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Atypical Antipsychotics

Also called second-generation antipsychotics

Atypical antipsychotics act on dopamine and serotonin signalling to treat psychosis, mania and, at lower doses, as add-on therapy in depression. They are called "atypical" because they cause fewer movement side effects than the older antipsychotics — but they carry their own burden, chiefly weight gain, sedation and metabolic changes, which vary a great deal from one drug to the next.

What this class is used for
Schizophrenia, bipolar disorder, treatment-resistant depression (as add-on)

2 Atypical Antipsychotics in this directory

Abilify
Aripiprazole
An oral or injectable medication used to treat schizophrenia, bipolar disorder, and major depression.
Seroquel
Quetiapine
An oral daily medication used to treat schizophrenia, bipolar disorder, and major depressive disorder.

Compare Atypical Antipsychotics side by side

Abilify VS Seroquel

Browse other drug classes

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Class descriptions are written by the Priya Life Science editorial team. Individual drug pages combine that summary with live label, approval, manufacturer and shortage data from the U.S. FDA via the openFDA API. This page is general information and is not medical advice — it is not exhaustive, drugs within a class are not automatically interchangeable, and approvals and brand names differ between the US, EU/Ireland (EMA/HPRA) and other regions. Always consult the official prescribing information and your clinician or pharmacist. Related: Drug Shortages Tracker · FDA Approvals · All drug comparisons