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TNF Inhibitors

Also called anti-TNF biologics, TNF blockers

TNF inhibitors were the first blockbuster biologics and they still anchor treatment across inflammatory disease. Tumour necrosis factor is a signalling protein that drives inflammation; mopping it up calms rheumatoid arthritis, psoriasis, inflammatory bowel disease and ankylosing spondylitis. They differ mainly in structure and dosing — some are fully human antibodies, one is a fusion protein, one is a PEGylated fragment — which affects how often they are injected and how they behave in pregnancy.

Reviewed by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from official FDA data · Last verified · Editorial standards
What this class is used for
Rheumatoid arthritis, psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis

5 TNF Inhibitors in this directory

Humira
Adalimumab
A widely used anti-TNF biologic for rheumatoid arthritis, psoriasis and Crohn's.
Enbrel
Etanercept
An anti-TNF biologic for rheumatoid arthritis and psoriasis.
Remicade
Infliximab
An anti-TNF infusion biologic for inflammatory bowel disease and arthritis.
Simponi
Golimumab
An injectable or intravenous biological therapy used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Cimzia
Certolizumab Pegol
An injectable biological therapy used to treat Crohn's disease, rheumatoid arthritis, and plaque psoriasis.

Compare TNF Inhibitors side by side

Humira VS Enbrel Humira VS Remicade Humira VS Simponi Humira VS Cimzia Enbrel VS Remicade Enbrel VS Simponi Enbrel VS Cimzia Remicade VS Simponi Remicade VS Cimzia Simponi VS Cimzia

Browse other drug classes

ARBs Anti-amyloid Antibodies Antibiotics Antibody-drug Conjugates Anticoagulants Anticonvulsants Antihistamines Antiplatelets Asthma & COPD Inhalers Atypical Antipsychotics BTK Inhibitors Beta Blockers CD20 Antibodies CDK4/6 Inhibitors CGRP Inhibitors COVID-19 Antivirals Checkpoint Inhibitors Cholinesterase Inhibitors Complement Inhibitors DPP-4 Inhibitors EGFR Inhibitors Enzyme Replacement Therapy GLP-1 Agonists Gene & Cell Therapies HIV Antiretrovirals Hepatitis C Antivirals IL-1 Inhibitors IL-17 Inhibitors IL-23 Inhibitors IL-5 Inhibitors IL-6 Inhibitors Insulins JAK Inhibitors PARP Inhibitors PCSK9 Inhibitors Proton Pump Inhibitors SGLT2 Inhibitors SSRIs & SNRIs Statins TTR Silencers Tyrosine Kinase Inhibitors

How this page is built

The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.

Plain-English summaries and drug-class explainers are written and reviewed by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 12 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.