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Trackers› Clinical trials› South Carolina
Clinical trial register · United States · industry-sponsored

Clinical Trials in South Carolina, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
Takeda7 Sanofi6 Merck Sharp & Dohme LLC6 GlaxoSmithKline5 Novartis Pharmaceuticals4
State
California5290 Florida4430 Illinois2481 Georgia2368 Arizona2238
All 51 states
Target enrolment
to

Trials with a site in South Carolina

284 of 9118 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Not yet open
A Study of Vepugratinib (LY3866288) in Adults With Non-Muscle Invasive Bladder Cancer and Upper Tract Urothelial Cancer
NCT07827612Urinary Bladder Neoplasms, Urologic Neoplasms, Receptor, Fibroblast Growth Factor, Type 3
DrugVepugratinib
Eli Lilly and Company
Phase 2
161
South Carolina
2026-12
Recruiting
SPI-1005 in Adults Receiving Cochlear Implant
NCT06340633Hearing Loss, Cochlear Trauma
DrugEbselen
Sound Pharmaceuticals, Incorporated
Phase 2
40
Iowa, Ohio, Pennsylvania, South Carolina, Texas, Wisconsin
2026-12
Recruiting
A Study of Lurbinectedin in Combination With Durvalumab for the Treatment of Participants With ES-SCLC
NCT07459634Extensive-stage Small-cell Lung Cancer
DrugsLurbinectedin·Durvalumab
Jazz Pharmaceuticals
Phase 2
50
California, Florida, Georgia, Kentucky, South Carolina
2026-11-30
Not yet open
Prescriptive Infusion Algorithm (PIA)
NCT07215403PARKINSON DISEASE (Disorder)
DrugAB-1005
AskBio Inc
Phase 2
18
Ohio, Pennsylvania, South Carolina
2026-11
Not yet open
Evaluation of F&P Mask, US, 2026
NCT07847814Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Fisher and Paykel Healthcare
Not applicable
45
South Carolina
2026-10-26
Recruiting
A Study to Evaluate the Efficacy and Safety of Maintenance Ublituximab Following Induction With Efgartigimod Administration in Participants With Myasthenia Gravis (MG)
NCT07673744Myasthenia Gravis
DrugUblituximab
TG Therapeutics, Inc.
Phase 2
120
Colorado, Florida, Michigan, North Carolina, South Carolina
2026-10-01
Not yet open
A Phase 1 Dose-escalation Study of UGN-501 Administered Intravesically in Adult Participants With Recurrent NMIBC
NCT07725796Bladder (Urothelial, Transitional Cell) Cancer, NMIBC, Urothelial Carcinoma Bladder, Urothelial Carcinoma in Situ
UroGen Pharma, Inc., a subsidiary of UroGen Pharma Ltd.
Phase 1
30
Arizona, California, Massachusetts, Nebraska, New York, Pennsylvania, South Carolina, Texas
2026-09-30
Recruiting
A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)
NCT07705607Diabetic Retinopathy, Macular Edema
DrugsTiespectus·Eylea·Aflibercept
Merck Sharp & Dohme LLC
Phase 3
1,104
Florida, South Carolina, Texas
2026-09-25
Recruiting
BHB-1893 Versus Metoprolol for Symptomatic Obstructive Hypertrophic Cardiomyopathy
NCT07755904Cardiomyopathy, Hypertrophic Obstructive
DrugMetoprolol
Braveheart Bio, Inc.
Phase 3
210
New York, South Carolina, Texas
2026-09-02
Recruiting
A Study to Compare Safety of 4 Weeks Exposure to Propellants Hydrofluoroalkane 1,1-difluoroethane (HFA-152a) and HFA-1,1,1,2-tetrafluoroethane (134a)
NCT07645248Asthma
GlaxoSmithKline
Phase 3
110
Florida, Kentucky, Missouri, Nevada, Oregon, South Carolina, Texas
2026-09-01
Recruiting
A Phase 3 Study to Evaluate the Efficacy and Safety of Samelisant in Patients With Narcolepsy (AWAKE)
NCT07540364Narcolepsy
Suven Life Sciences Limited
Phase 3
240
South Carolina
2026-09
Recruiting
HS235 Study in Overweight and Obese Participants With Combined Pre and Post-Capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction
NCT07123779Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction
DrugHS235
35Pharma Inc
Phase 1/2
126
Missouri, South Carolina
2026-09
Not yet open
A Study of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa (The SKYLIGHT Trial)
NCT07766005Hidradenitis Suppurativa (HS)
DrugsSPY072·Bimekizumab
Spyre Therapeutics, Inc.
Phase 2
150
California, Indiana, Kentucky, Louisiana, Massachusetts, New York, South Carolina, Texas
2026-09
Recruiting
A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)
NCT07705555Diabetic Retinopathy, Macular Edema
DrugsTiespectus·Eylea·Aflibercept
Merck Sharp & Dohme LLC
Phase 3
960
California, Colorado, Florida, Maryland, New Jersey, New York, North Carolina, South Carolina
2026-08-27
Recruiting
A Study to Investigate Canvuparatide Compared With Placebo in Adult Patients With Hypoparathyroidism
NCT07699471Hypoparathyroidism
MBX Biosciences
Phase 3
160
Florida, Louisiana, Nevada, New York, North Carolina, South Carolina, Texas, Washington
2026-08-26
Recruiting
A Study to Evaluate Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)
NCT07700056Chronic Pruritus of Unknown Origin
DrugRemibrutinib
Novartis Pharmaceuticals
Phase 3
180
Florida, Georgia, Indiana, New York, Ohio, South Carolina, Texas
2026-08-24
Recruiting
Pacritinib Effectiveness in Real-world Settings
NCT07774455Myelofibrosis (MF)
Swedish Orphan Biovitrum
Observational
60
Connecticut, Ohio, South Carolina
2026-08-13
Recruiting
A Study to Evaluate the Efficacy, Safety and Tolerability of ALKS 2680 in Adults With Narcolepsy Type 1 (Brilliance NT1 - 304)
NCT07540897Narcolepsy Type 1
DrugAlixorexton
Alkermes, Inc.
Phase 3
150
Florida, Georgia, Michigan, Missouri, North Carolina, Ohio, South Carolina, Texas
2026-08-13
Recruiting
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants
NCT07494045CKD Stage 3, CKD Stage 4, Secondary Hyperparathyroidism, VDI
OPKO Health, Inc.
Phase 2
40
Missouri, Ohio, Pennsylvania, South Carolina, Wisconsin
2026-08-05
Recruiting
A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight
NCT07745504Overweight, Obesity
DrugCagrilintide
Novo Nordisk A/S
Phase 3
285
Georgia, Hawaii, Illinois, Indiana, Kentucky, North Carolina, South Carolina, Virginia
2026-08-04
Recruiting
A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants With DME - ALTO
NCT07734844Diabetic Macular Edema (DME)
DrugsTabirafusp tedromer·Eylea·Aflibercept
Kodiak Sciences Inc
Phase 3
910
California, Florida, Maryland, Minnesota, South Carolina
2026-08-03
Recruiting
Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.
NCT07779408Healthy Volunteers, Influenza
Sanofi
Phase 1/2
640
Arizona, California, Florida, Georgia, Illinois, Kansas, New York, South Carolina
2026-08-03
Recruiting
A Study to Learn About the Investigational Drug Rinzimetostat (ORIC-944) in Patients With mCRPC Who Were Previously Treated With Abiraterone Acetate (Himalayas-1)
NCT07723248Metastatic Castration Resistant Prostate Cancer
DrugsRinzimetostat·Xtandi·Taxotere·Darolutamide
ORIC Pharmaceuticals
Phase 3
600
Florida, Indiana, Michigan, North Carolina, Ohio, South Carolina, Tennessee, Texas
2026-08-03
Recruiting
Cryoablation for Monomorphic Ventricular Tachycardia (VTS)
NCT07650032Ventricular Tachycardia, Sustained, Ventricular Tachycardia, Monomorphic
Adagio Medical
Not applicable
100
Arizona, California, Massachusetts, New York, Pennsylvania, South Carolina, Tennessee, Virginia
2026-08-01
Recruiting
A Study to Evaluate Claudin 18.2-Directed ADC LCB02A in Advanced Solid Tumors
NCT07460375Advanced Solid Tumors
LigaChem Biosciences, Inc.
Phase 1/2
191
Massachusetts, New York, South Carolina, Texas
2026-08
Recruiting
A Phase 1/2 Study of KK2430 in Participants With Hematologic Neoplasms
NCT07629726Hematologic Neoplasms
Kyowa Kirin Co., Ltd.
Phase 1/2
72
South Carolina
2026-08
Recruiting
A Phase 2 Study to Evaluate the Safety, PD, PK, and Clinical Activity of ADX-097 in Participants With IgAN, LN or C3G
NCT06419205IgA Nephropathy, Lupus Nephritis (LN), C3 (Complement Component 3) Glomerulopathy
Akebia Therapeutics
Phase 2
30
Florida, Georgia, South Carolina
2026-07-30
Recruiting
Prospective Post Market Clinical Registry for the Zenflow Spring System - A Minimally Invasive Treatment for LUTS Associated With BPH Spring System Registry
NCT07538622BPH (Benign Prostatic Hyperplasia)
Zenflow, Inc.
Observational
300
Arizona, California, Florida, Idaho, New York, South Carolina, Texas
2026-07-29
Recruiting
Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes
NCT07685808Overweight or Obesity
DrugOlatorepatide
Regeneron Pharmaceuticals
Phase 2
360
Alabama, California, Florida, Illinois, Kansas, Kentucky, New York, South Carolina
2026-07-28
Recruiting
Efficacy and Safety Study to Evaluate SD-101 in Epidermolysis Bullosa
NCT07482787Epidermolysis Bullosa (EB)
Paradigm Therapeutics
Phase 3
80
California, South Carolina
2026-07-21
Recruiting
A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)
NCT07481981Pulmonary Arterial Hypertension
DrugTreprostinil Palmitil
Insmed Incorporated
Phase 3
344
California, Kansas, Nebraska, New York, Pennsylvania, South Carolina
2026-07-21
Recruiting
DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea.
NCT07635563Obstructive Sleep Apnea (OSA)
DrugAcetazolamide
Incannex Healthcare Ltd
Phase 2
120
California, Florida, Louisiana, Maryland, Ohio, South Carolina, Tennessee, Texas
2026-07-21
Recruiting
A Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients With Severe Asthma
NCT07532265Severe Asthma
Kinaset Therapeutics Inc
Phase 2
512
California, Florida, Illinois, Missouri, North Carolina, Pennsylvania, South Carolina, Texas
2026-07-16
Recruiting
Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation
NCT07575269Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
Boston Scientific Corporation
Not applicable
571
Arkansas, Georgia, Iowa, New York, Ohio, Pennsylvania, South Carolina, Texas
2026-07-07
Recruiting
A Study in Patients With Metastatic Castration-Resistant Prostate Cancer
NCT07719361Metastatic Castration Resistant Prostate Cancer, mCRPC, mCRPC (Metastatic Castration-resistant Prostate Cancer), Prostatic Neoplasms
Flare Therapeutics Inc.
