Which JAK Inhibitors are available?

This directory covers 4: Rinvoq, Xeljanz, Olumiant, Jakafi.

JAK Inhibitors

Also called Janus kinase inhibitors, jakinibs

JAK inhibitors are oral small molecules that interrupt the Janus kinase signalling pathway, which many inflammatory cytokines share. Because they are tablets rather than injections, they offered the first real oral alternative to biologics in rheumatoid arthritis. Regulators in the US and EU have since added warnings about cardiovascular events, blood clots, serious infection and cancer, so they are generally used after a TNF inhibitor has failed.

What this class is used for

Rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, atopic dermatitis, myelofibrosis

4 JAK Inhibitors in this directory

Rinvoq

Upadacitinib

An oral daily medication used to treat rheumatoid arthritis, eczema, ulcerative colitis, and Crohn's disease.

Xeljanz

Tofacitinib

An oral JAK inhibitor for rheumatoid arthritis and ulcerative colitis.

Olumiant

Baricitinib

An oral daily medication used to treat rheumatoid arthritis, alopecia areata, and severe COVID-19.

Jakafi

Ruxolitinib

An oral medication used to treat bone marrow disorders like myelofibrosis and polycythemia vera.

Compare JAK Inhibitors side by side

Rinvoq VS Xeljanz Rinvoq VS Olumiant Rinvoq VS Jakafi Xeljanz VS Olumiant Xeljanz VS Jakafi Olumiant VS Jakafi

Browse other drug classes

ARBs Anti-amyloid Antibodies Antibiotics Antibody-drug Conjugates Anticoagulants Anticonvulsants Antihistamines Antiplatelets Asthma & COPD Inhalers Atypical Antipsychotics BTK Inhibitors Beta Blockers CD20 Antibodies CDK4/6 Inhibitors CGRP Inhibitors COVID-19 Antivirals Checkpoint Inhibitors Cholinesterase Inhibitors Complement Inhibitors DPP-4 Inhibitors EGFR Inhibitors Enzyme Replacement Therapy GLP-1 Agonists Gene & Cell Therapies HIV Antiretrovirals Hepatitis C Antivirals IL-1 Inhibitors IL-17 Inhibitors IL-23 Inhibitors IL-5 Inhibitors IL-6 Inhibitors Insulins PARP Inhibitors PCSK9 Inhibitors Proton Pump Inhibitors SGLT2 Inhibitors SSRIs & SNRIs Statins TNF Inhibitors TTR Silencers Tyrosine Kinase Inhibitors

Class descriptions are written by the Priya Life Science editorial team. Individual drug pages combine that summary with live label, approval, manufacturer and shortage data from the U.S. FDA via the openFDA API. This page is general information and is not medical advice — it is not exhaustive, drugs within a class are not automatically interchangeable, and approvals and brand names differ between the US, EU/Ireland (EMA/HPRA) and other regions. Always consult the official prescribing information and your clinician or pharmacist. Related: Drug Shortages Tracker · FDA Approvals · All drug comparisons