Which IL-23 Inhibitors are available?

This directory covers 4: Skyrizi, Stelara, Tremfya, Omvoh.

IL-23 Inhibitors

Also called interleukin-23 blockers, IL-12/23 inhibitors

IL-23 inhibitors block interleukin-23, a cytokine that sustains the inflammatory T-cells behind psoriasis and inflammatory bowel disease. Targeting IL-23 specifically — rather than the broader immune suppression of older drugs — has produced some of the highest skin-clearance rates ever seen in psoriasis, with dosing as infrequent as every 12 weeks. Ustekinumab, the oldest of the group, blocks IL-12 as well as IL-23.

What this class is used for

Plaque psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis

4 IL-23 Inhibitors in this directory

Skyrizi

Risankizumab

An injectable biological therapy used to treat plaque psoriasis, Crohn's disease, and psoriatic arthritis.

Stelara

Ustekinumab

A biologic for psoriasis, psoriatic arthritis and Crohn's disease.

Tremfya

Guselkumab

An injectable biological therapy used to treat plaque psoriasis and psoriatic arthritis.

Omvoh

Mirikizumab

An intravenous or injectable biological therapy used to treat moderate-to-severe ulcerative colitis.

Compare IL-23 Inhibitors side by side

Skyrizi VS Stelara Skyrizi VS Tremfya Skyrizi VS Omvoh Stelara VS Tremfya Stelara VS Omvoh Tremfya VS Omvoh

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Class descriptions are written by the Priya Life Science editorial team. Individual drug pages combine that summary with live label, approval, manufacturer and shortage data from the U.S. FDA via the openFDA API. This page is general information and is not medical advice — it is not exhaustive, drugs within a class are not automatically interchangeable, and approvals and brand names differ between the US, EU/Ireland (EMA/HPRA) and other regions. Always consult the official prescribing information and your clinician or pharmacist. Related: Drug Shortages Tracker · FDA Approvals · All drug comparisons