Phase 1
60
California, Massachusetts, Michigan, New Jersey, South Carolina, Tennessee, Texas
2026-07-01
Recruiting
An Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of North Star Desiccated Porcine Thyroid Extract Tablets.
NCT07747103Hypothyroidism
Neuvosyn Laboratories, LLC
Phase 3
466
California, Colorado, Florida, Idaho, Massachusetts, Nevada, North Carolina, South Carolina
2026-06-30
Recruiting
Idiopathic Pulmonary Fibrosis (IPF)-Related Chronic Cough Reduction With Nalbuphine Extended-Release (NAL ER) Tablets
NCT07671911Idiopathic Pulmonary Fibrosis
DrugNalbuphine
Trevi Therapeutics
Phase 3
306
California, Colorado, Florida, Louisiana, Missouri, North Carolina, Pennsylvania, South Carolina
2026-06-29
Recruiting
Trial to Evaluate the Efficacy and Safety of LYT-100 (Deupirfenidone) Compared to Pirfenidone in Adults With Idiopathic Pulmonary Fibrosis (IPF)
NCT07284602Idiopathic Pulmonary Fibrosis (IPF)
DrugsDeupirfenidone·Pirfenidone
PureTech
Phase 3
1,100
California, Massachusetts, Nevada, Pennsylvania, South Carolina, Tennessee, Texas
2026-06-26
Recruiting
Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension
NCT07511361Hypertension, Acute Severe Hypertension, Hypertensive Emergency, Hypertensive Urgency
Kardigan, Inc.
Phase 2
140
Colorado, Florida, Illinois, Michigan, New York, Ohio, South Carolina, Tennessee
2026-06-23
Recruiting
ColoSeal™ ICD System Anastomotic Protection Pivotal Study
NCT07429110Rectal Cancer Surgery
Averto Medical, Inc.
Not applicable
250
Florida, Ohio, South Carolina, Tennessee, Utah
2026-06-19
Recruiting
Ixoberogene Soroparvovec (Ixo-vec) Contralateral Dosing Study in Participants With Neovascular Age-related Macular Degeneration
NCT07630649Neovascular Age-Related Macular Degeneration (nAMD) Wet AMD
Adverum Biotechnologies, Inc.
Phase 2
15
Arizona, California, Florida, Hawaii, Illinois, New Jersey, South Carolina, Texas
2026-06-02
Recruiting
Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis
NCT07290140Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Airiver Medical, Inc.
Not applicable
300
Alabama, California, Colorado, Iowa, Kentucky, Pennsylvania, South Carolina, Texas
2026-06-01
Recruiting
A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence
NCT07598708Narcolepsy Type 1, Narcolepsy Type 2
Centessa Pharmaceuticals (UK) Limited
Phase 2/3
222
Alabama, Colorado, Florida, Georgia, Mississippi, North Carolina, Ohio, South Carolina
2026-05-29
Recruiting
Efficacy and Safety of Intravesical TARA-002 Compared With Investigator's Choice of Intravesical Chemotherapy in Participants With BCG-naïve High-grade Non-muscle Invasive Bladder Cancer
NCT07480356Bladder (Urothelial, Transitional Cell) Cancer, Non-Muscle Invasive Bladder Carcinoma, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
DrugTARA-002
Protara Therapeutics
Phase 3
284
Arizona, Arkansas, California, Georgia, Missouri, South Carolina, Texas
2026-05-29
Recruiting
Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events
NCT07607587Obesity, Overweight
DrugCagrilintide
Novo Nordisk A/S
Phase 1
114
California, Florida, North Carolina, South Carolina, Tennessee, Texas
2026-05-29
Recruiting
A Phase 2A Clinical Trial to Assess the Safety and Tolerability of ERX1000 in Men and Women for the Treatment of Obesity.
NCT07570758Obesity & Overweight
ERX Pharmaceuticals
Phase 2
80
Kentucky, North Carolina, South Carolina
2026-05-28
Recruiting
A Phase 1 Study of the Safety and Tolerability of CTX-10726
NCT07419841Gastroesophageal Cancer (GC), Hepatocellular Carcinoma (HCC), Endometrial Cancer, Renal Cell Carcinoma (RCC)
Compass Therapeutics
Phase 1
70
Arizona, Florida, Minnesota, Nebraska, New York, Pennsylvania, South Carolina, Tennessee
2026-05-28
Recruiting
Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation Research
NCT07623668Optic Neuritis
DrugMethylprednisolone
Oculis
Phase 3
210
Michigan, South Carolina, Texas
2026-05-28
Recruiting
Clareon TruPlus Study
NCT07502456Aphakia, Astigmatism
Alcon Research
Not applicable
122
Arizona, Ohio, South Carolina, Texas, Utah
2026-05-26
Recruiting
First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis
NCT07527923Healthy Volunteer, Atopic Dermatitis
Regeneron Pharmaceuticals
Phase 1
144
Alabama, California, South Carolina, Texas
2026-05-22
Recruiting
A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis
NCT07501702Myasthenia Gravis, Generalized
DrugPovetacicept
Vertex Pharmaceuticals Incorporated
Phase 2
30
California, Florida, Hawaii, Illinois, Nevada, South Carolina, Tennessee, Texas
2026-05-13
Recruiting
A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES Syndrome
NCT07285005Venous Malformations, Lymphatic Malformations, Klippel-Trenaunay Syndrome, CLOVES Syndrome
Kaken Pharmaceutical
Phase 3
150
South Carolina
2026-05-13
Recruiting
A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age
NCT07406360Measles, Measles-Mumps-Rubella+Chickenpox Vaccine
GlaxoSmithKline
Phase 3
1,209
Alabama, California, Florida, Georgia, Illinois, Michigan, Ohio, South Carolina
2026-05-11
Recruiting
A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)
NCT07555483Alpha 1 Antitrypsin Deficiency
Grifols Therapeutics LLC
Phase 3
40
Alabama, Arizona, California, Florida, Minnesota, Ohio, South Carolina, Texas
2026-05-05
Recruiting
Aquarius Pilot Study to Evaluate the New Axonics Trial System
NCT07335484Urinary Urge Incontinence (UUI), Urinary Frequency (UF), Fecal Incontinence (FI), Overactive Bladder (OAB)
Axonics, Inc.
Not applicable
75
South Carolina
2026-04-30
Recruiting
Study to Evaluate Long-Term Safety of Intravitreal OTX-TKI (Axitinib Implant) in Participants With Neovascular Age-Related Macular Degeneration Who Successfully Completed 2-Year OTX-TKI-2023-AMD-301 or OTX-TKI-2023-AMD-303 Study
NCT07516132Neovascular Age-Related Macular Degeneration (nAMD)
DrugOtx-Tki
Ocular Therapeutix, Inc.
Phase 3
850
California, Connecticut, Florida, Maryland, South Carolina, Texas
2026-04-27
Recruiting
Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP)
NCT07222813Heart Failure, Heart Failure - NYHA II - IV
Echosens
Not applicable
149
California, Minnesota, South Carolina, Texas
2026-04-23
Recruiting
A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)
NCT07227207Alpha-1 Antitrypsin Deficiency (AATD)
Tessera Therapeutics, Inc.
Phase 1/2
72
Florida, Massachusetts, Minnesota, South Carolina, Washington
2026-04-21
Recruiting
EVERO Drug-coated Balloon (DCB) Randomized Trial
NCT07144150Peripheral Vascular Disease, Peripheral Arterial Disease
Cook Research Incorporated
Not applicable
410
Connecticut, Florida, Iowa, Michigan, Mississippi, New Jersey, South Carolina, Texas
2026-04-17
Recruiting
A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy
NCT07137338Dilated Cardiomyopathy (DCM)
Rocket Pharmaceuticals Inc.
Phase 1
8
California, Minnesota, South Carolina
2026-04-17
Active, closed
The Glean Registry
NCT07558655Urology, Urodynamics
Bright Uro
Observational
500
South Carolina
2026-04-16
Recruiting
Study of JANX014 in Subjects With Metastatic Castration-Resistant Prostate Cancer
NCT07545811Prostate Cancer, Metastatic Castration-resistant Prostate Cancer, Castration-resistant Prostate Cancer
Janux Therapeutics
Phase 1
43
California, Missouri, South Carolina, Tennessee, Texas
2026-04-15
Recruiting
A Study of GEN1106 in Participants With Solid Tumors
NCT07416123Solid Tumors, Urothelial Carcinoma
Genmab
Phase 1
103
Connecticut, New York, South Carolina, Tennessee, Texas
2026-04-14
Recruiting
AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
NCT07533175Diabetes Mellitus, Overweight, Obesity
DrugNNC0487-0111
Novo Nordisk A/S
Phase 3
630
Alabama, California, Florida, Minnesota, New York, South Carolina, Tennessee, Texas
2026-04-13
Recruiting
Prostate Cancer Risk Identification in a Multi-Ethnic Cohort: a Prospective US-based Multi-center Validation Study of Proclarix
NCT07543757Prostate Cancer Detection
Sequenom, Inc.
Observational
500
California, Idaho, Kentucky, Maryland, New York, South Carolina
2026-04-03
By invitation
A Long-Term Follow-Up Study of Subjects Completing the AU-011-301(CoMpass) for Early Choroidal Melanoma
NCT07338968Choroidal Melanoma, Indeterminate Lesions
Aura Biosciences
Observational
100
California, Michigan, Minnesota, Oklahoma, South Carolina, Tennessee, Texas, Utah
2026-03-27
Recruiting
A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy
NCT07493265Narcolepsy
DrugE2086
Eisai Inc.
Phase 2
64
California, Florida, Georgia, Maryland, Michigan, North Carolina, South Carolina, Texas
2026-03-26
Active, closed
A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults
NCT07496450Influenza
ModernaTX, Inc.
