/allergic rhinoconjunct…

Alk-Abello A/S

Immune System Diseases

France

21/09/2026

Phase IV

Influence of Antimicrobial Drugs on Mycophenolic acid and Tacrolimus Pharmacokinetics and the Gut Microbiome in Kidney Transplant Recipients (AXIS)

2026-527106-20-00Kidney transplantation

DrugsMycophenolate Mofetil·Tacrolimus

Oslo Universitetssykehus HF

Microbiological Phenomena

Norway

21/09/2026

Phase IV

A Pragmatic Randomized Trial to Evaluate the Relative Effectiveness of Abrysvo® Revaccination Versus a Single Primary Dose for Preventing RSV-associated Lower Respiratory Tract Disease in Immunocompromised Adults (DAN-RSV IC REVAX)

2026-527536-14-00Respiratory syncytial virus infection

DrugVaxzevria

Region Hovedstaden, Pfizer Inc.

Virus Diseases

Denmark

21/09/2026

Phase IV

Multicentre, randomized, open label study comparing the concomitant administration of trabectedin and low-dose radiotherapy versus trabectedin alone in patients with advanced sarcoma

2026-525703-27-00Soft tissue sarcoma, osteosarcoma, or Ewing's sarcoma

DrugTrabectedin

Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz

Musculoskeletal Diseases

Spain

18/09/2026

Phase IV

Antibiotic Prophylaxis in Hematopoietic Stem Cell Transplantation: a Randomised Controlled Trial - The ANTURA trial

2025-524982-25-00Primary immunodeficiencies and other non‑malignant disorder…

DrugLevofloxacin

HUS-yhtymae

Hemic and Lymphatic Diseases

Finland

18/09/2026

Phase IV

Attachment Development and Learning in ADHD: The Role of Dopamine.

2025-525122-35-00Attention-Deficit/Hyperactivity Disorder (ADHD)

UZ Leuven

Mental Disorders

Belgium

15/09/2026

Phase IV

Effects of General Anaesthetic Agents on the Efficacy of Electroconvulsive Therapy and EEG Changes in Patients with Depression

2025-524829-40-00Severe unipolar depression treated with electroconvulsive t…

DrugsEtomidate·Propofol

Varsinais-Suomen hyvinvointialue

Mental Disorders

Finland

15/09/2026

Phase IV

REconsidering Long-TErm ASpirin in the Elderly in Secondary Prevention of Coronary Artery Disease (RELEASE) Norway: A Randomised, Registry-based Trial

2026-526941-91-00Chronic coronary syndrome

Vestre Viken HF

Circulatory and Respiratory Physiological Phenomena

Norway

15/09/2026

Phase IV

A Rollover Study to Follow the Long-term Durability of Response to UGN-103 in Participants From Study BL013

2026-526359-75-00Non-Muscle Invasive Bladder Cancer

Urogen Pharma Ltd.

Neoplasms

Estonia, Romania, Spain, Bulgaria, Latvia

11/09/2026

Phase IV

AIRITY: A hybrid cross-sectional and prospective study to assess patient characteristics, disease burden, disease control, phenotypes, endotypes, and outcomes in a real-world setting in patients with asthma

2025-524916-13-00Asthma

Sanofi-Aventis Recherche & Developpement

Respiratory Tract Diseases

France, Spain, Germany, Italy

09/09/2026

Phase IV

Randomized study evaluating the impact of an innovative and cooperative pathway integrating oncogeriatric, pharmaceutical and pharmacological follow-up in elderly patients (>70 years old) presenting with cancer and treated with oral therapy _ POG

2025-523610-83-00Elderly patients (>70 years old) presenting with cancer and…

DrugsBrigatinib·Pazopanib·Sunitinib·Alectinib

Institut Gustave Roussy

Immune System Diseases

France

08/09/2026

Phase IV

A double-blind, randomised, 30-week placebo-controlled phase IV study to assess the efficacy and safety of osilodrostat in patients with hypertension caused by hypercortisolaemia due to Cushing’s Syndrome

2025-524649-28-00Cushing's syndrome

DrugOsilodrostat

Recordati AG

Hormonal diseases

Germany, Bulgaria, France, Romania, Italy, Poland, Spain

08/09/2026

Phase IV

POISON – Perioperative Safety and Effective Opioid Dosing in Chronic Opioid Use – a Randomized Clinical Study

2026-526719-13-00Opioid dependent chronic pain

DrugOxycodone

Region Hovedstaden

Anesthesia and Analgesia

Denmark

08/09/2026

Phase IV

A Phase IV, open label, single arm trial to assess the safety and immunogenicity of BIMERVAX® XFG.1.1 against SARS-CoV-2 Omicron XFG.1.1 variant.

2026-527363-16-00COVID-19

Hipra Scientific S.L.

Virus Diseases

Spain

07/09/2026

Phase IV

ACTOR – AUC Control of Tacrolimus in Organ Recipients

2026-527107-22-00Kidney transplantation

Oslo Universitetssykehus HF

Therapeutics

Norway

02/09/2026

Phase IV

Reduced-dose versus full-dose systemic thrombolysis for high-risk pulmonary embolism: a multicentre, randomised, open-label, blinded-endpoint trial

2024-515904-37-00Pulmonary embolism

DrugAlteplase

Vaestra Goetalandsregionen, University Of Gothenburg

Cardiovascular Diseases

Denmark, Sweden, Norway

02/09/2026

Phase IV

Optimization of Dupilumab Maintenance Dosing in Eosinophilic Esophagitis: A Phase IV, Randomized, Controlled, Single-Blind, Non-Inferiority Study

2026-526348-11-01Eosinophilic Esophagitis

DrugDupilumab

Amsterdam UMC Stichting

Digestive System Diseases

Netherlands

01/09/2026

Phase IV

Incidence and severity of postoperative delirium associated with Dexmedetomidine sedation during femur osteosynthesis in the elderly population

2025-523070-16-00Postoperative delirium

DrugsPropofol·Dexmedetomidine

Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer

Nervous System Diseases

Spain

31/08/2026

Phase IV

A prospective, randomized, double-blinded, placebo-controlled, cross-over study investigating the effects of metyrapone treatment on cardio-metabolic outcome parameters and chronobiology in patients with mild autonomous cortisol secretion

2026-526837-24-00Mild autonomous cortisol secretion

Medical University Of Vienna

Hormonal diseases

Austria

29/08/2026

Phase IV

A prospective, exploratory, parallel-group, low-intervention, phase IV, randomized, double-blind, placebo-controlled, multi-center, national, 2-arm trial to investigate efficacy and safety of Amara-Tropfen (Amara drops) in patients with irritable bowel syndrome (IBS)

2026-526668-19-00Irritable Bowel Syndrome

Weleda AG

Digestive System Diseases

Germany

28/08/2026

Phase IV

S-KETamine vs. propofol for prehospital sedation of patients with severe Acute Brain Injury: The KETABI randomised trial

2026-525588-41-00traumatic brain injury, subarachnoid haemorrhage, intracere…

DrugPropofol

Region Hovedstaden

Pathological Conditions, Signs and Symptoms

Denmark

27/08/2026

Phase IV

Piperacillin/tazobactam or ampicillin and gentamicin for empirical treatment of community acquired infection: A randomised clinical trial (PAGER)

2026-526131-20-00Urosepsis, Infection of unknown origin, Pyelonephritis, Cys…

DrugsAmpicillin·Gentamicin

Region Hovedstaden

Bacterial Infections and Mycoses

Denmark

25/08/2026

Phase IV

Adalimumab Treatment for Patients with Hidradenitis Suppurativa at high risk of Progressing to Severe Disease: An Unblinded Randomized, Controlled Trial

2025-522505-37-00Hidradenitis suppurativa

DrugsDoxycycline·Adalimumab

Gentofte Hospital

Skin and Connective Tissue Diseases

Denmark

24/08/2026

Phase IV

Effects of Menopausal Hormone Therapy on QTc in Genetically Confirmed Long QT Syndrome: A Prospective Randomized Sequential Crossover Study with Long-Term Observational Follow-Up (LQTS-HER)

2026-526442-28-00Long QT syndrome

DrugsEstradiol·Progesterone

Oslo Universitetssykehus HF

Cardiovascular Diseases

Norway

20/08/2026

Phase IV

An Open-Label Study to Investigate the Long-Term Effects of Acoramidis on Cardiac Function, Structure and Cardiac Amyloid Burden in Participants with Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

2026-526068-19-00Transthyretin Amyloidosis

DrugAcoramidis

Eidos Therapeutics Inc.

Cardiovascular Diseases

Spain, Denmark

20/08/2026

Phase IV

Phase IV Low Intervention Clinical Trial to Study Biomarkers of "inflammageing" and Senescence in Pre-diabetic Patients Treated with Metformin: A Study nested within the project “NLRP3 Inflammasome at the Crossroad of Vascular Inflammageing: A Novel Target for Senomorphic Drugs”.

2026-527080-15-00Pre-diabetic Patients

Universidad Autonoma De Madrid

Metabolism

Spain

14/08/2026

Phase IV

A randomized, double blind, placebo-controlled study comparing the efficacy of dupilumab to standard of care (SOC) treatment following hospitalization for a COPD exacerbation

2025-524392-23-00Chronic obstructive pulmonary disease (COPD)

DrugDupilumab

Regeneron Pharmaceuticals Inc.

Respiratory Tract Diseases

Belgium, Italy, Spain

13/08/2026

Phase IV

Patient-Controlled Anesthesia for endoscopic Procedural Sedation – PCAPS study

2025-524859-31-00Adenoma

DrugsMidazolam·Propofol

Karolinska Institutet

Digestive System Diseases

Sweden

11/08/2026

Phase IV

The RHINOME study

2026-527032-14-00Severe asthma

Region Hovedstaden

Respiratory Tract Diseases

Denmark

10/08/2026

Phase IV

HORUS-Cytomegalovirus Open Proof-of-concept Exploratory trial

2025-524845-28-00Cytomegalovirus infection in solid-organ transplant recipie…

DrugEverolimus

Centre Hospitalier Universitaire Vaudois

Virus Diseases

France, Spain

07/08/2026

Phase IV

A Phase 4, Pragmatic, Randomized Trial to Evaluate the Effectiveness of An Influenza/COVID-19 Vaccine (mCombriax [mRNA-1083]) in Adults ≥ 65 Years (DAN-COMBO)

2026-526720-49-00SARS-CoV-2 infection, Influenza infection

Gentofte Hospital, Moderna Inc.

