TNF inhibitors were the first blockbuster biologics and they still anchor treatment across inflammatory disease. Tumour necrosis factor is a signalling protein that drives inflammation; mopping it up calms rheumatoid arthritis, psoriasis, inflammatory bowel disease and ankylosing spondylitis. They differ mainly in structure and dosing — some are fully human antibodies, one is a fusion protein, one is a PEGylated fragment — which affects how often they are injected and how they behave in pregnancy.
The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.
Plain-English summaries and drug-class explainers are written and reviewed by the Priya Life Science editorial team, led by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 28 Aug 2026.