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Proton Pump Inhibitors (PPIs)

Also called PPIs, acid reflux medicines

Proton pump inhibitors shut down the enzyme in the stomach lining that pumps acid into the stomach. They are the most effective acid suppressants available and are used for reflux, ulcers and to protect the stomach from anti-inflammatory painkillers. Because they act on the pump itself rather than on a signalling receptor, they take a day or two to reach full effect but last much longer than an H2 blocker.

Reviewed by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from official FDA data · Last verified · Editorial standards
What this class is used for
Acid reflux (GORD), stomach and duodenal ulcers, H. pylori eradication, NSAID stomach protection

3 Proton Pump Inhibitors in this directory

Prilosec
Omeprazole
An acid-reducing medicine for reflux and ulcers.
Nexium
Esomeprazole
An oral daily medication used to treat gastroesophageal reflux disease and reduce stomach acid.
Protonix
Pantoprazole
An oral or intravenous medication used to treat acid reflux and erosive esophagitis.

Compare Proton Pump Inhibitors side by side

Prilosec VS Nexium Prilosec VS Protonix Nexium VS Protonix

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How this page is built

The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.

Plain-English summaries and drug-class explainers are written and reviewed by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 11 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.