Phase 3
4,050
California, Georgia, Idaho, Maryland, Nebraska, Ohio, Rhode Island, South Carolina
2026-03-23
By invitation
Evaluation of the Safety and Performance of a Bioresorbable Nasal Dressing Containing Mometasone Furoate (MF)
NCT07286201Chronic Rhinosinusitis (CRS), Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Polyganics BV
Not applicable
110
Colorado, Georgia, Illinois, Louisiana, Maryland, South Carolina, Texas, Utah
2026-03-19
Recruiting
Post Approval Effectiveness and Durability Evaluation of the Altaviva™ Tibial Device
NCT07456865Urge Urinary Incontinence
MedtronicNeuro
Not applicable
256
Alabama, Idaho, Missouri, North Carolina, Ohio, Pennsylvania, South Carolina, South Dakota
2026-03-17
By invitation
Long-Term Open-Label Extension Study of Oral Levosimendan
NCT07436689Pulmonary Hypertension Associated With HFpEF
DrugTNX-103
Tenax Therapeutics, Inc.
Phase 3
800
Illinois, Massachusetts, Minnesota, Missouri, Nebraska, North Carolina, South Carolina, Wisconsin
2026-03-13
Recruiting
A Study to Find Out if Enfortumab Vedotin Given With Pembrolizumab Helps People With Muscle-invasive Bladder Cancer Keep Their Bladder
NCT07475806Muscle-invasive Bladder Cancer
DrugsEnfortumab Vedotin·Pembrolizumab
Astellas Pharma Global Development, Inc.
Phase 2
240
Arkansas, Illinois, Indiana, Michigan, New Jersey, New York, Pennsylvania, South Carolina
2026-03-12
Recruiting
A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT07287150Metastatic Castration-Resistant Prostate Cancer
DrugsInavolisib·Abiraterone·Enzalutamide·Docetaxel
Hoffmann-La Roche
Phase 2
100
California, Iowa, New York, Rhode Island, South Carolina
2026-03-11
Recruiting
Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions)
NCT07290244Open Angle Glaucoma (OAG), NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
Life Biosciences Inc.
Phase 1
18
California, Massachusetts, New York, South Carolina
2026-03-02
Active, closed
A Study to Assess the Effectiveness and Safety of IPN10200 in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows
NCT07427797Moderate to Severe Glabellar Lines
DrugCorabotase
Ipsen
Phase 3
309
Alabama, Arizona, California, Florida, Maryland, South Carolina, Texas, Virginia
2026-02-27
Recruiting
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
NCT07280065PTSD - Post Traumatic Stress Disorder
Senseye, Inc.
Phase 3
1,900
Colorado, Georgia, Idaho, Massachusetts, South Carolina
2026-02-23
Active, closed
AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction
NCT07368959Corneal Edema, Corneal Endothelial Dysfunction, Fuchs Endothelial Corneal Dysfunction, Pseudophakic Bullous Keratopathy (PBK)
Aurion Biotech
Phase 3
130
Arizona, Arkansas, Colorado, Georgia, Missouri, North Carolina, Pennsylvania, South Carolina
2026-02-19
Recruiting
Ambulatory Long Length URodynamics Evaluation
NCT07425015Urology, Urinary Bladder, Overactive, Benign Prostatic Hyperplasia, Urodynamics
Bright Uro
Not applicable
101
Louisiana, Maryland, Missouri, Ohio, South Carolina, South Dakota, Texas, Washington
2026-02-17
Recruiting
A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
NCT07118501Post Traumatic Arthritis, Osteoarthritis, Total Ankle Replacement, Total Ankle Prosthesis
Stryker Trauma and Extremities
Observational
200
Illinois, Indiana, Kentucky, Oregon, South Carolina
2026-02-06
Not yet open
Simeox 200 US Study
NCT07443124Bronchiectasis, Mucus; Plug
Inogen Inc.
Not applicable
35
South Carolina
2026-02
Active, closed
A Trial of TAK-861 for the Treatment of Narcolepsy With Cataplexy
NCT07363720Narcolepsy Type 1 (NT1), Narcolepsy With Cataplexy
DrugTAK-861
Takeda
Phase 3
98
California, Florida, Michigan, New Jersey, North Carolina, Ohio, South Carolina, Texas
2026-01-29
Recruiting
Lot-to-lot Consistency Study of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From 2 Months of Age
NCT07348692Pneumococcal Immunization, Healthy Volunteers
DrugsPCV21 vaccine·Prevnar 20
Sanofi
Phase 3
2,195
Arkansas, California, Florida, Kentucky, Michigan, New York, South Carolina, Texas
2026-01-20
Recruiting
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
NCT07359846Severe Asthma
DrugGB-0895
Generate Biomedicines
Phase 3
786
California, Florida, Massachusetts, Michigan, New York, Ohio, Oklahoma, South Carolina
2026-01-20
Recruiting
A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)
NCT07300267Pneumococcal Infection
DrugPrevnar 20
Merck Sharp & Dohme LLC
Phase 1
210
California, Florida, Kansas, Kentucky, Maryland, Missouri, New York, South Carolina
2026-01-13
Recruiting
TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
NCT07190300Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
DrugsTulmimetostat·Prednisone/Prednisolone·Abiraterone·Darolutamide
Novartis Pharmaceuticals
Phase 1/2
181
Alabama, Iowa, Kansas, North Carolina, South Carolina, Utah
2026-01-13
Recruiting
EndoForce Post Approval Study
NCT07146854End Stage Renal Disease (ESRD)
Phraxis, Inc.
Observational
150
South Carolina
2026-01-13
Recruiting
NV PSR INSPIRE-A Pipeline™ Vantage Post Approval Study
NCT06604884Intracranial Aneurysm
Medtronic Neurovascular Clinical Affairs
Observational
118
Florida, Georgia, Illinois, Indiana, Iowa, Michigan, Missouri, South Carolina
2025-12-12
Recruiting
A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)
NCT07222488Bladder Cancer, Urinary Bladder Neoplasms
DrugMK-3120
Merck Sharp & Dohme LLC
Phase 1/2
45
California, New Jersey, South Carolina, Texas
2025-12-09
Recruiting
Pharmacokinetics, Safety, and Tolerability Study of GOPRELTO® Nasal Solution and NUMBRINO™ Nasal Solution
NCT04792034ENT Disorder, Nasal Procedures, Nasal Anesthesia, Nasal Mucosa Surgery
Noden Pharma
Phase 3
40
South Carolina
2025-12-06
Recruiting
A Long-Term Study of Zasocitinib in Children and Teenagers With Plaque Psoriasis
NCT07250802Plaque Psoriasis
DrugZasocitinib
Takeda
Phase 3
110
California, Florida, Illinois, Ohio, South Carolina, Texas, Wisconsin
2025-12-04
Recruiting
A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)
NCT07244341Metastatic Castration-resistant Prostate Cancer
DrugsValemetostat·Darolutamide
Daiichi Sankyo
Phase 1
60
California, Massachusetts, Michigan, New York, South Carolina, Texas, Virginia, Wisconsin
2025-12-03
Active, closed
Study to Evaluate HM15275 in Obese or Overweight Subjects Without Diabetes Mellitus
NCT07205900Obese, Obesity
DrugHM15275
Hanmi Pharmaceutical Company Limited
Phase 2
267
California, Illinois, Iowa, North Carolina, South Carolina, Tennessee, Texas
2025-12-02
Recruiting
A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema
NCT06807281Atopic Dermatitis
DrugAbrocitinib
Pfizer
Phase 3
500
Alabama, Arkansas, California, Florida, Idaho, Indiana, Missouri, South Carolina
2025-12-02
Active, closed
Aleniglipron Phase 2 in Type 2 Diabetes Mellitus
NCT07400588Obese, Obesity, Obesity Type 2 Diabetes Mellitus, Weight Loss
DrugAleniglipron
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Phase 2
58
Alabama, California, Missouri, Ohio, South Carolina, Tennessee, Texas
2025-12-01
Recruiting
A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)
NCT07103018Metastatic Castration-resistant Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer Patients, Metastatic Castration-resistant Prostate Cancer, mCRPC, mCRPC
DrugDarolutamide
K36 Therapeutics, Inc.
Phase 1
144
California, Florida, Minnesota, New York, North Carolina, Ohio, South Carolina, Texas
2025-11-21
Recruiting
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp
NCT07144345Actinic Keratosis
Sun Pharmaceutical Industries, Inc.
Phase 3
160
California, Florida, Illinois, Indiana, Minnesota, Missouri, Oregon, South Carolina
2025-11-19
Recruiting
Study of 30-Minute Stimulation With the Neuspera Sacral Neuromodulation (SNM) System
NCT07247136Urinary Urge Incontinence
Neuspera Medical, Inc.
Not applicable
30
South Carolina
2025-11-19
By invitation
A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Associated With Nectin-4
NCT07218003Non Small Cell Lung Cancer, Cervical Cancer, Head and Neck Squamous Cell Cancer, Triple Negative Breast Cancer (TNBC)
DrugPembrolizumab
Rondo Therapeutics
Phase 1
149
California, Connecticut, Michigan, New York, North Carolina, South Carolina, Tennessee, Texas
2025-11-17
Recruiting
Development of Optical Biometer
NCT07325162Cataract and IOL Surgery
Cassini Technologies
Not applicable
100
South Carolina
2025-11-07
Recruiting
Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
NCT07190807Chronic Pain, Intractable Pain, Low Back Pain, Chronic Low-back Pain
Boston Scientific Corporation
Not applicable
70
Colorado, Florida, Louisiana, New York, Pennsylvania, South Carolina, Texas
2025-11-07
Recruiting
A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse
NCT07223840Smoking
DrugBrenipatide
Eli Lilly and Company
Phase 2
222
Arkansas, Florida, Georgia, Michigan, Missouri, Nevada, New York, South Carolina
2025-11-03
Recruiting
SAINT in Postpartum Depression (PPD)
NCT07210255Postpartum Depression (PPD)
Magnus Medical
Not applicable
192
Massachusetts, New York, South Carolina, Texas
2025-11-01
Recruiting
A Biomarker Study in Men With Localized Prostate Cancer Treated With Aglatimagene Besadenovec
NCT07332000Prostate Cancer Patients Treated by Radiotherapy, Prostate Cancer (Adenocarcinoma)
DrugsAglatimagene besadenovec·Valacyclovir
Candel Therapeutics, Inc.
Phase 2
45
Arizona, Colorado, Maryland, Nevada, New Jersey, South Carolina
2025-10-30
Active, closed
A Study of Annual Doses of MK-1406/CD388 in Healthy Adults (MK-1406-006/CD388.SQ.2.07)
NCT07225959Healthy Participants
Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 2
400
Florida, South Carolina
2025-10-29
Active, closed
SPI-1005 for the Treatment of Meniere's Disease (Open Label)
NCT06859788Meniere's Disease, Ménière's Disease
DrugEbselen
Sound Pharmaceuticals, Incorporated
Phase 3
200
California, Florida, New York, Pennsylvania, South Carolina, Texas, Wisconsin
2025-10-29
Active, closed
Comparability Trial of the MVA-BN Vaccine Manufactured in Different Production Cells
NCT07199569Monkeypox (Mpox)
DrugJynneos
Bavarian Nordic
Phase 2
970
Iowa, Kansas, New York, North Carolina, South Carolina, Tennessee, Texas, Virginia
2025-10-27
Recruiting
A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer
NCT06992258Colorectal Cancer
DrugsLonsurf·Fruquintinib
Criterium, Inc.
