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CDK4/6 Inhibitors

Also called cyclin-dependent kinase inhibitors

CDK4/6 inhibitors stall the cell cycle. By blocking cyclin-dependent kinases 4 and 6, they stop breast cancer cells from moving out of the growth phase and dividing. They are given as a daily tablet alongside hormone therapy in hormone-receptor-positive, HER2-negative advanced breast cancer, where adding them roughly doubles the time before the disease progresses.

Reviewed by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from official FDA data · Last verified · Editorial standards
What this class is used for
HR-positive, HER2-negative advanced or metastatic breast cancer

3 CDK4/6 Inhibitors in this directory

Ibrance
Palbociclib
An oral therapy for hormone-receptor-positive advanced breast cancer.
Kisqali
Ribociclib
An oral targeted therapy used to treat hormone receptor-positive advanced breast cancer.
Verzenio
Abemaciclib
An oral targeted therapy used to treat hormone receptor-positive breast cancer.

Compare CDK4/6 Inhibitors side by side

Ibrance VS Kisqali Ibrance VS Verzenio Kisqali VS Verzenio

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How this page is built

The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.

Plain-English summaries and drug-class explainers are written and reviewed by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 8 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.