Virus Diseases

Denmark, Spain

07/08/2026

Phase IV

CLINIC-CURE, a pilot exploratory clinical trial of analytical treatment interruption in people with HIV with a highly favorable profile

2026-526395-23-00HIV

DrugEmtricitabine

Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer

Virus Diseases

Spain

06/08/2026

Phase IV

Influence of Doxycycline Use as Prophylaxis for Sexually Transmitted Infections on Bacterial Resistance and Gut Microbiota: MiDoxyR-PEP Study

2025-525150-19-01Colonization by methicillin-resistant S. aureus and gut mic…

Instituto De Investigacion Marques De Valdecilla

Virus Diseases

Spain

06/08/2026

Phase IV

A Phase IV, Randomized Controlled Trial to Evaluate the Effects of Resistance Training Versus Usual Care on Thigh Muscle Volume During Treatment with the Dual GIP/GLP-1 Receptor Agonist Tirzepatide in Adults with Obesity

2026-526200-69-00Obesity

Klinikum der Technischen Universitaet Muenchen (TUM Klinikum)

Nutritional and Metabolic Diseases

Germany

04/08/2026

Phase IV

Non-inferiority of surgical treatment of cartilage defects of the knee with autologous minced cartilage implantation (AMCI) and matrix-asscociated autologous chondrocyte implantation with respect to KOOS at 24 months (M ACI) - MinCaRCT

2026-526179-49-00Full-thickness cartilage defects of the knee

Medical Center - University Of Freiburg

Musculoskeletal Diseases

Germany

03/08/2026

Phase IV

Effectiveness of Trazodone on Emotional Blunting in Patients with Major Depressive: a Phase IV, Open-label, clinical study

2025-523267-38-00Major depressive disorder (MDD)

Angelini Pharma Italia Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. Enunciabile Anche Angelini Pharma Italia S.p.A. Angelini Pharma S.p.A. A.C.R.A.F. S.p.A. Acraf S.p.A. Angelini S.p.A. aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.

Mental Disorders

Bulgaria, Poland, Hungary

29/07/2026

Phase IV

Comparative study of two vaccination schedules for the subunit Herpes Zoster vaccine in Multiple Sclerosis and Neuromyelitis optica spectrum disease patients treated with anti-CD20 therapy: an open-label randomised controlled trial.

2025-525106-37-00Multiple Sclerosis and Neuromyelitis optica spectrum

DrugsOcrelizumab·Rituximab

Centre Hospitalier Universitaire De Toulouse

Nervous System Diseases

France

28/07/2026

Phase IV

STRategiEs for Antiplatelet Management foLlowIng acute coroNary syndromE (STREAMLINE)

2026-525933-22-00ischemic heart disease

DrugsPrasugrel·Acetylsalicylic acid·Ticagrelor

Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz

Cardiovascular Diseases

Spain, Norway

28/07/2026

Phase IV

Within-Patient Comparison of Serum Transthyretin Response to Tafamidis Versus Acoramidis: A Pilot Crossover Study in Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

2026-526526-41-01Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

DrugAcoramidis

Medical University Of Vienna

Cardiovascular Diseases

Austria

27/07/2026

Phase IV

Thromboprophylaxis with apixaban during neoadjuvant therapy for muscle-invasive bladder cancer (ACB): An international randomized controlled trial evaluating apixaban versus no anticoagulation in patients scheduled to undergo radical cystectomy or chemoradiotherapy for muscle-invasive bladder cancer

2024-518861-90-00Venous thromboembolism (in bladder cancer patients)

DrugApixaban

HUS-Yhtymae

Therapeutics

Finland

27/07/2026

Phase IV

VATS or Intrapleural Enzymatic Therapy for patientS with empyema (the VIETS trial)

2026-526289-25-00Parapneumonic pleural infection/pleural empyema

DrugsDornase Alfa·Alteplase

Amsterdam UMC Stichting

Therapeutics

Netherlands

24/07/2026

Phase IV

Real-World Effectiveness of the Adjuvanted RSVPreF3 Vaccine in Adults ≥60 Years: A Pragmatic Randomized Trial (BronquiVal)

2026-526804-59-00Respiratory syncytial virus infection–related respiratory d…

Fundacion Para El Fomento De La Investigacion Sanitaria Y Biomedica De La Comunitat Valenciana

Respiratory Tract Diseases

Spain

22/07/2026

Phase IV

Do GLP-1 based therapies improve the immunological response to vaccination in diabetes?

2026-525909-13-00Diabetes

DrugsPneumococcal Vaccine·Liraglutide

Radboud universitair medisch centrum Stichting

Immune System Diseases

Netherlands

22/07/2026

Phase IV

Early TRIPLE versus dual LIPID lowering treatment in peOple with atherosclerotic cardiovascular disease and hypercholesterolemia Undergoing elecTive revascularisation - The randomized, controlled, open-label, parallel group TRIPLE-LIPID-OUT trial

2026-525917-29-00Peripheral arterial disease, Coronary artery atheroscleroti…

Medical University Of Graz

Cardiovascular Diseases

Germany, Austria

14/07/2026

Phase IV

Efficacy of oral bicarbonate versus placebo on the risk of assisted delivery in nulliparous women with prolonged labour (ProLabour): protocol fora randomized controlled trial

2026-525682-45-00Prolonged labour

Region Hovedstaden

Female Urogenital Diseases and Pregnancy Complications

Denmark

14/07/2026

Phase IV

Phase IV randomized, single-blind clinical trial with three parallel arms to compare ovulation triggering strategies in IVF cycles with fresh embryo transfer.

2026-526292-37-01Women with infertility and low ovarian reserve.

DrugFollitropin delta

Instituto De Investigacion Sanitaria Fundacion Para La Investigacion Del Hospital Clinico De Valencia-INCLIVA

Reproductive and Urinary Physiological Phenomena

Spain

13/07/2026

Phase IV

Early switch to oral antibiotic therapy in vertebral osteomyelitis: a multicentre, open-label, randomised, active control, parallel group, non-inferiority trial (sWITCH-VO)

2026-526270-17-00bone and joint infections

University Of Cologne

Musculoskeletal Diseases

Germany

09/07/2026

Phase IV

Oral versus Intravenous Tranexamic Acid for Blood Loss Prevention in Off-Pump Coronary Artery Bypass Surgery: A Randomised Non-Inferiority Trial (TRANSCAB Study)

2026-526581-24-01Coronary artery disease requiring off-pump coronary artery …

DrugTranexamic Acid

Sante et Prevoyance

Cardiovascular Diseases

Belgium

06/07/2026

Phase IV

Efficacy, Safety, and Patient Satisfaction of Patient-Controlled Remimazolam Sedation in Outpatient Colonoscopy: A randomized controlled trial.

2026-525809-13-00The trial will study sedation related to colonoscopy, there…

Region Hovedstaden

Digestive System Diseases

Denmark

06/07/2026

Phase IV

Optimising Arthritis Strategies in Elderly patients (≥70 years) with rheumatoid arthritis in sustained low disease activity (the OASE study): A Prospective Target Trial Emulation Study Evaluating Tapering of Disease-Modifying Anti-Rheumatic Drugs vs. Usual Care Based on Patient Preference

2026-525221-21-01Rheumatoid arthritis

DrugsCertolizumab Pegol·Sulfasalazine·Golimumab·Leflunomide

Aalborg University Hospital, Aalborg University Hospital

Musculoskeletal Diseases

Denmark

06/07/2026

Phase IV

Progesterone Luteal Support in Unexplained Infertility Management (PLUIM study)

2026-525747-33-00unexplained subfertillity, infertillity

DrugProgesterone

Universitair Medisch Centrum Utrecht

Female Urogenital Diseases and Pregnancy Complications

Netherlands

30/06/2026

Phase IV

ObStructive Sleep Apnoea ManageMent in Older AdUlts with Overweight or ObEsity: A Randomized ClinicaL Trial (SAMUEL study)

2026-525500-10-00Obstructive sleep apnea syndrome, Obesity

DrugTirzepatide

Institut De Recerca Biomedica De Lleida Fundacio Dr. Pifarre

Nutritional and Metabolic Diseases

Spain

29/06/2026

Phase IV

Unprescribing the Pill to Reassess Symptom and Cognitive Recovery in Depression (UNPRESCRIB-D)

2026-526314-90-00Major Depressive Disorder

DrugsSertraline·Duloxetine

Region Hovedstaden

Mental Disorders

Denmark

29/06/2026

Phase IV

Randomized Evaluation of fleCAinide safety vs. STandard of care in patients with coronary artery disease and Atrial Fibrillation (ReCAST AF).

2025-525121-13-00Coronary artery disease, Atrial fibrillation

UZ Leuven

Cardiovascular Diseases

Belgium

26/06/2026

Phase IV

Prospective, multicenter, randomized study on combined LT4 + LT3 therapy versus LT4 in the control of TSH in patients with advanced thyroid cancer treated with tyrosine kinase inhibitors.

2026-526113-28-00Advanced thyroid carcinoma. Post-thyroidectomy hypothyroidi…

Ceinge Biotecnologie Avanzate Franco Salvatore S.c.a.r.l.

