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CGRP Inhibitors (Migraine)

Also called gepants, CGRP monoclonal antibodies, migraine preventives

CGRP is a peptide released during a migraine attack that dilates blood vessels and transmits pain. Blocking it was the first migraine-specific advance since the triptans. The class splits in two: monthly or quarterly antibody injections that prevent attacks, and oral "gepants" taken either to stop an attack in progress or, in some cases, to prevent them.

What this class is used for
Migraine — acute treatment and prevention (episodic and chronic)

5 CGRP Inhibitors in this directory

Aimovig
Erenumab
A monthly self-injectable biological therapy used to prevent migraine headaches in adults.
Emgality
Galcanezumab
An injectable biological therapy administered monthly to prevent migraine headaches.
Ajovy
Fremanezumab
An injectable biological therapy administered monthly or quarterly to prevent migraine headaches.
Nurtec ODT
Rimegepant
An orally disintegrating tablet used to prevent and treat acute migraine attacks.
Ubrelvy
Ubrogepant
An oral acute medication taken at the onset of migraine headaches to relieve pain.

Compare CGRP Inhibitors side by side

Aimovig VS Emgality Aimovig VS Ajovy Aimovig VS Nurtec ODT Aimovig VS Ubrelvy Emgality VS Ajovy Emgality VS Nurtec ODT Emgality VS Ubrelvy Ajovy VS Nurtec ODT Ajovy VS Ubrelvy Nurtec ODT VS Ubrelvy

Browse other drug classes

ARBs Anti-amyloid Antibodies Antibiotics Antibody-drug Conjugates Anticoagulants Anticonvulsants Antihistamines Antiplatelets Asthma & COPD Inhalers Atypical Antipsychotics BTK Inhibitors Beta Blockers CD20 Antibodies CDK4/6 Inhibitors COVID-19 Antivirals Checkpoint Inhibitors Cholinesterase Inhibitors Complement Inhibitors DPP-4 Inhibitors EGFR Inhibitors Enzyme Replacement Therapy GLP-1 Agonists Gene & Cell Therapies HIV Antiretrovirals Hepatitis C Antivirals IL-1 Inhibitors IL-17 Inhibitors IL-23 Inhibitors IL-5 Inhibitors IL-6 Inhibitors Insulins JAK Inhibitors PARP Inhibitors PCSK9 Inhibitors Proton Pump Inhibitors SGLT2 Inhibitors SSRIs & SNRIs Statins TNF Inhibitors TTR Silencers Tyrosine Kinase Inhibitors

Class descriptions are written by the Priya Life Science editorial team. Individual drug pages combine that summary with live label, approval, manufacturer and shortage data from the U.S. FDA via the openFDA API. This page is general information and is not medical advice — it is not exhaustive, drugs within a class are not automatically interchangeable, and approvals and brand names differ between the US, EU/Ireland (EMA/HPRA) and other regions. Always consult the official prescribing information and your clinician or pharmacist. Related: Drug Shortages Tracker · FDA Approvals · All drug comparisons