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Clinical Trials in the USA / NCT07205900
Active, not recruiting Phase 2

Study to Evaluate HM15275 in Obese or Overweight Subjects Without Diabetes Mellitus

NCT07205900 · tracked via the Priya Life Science USA tracker
Sponsor
Hanmi Pharmaceutical Company Limited
Phase
Phase 2
Started
2025-12-02
Last updated
2026-04-08

Condition(s) studied

ObeseObesity

Investigational drug(s) / intervention(s)

HM15275Placebo of HM15275

HM15275: HM15275 is a sterile solution for subcutaneous injection, supplied pre-filled syringes.

Placebo of HM15275: A sterile, matching solution supplied in pre-filled syringes.

Study summary

This Study is a Phase 2 Study to Evaluate Efficacy, Safety, and Tolerability of HM15275 for 36 Weeks in Obese or Overweight Subjects Without Diabetes Mellitus.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Key Inclusion Criteria 1. Participant's age at the time of signing the informed consent: * United States: 18 to 75 years (inclusive) * Korea: 19 to 75 years (inclusive) 2. BMI ≥30 kg/m² and ≤50 kg/m², or ≥27 kg/m² and \<30 kg/m² with ≥1 weight-related comorbidity 3. Body weight change \<5% over the past 3 months prior to screening 4. Capable of giving signed informed consent, ability and willingness to comply with all protocol procedures Key Exclusion Criteria: 1. Type 1 diabetes mellitus or T2DM, or HbA1c ≥6.5% / FPG ≥126 mg/dL 2. Obesity due to endocrine/genetic disorders 3. Planned or prior obesity surgery (unless \>1 year ago for liposuction/abdominoplasty), or device-based obesity therapy (unless removed \>6 months ago) 4. Personal history or current diagnosis of acute or chronic pancreatitis or factors that may increase the risk of pancreatitis, such as a history of cholelithiasis (without cholecystectomy) or alcohol abuse. 5. Personal or family history of medullary thyroid carcinoma (MTC) or a known genetic condition (e.g., multiple endocrine neoplasia type 2) that predisposes the participant to MTC. 6. Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening. 7. History or current diagnosis of congestive heart failure (NYHA class Ⅲ or Ⅳ), or myocardial infarction, stroke, unstable angina, transient ischemic attack, or revascularization procedure (e.g., stent or bypass graft surgery) within 3 months prior to screening visit 8. Personal history or current diagnosis of acute or chronic pancreatitis or factors that may increase the risk of pancreatitis, such as a history of cholelithiasis (without cholecystectomy) or alcohol abuse.

Primary outcome measure(s)

Trial sites (14)

FacilityCityRegionStatus
ProSciento Inc Chula Vista California
Accellacare of Duly - Duly Oak Lawn Oak Lawn Illinois
Accellacare of McFarland Ames Iowa
Accellacare of Cary - Cary Medical Group Cary North Carolina
Accellacare of Hickory Hickory North Carolina
Raleigh Medical Group, P.A. Raleigh North Carolina
Accellacare of Piedmont - Piedmont HealthCare Statesville North Carolina
Accellacare of Wilmington, LLC Wilmington North Carolina
Accellacare of Winston Salem Winston-Salem North Carolina
Accellacare of Charleston Mt. Pleasant South Carolina
Accellacare of Bristol-PAC of Tennessee Bristol Tennessee
Bristol-Internal Medicine and Pediatric Associates of Bristol, P.C. Bristol Tennessee
Texas Clinical Research Institute Arlington Texas
Velocity Clinical Research, Dallas Dallas Texas

More Hanmi Pharmaceutical Company Limited trials in the USA

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07205900 on ClinicalTrials.gov ↗ ← All trials in the USA