Impact of influenza vaccination on nasal resident memory immune responses and respiratory peripheral memory immune responses - MUCOVAC 2

Condition studied

Adults seeking active immunisation against the seasonal influenza virus

Investigational medicinal product(s)

Eligibility

Primary endpoint

Frequency of resident memory lymphocytes in the nasal mucosa and expression rate of migration markers towards the respiratory mucosa on peripheral memory lymphocytes before and after intramuscular influenza vaccination: variation in frequency between before and after vaccination

Endpoint detail

The frequencies of resident memory T and B lymphocytes in the nasal cavity and the percentage of migration markers specific to the respiratory mucosa expressed on peripheral memory T and B lymphocytes., Correlation coefficients between the frequency of nasal resident memory lymphocytes, the percentage of migration markers expressed on peripheral memory lymphocytes, as well as anti-Influenza titers and Influenza neutralising antibody titers in mucosa and serum, the systemic cellular response specific to Influenza and the percentage of expression of genes involved in the systemic immune response.