Phase 2
120
Connecticut, Florida, New Jersey, New York, Pennsylvania, South Carolina, Tennessee, Texas
2025-10-27
Recruiting
Pivotal Study of the Velocity™ pAVF System
NCT07153939Chronic Kidney Disease, Hemodialysis Access, Arteriovenous Fistula, End Stage Renal Disease (ESRD)
Venova Medical
Not applicable
126
Alabama, California, Florida, New York, North Carolina, South Carolina, Texas
2025-10-21
Recruiting
Long-Term Stability of the Glide Control Strategy
NCT07222085Upper Limb Amputation Above Elbow, Upper Limb Amputation Below Elbow
Infinite Biomedical Technologies
Not applicable
12
Maryland, Massachusetts, North Carolina, South Carolina, Virginia
2025-10-15
Recruiting
A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients
NCT07219771Knee Osteoarthritis
Doron Therapeutics Inc.
Phase 3
260
Alabama, California, Florida, Illinois, Pennsylvania, South Carolina, Utah
2025-10-14
Active, closed
Post Market Clinical Evaluation of Clareon PanOptix Pro and Clareon PanOptix Pro Toric IOLs
NCT07161635Aphakia, Presbyopia
Alcon Research
Not applicable
110
California, Missouri, South Carolina, Texas, Utah
2025-10-14
Active, closed
A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin
NCT07215312Diabetes Mellitus, Type 2
DrugsLY3938577·Degludec
Eli Lilly and Company
Phase 2
100
Arizona, California, Florida, Iowa, Missouri, North Carolina, Oklahoma, South Carolina
2025-10-13
Recruiting
Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: The PROTEA-PFO Study
NCT07172464PFO, PFO - Patent Foramen Ovale, Cryptogenic Stroke, Patent Foramen Ovale
Recross Cardio, Inc.
Not applicable
30
California, Florida, Massachusetts, New York, South Carolina
2025-10-09
Recruiting
FebriDx® Pediatric Validation Study
NCT07211997Acute Respiratory Infections (ARIs)
Lumos Diagnostics
Observational
800
California, Florida, Ohio, Pennsylvania, South Carolina, Texas
2025-10-09
Recruiting
Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer
NCT07140900Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
DrugsXaluritamig·Abiraterone·Darolutamide
Amgen
Phase 1
60
California, Massachusetts, Minnesota, Ohio, Pennsylvania, South Carolina, Tennessee
2025-10-07
Recruiting
Clinical Trial of N-803 Plus Tislelizumab or Prior Failed Immune Checkpoint Inhibitor and Docetaxel Versus Docetaxel Monotherapy in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Acquired Resistance to Immune Checkpoint In
NCT06745908NSCLC Stage IV
DrugsTislelizumab·Docetaxel
ImmunityBio, Inc.
Phase 3
507
Arkansas, California, Florida, Georgia, Missouri, North Carolina, Ohio, South Carolina
2025-10-01
Recruiting
Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer
NCT07181161Metastatic Prostate Cancer
DrugPalacaparib
AstraZeneca
Phase 1/2
283
Arkansas, California, Maryland, Massachusetts, Michigan, New York, Rhode Island, South Carolina
2025-10-01
Recruiting
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
NCT07199738Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis), Post-traumatic Arthritis
Smith & Nephew, Inc.
Observational
144
Massachusetts, New York, South Carolina, Wisconsin
2025-09-25
Recruiting
A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
NCT07123454B-cell Non-Hodgkin Lymphoma
AstraZeneca
Phase 1/2
91
California, Florida, Minnesota, New York, Ohio, South Carolina, Tennessee
2025-09-24
Recruiting
Real Life Evaluation of the LibAirty Airway Clearance System in Adults With Bronchiectasis (RELACS)
NCT07135284Bronchiectasis Adult
Synchrony-Medical, Ltd
Observational
200
Alabama, Georgia, South Carolina
2025-08-20
Recruiting
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
NCT07005154Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer, Metastatic Hormone Sensitive Prostate Cancer
DrugsPRL-02·Abiraterone acetate·Prednisolone·Prednisone
Astellas Pharma Global Development, Inc.
Phase 2
218
Alabama, California, Florida, Illinois, Louisiana, New Mexico, Ohio, South Carolina
2025-08-19
Recruiting
MiREA-AC for Reducing Problematic Alcohol and Marijuana Use in College Students
NCT07339150Alcohol Misuse, Cannabis Misuse
mHealth Systems Inc.
Not applicable
150
North Carolina, South Carolina
2025-08-15
Active, closed
Aleniglipron Phase 2 Body Composition Study
NCT07169942Obesity, Overweight, or Chronic Weight Management
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Phase 2
71
Arizona, Illinois, Minnesota, Missouri, New York, North Carolina, Oklahoma, South Carolina
2025-08-15
Recruiting
Saline Enhanced Radiofrequency (SERF) Needle Ablation for Refractory VT
NCT05337241Refractory Ventricular Tachycardia
Thermedical, Inc.
Not applicable
130
Alabama, Pennsylvania, South Carolina, Tennessee, Utah
2025-08-09
Recruiting
Trial Investigating Visugromab in Combination With Immunochemotherapy in 1L Treatment of Participants With Metastatic NSCLC
NCT07098988Metastatic Non-Squamous Non-Small Cell Lung Cancer, Adult Solid Tumor
DrugsPemetrexed /m^2·Carboplatin (AUC 5)·Visugromab·Visugromab RDE
CatalYm GmbH
Phase 2
107
Alabama, California, Connecticut, Florida, New York, North Carolina, South Carolina
2025-08-01
Recruiting
WRAP North America
NCT06807099Venous Stenosis, Venous Occlusion
Merit Medical Systems, Inc.
Observational
250
Alabama, Arizona, California, Florida, Kentucky, Rhode Island, South Carolina, Tennessee
2025-07-31
Recruiting
A Study of the Medicine Called Abrocitinib in Children 6 to Less Than 12 Years of Age With Moderate-to-Severe Eczema
NCT06807268Eczema
DrugAbrocitinib
Pfizer
Phase 3
150
Alabama, Arkansas, California, Florida, Idaho, Indiana, Missouri, South Carolina
2025-07-24
Recruiting
A Study to Evaluate the SENSE Device's Ability to Detect TBI
NCT06828107Traumatic Brain Injury
Sense Diagnostics, LLC
Observational
150
Florida, Ohio, Pennsylvania, South Carolina, Texas
2025-07-11
Recruiting
Comparing Standard of Care Biopsy System to a Novel Biopsy Needle System by Computational Pathologic Analysis
NCT06830265Prostate Cancer Screening
Uro-1 Medical
Not applicable
200
New York, North Carolina, South Carolina
2025-07-07
Active, closed
A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD
NCT06981078Chronic Obstructive Pulmonary Disease
DrugVerekitug
Upstream Bio Inc.
Phase 2
666
California, Florida, Georgia, Illinois, Maryland, Minnesota, North Carolina, South Carolina
2025-07-02
Recruiting
Galvanize Prospective/Retrospective Pulsed Electric Field Device Registry
NCT05851430Soft Tissue Lesion
Galvanize Therapeutics, Inc.
Observational
1,000
Arizona, California, Florida, New York, North Carolina, Pennsylvania, South Carolina, Texas
2025-06-23
Recruiting
Digital Wellness Nurse - FIT Families: Virtual Family Intervention for Adolescent Obesity
NCT07087808Obese Children and Adolescents
Machine and Human Interaction
Not applicable
32
South Carolina
2025-06-20
Recruiting
Contour Neurovascular System™ ContiNued Access Investigational Device EXempTion (IDE) Trial (NEXT Trial)
NCT06693011Cerebral Aneurysms
Cerus Endovascular, Inc.
Not applicable
250
Illinois, Kansas, New York, North Carolina, Pennsylvania, South Carolina, Washington
2025-06-10
Recruiting
A Study of T3011 in Patients With BCG-Unresponsive NMIBC or BCG-Exposed, Chemotherapy-Unresponsive NMIBC
NCT06971614Nonmuscle-invasive Bladder Cancer
DrugT3011
ImmVira Pharma Co. Ltd
Phase 2
160
Arizona, California, Florida, New Jersey, Ohio, Pennsylvania, South Carolina
2025-06-09
By invitation
Virtuos Bone Graft in Lumbar Fusion
NCT06686017Degenerative Disc Disease
Orthofix Inc.
Observational
150
Indiana, Michigan, Montana, North Carolina, South Carolina, Texas, Virginia
2025-06-05
Recruiting
A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas
NCT06999187Triple Negative Breast Cancer, HER2-negative Breast Cancer, Non Small Cell Lung Cancer, Cervical Cancer
Dren Bio
Phase 1
96
Colorado, Florida, North Carolina, Oklahoma, South Carolina, Texas, Virginia
2025-06-03
Recruiting
STimulation to Activate RespIration
NCT06832306ARDS (Moderate or Severe), AHRF, Mechanically Ventilated ICU Patients
Lungpacer Medical Inc.
Not applicable
30
California, Louisiana, North Carolina, Ohio, Pennsylvania, South Carolina
2025-05-28
Active, closed
A Phase 1 Trial of Intranasal Mumps Virus Vaccines in Healthy Adults
NCT06967181Mumps
CyanVac LLC
Phase 1
60
New York, Ohio, South Carolina
2025-05-14
Recruiting
Phase 1 Study of ACE-232 to Treat Patients With Metastatic Castration-Resistant Prostate Cancer
NCT06801236Prostate Cancer (Adenocarcinoma), mCRPC (Metastatic Castration-resistant Prostate Cancer)
Acerand Therapeutics (Hong Kong) Limited
Phase 1
88
California, Florida, Maryland, Massachusetts, Minnesota, Nebraska, South Carolina, Washington
2025-05-12
Active, closed
A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)
NCT06924970Sickle Cell Disease
DrugTebapivat
Agios Pharmaceuticals, Inc.
