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PARP Inhibitors

Also called poly(ADP-ribose) polymerase inhibitors

PARP inhibitors exploit a weakness in cancers that already struggle to repair their DNA — typically those with BRCA mutations. Healthy cells have a backup repair pathway; BRCA-mutated cancer cells do not. Blocking PARP removes the remaining repair route, so damage accumulates until the cancer cell dies. This "synthetic lethality" is one of precision oncology's clearest success stories.

Reviewed by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from official FDA data · Last verified · Editorial standards
What this class is used for
BRCA-mutated ovarian, breast, prostate and pancreatic cancers

4 PARP Inhibitors in this directory

Lynparza
Olaparib
A targeted oral therapy for BRCA-mutated ovarian, breast and prostate cancers.
Zejula
Niraparib
An oral targeted therapy used to treat advanced ovarian, fallopian tube, and peritoneal cancers.
Rubraca
Rucaparib
An oral targeted therapy used to treat advanced ovarian and prostate cancers.
Talzenna
Talazoparib
An oral targeted therapy used to treat BRCA-mutated breast cancer.

Compare PARP Inhibitors side by side

Lynparza VS Zejula Lynparza VS Rubraca Zejula VS Rubraca

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How this page is built

The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.

Plain-English summaries and drug-class explainers are written and reviewed by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 9 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.