Hormonal diseases

Italy

26/06/2026

Phase IV

Short and long-term Hemodynamic and Physiological Effects of Mavacamten in Obstructive Hypertrophic Cardiomyopathy

2025-524722-17-00Obstructive Hypertrophic Cardiomyopathy

Region Skane

Cardiovascular Diseases

Sweden

26/06/2026

Phase IV

Phase IV study evaluating the efficacy and safety of the venetoclax + rituximab (VR) regimen in patients with relapsed chronic lymphocytic leukemia in Polish clinical practice

2025-524795-35-00Adult with chronic lymphocytic leukemia/small lymphocytic l…

DrugsVenetoclax·Rituximab

Uniwersytet Medyczny W Lublinie

Hemic and Lymphatic Diseases

Poland

26/06/2026

Phase IV

A multicentre, adaptive, randomised, multidomain, platform trial for dose optimization in the treatment of adult patients with haematological diseases (BLOOD-dose): core protocol

2026-525658-13-00Haematological diseases; any disorder that primarily affect…

DrugsLinvoseltamab·Talquetamab·Elranatamab·Teclistamab

Region Hovedstaden

Hemic and Lymphatic Diseases

Denmark

25/06/2026

Phase IV

ECETEP : Pilot study evaluating PSMA positron emission tomography for monitoring clinically significant prostate cancer after focal HIFU treatment

2026-525181-22-00prostate cancer

DrugPiflufolastat

Centre Hospitalier Universitaire De Toulouse

Diagnosis

France

25/06/2026

Phase IV

Morphine for resting breathlessness in severe illness and palliative care (MORE-B): a randomized clinical trial

2026-525838-32-00Serious, chronic, life-limiting disease

Region Skane

Respiratory Tract Diseases

Sweden

24/06/2026

Phase IV

The impact of ovarian stimulation with hMG on embryo quality in advanced age women. A randomized controlled trial

2025-524761-25-00infertility

DrugsFollitropin delta·Progesterone

Santiago Dexeus Font Fundacio Privada

Female Urogenital Diseases and Pregnancy Complications

Spain

23/06/2026

Phase IV

USEFULNESS OF HIGH-FLOW OXYGEN THERAPY TO IMPROVE THE SAFETY OF PATIENTS AT HIGH RISK OF HYPOXEMIA UNDERGOING DIGESTIVE ENDOSCOPY UNDER DEEP SEDATION: A RANDOMIZED MULTICENTER COMPARATIVE STUDY. THE ENDOALF-TRIAL.

2026-525766-21-01Hypoxemic episodes in patients undergoing gastroscopy, colo…

Hospital Universitario Rio Hortega

Respiratory Tract Diseases

Spain

23/06/2026

Phase IV

Treatment strategies for juvenile idiopathic arthritis patients with sustained inactive disease: A phase 4, multicentre, randomised trial comparing maintenance versus tapered TNF alpha inhibitor monotherapy - the Treat-JIA trial

2026-525611-13-00Juvenil Idiopatic Arthritis

DrugsGolimumab·Etanercept·Adalimumab

Oslo Universitetssykehus HF

Musculoskeletal Diseases

Norway

23/06/2026

Phase IV

Sample Collection Study to Monitor the Risk of Malignancy Due to Insertional Oncogenesis in Early Onset Patients with Metachromatic Leukodystrophy Treated with OTL-200 in the Clinical Development Program

2025-522275-28-00Metachromatic leukodystrophy

Orchard Therapeutics (Europe) Limited

Musculoskeletal Diseases

Netherlands, Germany, Italy, Sweden, France

22/06/2026

Phase IV

Insulin resistance in type 2 diabetes: evaluating the pathogenic mechanisms of insulin resistance in the myocardium and the effects of the treatments with GLP-1RA and SGLT2i

2025-523374-17-03Type 2 diabetes

DrugsDapagliflozin·Semaglutide

Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca

Nutritional and Metabolic Diseases

Spain

19/06/2026

Phase IV

Tacrolimus as prophylaxis of post-ERCP pancreatitis: a DPSG (Dutch Pancreatitis Study Group) multicenter, double-blind, randomized, placebo-controlled study.

2025-522900-26-00Post-ERCP Pancreatitis

Amsterdam UMC Stichting

Digestive System Diseases

Netherlands

19/06/2026

Phase IV

STOP - Safety and efficacy of a STOPping strategy versus classical maintenance dose of JAK inhibitors in deep remission patients with ulcerative colitis: a randomized controlled trial

2026-525643-32-00ulcerative colitis

DrugsFilgotinib·Tofacitinib·Upadacitinib

Centre Hospitalier Regional De Marseille

Digestive System Diseases

France

17/06/2026

Phase IV

Real-World Effectiveness and Safety of Pegcetacoplan in Patients with C3 Glomerulopathy (C3G) or Primary Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN): A Multi-Country Study (PRISMC3)

2025-524487-37-00Primary Immune Complex Membranoproliferative Glomerulonephr…

DrugPegcetacoplan

Swedish Orphan Biovitrum AB (publ)

Immune System Diseases

France, Italy, Spain, Germany, Austria, Belgium, Czechia

15/06/2026

Phase IV

BEAT Fatigue – Benefit of Elevated Administration of Thiamine for Fatigue in Rheumatoid Arthritis: A randomized, double-blind, placebo-controlled trial

2024-519268-41-00Fatigue in rheumatoid arthritis patients

Odense University Hospital

Musculoskeletal Diseases

Denmark

12/06/2026

Phase IV

Efficacy of top-down therapy with mirikizumab versus standard of care with azathioprine in patients with newly diagnosed, moderate-to-severe Crohn’s disease: A 52-week, multicenter, open-label, randomized controlled trial

2026-525191-26-00Crohn’s disease

DrugsAzathioprine·Mirikizumab

Universitaetsklinikum Schleswig-Holstein AöR

Digestive System Diseases

Germany, Poland

11/06/2026

Phase IV

Clinical trial to evaluate the correlation between variation in intestinal lactase activity measured with LacTEST 0.45g and alteration of intestinal barrier integrity and/or intestinal permeability in patients with celiac disease

2026-525518-70-00Patients with celiac disease

Venter Pharma S.L.

Digestive System Diseases

Spain

11/06/2026

Phase IV

DISCO-RA:DIScontinuation of COncomitant disease modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis patients also using TNF inhibitors - a randomized long-term non-inferiority strategy trial

2026-525316-33-00Rheumatoid arthritis

Sint Maartenskliniek Stichting

Immune System Diseases

Netherlands

09/06/2026

Phase IV

A neuropsychobiological approach to optimize patient selection for GLP-1-based pharmacotherapy for weight management across the binge eating spectrum

2026-526016-36-00obesity

UZ Leuven

Nutritional and Metabolic Diseases

Belgium

08/06/2026

Phase IV

OCTAGON:A Phase 4, Single Arm Study to Investigate Oral Corticosteroid Tapering in Adult Patients with Generalized Myasthenia Gravis Treated with Ravulizumab

2025-522555-26-00Generalized Myasthenia Gravis

Alexion Pharmaceuticals Inc.

Nervous System Diseases

Italy, Germany

08/06/2026

Phase IV

PREP-ANCA - Comparison of a strategy based on clinic-biological surveillance versus pre-emptive treatment with rituximab in the event of ANCA (anti-neutrophil cytoplasm antibodies) repositivation in patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)

2025-522049-23-00granulomatosis with polyangiitis and microscopic polyangiit…

DrugsPrednisone·Rituximab

Assistance Publique Hopitaux De Paris

Immune System Diseases

France

08/06/2026

Phase IV

Measles-mumps-rubella vaccine (MMR) at 6 months of age: Long-term follow-up

2026-526160-21-00Prevention of measles, mumps, and rubella by vaccination

Rigshospitalet

Virus Diseases

Denmark

08/06/2026

Phase IV

ANTIMIDIS - Cefazolin mediastinal distribution using microdialysis

2025-521988-13-00Infection prophylaxis

DrugCefazolin

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

05/06/2026

Phase IV

BIOlogical treatment GRAdual Interval Longing in severe Asthma (BIO-GRAIL)

2025-524741-28-00Severe Asthma

DrugsBenralizumab·Mepolizumab·Tezepelumab·Dupilumab

Amsterdam UMC Stichting

Respiratory Tract Diseases

Netherlands

05/06/2026

Phase IV

A randomised, double-blind, three parallel-group, placebo controlled superiority trial assessing the effect of intravenous versus oral iron supplementation on physical performance, quality of life and cognitive function in iron deficient FRAIL elderly IndiviDuals with cardiovascular disease (FRAIL-ID trial)

2025-521570-34-00Frailty with Iron Deficiency in Elderly Patients with Cardi…

Wroclaw Medical University

Nutritional and Metabolic Diseases

Poland

05/06/2026

Phase IV

Pulmonary Embolism & Anticoagulation Evaluation in Cancer Patient - PEACE

2025-524110-28-00Incidental Subsegmental Pulmonary Embolism in cancer patien…

DrugsDalteparin·Tinzaparin·Edoxaban·Enoxaparin

Region Hovedstaden

Cardiovascular Diseases

Denmark

04/06/2026

Phase IV

IJAMP-Trial

2025-523131-19-00prick test-induced itch

Johannes Kepler University Linz

Skin and Connective Tissue Diseases

Austria

01/06/2026

Phase IV

Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery: Impact on Postoperative Cardiovascular Outcomes – DISCO Study

2025-524395-30-00heart failure

DrugsMetformin·Dapagliflozin

Centre Hospitalier Universitaire De Toulouse

Cardiovascular Diseases

France

29/05/2026

Phase IV

A Phase 4, Multicenter, Double-blind, Study to Investigate the Efficacy, Safety, and Tolerability of 3 Active Doses of Respreeza® / Zemaira® Weekly Intravenous Infusions Administered over 3 Years as Longterm Maintenance Therapy in Adult Subjects with Emphysema Related to Alpha1 Antitrypsin Deficiency

2025-522964-33-00Alpha1 antitrypsin deficiency, Emphysema, Alpha1-proteinase…

CSL Behring LLC

Respiratory Tract Diseases

Denmark

28/05/2026

Phase IV

A multicenter, randomized, double-blind, placebo-controlled, adaptive, non-inferiority trial to investigate shortening treatment duration in uncomplicated candidemia: the CanTEN trial

2026-525640-14-00Candidemia

DrugsCaspofungin·Sodium Lactate

University Of Cologne

Bacterial Infections and Mycoses

Germany

28/05/2026

Phase IV

A randomized, Phase 4, double-blind, placebo-controlled, 6-arm crossover study to investigate the systemic effect of lidocaine and ropivacaine when used for Transversus Abdominis Plane (TAP) blocks on hyperalgesia and pain perception in healthy volunteers aged 18 to 64 years.

2025-520910-67-01Acute pain

DrugsRopivacaine·Lidocaine

Oslo University Hospital HF

Anesthesia and Analgesia

Norway

28/05/2026

Phase IV

Optimising the protocol of labour induction using misoprostol – randomised open-label clinical trial (OPTIMISO)

2026-525770-19-00Labour induction

Fakultni Nemocnice Brno

Female Urogenital Diseases and Pregnancy Complications

Czechia

28/05/2026

Phase IV

Platelet function testing in outpatients after heart transplantation on aspirin therapy

2025-521699-71-01Patients who have undergone heart transplantation.

