SGLT2 inhibitors work in the kidney, blocking the transporter that reabsorbs glucose back into the blood — so excess sugar leaves in the urine. They began as diabetes drugs, but large trials found they also protect the heart and kidneys, cutting hospitalisation for heart failure even in people without diabetes. That has made them a cornerstone of cardiology and nephrology as much as of diabetes care.
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Plain-English summaries and drug-class explainers are written and reviewed by the Priya Life Science editorial team, led by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 28 Aug 2026.