Phase 2
59
Connecticut, District of Columbia, Georgia, Michigan, New York, Pennsylvania, South Carolina, Texas
2025-05-01
Recruiting
Access Cannulation Trial II
NCT05490225Dialysis; Complications, Vascular Access Complication
Voyager Biomedical
Not applicable
100
Alabama, California, Massachusetts, New York, South Carolina, Texas, Virginia
2025-04-23
Recruiting
Pivotal Study for the Cardiac Performance System (CPS)
NCT06870591Cardiovascular Diseases
Sensydia Corporation
Observational
1,000
Alabama, Illinois, New Jersey, New York, Ohio, Pennsylvania, South Carolina, Tennessee
2025-04-22
Active, closed
Study to Evaluate the Safety and the Immunogenicity of a Second Generation Structurally Designed mRNA Vaccine Candidate Against Pandemic Influenza H5 HA Strain in Healthy Adult Participants Aged 18 Years and Older
NCT06907511Pandemic Influenza Immunization, Healthy Volunteers
Sanofi
Phase 1/2
720
California, Florida, Georgia, Michigan, Nebraska, Ohio, South Carolina, Texas
2025-04-17
Recruiting
An Engineered Sirpα Fused to Anti-Pd-L1 And Tgf-β Fusion Protein (HCB301) in Subjects With Selected Advanced Tumors
NCT06487624Advanced Solid Tumor, Refractory Hodgkin Lymphoma
FBD Biologics Limited
Phase 1
50
South Carolina
2025-04-02
Active, closed
Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea
NCT06776432Sleep Apnea
DrugAcetazolamide
Shionogi
Phase 2
60
California, Florida, Massachusetts, Michigan, Minnesota, Ohio, South Carolina, Texas
2025-04-02
Recruiting
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain
NCT06908538Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss
AtriCure, Inc.
Observational
2,000
Massachusetts, New Hampshire, New York, Ohio, South Carolina, Wisconsin
2025-04-01
Recruiting
A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.
NCT06898450Advanced Solid Tumors Cancer, MSI-H Cancer
Nimbus Wadjet, Inc.
Phase 1/2
134
California, Illinois, Kentucky, New York, North Carolina, Ohio, Rhode Island, South Carolina
2025-03-31
Not yet open
A Prospective Interventional Cohort Study to Evaluate the Efficacy and Safety of the AquaLumen, a Novel Filtration Procedure for the Treatment of Open Angle Glaucoma
NCT06809647Glaucoma Open-Angle
PLU Ophthalmic
Not applicable
10
South Carolina
2025-03-30
Recruiting
A Phase 1 Study of BHV-1530 in Advanced Solid Tumors
NCT06874335Solid Tumor
DrugCemiplimab
Biohaven Therapeutics Ltd.
Phase 1
140
California, Colorado, Florida, Michigan, North Carolina, Ohio, South Carolina, Tennessee
2025-03-20
Active, closed
Study of Mixed Vaccination Schedules With a 21-valent Pneumococcal Conjugate Vaccine and a 20-valent Pneumococcal Conjugate Vaccine in Healthy Infants From Approximately 2 Months of Age
NCT06824181Pneumococcal Immunization
DrugsHavrix·Vaqta·M-M-R II vaccine·Prevnar 20 vaccine
Sanofi
Phase 3
580
California, Florida, Iowa, Kentucky, Louisiana, New York, Pennsylvania, South Carolina
2025-02-27
Recruiting
Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)
NCT06686394Breast Neoplasms, Breast Cancer
DrugsOgivri·Herzuma·Patritumab deruxtecan·Tucatinib
Merck Sharp & Dohme LLC
Phase 1/2
81
Colorado, Massachusetts, New Jersey, South Carolina, Virginia
2025-02-26
Active, closed
Study of BMN 349 Single Dose in PiZZ and PiMZ/MASH Adult Participants
NCT06738017Alpha 1-Antitrypsin Deficiency
BioMarin Pharmaceutical
Phase 1
6
California, Missouri, Ohio, South Carolina
2025-02-21
Recruiting
Analysis of Velmanase Alfa (Lamzede®)'s Effects in the Body of Children With Alpha-Mannosidosis Under the Age 3
NCT06184503Alpha-Mannosidosis
Chiesi Farmaceutici S.p.A.
Observational
5
Florida, South Carolina
2025-02-19
Recruiting
OurRelationship-S: A Digital Relationship-Strengthening Program for Couples Experiencing Substance Misuse
NCT07159633Relationship Conflict, Relationship Distress
OurRelationship
Not applicable
120
Georgia, Maryland, New York, South Carolina, Texas
2025-02-15
Active, closed
A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity
NCT06780449Obesity
DrugsCagrilintide·Semaglutide
Novo Nordisk A/S
Phase 3
400
California, Connecticut, Hawaii, Kentucky, Missouri, South Carolina, Tennessee, Texas
2025-02-10
Recruiting
A Study of TAK-360 in Adults With Idiopathic Hypersomnia
NCT06812078Idiopathic Hypersomnia
DrugTAK-360
Takeda
Phase 2
96
California, Colorado, Florida, Missouri, North Carolina, Ohio, South Carolina, Texas
2025-02-07
Active, closed
Pivotal Clinical Trial Evaluating the Safety and Efficacy of the Fully Implanted Acclaim Cochlear Implant
NCT06699797Sensori-Neural Deafness, Sensorineural Hearing Loss, Sensorineural Hearing Loss (Disorder), Sensorineural Hearing Loss, Bilateral
Envoy Medical Corporation
Not applicable
56
Arizona, California, Florida, Minnesota, Ohio, Oklahoma, South Carolina
2025-02-06
Recruiting
Integrity Implant System Post Market Clinical Follow-Up Study
NCT06741527Rotator Cuff Tears of the Shoulder
Anika Therapeutics, Inc.
Not applicable
150
Arizona, California, Florida, Georgia, Indiana, Maryland, New Jersey, South Carolina
2025-02-01
Active, closed
Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)
NCT06710132Solid Tumors, Gastric Cancer, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Cancer
DrugM9140
EMD Serono Research & Development Institute, Inc.
Phase 1/2
184
California, District of Columbia, Florida, South Carolina, Tennessee, Texas, Virginia
2025-01-29
Recruiting
Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors
NCT06750185Advanced Solid Tumor
BioNTech SE
Phase 1/2
248
Kentucky, Michigan, North Carolina, Rhode Island, South Carolina, Texas
2025-01-13
Recruiting
Post Market Study for VasQ, an External Support Implant for Arteriovenous Fistula
NCT06516653End Stage Renal Disease
Laminate Medical Technologies
Not applicable
300
California, Florida, Georgia, Massachusetts, Mississippi, Nevada, South Carolina, Texas
2025-01-13
Recruiting
UC-MSC Cell Therapy Study for Systemic Lupus Erythematosus (SLE) Patients
NCT06737380SLE, Lupus, Systemic Lupus Erthematosus, Systemic Lupus Erythematosus
LiveKidney.Bio
Phase 1
10
South Carolina
2025-01-07
Recruiting
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
NCT06227910Crohn's Disease
DrugsVedolizumab·Upadacitinib
Takeda
Phase 3
396
California, Colorado, Florida, Indiana, Kentucky, New York, South Carolina, South Dakota
2025-01-02
Recruiting
A Study to Assess the Incidence of Skin Cancers in Patients With Epidermolysis Bullosa Receiving Filsuvez
NCT06423573Epidermolysis Bullosa, Dystrophic, Epidermolysis Bullosa, Junctional
Chiesi Farmaceutici S.p.A.
Observational
170
California, Colorado, Florida, Ohio, Pennsylvania, South Carolina
2024-12-18
Recruiting
ViewFlex X ICE First-in-Human Study
NCT06772493Cardiac Arrhythmias
Abbott Medical Devices
Observational
500
Arkansas, California, Florida, Missouri, New York, Pennsylvania, South Carolina, Texas
2024-12-16
Recruiting
Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer
NCT06613100Prostate Cancer
DrugXaluritamig
Amgen
Phase 1
40
California, Missouri, Ohio, Pennsylvania, South Carolina, Washington, Wisconsin
2024-11-25
Recruiting
A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.
NCT06629779Metastatic Castration-Resistant Prostate Cancer
DrugsMevrometostat·Xtandi·Enzalutamide
Pfizer
Phase 3
900
Arizona, Arkansas, California, Illinois, Nebraska, New Mexico, New York, South Carolina
2024-10-22
Active, closed
A Phase 2 Study to Evaluate JCXH-105, an srRNA-based Herpes Zoster Vaccine
NCT06581575Herpes Zoster (HZ), Infectious Diseases, Shingles
DrugShingrix
Immorna Biotherapeutics, Inc.
Phase 2
467
Arizona, California, Illinois, Nebraska, New Jersey, South Carolina, Texas
2024-10-16
Recruiting
FK-PC101 as Adjuvant Therapy for Men With High-Risk Prostate Cancer
NCT06636682Prostate Cancer (Adenocarcinoma), Prostate CA, Prostate Cancers, Prostate Cancer (Post Prostatectomy)
Cellvax Therapeutics Inc
Phase 2
100
Illinois, Ohio, South Carolina
2024-10-14
Recruiting
A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine
NCT06602479Migraine
AbbVie
Phase 2
488
Alabama, California, Florida, Kentucky, New York, Rhode Island, South Carolina, Texas
2024-10-07
Recruiting
A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)
NCT06551142Neoplasms
DrugsRis-Rez·Tarlatamab·Dostarlimab·Cetuximab
GlaxoSmithKline
Phase 1
845
California, Colorado, Connecticut, Indiana, Massachusetts, Michigan, New Jersey, South Carolina
2024-09-30
Recruiting
A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems
NCT06512454Alpha1-Antitrypsin Deficiency
Takeda
Observational
500
Florida, South Carolina, Tennessee
2024-09-25
Recruiting
The TRICURE EFS Study
NCT06506942Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
TRiCares
Not applicable
15
Georgia, Illinois, Michigan, Minnesota, New York, Ohio, South Carolina
2024-09-11
Active, closed
A Phase 3 Study of UGN-103 for Treatment of Patients With Low-grade Intermediate-risk Non-muscle Invasive Bladder Cancer
NCT06331299Bladder Cancer, Urothelial Carcinoma, Urothelial Carcinoma Bladder
UroGen Pharma Ltd.
Phase 3
99
California, District of Columbia, Georgia, Indiana, Minnesota, New Jersey, New York, South Carolina
2024-08-29
Recruiting
Nafamostat Efficacy in Phase 3 Registrational CRRT Study
NCT06150742Acute Kidney Injury
Talphera, Inc
Not applicable
70
California, Florida, Michigan, New Mexico, New York, Ohio, Pennsylvania, South Carolina
2024-08-15
Recruiting
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
NCT06545942Advanced Solid Tumor, Metastatic Solid Tumor, Prostate Cancer, Pancreas Cancer
DrugOlaparib
MOMA Therapeutics
Phase 1
220
Arizona, California, Florida, Missouri, New York, Pennsylvania, South Carolina, Tennessee
2024-08-13
Recruiting
Melodi Matrix™ in Breast Reconstruction
NCT06027996Breast Reconstruction
Melodi Health, Inc.