Medical University Of Vienna

Cardiovascular Diseases

Austria

25/05/2026

Phase IV

Reassessment of statin-associated musscle symptoms in adults with familial hypercholesterolemia: A phase IV randomized double-blinded n-of-1 crossover trial including periods with atorvastatin, placebo and no study treatment

2025-521589-83-00Familial hypercholesterolaemia

DrugAtorvastatin

Oslo University Hospital HF

Cardiovascular Diseases

Norway

22/05/2026

Phase IV

Comparing intraoperative indocyanine green fluorescence imaging with standard clinical assessment for flap perfusion in head and neck reconstruction: A randomised controlled Trial (VISION Trial)

2025-524710-29-00Head and neck cancer

Region Skane

Neoplasms

Sweden

22/05/2026

Phase IV

A randomized, placebo-controlled, blinded, parallel-group clinical trial to assess the efficacy of N-acetylcysteine in adults with acute infections or sepsis and evidence of liver dysfunction: the IMPACT-NAC trial

2026-525895-25-00Acute infection, Sepsis

Region Hovedstaden

Bacterial Infections and Mycoses

Denmark

22/05/2026

Phase IV

Exogenous progesterone as ovulation trigger – a pilot study

2025-523850-15-00Infertility

Instituto Valenciano De Infertilidade Clinica De Reproducao Assistida Lda.

Female Urogenital Diseases and Pregnancy Complications

Portugal

22/05/2026

Phase IV

Effect of an adjunctive intervention on the tolerability of semaglutide in overweight adults without diabetes: a prospective, randomised, double-blind, single-centre, placebo-controlled clinical trial (SEMTOL)

2025-524612-11-00Overweight and obesity

University Of Tartu

Nutritional and Metabolic Diseases

Estonia

21/05/2026

Phase IV

Intensified Monitoring of PhArmacology of Cabozantinib as a tool for Toxicity management in patients with renal cell carcinoma

2026-525267-40-00Renal cell carcinoma

Centro Di Riferimento Oncologico Di Aviano

Neoplasms

Italy

21/05/2026

Phase IV

Erdosteine effect on oxidative stress, inflammatory response and immune modulation in patients with COPD. A single center, open label, double arm, controlled, 4-week, explorative, ex vivo study.

2025-524821-42-00COPD

ASST Fatebenefratelli Sacco

Respiratory Tract Diseases

Italy

20/05/2026

Phase IV

A Multicenter Randomized Controlled Trial Assessing the Efficacy and Safety of Recombinant Human Follicle Stimulating Hormone (r-hFSH-alfa originator) and Human Chorionic Gonadotropin (hCG) in Enhancing Sperm Concentration in Men with Oligozoospermia, Low Testosterone, and Normal FSH Serum Levels (APHRODITE Group 3): A Collaborative Research Initiative

2025-525005-20-00Male Infertility

DrugGonal-F

Martin-Luther-Universitaet Halle-Wittenberg

Reproductive and Urinary Physiological Phenomena

Italy, Spain, Germany

18/05/2026

Phase IV

Prognostic value of early assessment by ⁶⁸Ga-DOTATATE PET/CT for the treatment of well-differentiated grade 2 gastroenteropancreatic neuroendocrine tumors with ¹⁷⁷Lutetium-oxodotreotide.”

2025-524942-87-00Gastroenteropancreatic neuroendocrine tumors

Centre De Lutte Contre Le Cancer Eugene Marquis

Neoplasms

France

18/05/2026

Phase IV

The effect of beta-blockers on how you feel and recover after a heart attack when your heart is still pumping well

2026-525475-96-00Myocardial infarction without reduced ejection fraction

UZ Leuven

Cardiovascular Diseases

Belgium

18/05/2026

Phase IV

A pragmatic, phase IV, randomized, open-label, multinational, multicentre, 2-arm parallel group, prospective study comparing efficacy and safety of Single Inhaler ICS/LABA/LAMA (beclometasone/formoterol fumarate/glycopyrronium bromide [87/5/9 pMDI {BD/FF/GB - 100/6/12.5 µg}]) vs Single Inhaler ICS/LABA (beclometasone dipropionate plus formoterol fumarate [200/6 pMDI {BD/FF - 200/6 µg}]) in asthma subjects.

2025-524289-56-00Asthma

Chiesi Farmaceutici S.p.A.

Respiratory Tract Diseases

Germany, Romania, Italy, Bulgaria, Poland, Slovakia, Spain, France

18/05/2026

Phase IV

Reproductive outcomes with letrozole co-treatment during ovarian stimulation in women with endometriosis undergoing IVF/ICSI: a randomised, multicentre, parallel group pragmatic trial

2025-524995-53-00Women with endometriosis undergoing IVF/ICSI

UZ Brussel

Reproductive and Urinary Physiological Phenomena

Belgium

13/05/2026

Phase IV

A phase IV proof-of-concept study to assess the safety and efficacy of Maribavir to inhibit high Virus Epstein-Barr (VEB) replication among young adult kidney transplant recipie

2025-524786-25-00Transplant patients with high recurrent Epstein-Barr infect…

DrugMaribavir

Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca

Virus Diseases

Spain

13/05/2026

Phase IV

PROTECx - Pembrolizumab Registry for Outcomes and Treatment Evaluation in Cervical Cancer

2025-522883-34-00Metastatic cervical cancer

Universitair Medisch Centrum Groningen

Neoplasms

Netherlands

11/05/2026

Phase IV

Colchicine Assessment of Low-grade Inflammation and Biomarker Response in Atherosclerosis with Targeted Evaluation

2026-525547-32-01Ischemic Heart Disease, Coronary Artery Disease, Chronic Co…

Region Hovedstaden

Cardiovascular Diseases

Denmark

06/05/2026

Phase IV

Phase IV, randomized, open label, parallel groups clinical trial for evaluating the early Stop of antibiotic Treatment in high-risk febrile neutropenic Oncohaematological Paediatric patients (e-STOP 2)

2025-524264-38-00Infectious diseases

Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca

Not possible to specify

Spain

05/05/2026

Phase IV

Efficacy and Safety of Daridorexant in Patients with Major Depressive Disorder (MDD) and Insomnia: Double-blind, randomized, controlled trial

2025-524794-16-00Patients with major depressive episode and moderate to seve…

Fundacio Institut D'Investigacio Biomedica De Bellvitge IDIBELL

Mental Disorders

Spain

04/05/2026

Phase IV

PHASE IV, PROSPECTIVE, OPEN-LABEL, SINGLE ARM STUDY ON THE PAIN-RELIEF EFFECT OF BENZYDAMINE HYDROCHLORIDE LOZENGES 3 MG MINT TASTE (TANTUM VERDE) IN NON STREPTOCOCCAL PHARYNGOTONSILLITIS IN PEDIATRIC AGE (6-11 YEARS OLD).

2025-521526-15-00NON STREPTOCOCCAL PHARYNGOTONSILLITIS

Angelini Pharma Italia Aziende Chimiche Riunite Angelini Francesc O A.C.R.A.F. S.p.A. Enunciabile Anche Angelini Pharma Italia S.p.A. Angelini Pharma S.p.A. A.C.R.A.F. S.p.A. Acraf S.p.A. Angelini S.p.A. Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.

Respiratory Tract Diseases

Italy

30/04/2026

Phase IV

Multicenter clinical trial on the effectiveness and safety of outpatient treatment of acute uncomplicated diverticulitis without antibiotics versus antibiotic treatment. ADIANA Trial.

2025-523121-17-00Diverticular disease of the intestine,

Fundacion Para La Formacion E Investigacion Sanitaria De La Region De Murcia

Digestive System Diseases

Spain

30/04/2026

Phase IV

Switching to Mesalazine Monotherapy vs Continuing Thiopurines in Older Patients with Ulcerative Colitis in Sustained Remission: A Multicenter Randomized Controlled Trial (IDEA).

2025-524675-23-00Ulcerative Colitis

Grupo Espanol De Trabajo En Enfermedad De Crohn y Colitis Ulcerosa

Digestive System Diseases

Spain

30/04/2026

Phase IV

EaRly impAct theraPy with ceftazidime-avibactam via rapID diagnostics versus standard of care antibiotics and diagnostics in patients with bloodstream infection, hospital-acquired pneumonia or ventilator-associated pneumonia due to Pseudomonas aeruginosa or carbapenemase producing Enterobacterales ("RAPID")

2024-520067-13-00Bloodstream Infection, Ventilator Associated Pneumonia and …

National University Of Singapore

Bacterial Infections and Mycoses

Italy, Greece

29/04/2026

Phase IV

MERCURE study: MEthotrexate in ReCurrent dVIN

2025-524373-17-00dVIN caused by Lichen Sclerosus

Amsterdam UMC Stichting

Skin and Connective Tissue Diseases

Netherlands

28/04/2026

Phase IV

A Study to Evaluate Mirikizumab Concentrations in Breast Milk Following Administration of Mirikizumab by Subcutaneous Injection in Lactating Participants Receiving Mirikizumab Therapeutically for an Approved Indication

2025-522362-78-00severely active ulcerative colitis (US) and CD (Crohn’s dis…

DrugMirikizumab

Eli Lilly & Co.

Immune System Diseases

Spain, Denmark, Germany, Italy, Poland

27/04/2026

Phase IV

Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure (INFUSE-AHF)

2025-523589-26-00Acute heart failure with volume overload

Region Midtjylland

Cardiovascular Diseases

Denmark

24/04/2026

Phase IV

A randomized double-blind placebo-controlled study to demonstrate the efficacy of PMBL® sublingual tablets in reducing the incidence of respiratory tract infections in children aged 3-12 years (PIRTIK).

2025-524212-11-00Respiratory Tract Infections

Lallemand Pharma Europe filial af Lallemand Pharma AG Schweiz

Respiratory Tract Diseases

Poland

23/04/2026

Phase IV

CoCo-PCOS - Comprehensive Health Effects of Combined Contraceptives: a 6-month randomized, controlled, open-label trial of E4+DRSP, EE20µg+DRSP, and DRSP-only in women with PCOS

2025-523358-15-00Contraception

Pohjois-Pohjanmaan hyvinvointialue, University Of Oulu

Reproductive and Urinary Physiological Phenomena

Finland

20/04/2026

Phase IV

Impact of treatment with TransCon PTH on Quality of Life, cognitive function, brain structure, and cerebral capillary bloodflow in patients with hypoparathyroidism

2025-523930-14-00Hypoparathyroidism

Region Midtjylland

Hormonal diseases

Denmark

20/04/2026

Phase IV

Effects of CLADribine tablets on the Immune Synapse, in Relapsing Multiple Sclerosis (RMS) patients_CLADIS.

