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CGRP Inhibitors (Migraine)

Also called gepants, CGRP monoclonal antibodies, migraine preventives

CGRP is a peptide released during a migraine attack that dilates blood vessels and transmits pain. Blocking it was the first migraine-specific advance since the triptans. The class splits in two: monthly or quarterly antibody injections that prevent attacks, and oral "gepants" taken either to stop an attack in progress or, in some cases, to prevent them.

Reviewed by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from official FDA data · Last verified · Editorial standards
What this class is used for
Migraine — acute treatment and prevention (episodic and chronic)

5 CGRP Inhibitors in this directory

Aimovig
Erenumab
A monthly self-injectable biological therapy used to prevent migraine headaches in adults.
Emgality
Galcanezumab
An injectable biological therapy administered monthly to prevent migraine headaches.
Ajovy
Fremanezumab
An injectable biological therapy administered monthly or quarterly to prevent migraine headaches.
Nurtec ODT
Rimegepant
An orally disintegrating tablet used to prevent and treat acute migraine attacks.
Ubrelvy
Ubrogepant
An oral acute medication taken at the onset of migraine headaches to relieve pain.

Compare CGRP Inhibitors side by side

Aimovig VS Emgality Aimovig VS Ajovy Aimovig VS Nurtec ODT Aimovig VS Ubrelvy Emgality VS Ajovy Emgality VS Nurtec ODT Emgality VS Ubrelvy Ajovy VS Nurtec ODT Ajovy VS Ubrelvy Nurtec ODT VS Ubrelvy

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How this page is built

The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.

Plain-English summaries and drug-class explainers are written and reviewed by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 12 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.