Not applicable
702
California, Michigan, Minnesota, New York, Ohio, Pennsylvania, South Carolina, South Dakota
2024-08-09
Active, closed
A Phase 2 Study Evaluating the Co-Administration of Bremelanotide With Tirzepatide for the Treatment of Obesity
NCT06565611Obesity
DrugTirzepatide
Palatin Technologies, Inc
Phase 2
108
Florida, Oklahoma, South Carolina, Tennessee
2024-08-05
Active, closed
A Study to Assess the Efficacy, Safety, and Pharmacokinetics of Debio 4326 in Pediatric Participants With Central Precocious Puberty (LIBELULA™ Clinical Trial)
NCT06129539Central Precocious Puberty
Debiopharm International SA
Phase 3
56
California, South Carolina
2024-07-31
Recruiting
Vitaccess Real MG Registry
NCT06064461Myasthenia Gravis
Vitaccess Ltd
Observational
600
California, Illinois, Kentucky, New Jersey, South Carolina, Texas
2024-07-31
Recruiting
Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT
NCT05399537Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury (AKI)
Vantive Health LLC
Phase 3
40
Alabama, California, Florida, Georgia, Michigan, Ohio, Pennsylvania, South Carolina
2024-07-12
Active, closed
A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Ustekinumab in Children and Adolescents From 6 Years to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis
NCT06425549Moderate to Severe Plaque Psoriasis
DrugsBimekizumab·Ustekinumab
UCB Biopharma SRL
Phase 3
176
California, Indiana, South Carolina, Texas
2024-06-25
Recruiting
Enzalutamide Implants (Enolen) in Patients With Prostate Cancer
NCT06257693Prostate Adenocarcinoma
DrugEnzalutamide
Alessa Therapeutics Inc.
Phase 1
45
California, Illinois, Louisiana, Maryland, Oregon, South Carolina, Virginia, Wisconsin
2024-06-21
Recruiting
A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
NCT06389877Alpha 1-Antitrypsin Deficiency
Beam Therapeutics Inc.
Phase 1/2
192
Alabama, Massachusetts, South Carolina
2024-06-19
Recruiting
CraniSeal Post Approval Study
NCT06406790Leak, Cerebrospinal Fluid
Pramand LLC
Phase 4
224
California, Florida, Georgia, Massachusetts, Minnesota, New York, South Carolina
2024-05-29
Recruiting
A Prospective Real World Evidence Study (PROWES) for Concordance Rate of Blood-based 3D Genome Conformation Mapping (Episwitch CiRT®) to Identify Likelihood of Response and Actual Response Rates to PD-(L)-1 Checkpoint Inhibitors Across Multiple Oncological Indications.
NCT06635954Cancer, Immunotherapy, PD-1, PD-L1
Oxford Biodynamics Inc.
Observational
2,000
Connecticut, Georgia, South Carolina
2024-05-14
Active, closed
Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients
NCT06408935Crohn's Disease
DrugsTremfya·Guselkumab
Janssen-Cilag Ltd.
Phase 3
120
California, Illinois, Missouri, South Carolina
2024-04-17
Recruiting
Project Mountain - Comparing SpO2 and SaO2 for Accuracy
NCT06372106SpO2, Nasal Alar Collapse, Bilateral, Oxygen, Measurement
Philips Clinical & Medical Affairs Global
Observational
560
Arizona, Nebraska, North Carolina, South Carolina, Texas
2024-04-04
Active, closed
An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)
NCT06073132Generalized Epidermolysis Bullosa Simplex
TWi Biotechnology, Inc.
Phase 2/3
80
California, Colorado, Illinois, Ohio, South Carolina, Texas
2024-04-04
Recruiting
Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( VISTA-US)
NCT05848284Tricuspid Regurgitation, Tricuspid Valve Disease, Tricuspid Valvular Disorders
VDyne, Inc.
Not applicable
30
California, Michigan, Minnesota, New York, Ohio, Oregon, South Carolina, Tennessee
2024-04-01
Active, closed
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis
NCT06254950Ulcerative Colitis
DrugZasocitinib
Takeda
Phase 2
213
California, Florida, Georgia, Kentucky, Maryland, Nevada, Rhode Island, South Carolina
2024-03-29
Recruiting
Efficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis
NCT06205121Pulmonary Sarcoidosis
Molecure S.A.
Phase 2
96
Alabama, Kansas, Maryland, Minnesota, Ohio, Pennsylvania, South Carolina
2024-03-21
Active, closed
Gene Therapy for ACM Due to a PKP2 Pathogenic Variant
NCT06109181Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
Lexeo Therapeutics
Phase 1/2
10
California, Maryland, Michigan, New York, South Carolina
2024-02-29
By invitation
Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)
NCT06052072Group 2 Pulmonary Hypertension, Heart Failure
Gradient Denervation Technologies
Not applicable
50
Illinois, Massachusetts, North Carolina, South Carolina, Texas, Wisconsin
2024-02-20
Recruiting
A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency
NCT06049082Alpha 1-Antitrypsin Deficiency
Krystal Biotech, Inc.
Phase 1
15
Florida, South Carolina, Texas
2024-02-15
Recruiting
Study Evaluating INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis
NCT05975983Idiopathic Pulmonary Fibrosis (IPF)
DrugINS018_055
InSilico Medicine Hong Kong Limited
Phase 2
40
Alabama, Arizona, California, Florida, North Carolina, Oklahoma, Pennsylvania, South Carolina
2024-02-08
Active, closed
Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)
NCT06225596Metastatic Urothelial Cancer
DrugsZelenectide pevedotin·Avelumab·Gemcitabine·Cisplatin
BicycleTx Limited
Phase 2
375
Colorado, Florida, Kansas, Kentucky, Nebraska, New York, South Carolina, Tennessee
2024-01-24
Active, closed
Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in Children
NCT06285812Otitis Media Acute
PhotoniCare, Inc.
Observational
700
District of Columbia, Florida, New York, Oregon, South Carolina, Tennessee
2024-01-10
Active, closed
A Phase 1/1b Study of ZH9 Treatment in Patients With Non-Muscle Invasive Bladder Cancer
NCT06181266NMIBC, High Risk NMIBC, Non Muscle Invasive Bladder Cancer
Prokarium Ltd
Phase 1
22
California, North Carolina, South Carolina, Texas
2024-01-08
Active, closed
Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis
NCT06046222Eosinophilic Granulomatosis With Polyangiitis, Churg-Strauss Syndrome
NS Pharma, Inc.
Phase 2
45
Colorado, Minnesota, Ohio, Pennsylvania, South Carolina, Tennessee
2023-12-20
Active, closed
F15 Recharge Free Axonics SNM System Clinical Study
NCT06186765Urinary Urge Incontinence (UUI), Urinary Frequency (UF), Fecal Incontinence (FI)
Axonics, Inc.
Not applicable
144
Connecticut, Florida, Georgia, Minnesota, Nebraska, New York, Oregon, South Carolina
2023-12-08
Active, closed
Early Feasibility Study Evaluating the 3P-100 Device in Subjects With PH-ILD
NCT05867914Hypertension, Pulmonary, Lung Diseases, Interstitial
Third Pole Therapeutics, Inc.
Not applicable
5
Florida, Ohio, South Carolina
2023-12-04
Active, closed
A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
NCT06154837Pulmonary Disease, Chronic Obstructive
DrugGSK3862995B
GlaxoSmithKline
Phase 1
127
Arizona, Florida, Georgia, North Carolina, Oregon, Pennsylvania, South Carolina, Texas
2023-11-27
Active, closed
A Post-Market Study for Long-Term Effectiveness and Safety of the TOMAC System for RLS
NCT06076499Restless Legs Syndrome
Noctrix Health, Inc.
Observational
325
California, Massachusetts, Missouri, Ohio, Pennsylvania, South Carolina
2023-11-15
Recruiting
A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases
NCT06136884Solid Tumor Malignancies, Brain Metastases From Solid Tumors
A2A Pharmaceuticals Inc.
Phase 1
86
Michigan, Oklahoma, South Carolina, Texas, Virginia
2023-11-02
Recruiting
VALOR: Vaginal Atrophy & Long-term Observation of Recovery
NCT05953090Atrophic Vaginitis, Vaginal Atrophy, Genitourinary Syndrome of Menopause, Lichen Sclerosus of Vulva
Stratpharma AG
Not applicable
2,000
Alabama, California, Florida, Georgia, Nevada, North Carolina, South Carolina, Tennessee
2023-10-30
Recruiting
Study to Evaluate the Efficacy, Safety, and Tolerability of Efzofitimod in Patients With Systemic Sclerosis (SSc)-Related Interstitial Lung Disease (ILD) (SSc-ILD)
NCT05892614Interstitial Lung Disease
aTyr Pharma, Inc.
Phase 2
25
California, Florida, Illinois, Louisiana, New York, Ohio, Oklahoma, South Carolina
2023-10-26
Recruiting
A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors
NCT05892718Advanced Solid Tumor, Refractory Non-Hodgkin Lymphoma
DrugHCB101
FBD Biologics Limited
Phase 1
80
Florida, North Carolina, South Carolina, Texas
2023-10-02
Recruiting
Pulse Endovascular ReperFUSION for Acute Ischemic Stroke
NCT06052969Acute Ischemic Stroke AIS, Cerebral Arterial Disease
Euphrates Vascular, Inc.
Not applicable
8
South Carolina
2023-10-01
Recruiting
A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension
NCT06040827Knee Osteoarthritis
Canary Medical
Observational
626
Arkansas, Florida, Georgia, Indiana, Ohio, South Carolina
2023-09-12
Active, closed
Clairleafᵀᴹ: A Study to Test Long-term Treatment With BI 1291583 in People With Bronchiectasis Who Took Part in a Previous Study With This Medicine
NCT05846230Bronchiectasis
DrugVerducatib
Boehringer Ingelheim
Phase 2
268
California, Florida, Kansas, New York, Ohio, South Carolina, Texas
2023-09-08
Recruiting
A Registry Study to Assess Photobiomodulation in Dry Age-Related Macular Degeneration (GLOBALIGHT)
NCT06351605Dry Age-related Macular Degeneration
LumiThera, Inc.