2025-521910-24-00Multiple Sclerosis

DrugCladribine

Aristotle University Of Thessaloniki

Nervous System Diseases

Greece

17/04/2026

Phase IV

CoCo3 - Comprehensive Health Effects of Combined Contraceptives: a 12-month randomized, controlled, open-label trial of E4+DRSP, EE20μg+DRSP and DRSP-only

2025-523359-71-00Contraception

Pohjois-Pohjanmaan hyvinvointialue, University Of Oulu

Reproductive and Urinary Physiological Phenomena

Finland

17/04/2026

Phase IV

OPTIMAL CARE WITH GUSELKUMAB IN CROHN’S DISEASE

2025-524573-16-00Crohn's disease

i-GETAID

Digestive System Diseases

France

16/04/2026

Phase IV

A low-intervention randomised, double-blind, placebo-controlled pilot trial evaluating the feasibility, tolerability and adherence of alternate-day oral Duroferon (ferrous sulphate) in adolescent girls with iron deficiency, and the diagnostic performance of the IRON-5 screening tool (IRONGIRLS-PILOT).

2025-522498-12-00iron deficiency in adolescent girls

Region Skane

Not possible to specify

Sweden

14/04/2026

Phase IV

A single-center, randomized, single-blind, phase 4 study to evaluate the enhancement of mucosal immunity in infants through maternal vaccination during breastfeeding (MEALAC-01).

2025-524862-12-00Measles

DrugYellow fever vaccine

Universite Libre de Bruxelles

Virus Diseases

Belgium

14/04/2026

Phase IV

Methotrexate in paediatric and adolescent Crohn’s disease: an observational study

2025-524129-42-00Crohn’s disease

Amsterdam UMC Stichting

Digestive System Diseases

Netherlands

11/04/2026

Phase IV

Pilot Study - Safety and Efficacy of Dalbavancin in Early Outpatient Treatment of Erysipelas and Limited Cellulitis

2025-524877-18-00Acute bacterial skin and skin structure infection (ABSSSI) …

DrugDalbavancin

Gemeinnutzige Salzburger Landes kliniken Betriebsgesellschaft mbH

Skin and Connective Tissue Diseases

Austria

07/04/2026

Phase IV

Application of radiomics in molecular imaging (18F-FDG-PET/CT) for diagnosis and follow-up of cardiovascular device infections: PREDICT study

2025-524624-21-00Cardiovascular device infections

Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer

Virus Diseases

Spain

07/04/2026

Phase IV

Standard dosed abiraterone versus Therapeutic Drug Monitoring guided abiraterone dosing – The Adapt Abi trial

2025-524440-35-00metastatic castration resistant prostate cancer (mCRPC)

Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting

Neoplasms

Netherlands

07/04/2026

Phase IV

GLIFLOFASTER : EARLY GLIFLOZIN TREATMENT IN ELDERLY PATIENT HOSPITALIZED FOR DECOMPENSATED CHRONIC HEART FAILURE ADMITTED IN THE EMERGENCY ROOM - A FEASIBILITY STUDY

2025-521101-40-00CHRONIC DECOMPENSATED HEART FAILURE

Centre Hospitalier Regional Universitaire

Cardiovascular Diseases

France

31/03/2026

Phase IV

Combined impact of cardiovascular polypill treatment and a specific nurse education program on adherence to therapy in patients with ACS: a randomized study

2025-524751-32-00Acute coronary syndrome

Fundacion Epic

Cardiovascular Diseases

Spain

30/03/2026

Phase IV

Healing Diabetic Foot Ulcers with Semaglutide

2025-524738-24-00Diabetic foot ulcer

Radboud universitair medisch centrum Stichting

Cardiovascular Diseases

Netherlands

30/03/2026

Phase IV

Identification of mitochondrial biomarkers reflecting omaveloxolone treatment (in FA patients)

2025-523881-26-00Friedreich's ataxia

Fakultni Nemocnice V Motole

Nervous System Diseases

Czechia, Poland

30/03/2026

Phase IV

TheRapeutic StrAtegies for Obstructive SleeP Apnea in Older Adults with OverweigHt or Obesity: A RandomizEd Clinical TriaL (RAPHAEL study)

2025-524819-37-00obstructive sleep apnea

DrugSemaglutide

Institut De Recerca Biomedica De Lleida Fundacio Dr. Pifarre

Respiratory Tract Diseases

Spain

30/03/2026

Phase IV

Evidence based empirical antibiotic treatment for urinary tract infections requiring hospitalisation - TRI-AB trial

2024-520251-24-00Complicated urinary tract infections (cUTI) requiring hospi…

Odense University Hospital

Bacterial Infections and Mycoses

Denmark

27/03/2026

Phase IV

Dexamethasone for the treatment of traumatic brain injured patients with brain contusions and pericontusional edema: Study protocol for a prospective, randomized and double blind trial

2025-520887-17-00Post-traumatic brain contusion with edema

University Hospital Son Espases

Nervous System Diseases

Spain

26/03/2026

Phase IV

Randomized, multicenter, open-label clinical trial to evaluate the clinical and microbiological impact of methenamine hippurate as an alternative prophylaxis to antibiotics in the management of recurrent urinary tract infections in women

2025-523922-42-00recurrent urine infections

Consorci Mar Parc De Salut De Barcelona

Female Urogenital Diseases and Pregnancy Complications

Spain

25/03/2026

Phase IV

Non-inferiority study of TOCILIZUMAB in dose-banding versus dose-weight in rheumatoid arthritis with low activity or clinical remission

2025-522319-41-00rheumatoid arthritis

DrugTocilizumab

Centre Hospitalier Universitaire De Nice

Musculoskeletal Diseases

France

24/03/2026

Phase IV

Fludarabine exposure in patients undergoing Fludarabine based lymphodepletion prior to CAR-T cell therapy

2025-524278-40-00Patients undergoing Fludarabine based lymphodepletion prior…

Universitair Ziekenhuis Gent

Hemic and Lymphatic Diseases

Belgium

23/03/2026

Phase IV

Direct comparison of Tezepelumab and Dupilumab in CRSwNP in a real world setting

2025-524495-39-00Chronic Rhinosinusitis with Nasal Polyps

DrugsTezepelumab·Dupilumab

Medical University Of Vienna

Otorhinolaryngologic Diseases

Austria

22/03/2026

Phase IV

GUselkumAb inteRvention and DIet evaluAtioN for pouchitis

2025-521683-35-00Pouchitis

UZ Leuven

Nutritional and Metabolic Diseases

Belgium

19/03/2026

Phase IV

Efficacy and safety of pharmacological therapy of obesity in liver transplant candidates

2026-526044-12-00Obesity

DrugTirzepatide

Institute For Clinical And Experimental Medicine

Digestive System Diseases

Czechia

18/03/2026

Phase IV

Use of half the iodinated contrast medium for monitoring thoracic neoplasms using spectral CT: Randomized, crossover, non-inferiority clinical trial

2025-524901-33-00Thoracic neoplasm

Fundacion De La Comunitat Valenciana Para La Gestion Del Instituto De Investigacion Sanitaria Y Biomedica De Alicante

Diagnosis

Spain

17/03/2026

Phase IV

Cholesterol lowering with atorvastatine for the prevention of gallstones following bariatric surgery (CHOLSTONE): an investigator- blinded randomised controlled trial

2025-524191-38-00Gallstones (chole(cysto)lithiasis) following bariatric surg…

DrugAtorvastatin

Spaarne Gasthuis Stichting

Nutritional and Metabolic Diseases

Netherlands

17/03/2026

Phase IV

PREDICTION OF COMPLICATIONS IN PATIENTS UNDERGOING SURGICAL TREATMENT OF HEPATIC TUMORS

2025-524477-17-00Hepatic tumor, Hepatic tumor(s)

Rigshospitalet

Neoplasms

Denmark

17/03/2026

Phase IV

Evaluating the clinical effectiveness of sodium bicarbonate for critically ill patients with metabolic acidosis and acute kidney injury

2025-523914-10-00Critical illness, Acute kidney injury, Metabolic acidosis

Universitaet Muenster

Nutritional and Metabolic Diseases

Germany

17/03/2026

Phase IV

The POST-PRANDIAL HYPO-AVOID STUDY Low-Dose Glucagon and Automated Insulin Delivery for Prevention of Spontaneous Exercise-Induced Hypoglycemia in People with Type 1 Diabetes

2025-523996-45-00Type 1 Diabetes Mellitus

Steno Diabetes Center Copenhagen

Hormonal diseases

Denmark

16/03/2026

Phase IV

The effect of Broncho-Vaxom on the COPD exacerbations in terms of lung function, lung mechanics, immune state, body composition, quality of life and physical activity.

2025-524501-32-02COPD exacerbation

Semmelweis University, University Of Pecs

Respiratory Tract Diseases

Hungary

13/03/2026

Phase IV

Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial Spondyloarthritis (UP-FOR-U)

2025-522118-21-00Axial Spondyloarthritis, Acute Anterior Uveitis

DrugUpadacitinib

Care Arthritis Ltd.

Eye Diseases

Spain, Poland, Netherlands, France, Bulgaria, Germany

13/03/2026

Phase IV

GASPS Study: General Anaesthesia vs Spinal anaesthesia: Patient outcomes and Success in Outpatient primary total knee and hip Arthroplasty

2024-520127-89-00Total knee and hip arthroplasties

DrugsRemifentanil·Sufentanil·Fentanyl·Bupivacaine

Region Oerebro Laen

Surgical Procedures, Operative

Sweden

12/03/2026

Phase IV

ILHEP : Effect of perioperative Intravenous Lidocaine on postoperative opioid related-side effects after open HEPatectomy: a multicentre prospective randomized controlled study

2025-522462-73-00Postanesthetic complications in patients undergoing open he…

DrugLidocaine

Centre Hospitalier Universitaire De Rennes

Anesthesia and Analgesia

France

10/03/2026

Phase IV

Luteal phase support following letrozole treatment in women undergoing intrauterine insemination: a multicenter randomized trial

2025-524327-53-00Infertility

Region Midtjylland

Not possible to specify

Denmark

09/03/2026

Phase IV

Botulinum toxin in open abdomen closure. A multicentric randomized controlled single-blind clinical trial to evaluate the efficacy of early administration of botulinum toxin for primary midline closure in patients with an open abdomen.

