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Antibody-Drug Conjugates (ADCs)

Also called ADCs, targeted chemotherapy

Antibody-drug conjugates are chemotherapy with a guidance system. A potent cytotoxic drug — too toxic to give on its own — is chemically tethered to an antibody that recognises a protein on the cancer cell surface. The antibody delivers the payload directly into the tumour cell, sparing healthy tissue. Each ADC is defined by three things: the target it homes in on, the payload it carries, and the linker holding them together.

What this class is used for
HER2-positive breast and gastric cancer, triple-negative breast cancer, lymphoma, bladder cancer

4 Antibody-drug Conjugates in this directory

Enhertu
Trastuzumab Deruxtecan
An intravenous targeted treatment for HER2-positive breast, lung, and stomach cancers.
Trodelvy
Sacituzumab Govitecan
An intravenous targeted treatment for advanced triple-negative breast cancer and bladder cancer.
Adcetris
Brentuximab Vedotin
An intravenous targeted therapy used to treat Hodgkin lymphoma and certain T-cell lymphomas.
Padcev
Enfortumab Vedotin
An intravenous targeted treatment for advanced urothelial (bladder) cancer.

Compare Antibody-drug Conjugates side by side

Enhertu VS Trodelvy

Browse other drug classes

ARBs Anti-amyloid Antibodies Antibiotics Anticoagulants Anticonvulsants Antihistamines Antiplatelets Asthma & COPD Inhalers Atypical Antipsychotics BTK Inhibitors Beta Blockers CD20 Antibodies CDK4/6 Inhibitors CGRP Inhibitors COVID-19 Antivirals Checkpoint Inhibitors Cholinesterase Inhibitors Complement Inhibitors DPP-4 Inhibitors EGFR Inhibitors Enzyme Replacement Therapy GLP-1 Agonists Gene & Cell Therapies HIV Antiretrovirals Hepatitis C Antivirals IL-1 Inhibitors IL-17 Inhibitors IL-23 Inhibitors IL-5 Inhibitors IL-6 Inhibitors Insulins JAK Inhibitors PARP Inhibitors PCSK9 Inhibitors Proton Pump Inhibitors SGLT2 Inhibitors SSRIs & SNRIs Statins TNF Inhibitors TTR Silencers Tyrosine Kinase Inhibitors

Class descriptions are written by the Priya Life Science editorial team. Individual drug pages combine that summary with live label, approval, manufacturer and shortage data from the U.S. FDA via the openFDA API. This page is general information and is not medical advice — it is not exhaustive, drugs within a class are not automatically interchangeable, and approvals and brand names differ between the US, EU/Ireland (EMA/HPRA) and other regions. Always consult the official prescribing information and your clinician or pharmacist. Related: Drug Shortages Tracker · FDA Approvals · All drug comparisons