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IL-23 Inhibitors

Also called interleukin-23 blockers, IL-12/23 inhibitors

IL-23 inhibitors block interleukin-23, a cytokine that sustains the inflammatory T-cells behind psoriasis and inflammatory bowel disease. Targeting IL-23 specifically — rather than the broader immune suppression of older drugs — has produced some of the highest skin-clearance rates ever seen in psoriasis, with dosing as infrequent as every 12 weeks. Ustekinumab, the oldest of the group, blocks IL-12 as well as IL-23.

Reviewed by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from official FDA data · Last verified · Editorial standards
What this class is used for
Plaque psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis

4 IL-23 Inhibitors in this directory

Skyrizi
Risankizumab
An injectable biological therapy used to treat plaque psoriasis, Crohn's disease, and psoriatic arthritis.
Stelara
Ustekinumab
A biologic for psoriasis, psoriatic arthritis and Crohn's disease.
Tremfya
Guselkumab
An injectable biological therapy used to treat plaque psoriasis and psoriatic arthritis.
Omvoh
Mirikizumab
An intravenous or injectable biological therapy used to treat moderate-to-severe ulcerative colitis.

Compare IL-23 Inhibitors side by side

Skyrizi VS Stelara Skyrizi VS Tremfya Skyrizi VS Omvoh Stelara VS Tremfya Stelara VS Omvoh Tremfya VS Omvoh

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How this page is built

The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.

Plain-English summaries and drug-class explainers are written and reviewed by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 11 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.