2025-522410-23-00open abdomen

Hospital Universitario La Paz

Not possible to specify

Spain

04/03/2026

Phase IV

Intrathecal drug delivery systems versus comprehensive medical management for severe cancer pain: a randomized controlled trial

2025-522381-68-00Severe refractory cancer pain

Vrije Universiteit Brussel

Anesthesia and Analgesia

Belgium

04/03/2026

Phase IV

A Pragmatic Randomized Trial to Evaluate the Effect of Recombinant Herpes Zoster Vaccine on Major Adverse Cardiovascular Events and Dementia in Adults Aged 65 Years or Above

2025-524944-37-00Herpes Zoster

Gentofte Hospital, GlaxoSmithKline Biologicals

Skin and Connective Tissue Diseases

Denmark

04/03/2026

Phase IV

Impact of Early Thyroid Hormone Replacement on Kidney Function and Health-Related Quality of Life in Patients at Risk of Postoperative Hypothyroidism after Hemithyroidectomy: A Randomised Controlled Trial

2025-524175-23-00Hypothyroidism, Incident Kidney Dysfunction, Chronic Kidney…

Region Midtjylland

Otorhinolaryngologic Diseases

Denmark

03/03/2026

Phase IV

A multicentre randomized double-blind placebo-controlled 48-week superiority study to compare the efficacy and safety of rituximab versus placebo in rheumatoid arthritis-associated interstitial lung disease - the BELLRA trial.

2025-524872-51-00Rheumatoid arthritis-associated interstitial lung disease (…

Vaestra Goetalandsregionen

Immune System Diseases

Sweden

27/02/2026

Phase IV

A multi-center, open label, longitudinal, observational, 12-week study of Flexilev treatment with the dosing device OraFID and accompanying digital app in Parkinson patients.

2025-524296-23-01Parkinsons Disease

Navamedic AB

Nervous System Diseases

Sweden

24/02/2026

Phase IV

Effect of Romosozumab vs. Denosumab on Coronary Atherosclerotic Damage in Postmenopausal Osteoporotic Women: A Phase IV, Low-Risk, Pharmacological Intervention Study. ATRIO Study.

2025-522592-29-00Coronary atherosclerotic status in women with postmenopausa…

DrugsRomosozumab·Denosumab

Ospedale Galeazzi S.p.A.

Musculoskeletal Diseases

Italy

23/02/2026

Phase IV

CANIDIAP; CANagliflozin In DIAlysis Patients

2025-522742-46-00Chronic Kidney disease

DrugCanagliflozin

Universitair Medisch Centrum Groningen

Not possible to specify

Netherlands

23/02/2026

Phase IV

Efficacy and tolerability of a simethicone-containing evacuating solution for colorectal cancer screening colonoscopy: a randomized parallel comparative trial. CLEAN+

2025-523748-11-00colorectal cancer early detection

Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer

Digestive System Diseases

Spain

20/02/2026

Phase IV

Two initial aflibercept 8 mg loading doses in treatment-naive neovascular AMD

2025-523478-17-00Neovascular age-related macular degeneration

DrugAflibercept

Medical University Of Graz

Eye Diseases

Austria

16/02/2026

Phase IV

Changes in the wound microbiome and their impact on chronic wound healing under hyperbaric conditions

2025-523863-39-00chronic wounds

Medical University Of Graz

Skin and Connective Tissue Diseases

Austria

16/02/2026

Phase IV

A randomized, placebo controlled, observer-blind, phase IV pragmatic trial to evaluate the effect of Recombinant Zoster Vaccine (Shingrix®) on incident dementia diagnosis in an older adult population aged ≥76 years in Finland

2025-524598-17-00Incident dementia

GlaxoSmithKline Biologicals

Nervous System Diseases

Finland

16/02/2026

Phase IV

An interventional, Open-label Study to Evaluate the effect of lebrikizumab on eczema and Skin Barrier Function parameters in lesional and non-lesional skin in Adults and Adolescents with Moderate to Severe Atopic Dermatitis

2024-519811-32-00Atopic dermatitis

DrugLebrikizumab

Region Oestergoetland

Skin and Connective Tissue Diseases

Sweden

12/02/2026

Phase IV

Long-term Safety Outcomes in Patients Treated With Replimune Oncolytic Immunotherapy Products

2025-521621-33-00Hepatocellular Carcinoma, Metastatic Melanoma, Melanoma, Ad…

Replimune Group Inc.

Neoplasms

Germany, Greece, France, Poland, Spain

09/02/2026

Phase IV

Caffeine Administration for Preterms: Pharmacokinetics, Utilization and Correlation Inhibiting Nociception Outcome

2025-523475-33-00Primary apnea in preterms newborns

Masarykova Univerzita

Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Czechia

09/02/2026

Phase IV

(23026) A prospective, single-arm, Phase 4 study to evaluate the course of serum transthyretin (TTR) level with acoramidis in adult patients with variant or wild-type transthyretin amyloidosis with cardiomyopathy (ATTR-CM) previously treated with tafamidis.

2025-521831-35-00Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Bayer Consumer Care AG

Cardiovascular Diseases

Austria, Germany, Italy, Belgium

07/02/2026

Phase IV

The effect of anifrolumab on cutaneous lupus erythematosus characterized by the change of the inflammatory infiltrate analyzed by immunohistochemistry, spatial transcriptomics and single-cell RNA- and TCR-sequencing as well as on the clinical outcome - an open label, single arm phase IV pilot study

2025-523133-26-00cutaneous lupus erythematosus

Medical University Of Vienna

Skin and Connective Tissue Diseases

Austria

07/02/2026

Phase IV

Rapid Oral Switch in Infectious Endocarditis, the ROSIE trial

2025-524484-20-00Infective Endocarditis

UZ Leuven

Bacterial Infections and Mycoses

Belgium

06/02/2026

Phase IV

A Randomized, Non-inferiority Trial Comparing 7-Day Versus 4-Week Esomeprazole Treatment in Patients with Unexplained Dyspepsia

2025-524044-35-00Dyspepsia

Landspitali

Digestive System Diseases

Iceland

06/02/2026

Phase IV

Adductor canal and IPACK (infiltration between the popliteal artery and the capsule of the knee) blocks versus genicular nerves block for total knee arthroplasty: A randomized clinical trial

2025-523071-34-00Knee Osteoarthritis

Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer

Musculoskeletal Diseases

Spain

06/02/2026

Phase IV

Efficacy of MIrikizumab to achieve traNsmural healing in patiENTs with Crohn’s Disease : EMINENT CD

2025-521889-95-00Crohn's Disease

Groupe D'etude Therapeutique Des Affections Inflammatoires Du Tube Digestif

Digestive System Diseases

France

05/02/2026

Phase IV

Changes in Coronary Plaque Composition By Semaglutide Use in Diabetic Patients With Acute Coronary Syndrome: A Randomized Optical Coherence Tomography Trial - ARMYDA - 10 study

2025-523977-40-00diabetes mellitus, ST-elevation myocardial infarction (STEM…

DrugSemaglutide

Azienda Ospedaliero-Universitaria Maggiore Della Carita

Cardiovascular Diseases

Italy

28/01/2026

Phase IV

Tailored antiplatelet secondary prevention in non-cardioembolic ischemic stroke: a phase IV gender-stratified randomized controlled trial (TAILOR trial)

2025-523065-16-00Non-cardioembolic ischemic stroke

Azienda Unita Sanitaria Locale Di Bologna

Cardiovascular Diseases

Italy

28/01/2026

Phase IV

Multicentre, open-label, randomized controlled non-inferiority trial comparing single dose intrathecal morphine and continuous thoracic epidural analgesia for multimodal analgesia in open colorectal surgery: the ColoREDIT protocol

2024-520262-58-01All diseases requiring resective colorectal surgery with a …

DrugsFentanyl·Morphine·Bupivacaine

Region Vaestmanland

Anesthesia and Analgesia

Sweden

28/01/2026

Phase IV

EFFICACY OF INFILTRATED MEPIVACAINE AS A LOCAL ANESTHETIC PRIOR TO ARTERIAL PUNCTURE: A RANDOMIZED CONTROLLED CLINICAL TRIAL

2025-522974-35-00Respiratory disease. Prescripcion o indicación de gasometrí…

University Of The Basque Country

Respiratory Tract Diseases

Spain

28/01/2026

Phase IV

The efficacy of pipamperone and aripiprazole on behaviors that challenge in people with intellectual disabilities: A series of N-of-1 cross-over trials

2024-519833-51-00Behaviors that challenge

Stichting GGZ Drenthe

Behavioral Disciplines and Activities

Netherlands

28/01/2026

Phase IV

Exploring the Psychoactive Effects of Paracetamol: A parallel group, basic science, double blind, two armed study, to investigate potential emotional and cognitive effects of paracetamol (tablet form) compared to a placebo (tablet form) in healthy male and female participants between ages 18 and 30.

2025-522753-19-02Healthy adults aged 18-30.

DrugParacetamol

Oslo Metropolitan University

Psychological Phenomena

Norway

27/01/2026

Phase IV

Intrathecal baclofen pump versus selective dorsal rhizotomy for non-ambulatory children with cerebral palsy

2024-518822-33-01Cerebral Palsy

DrugBaclofen

UZ Leuven

Nervous System Diseases

Netherlands, Belgium

27/01/2026

Phase IV

Early Lyophilised plasma In Patients with haemorrhagic Shock (ELIPS-Trial)

2025-523151-66-00Haemorrhagic shock

Johannes Kepler University Linz

Anesthesia and Analgesia

Austria

26/01/2026

Phase IV

Morphine PCA vs Morphine and Lidocaine PCA for the treatment of vaso-occlusive crisis-related pain in sickle-cell anaemia patients: a prospective, randomized, double blind monocentric trial.

