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Complement Inhibitors

Also called C5 inhibitors, terminal complement blockers

The complement system is part of innate immunity — a cascade of proteins that punches holes in cells marked for destruction. In a handful of rare diseases it turns on the body's own red blood cells, nerves or kidneys. Complement inhibitors block the cascade at C5, before the damaging final step. They are transformative in these conditions, and they raise the risk of meningococcal infection, so vaccination beforehand is mandatory.

Reviewed by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from official FDA data · Last verified · Editorial standards
What this class is used for
Paroxysmal nocturnal haemoglobinuria (PNH), atypical HUS, myasthenia gravis, NMOSD

2 Complement Inhibitors in this directory

Soliris
Eculizumab
An intravenous biological therapy used to treat paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.
Ultomiris
Ravulizumab
An intravenous biological therapy administered every 8 weeks to treat rare blood and neurological disorders.

Compare Complement Inhibitors side by side

Soliris VS Ultomiris

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How this page is built

The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.

Plain-English summaries and drug-class explainers are written and reviewed by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 12 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.