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PCSK9 Inhibitors

Also called PCSK9 blockers, injectable cholesterol drugs

PCSK9 is a protein that destroys the liver receptors responsible for clearing LDL cholesterol from the blood. Block PCSK9 and those receptors survive longer, pulling far more cholesterol out of circulation — LDL reductions of 50-60% on top of a statin. They are injections rather than tablets, and are reserved for people whose cholesterol stays high despite maximum statin therapy, or who cannot tolerate statins. Inclisiran achieves the same end differently, using RNA interference to stop PCSK9 being made in the first place, and is dosed only twice a year.

Reviewed by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from official FDA data · Last verified · Editorial standards
What this class is used for
Familial hypercholesterolaemia, high LDL cholesterol despite statins, established cardiovascular disease

3 PCSK9 Inhibitors in this directory

Repatha
Evolocumab
An injectable cholesterol-lowering medication used to reduce the risk of heart attacks and strokes.
Praluent
Alirocumab
An injectable cholesterol-lowering medication used to reduce cardiovascular risk and treat high cholesterol.
Leqvio
Inclisiran
An injectable small interfering RNA therapy administered twice yearly to lower LDL cholesterol.

Compare PCSK9 Inhibitors side by side

Repatha VS Praluent Repatha VS Leqvio Praluent VS Leqvio

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How this page is built

The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.

Plain-English summaries and drug-class explainers are written and reviewed by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 12 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.