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SGLT2 Inhibitors

Also called gliflozins, sodium-glucose co-transporter 2 inhibitors

SGLT2 inhibitors work in the kidney, blocking the transporter that reabsorbs glucose back into the blood — so excess sugar leaves in the urine. They began as diabetes drugs, but large trials found they also protect the heart and kidneys, cutting hospitalisation for heart failure even in people without diabetes. That has made them a cornerstone of cardiology and nephrology as much as of diabetes care.

Reviewed by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from official FDA data · Last verified · Editorial standards
What this class is used for
Type-2 diabetes, heart failure, chronic kidney disease

3 SGLT2 Inhibitors in this directory

Jardiance
Empagliflozin
An oral therapy for type-2 diabetes, heart failure and kidney disease.
Farxiga
Dapagliflozin
An oral therapy for diabetes, heart failure and chronic kidney disease.
Invokana
Canagliflozin
An oral daily medication used to lower blood sugar in adults with type 2 diabetes.

Compare SGLT2 Inhibitors side by side

Jardiance VS Farxiga Jardiance VS Invokana Farxiga VS Invokana

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How this page is built

The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.

Plain-English summaries and drug-class explainers are written and reviewed by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 12 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.