Observational
500
California, Ohio, South Carolina, Texas, Washington
2023-09-01
Active, closed
An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease
NCT05899673Alpha1-Antitrypsin Deficiency
DrugFazirsiran
Takeda
Phase 3
31
California, Florida, Iowa, South Carolina
2023-08-08
Active, closed
A Phase 1/Phase 2 Open-label Study to Evaluate the Safety, Tolerability, and Efficacy of a Single Intravenous Administration of SAR444836 in Adult Participants With Phenylketonuria
NCT05972629Phenylketonuria
Sanofi
Phase 1/2
32
California, Colorado, Florida, Ohio, Pennsylvania, South Carolina, Texas
2023-08-07
By invitation
A Long-Term Safety Trial of LUM-201 in Children With Idiopathic Growth Hormone Deficiency Who Have Previously Completed a LUM-201 Clinical Trial (OraGrowtH211)
NCT05796440Growth Hormone Deficiency
DrugLUM-201
Lumos Pharma
Phase 2
60
Iowa, Massachusetts, Missouri, South Carolina, Texas, Washington
2023-08-01
Active, closed
Abbott Ventricular Tachycardia PAS
NCT05839873Ventricular Tachycardia
Abbott Medical Devices
Observational
62
Florida, Indiana, Kansas, Massachusetts, Minnesota, North Carolina, Oklahoma, South Carolina
2023-07-24
Recruiting
Encore PFO Closure Device - The PerFOrm Trial
NCT05537753Patent Foramen Ovale, Cryptogenic Stroke
Encore Medical Inc.
Not applicable
500
Arkansas, California, Florida, Iowa, Kansas, Mississippi, Nebraska, South Carolina
2023-07-12
Active, closed
Early Feasibility Study of the NORM™ System in Heart Failure Patients (FUTURE-HFII)
NCT05763407Heart Failure
Foundry Innovation & Research 1, Limited (FIRE1)
Not applicable
25
Minnesota, New York, North Carolina, Ohio, South Carolina, Texas
2023-06-19
Recruiting
A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia
NCT05865535Cachexia
AVEO Pharmaceuticals, Inc.
Phase 1
30
California, Connecticut, Florida, Nebraska, New Jersey, New York, Oregon, South Carolina
2023-06-13
Recruiting
Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)
NCT05765175Tachycardia, Ventricular
Varian, a Siemens Healthineers Company
Not applicable
380
California, Connecticut, Massachusetts, Minnesota, Missouri, Ohio, Pennsylvania, South Carolina
2023-04-21
Recruiting
Pounce™ Thrombectomy System Retrospective Registry
NCT05868161Peripheral Arterial Disease, Acute Limb Ischemia
SurModics, Inc.
Observational
500
Illinois, Indiana, Louisiana, Minnesota, Ohio, South Carolina, South Dakota, Tennessee
2023-04-18
Active, closed
In-Office Clinical Study of the Solo+ TTD
NCT05741333Ear Infection, Otitis Media
AventaMed DAC
Not applicable
66
Alabama, California, Kentucky, Pennsylvania, South Carolina
2023-03-30
Active, closed
Assessment of GORE® SYNECOR Biomaterial in Focused Patient Populations and Long-Term Application
NCT05094089Hernia, Ventral, Hernia Incisional, Hernia Incisional Ventral
W.L.Gore & Associates
Observational
320
Georgia, Massachusetts, Michigan, New Mexico, New York, North Carolina, South Carolina, Virginia
2023-02-24
Active, closed
A Safety, Tolerability, and Immunogenicity Study of mRNA-1345 and mRNA-1365 in Participants Aged 5 Months to <24 Months
NCT05743881Respiratory Syncytial Virus, Human Metapneumovirus
DrugsMRNA-1345·MRNA-1365·Nimenrix
ModernaTX, Inc.
Phase 1
186
California, District of Columbia, Illinois, Louisiana, North Carolina, Rhode Island, South Carolina, Tennessee
2023-02-15
Active, closed
Stryker PEEK Customized Implant: A Prospective Post Market Follow Up to Evaluate Safety, Performance and Effectiveness
NCT05362370Cranioplasty, Craniofacial Abnormalities, Craniofacial Injuries
Stryker Craniomaxillofacial
Observational
99
Kentucky, New Jersey, New York, Pennsylvania, South Carolina
2023-02-01
Recruiting
The Impact of MeMed BV® on Management of Patients With Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) ("JUPITER" TRIAL)
NCT05762302Lower Respiratory Tract Infection
MeMed Diagnostics Ltd.
Not applicable
1,316
Florida, Kansas, New York, Pennsylvania, South Carolina, Texas, Wisconsin
2023-01-31
Recruiting
Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
NCT06311708Arrhythmogenic Right Ventricular Cardiomyopathy
Tenaya Therapeutics
Observational
200
California, Colorado, Maryland, Massachusetts, Minnesota, New York, Ohio, South Carolina
2023-01-31
Active, closed
Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID)
NCT05024773Bladder Carcinoma in Situ (CIS)
Fidia Farmaceutici s.p.a.
Phase 3
130
Arizona, Louisiana, Maryland, Minnesota, Ohio, South Carolina
2022-12-29
Recruiting
A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma
NCT05645107Hypogammaglobulinemia, Bacterial Infections, B-cell Chronic Lymphocytic Leukemia, Multiple Myleoma
DrugXembify
Grifols Therapeutics LLC
Phase 3
386
Arizona, California, Florida, Maryland, North Carolina, Ohio, South Carolina
2022-12-26
Active, closed
REDUCED 1 - Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study /
NCT05372679Uncontrolled Stage 2 Hypertension
SoniVie Inc.
Not applicable
25
Alabama, Arkansas, Connecticut, Illinois, Minnesota, New York, North Carolina, South Carolina
2022-11-11
Active, closed
Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type
NCT05397639Agitation, Alzheimer's Type Dementia
Suven Life Sciences Limited
Phase 3
375
California, Connecticut, Florida, Illinois, New Jersey, New York, Ohio, South Carolina
2022-11-01
Active, closed
A Retrospective Assessment of OviTex PRS (OviTex)
NCT05736848Reconstructive Surgical Procedures
Tela Bio Inc
Observational
200
Florida, Georgia, Massachusetts, Michigan, New Jersey, New York, South Carolina, Texas
2022-09-27
Active, closed
A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancer
NCT05483868Non-muscle-invasive Bladder Cancer, NMIBC, Non-Muscle Invasive Bladder Carcinoma, Non-Muscle Invasive Bladder Neoplasms
DrugBel-sar
Aura Biosciences
Phase 1
55
Arkansas, California, Colorado, New York, Pennsylvania, South Carolina, Tennessee, Texas
2022-09-26
Active, closed
XIENCE Skypoint Large Vessel Post Approval Study
NCT05423379Coronary Artery Disease
Abbott Medical Devices
Observational
102
Arkansas, Florida, Kansas, Nebraska, New York, Pennsylvania, South Carolina, Texas
2022-09-14
Recruiting
Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial
NCT05334368Hypereosinophilic Syndrome
DrugDepemokimab
GlaxoSmithKline
Phase 3
109
California, Georgia, Massachusetts, Michigan, Minnesota, New York, Ohio, South Carolina
2022-09-06
Active, closed
Neurostimulation to Improve NOWS Outcomes
NCT05129020Neonatal Opioid Withdrawal Syndrome, Neonatal Abstinence Syndrome
Spark Biomedical, Inc.
Not applicable
52
South Carolina, Texas
2022-07-27
Recruiting
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT05254743Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma
DrugsPirtobrutinib·Ibrutinib
Loxo Oncology, Inc.
Phase 3
737
California, Florida, Louisiana, Maryland, Montana, Pennsylvania, South Carolina, Tennessee
2022-07-22
Recruiting
Patient Specific Talus Spacer Post Approval Study
NCT05364606Avascular Necrosis of the Talus
Paragon 28
Observational
50
California, Indiana, Maryland, South Carolina, Texas
2022-07-08
Active, closed
SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM
NCT05405166Plasma Cell Myeloma Recurrent
DrugsParacetamol / Acetaminophen·Montelukast·Diphenhydramine·Isatuximab
Sanofi
Phase 3
531
Colorado, Florida, Mississippi, New Jersey, New York, North Carolina, Ohio, South Carolina
2022-06-23
Active, closed
Safety, Tolerability and Efficacy of QRX003 Lotion in Subjects With Netherton Syndrome
NCT05521438Netherton Syndrome
DrugQRX003, Lotion
Quoin Pharmaceuticals
Phase 2/3
30
California, Indiana, Massachusetts, South Carolina, Texas
2022-06-23
Active, closed
Longitudinal Bladder Cancer Study for Tumour Recurrence
NCT05080998Urothelial Bladder Cancer
Pacific Edge Limited
Observational
450
Florida, South Carolina, Texas, Vermont, Washington
2022-06-08
Active, closed
Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer
NCT05367440Metastatic Prostate Cancer
DrugsSaruparib·Zytiga·Apalutamide·Xtandi
AstraZeneca
Phase 1/2
174
Michigan, New York, South Carolina, Texas
2022-06-02
Recruiting
A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF SHR-A1904 IN SUBJECTS WITH ADVANCED SOLID TUMORS
NCT05277168Advanced Solid Tumors
DrugSHR-A1904
Jiangsu HengRui Medicine Co., Ltd.
Phase 1/2
83
Florida, Louisiana, Ohio, Rhode Island, South Carolina, Texas
2022-05-30
Recruiting
Study to Evaluate IMP9064 as a Monotherapy or in Combination in Patients With Advanced Solid Tumors
NCT05269316Solid Tumor, Advanced Solid Tumor
Impact Therapeutics, Inc.
Phase 1/2
61
New Jersey, New York, South Carolina, Texas
2022-02-11
Active, closed
Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer
NCT04905069Prostate Cancer
Boston Scientific Corporation
Not applicable
500
Florida, Kansas, Michigan, New Jersey, Pennsylvania, South Carolina
2021-12-21
Active, closed
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
NCT05197036Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Smith & Nephew, Inc.
Observational
299
Georgia, Massachusetts, Michigan, New York, North Carolina, Oregon, South Carolina, Tennessee
2021-12-21
Active, closed
RCT, Blinded, 2-Arm Efficacy Study of IP and Placebo in Patients With Chronic Pain Related to Osteoarthritis of the Knee
NCT05318521Degenerative Arthritis
DrugIbuprofen
Overseas Pharmaceuticals, Ltd.