2025-523777-41-01sickle cell anaemia

DrugsMorphine·Lidocaine

CHU Saint Pierre

Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Belgium

26/01/2026

Phase IV

A multicenter, prospective clinical TRrial evaluating patient’s ability to make an independent and safe decision regarding the USe of the medicinal product Sildenafil Polpharma100 mg indicated in the Treatment of erectile dysfunction. TRUST Trial on Responsible Use and Self-assessed Treatment.

2025-522923-81-00Erectile dysfunction

ZAKLADY FARMACEUTYCZNE POLPHARMA S.A.

Male Urogenital Diseases

Poland

26/01/2026

Phase IV

The effect op corticosteroids on quality of life following total hip arthroplasty: HIPSTER study

2025-524368-39-00Patients aged 60 years or older undergoing total hip arthro…

Ziekenhuis Oost Limburg

Anesthesia and Analgesia

Belgium

21/01/2026

Phase IV

International multicentre, open-label, phase IV clinical trial to evaluate the efficacy, safety and effect on quality of life of bilastine in children with allergic rhinoconjunctivitis

2024-519550-36-00Allergic rhinoconjunctivitis

Faes Farma S.A., A. Menarini Industrie Farmaceutiche Riunite S.r.l.

Immune System Diseases

Poland, Spain, Italy

19/01/2026

Phase IV

The impact of extra-fine inhalation corticosteroid particles on small-airway disease in Chronic Obstructive Pulmonary Disease (COPD): a randomized, prospective cross-over trial.

2025-524256-64-00Chronic Obstructive Pulmonary Disease

CHU Saint Pierre

Respiratory Tract Diseases

Belgium

19/01/2026

Phase IV

Arthritis interception with Guselkumab in subclinical psoriatic arthritis patients in clinical transition from skin to joint disease: a randomized clinical trial.

2025-523551-54-00PSORIATIC ARTHRITIS PATIENTS IN CLINICAL TRANSITION

DrugsCiclosporin·Guselkumab

Azienda Sanitaria Universitaria Friuli Centrale

Musculoskeletal Diseases

Italy

14/01/2026

Phase IV

BudapestICIVasc: Cardiovascular side effects of immune checkpoint inhibitor oncological therapies and their monitoring in the context of onco-cardiology

2025-523620-44-02non small cell lung cancer (NSCLC), renal cell carcinoma, s…

Semmelweis University

Neoplasms

Hungary

14/01/2026

Phase IV

A multicenter randomized, controlled, single-blind, adaptive phase IV clinical trial to evaluate the efficiency and effectiveness of a pre-emptive pharmacogenetic strategy for antidepressant selection in patients with depressive disorder: The PREDICT adaptive clinical trial.

2025-522967-13-00Depressive disorder

DrugsAmitriptyline·Citalopram

Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Paz

Mental Disorders

Spain

11/01/2026

Phase IV

Next Generation StaR TREC - Save the rectum by watchful waiting after (chemo)Radiotherapy or Total mesorectal excision for early REctal Cancer?

2025-522955-25-00Rectal cancer

DrugCapecitabine

Vaestra Goetalandsregionen

Neoplasms

Sweden

09/01/2026

Phase IV

DOSABEMA-Pharmacokinetic model of abemaciclib: correlation with severe diarrhea as the primary toxicity endpoint in patients with hormone receptor-positive localized breast cancer

2025-521696-31-00HR+, HER2- breast cancer at high risk of recurrence

DrugAbemaciclib

Centre Hospitalier Universitaire De Poitiers

Neoplasms

France

06/01/2026

Phase IV

Impact of EXercise on quality of life of early breast cancer patients on treatment with adjuvant Aromatase Inhibitors with or without CDK4/6 inhibitors. "The EX-AI study"

2025-522848-40-00Early Breast Cancer

Fundacion Grupo Espanol De Investigacion En Cancer De Mama

Neoplasms

Spain

29/12/2025

Phase IV

HYDrochlorothiazidE compared to valsartan to treat arterial hypertension in patients with Hypertrophic obstructive CardioMyopathy – the multicenter, randomized, double-blind, controlled, crossover HYDE-HCM Trial

2024-520086-31-00Hypertrophic cardiomyopathy

Medical University Of Graz

Cardiovascular Diseases

Austria

29/12/2025

Phase IV

Phase IV open-label clinical trial of the immunogenicity and safety of standard dose trivalent inactivated influenza vaccine (Influvac) in a population of people with obesity

2025-522698-13-00Influenza, Obesity, Type 2 diabetes

Region Stockholm – SLSO

Virus Diseases

Sweden

23/12/2025

Phase IV

TRAMORNOT: Tramadol versus morphine in postoperative analgesia after laparoscopic abdominal surgery: a randomized controlled trial

2025-523327-21-00Postoperative pain following scheduled major laparoscopic a…

DrugsTramadol·Morphine

Centre Hospitalier Universitaire Amiens Picardie

Anesthesia and Analgesia

France

22/12/2025

Phase IV

(ASK-PD0-CS002) Long-Term Safety and Efficacy Follow-up of AB-1005 Gene Transfer Study Participants with Parkinson’s Disease or Multiple System Atrophy

2025-522653-19-00Multiple System Atrophy, Parkinson's Disease

DrugPiflufolastat

Askbio Inc.

Nervous System Diseases

Poland

22/12/2025

Phase IV

Phase IV, single-center, randomized, crossover clinical trial to validate the use of gadopiclenol versus gadobutrol in the evaluation of magnetic resonance imaging (MRI) diagnosis of perianal fistula associated with Crohn's disease

2025-523278-18-00Perianal fistula associated with Crohn's disease

DrugGadobutrol

Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca

Diagnosis

Spain

18/12/2025

Phase IV

Evaluation of postoperative recovery when combining intravenous lidocaine with ropivacaine infiltration in laparoscopic colorectal oncologic surgery: a randomized controlled trial

2025-523207-29-00colorectal cancer laparoscopic surgery

Centre Hospitalier Universitaire Amiens Picardie

Not possible to specify

France

17/12/2025

Phase IV

Waiting on Atrial fibrillation Intervention Therapy (WAIT) Study

2025-524182-25-00Atrial fibrillation

DrugSemaglutide

Karolinska University Hospital

Cardiovascular Diseases

Sweden

17/12/2025

Phase IV

Assessing residual inflammation and macrophage presence in lupus nephritis after 3 months of intensified treatment with prednisolone, mycofenolate mofetil and voclosporin as compared to mycofenolate mofetil and prednisolone: an open label randomized controlled trial (MAPLE study)

2025-522187-32-01Lupus Nephritis

Amsterdam UMC Stichting

Immune System Diseases

Netherlands

15/12/2025

Phase IV

EFFICACY OF FARICIMAB IN PATIENTS WITH SUBRETINAL HYPERREFLECTIVE MATERIAL ASSOCIATED WITH TYPE 2 OR MIXED NEOVASCULAR MEMBRANES ASSESSED BY MULTIMODAL IMAGING

2025-522701-38-00SUBRETINAL HYPERREFLECTIVE MATERIAL

Asociacion Instituto De Investigacion Sanitaria Biobizkaia

Eye Diseases

Spain

15/12/2025

Phase IV

The effect of transdermal 17-β-estradiol/progesterone supplementation on glucose regulation in peri- and postmenopausal women with type 1 and type 2 diabetes

2025-523214-83-00Diabetes Mellitus, (peri) Menopause

Amsterdam UMC Stichting

Hormonal diseases

Netherlands

15/12/2025

Phase IV

The effect of early Landiolol in patients with ST-elevation acute coronary syndrome undergoing primary percutaneous coronary intervention – A prospective, randomized, double- blinded, placebo controlled, phase IV pilot trial (STEMILAND-1)

2025-523676-23-00ST-elevation acute coronary syndrome

DrugLandiolol

Medical University Of Vienna

Cardiovascular Diseases

Austria

14/12/2025

Phase IV

A randomized, double-blind, placebo-controlled, multicentre trial, assessing the impact of ferric carboxymaltose on exercise capacity and functional status in pulmonary hypertension (IRON-PH)

2025-522936-14-00Pulmonary hypertension, Iron deficiency

Ziekenhuis Oost Limburg

Cardiovascular Diseases

Belgium

12/12/2025

Phase IV

COPD-2VAX: Enhancing Protection Against Respiratory Infections Through AS01-Mediated Innate Immune Activation in High-Risk Patients

2024-519163-18-00Chronic Obstructive Pulmonary Disease (COPD)

Nordsjaellands Hospital

Virus Diseases

Denmark

08/12/2025

Phase IV

Evaluation of the persistency of the preoperative anxiolytic effect of music therapy vs midazolam: electroencephalographic and clinical analysis

2025-522575-29-00Preoperative anxiety

Consorci Mar Parc De Salut De Barcelona

Anesthesia and Analgesia

Spain

05/12/2025

Phase IV

Herpes zoster after recombinant herpes zoster vaccination - Immediate post-RHZ-vaccination evolution of CMI, HMI and lymphocyte count and typing.

2025-521547-20-00Herpes Zoster virus prevention

Centre hospitalier universitaire de Liege

Virus Diseases

Belgium

04/12/2025

Phase IV

Phase IV, open-label, randomized clinical trial on the effect of intravenous iron on quality of life in elderly patients with Acute Coronary Syndrome.

2025-522421-36-00Acute coronary syndrome

Instituto De Investigacion Sanitaria Fundacion Para La Investigacion Del Hospital Clinico De Valencia-INCLIVA

Cardiovascular Diseases

Spain

03/12/2025

Phase IV

Impact of influenza vaccination on nasal resident memory immune responses and respiratory peripheral memory immune responses - MUCOVAC 2

2025-521217-46-00Adults seeking active immunisation against the seasonal inf…

Centre Hospitalier Universitaire De Saint Etienne

Virus Diseases

France

02/12/2025

Phase IV

Rapid sequence emergence of general Anaesthesia

2024-516415-24-03General anesthesia

DrugsFlumazenil·Rocuronium·Sugammadex·Remimazolam

Stichting Radboud universitair medisch centrum

Anesthesia and Analgesia

Netherlands

02/12/2025

Phase IV

Duration of Surfactant administration and impact on Stabilisation of vital parameters in very preterm neonates: 1 minute versus 5 minutes – a prospective randomised-controlled phase IV trial

2025-522754-39-00Neonatal respiratory distress syndrome

Medical University Of Graz

Respiratory Tract Diseases

Austria

01/12/2025

Phase IV

Erector Spinae Plane Block for acute low back pain: a prospective double-blind randomized multicenter study. ESP-BACK

2024-511595-32-00Acute low back pain

DrugsKetoprofen·Tramadol·Paracetamol·Ropivacaine

Centre Hospitalier Universitaire De Montpellier

Anesthesia and Analgesia

France

26/11/2025

Phase IV

A Phase 4 Pragmatic, Randomized Trial to Evaluate the Effectiveness and Safety of mRNA-1273 Variant-Containing Vaccine Formulation Against Severe Outcomes in Adults Aged 50-64 Years Without Risk Factors for Severe COVID-19 (DAN-COVID)

2025-523841-82-00SARS-CoV-2 infection

Gentofte Hospital, Moderna Inc.

