Which BTK Inhibitors are available?

This directory covers 3: Imbruvica, Calquence, Brukinsa.

BTK Inhibitors

Also called Bruton tyrosine kinase inhibitors

BTK inhibitors block Bruton's tyrosine kinase, an enzyme that B-cells depend on to survive and multiply. Shutting it down starves B-cell cancers such as chronic lymphocytic leukaemia and mantle cell lymphoma. Ibrutinib was first; the newer, more selective agents were developed to hit BTK harder while touching fewer off-target kinases, which changes their side-effect profile.

What this class is used for

Chronic lymphocytic leukaemia, mantle cell lymphoma, Waldenström's macroglobulinaemia

3 BTK Inhibitors in this directory

Imbruvica

Ibrutinib

An oral targeted therapy for chronic lymphocytic leukaemia and lymphomas.

Calquence

Acalabrutinib

An oral targeted therapy used to treat chronic lymphocytic leukemia and mantle cell lymphoma.

Brukinsa

Zanubrutinib

An oral targeted therapy used to treat mantle cell lymphoma and other blood cancers.

Compare BTK Inhibitors side by side

Imbruvica VS Calquence Imbruvica VS Brukinsa Calquence VS Brukinsa

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Class descriptions are written by the Priya Life Science editorial team. Individual drug pages combine that summary with live label, approval, manufacturer and shortage data from the U.S. FDA via the openFDA API. This page is general information and is not medical advice — it is not exhaustive, drugs within a class are not automatically interchangeable, and approvals and brand names differ between the US, EU/Ireland (EMA/HPRA) and other regions. Always consult the official prescribing information and your clinician or pharmacist. Related: Drug Shortages Tracker · FDA Approvals · All drug comparisons