Phase 3
500
California, Florida, South Carolina, Virginia
2021-12-10
Recruiting
X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma
NCT04389281Advanced Solid Tumor Cancer
Immunolight, LLC
Phase 1
52
District of Columbia, North Carolina, South Carolina
2021-12-08
Active, closed
Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia
NCT04994717Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL)
DrugBlinatumomab
Amgen
Phase 3
303
California, Florida, Ohio, South Carolina, Texas
2021-11-02
By invitation
Multi-Center Clinical Database of Infants for the Investigation of Early Nutrition Biomarkers
NCT05049655Infant Development
ByHeart
Observational
2,000
Alabama, Arizona, Arkansas, Idaho, Ohio, South Carolina, Tennessee, Utah
2021-10-19
Active, closed
Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain
NCT04809376Osteoarthritis, Knee
DrugPentosan Polysulfate Sodium
Paradigm Biopharmaceuticals USA (INC)
Phase 2/3
602
Arizona, California, Florida, Illinois, Kansas, Louisiana, Nevada, South Carolina
2021-10-19
Recruiting
First in Human, Dose Escalation Study of AN4005
NCT04999384Advanced Solid Tumor, Advanced Lymphoma
Adlai Nortye Biopharma Co., Ltd.
Phase 1
31
New Jersey, New York, South Carolina, Virginia
2021-09-27
Active, closed
REFLECTION: A Clinical Practice Learning Program for Galleri®
NCT05205967Early Detection of Cancer, Cancer
GRAIL, Inc.
Observational
14,633
Arizona, California, Florida, Louisiana, Massachusetts, Oregon, Pennsylvania, South Carolina
2021-08-23
Active, closed
Virtual Incision Robotically Assisted Surgical Device Use in Minimally Invasive Colectomy
NCT04703829Colon Cancer, Colon Polyp, Diverticular Diseases, Inflammatory Bowel Diseases
Virtual Incision Corporation
Not applicable
30
Nebraska, Pennsylvania, South Carolina
2021-08-09
Active, closed
Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria
NCT04747613Paroxysmal Nocturnal Hemoglobinuria
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
208
California, Florida, Georgia, New York, Ohio, South Carolina
2021-07-27
Active, closed
Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
NCT04541108Solid Tumor
DrugsAZD9592·Sabestomig·Volrustomig·Rilvegostomig
Presage Biosciences
Phase EARLY_PHASE1
15
Louisiana, New York, North Carolina, Ohio, Oregon, Pennsylvania, South Carolina, Washington
2021-07-26
Active, closed
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 6 and 17 Years With Moderate to Severe Plaque Psoriasis Treated With Subcutaneous (SC) Injection of Risankizumab Who Have Completed Participation in Study M19-977
NCT04862286Psoriasis
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
132
Alabama, California, Florida, Illinois, Nevada, Ohio, South Carolina, West Virginia
2021-07-24
Recruiting
GORE® ENFORM Biomaterial Product Study
NCT04718168Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
W.L.Gore & Associates
Not applicable
245
California, Colorado, Florida, Illinois, Kentucky, North Carolina, South Carolina, Texas
2021-05-17
Active, closed
Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1
NCT04954001Neurofibromatosis 1, Plexiform Neurofibroma, NF1
DrugLuvometinib
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.
Phase 1/2
160
California, Florida, Michigan, South Carolina
2021-03-26
Active, closed
Safety and Immunogenicity of Extended 2-dose Regimens of 9-valent Human Papillomavirus (9vHPV) Vaccine (V503-069)
NCT04708041Papillomavirus Infections
DrugNonavalent HPV vaccine
Merck Sharp & Dohme LLC
Phase 3
700
California, Florida, South Carolina, Texas, Washington
2021-03-15
Recruiting
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
NCT04555161Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
Aria CV, Inc
Not applicable
30
California, Indiana, Massachusetts, Minnesota, New York, Ohio, South Carolina, Wisconsin
2021-03-15
Active, closed
INFINITY™ With ADAPTIS™ Technology Study
NCT04594993Arthritis, Rheumatoid
Stryker Trauma and Extremities
Observational
200
Arizona, California, Colorado, Florida, Illinois, New York, Oregon, South Carolina
2021-02-09
Active, closed
Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
NCT04652882Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
DrugTasimelteon
Vanda Pharmaceuticals
Phase 3
70
California, Colorado, Massachusetts, Missouri, New York, Ohio, South Carolina, Texas
2020-12-09
Active, closed
Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
NCT04384484Relapsed Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
DrugsLoncastuximab Tesirine·Rituximab·Oxaliplatin·Gemcitabine
ADC Therapeutics S.A.
Phase 3
440
California, Florida, Iowa, Kentucky, Nevada, Oregon, South Carolina, Virginia
2020-09-16
Recruiting
An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System
NCT04029337Mitral Regurgitation
HighLife SAS
Not applicable
30
Arizona, California, Georgia, Massachusetts, Minnesota, New York, Pennsylvania, South Carolina
2020-07-14
Active, closed
Efficacy and Safety of Tildrakizumab Compared to Placebo in Anti-TNF naïve Subjects With Active Psoriatic Arthritis II (INSPIRE 2)
NCT04314531Active Psoriatic Arthritis
Sun Pharmaceutical Industries Limited
Phase 3
296
California, Florida, Missouri, Nebraska, South Carolina, Texas, Washington
2020-07-01
Recruiting
Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System
NCT04065438Focal Segmental Glomerulosclerosis
Kaneka Medical America LLC
Not applicable
35
California, Delaware, Michigan, New York, North Carolina, Ohio, South Carolina, Virginia
2020-01-01
Active, closed
Study of RV001V in Biochemical Failure Following Curatively Intended Therapy For Localized Prostate Cancer
NCT04114825Prostate Cancer Recurrent
RhoVac APS
Phase 2
180
Florida, Maryland, Nebraska, Nevada, New York, South Carolina, Texas
2019-11-19
Active, closed
A Safety and Pharmacokinetics Study of IDP-122 Lotion in Pediatric Participants With Plaque Psoriasis
NCT03987763Psoriasis
Bausch Health Americas, Inc.
Phase 4
45
California, Florida, South Carolina, Washington
2019-10-22
Active, closed
Alfapump® System in the Treatment of Refractory or Recurrent Ascites (POSEIDON Study)
NCT03973866Ascites
Sequana Medical N.V.
Not applicable
110
Arizona, California, Massachusetts, Minnesota, North Carolina, Pennsylvania, South Carolina, South Dakota
2019-09-16
Recruiting
Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients
NCT03945162Non-Muscle Invasive Bladder Cancer ("NMIBC") Unresponsive/Intolerant to BCG
Theralase® Technologies Inc.
Phase 2
90
Illinois, Indiana, New York, Ohio, Pennsylvania, South Carolina, Tennessee, Texas
2019-08-30
Active, closed
A Study of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Participants With Advanced Kidney Cancer
NCT03873402Renal Cell Carcinoma
DrugsYervoy·Ipilimumab·Opdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
437
District of Columbia, Georgia, Massachusetts, Pennsylvania, South Carolina
2019-06-21
Active, closed
Durvalumab and Tremelimumab for Pediatric Malignancies
NCT03837899Pediatric Cancer, Solid Tumor Pediatric, Hematological Malignancies
DrugDurvalumab
AstraZeneca
Phase 1/2
50
Maryland, Massachusetts, New York, Oklahoma, South Carolina
2019-03-07
Active, closed
Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa
NCT03827798Hidradenitis Suppurativa
DrugsArumakimig·Ianalumab·Remibrutinib
Novartis Pharmaceuticals
Phase 2
248
Florida, Georgia, Illinois, Indiana, Pennsylvania, South Carolina
2019-02-27
Recruiting
A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System
NCT05653102Knee Arthroplasty, Total
Exactech
Observational
1,000
Colorado, Florida, Nevada, Ohio, South Carolina
2019-01-23
Active, closed
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).
NCT03653507Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
DrugsZolbetuximab·Capecitabine·Oxaliplatin
Astellas Pharma Global Development, Inc.
Phase 3
507
California, Kansas, Louisiana, New Mexico, New York, South Carolina, Texas, Utah
2018-11-28
Active, closed
Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts
NCT03687593Total Knee Arthroplasty
Smith & Nephew, Inc.
Observational
126
Minnesota, Nevada, South Carolina, Tennessee
2018-08-26
Active, closed
Open-Label Study of AG10 in Patients with Cardiomyopathy
NCT03536767Amyloid Cardiomyopathy
DrugAcoramidis
Eidos Therapeutics, a BridgeBio company
Phase 2
55
California, Connecticut, Illinois, Massachusetts, Minnesota, New York, Oregon, South Carolina
2018-08-08
Active, closed
Persona Partial Knee Clinical Outcomes Study
NCT03034811Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Conditional Tibial Condyle or Plateau Fractures
Zimmer Biomet
Not applicable
757
California, Colorado, Illinois, Indiana, Massachusetts, Michigan, New Mexico, South Carolina
2017-02-08
By invitation
Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency
NCT02796937Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency
Grifols Therapeutics LLC
Phase 3
290
Arizona, Florida, North Carolina, Oregon, South Carolina, Texas
2016-07
Active, closed
Long-term Follow-up of Subjects With Transfusion-Dependent β-Thalassemia (TDT) Treated With Ex Vivo Gene Therapy
NCT02633943Transfusion-dependent Beta-Thalassemia
Genetix Biotherapeutics Inc.
Observational
66
California, Illinois, Maryland, New York, Pennsylvania, South Carolina
2014-01
By invitation
Comparison of Human Allograft to Apligraf for Venous Leg Ulcers
NCT02047084Venous Leg Ulcers
Solsys Medical LLC
Observational
50
South Carolina
2013-06
Active, closed
Optetrak Knee System Post Market Clinical Follow-Up
NCT05788757Knee Arthroplasty, Total
Exactech
Observational
4,588
Massachusetts, Nevada, South Carolina
2011-06-01
Recruiting
Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy
NCT01429389Down Syndrome, Fetal Aneuploidy
Sequenom, Inc.
Observational
2,000
Alabama, California, Illinois, Iowa, Michigan, New Jersey, South Carolina
2011-05
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/south-carolina

Query this register directly
GET /api/trials?country=usa&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 284 of those studies with a site in South Carolina.

How many clinical trials are recruiting in South Carolina?

179 of the 284 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 7 have not yet opened recruitment, 88 are active but closed to new participants, and 10 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (South Carolina), 284 studies
PhaseStudiesRecruitingShare
Phase 3663923.2%
Not applicable574020.1%
Phase 2502817.6%
Observational472816.5%
Phase 1352712.3%
Phase 1/222157.7%
Phase 2/3411.4%
Phase 4210.7%
Phase EARLY_PHASE1100.4%

Most active sponsors

Lead sponsors with the most studies (South Carolina)
Lead sponsorStudiesRecruiting
Takeda74
Merck Sharp & Dohme LLC65
Sanofi62
GlaxoSmithKline54
AstraZeneca42
Novartis Pharmaceuticals42
Novo Nordisk A/S43
Abbott Medical Devices31
Amgen32
Astellas Pharma Global Development, Inc.32
Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.