Virus Diseases

Denmark

26/11/2025

Phase IV

Comparison of morphine and alfentanil in the emergency treatment of severe acute pain in the pre-hospital setting

2025-522817-50-00Severe pain

DrugMorphine

CHU De Martinique

Population Characteristics

France

24/11/2025

Phase IV

Optimization of pain management for acute renal colic in the Emergency Department – The OPTIMIZED trial

2025-521316-19-00Urolithiasis

Leids Universitair Medisch Centrum (LUMC)

Anesthesia and Analgesia

Netherlands

21/11/2025

Phase IV

Pharmacological optimization in prevention in Heart Failure: A Sex-gap? (PopS-HF Trial)

2025-520660-18-00Heart Failure

Policlinico San Donato S.p.A.

Cardiovascular Diseases

Italy

17/11/2025

Phase IV

Enhancing Lung Health in Kids with structural Lung Damage and Malformations: a randomized controlled trial on Azithromycin (AZI) for Airway Infection Prevention

2024-518730-88-00Post-Vascular Ring with central airway compression, Bronchi…

Rigshospitalet

Respiratory Tract Diseases

Denmark

14/11/2025

Phase IV

Remimazolam versus propofol for deep sedation during Endoscopic Ultrasound (EUS) procedures. A randomized controlled trial.

2025-521784-12-00Gastric and pancreatic cancer

Ospedale San Raffaele S.r.l.

Digestive System Diseases

Italy

11/11/2025

Phase IV

A prospective, randomized, controlled clinical pilot trial investigating the partial down-titration of guideline-directed medical therapy in patients with heart failure in remission

2025-522560-32-01Heart failure in remission

Ziekenhuis Oost Limburg

Cardiovascular Diseases

Belgium

10/11/2025

Phase IV

Nitraattien vaikutus matalapaineglaukoomassa

2025-522059-24-00Normal tension glaucoma

University Of Helsinki

Eye Diseases

Finland

06/11/2025

Phase IV

Is magnesium sulfate an alternative with an analgesic and safety profile equivalent to dexmedetomidine as an adjuvant to ropivacaine in erector block in mastectomy?

2025-523152-31-00Breast cancer

Fundacion Para El Fomento De La Investigacion Sanitaria Y Biomedica De La Comunitat Valenciana

Neoplasms

Spain

03/11/2025

Phase IV

Post-operative analgesia and spinal block duration following total hip arthroplasties - comparison of single-shot intrathecal ropivacaine, and bupivacaine: a randomized, double blinded controlled study

2025-522358-38-02Hip osteoarthrosis and postoperative pain

Turku University Hospital

Musculoskeletal Diseases

Finland

31/10/2025

Phase IV

LIVER AKI: A randomized, open-label trial to evaluate the efficacy of intravenous human albumin administration versus saline solution (NaCl 0.9%) in patients with decompensated cirrhosis and AKI 1B or grater.

2025-521457-16-00descompensated hepatic cirrosis

Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer

Digestive System and Oral Physiological Phenomena

Spain

29/10/2025

Phase IV

PROlonged versus Single dose in PEnicillin oral Challenge Testing double-blind parallel randomized placebo cOntrolled tRial – PROSPECTOR-2 Study

2025-520888-41-00Penicillin allergy

Gentofte Hospital, Austin Health

Immune System Diseases

Belgium, Denmark

28/10/2025

Phase IV

A Phase IV, open label, single arm trial to assess the safety and immunogenicity of BIMERVAX® LP.8.1 against SARS-CoV-2 variants.

2025-524021-41-00COVID-19

Hipra Scientific S.L.

Virus Diseases

Spain

27/10/2025

Phase IV

Long-term muscle synthetic effects of intradialytic parenteral nutrition in chronic hemodialysis patients

2025-522111-42-02muscle protein turnover hemodialysis

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

Nutritional and Metabolic Diseases

Netherlands

27/10/2025

Phase IV

Effect of Semaglutide on embryo quality in overweight and obese patients undergoing In Vitro Fertilization. A Randomized Controlled Trial

2025-522525-34-00Infertility

Santiago Dexeus Font Fundacio Privada

Female Urogenital Diseases and Pregnancy Complications

Spain

24/10/2025

Phase IV

The Role of Beta-Blockade During Cardiac CT in Patients with Atrial Fibrillation

2025-523391-22-01Atrial fibrillation, Coronary artery disease

Semmelweis University

Cardiovascular Diseases

Hungary

22/10/2025

Phase IV

F-puff_SE_2024

2024-519131-42-02PAIN MANAGEMENT

DrugFentanyl

Semmelweis University

Not possible to specify

Hungary

22/10/2025

Phase IV

ENDO-67 project: Investigating ENDOcrine therapy-related questions using Ki67 changes in the window-of-opportunity before breast surgery

2025-521385-10-00Breast cancer

DrugTamoxifen

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

Neoplasms

Netherlands

21/10/2025

Phase IV

MetAddon: Methadone as co-analgesic for patients with metastatic bone pain: a double-blind randomized controlled trial

2025-522710-22-00Cancer, bone metastasis, pain

Universiteit Maastricht

Neoplasms

Netherlands

20/10/2025

Phase IV

Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.

2024-516232-10-00Serious infections in critically ill patients treated with …

Centre Hospitalier Universitaire De Nimes

Bacterial Infections and Mycoses

France

17/10/2025

Phase IV

Steroids and/ or Non-steroidal Anti-inflammatory Drugs in the Postoperative Regime After Trabeculectomy. (SNAP)

2025-523957-32-00Medically uncontrolled glaucoma that requires filtration su…

Rigshospitalet

Eye Diseases

Denmark

17/10/2025

Phase IV

Inhaled corticosteroids in young children with episodic wheezing: a multicenter cluster RCT

2025-522694-11-00Episodic expiratory wheezing

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

Respiratory Tract Diseases

Netherlands

09/10/2025

Phase IV

Influence of patient’s morphological characteristics on pharmacokinetic and toxicity of trastuzumab-deruxtecan administered for metastatic breast cancers (TDXdose)

2025-522656-68-00Metastatic breast cancers

Oncopole Claudius Regaud

Neoplasms

France

08/10/2025

Phase IV

TIME-TO-LIA : Optimal Duration of Antibiotic Therapy in Drained Pyogenic Liver Abscess: 3 weeks versus 6 weeks, a non-inferiority trial

2025-520940-14-00Pyogenic liver abscess

DrugsDaptomycin·Colistin·Imipenem·Amikacin

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

06/10/2025

Phase IV

Phase IV multicenter immunogenicity and safety study of the Seqirus licensed zoonotic influenza vaccine (H5N8) in adults immunized with an H5N1/MF59 influenza vaccine, approximately 20 years before the trial, compared to H5 naive adult participants.

2025-522116-16-00Avian Influenza

University Of Antwerp

Virus Diseases

Italy, Belgium

06/10/2025

Cite this view

Priya Life Science (2026). EU Clinical Trials Register (CTIS), filtered. Derived from the EMA Clinical Trials Information System. Retrieved 7 November 2026. https://priyalifescience.com/clinical-trials-europe

Query this register directly

GET /api/export.php?register=trials-eu&format=json Try it now →

About this register

This register is built from the EU Clinical Trials Information System (CTIS), run by the European Medicines Agency: the single register for every trial authorised under the EU Clinical Trials Regulation (536/2014). CTIS held 12,788 trial records at the last sync on 07 Nov 2026, 03:17 UTC; this register shows the 2,557 most recently authorised of them, a stated recency window rather than the full archive. The list can be downloaded as CSV or JSON.

This page shows the 252 of those trials that match the filters currently applied.

How many clinical trials does CTIS hold?

CTIS held 12,788 trial records at the last sync. Of the 2,557 most recently authorised trials shown in this register, 789 are Phase III, and 252 match the filters currently applied. Trials are counted by authorisation, not by recruitment status, which CTIS does not publish in the same form as ClinicalTrials.gov.

Summary by phase

Trials by phase, 252 trials
Phase	Trials	Share
Phase IV	252	100%

Most active sponsors

Lead sponsors with the most trials
Lead sponsor	Trials
Region Hovedstaden	11
Amsterdam UMC Stichting	9
UZ Leuven	8
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer	6
Medical University Of Vienna	6
Medical University Of Graz	5
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)	4
Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca	4
Fundacion Para El Fomento De La Investigacion Sanitaria Y Biomedica De La Comunitat Valenciana	4
Oslo Universitetssykehus HF	4

Member states with the most trials

Member states by number of trials with a site there
Member state	Trials
Spain	57
France	36
Denmark	34
Netherlands	30
Belgium	25
Italy	25
Germany	21
Austria	16
Sweden	16
Poland	14

→

Browse trials by member state

Spain (1074) France (933) Germany (893) Italy (777) Poland (614) Netherlands (544) Belgium (453) Czechia (340) Denmark (316) Hungary (255) Greece (237) Bulgaria (217) Romania (217) Austria (216) Sweden (200)

→

Browse trials by condition

Advanced solid tumors (23) Atopic Dermatitis (19) Non-Small Cell Lung Cancer (15) Obesity (14) Parkinson’s disease (14) Multiple sclerosis (13) Rheumatoid arthritis (13) Ulcerative Colitis (12) Breast Cancer (11) Prostate Cancer (10)

Listing here is informational and not medical advice; eligibility is determined by each study team. Looking for Irish sites? See the Ireland, UK or USA registers. For approved medicines, see the EMA Approvals Tracker.