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Trackers› Clinical trials› North Carolina
Clinical trial register · United States · industry-sponsored

Clinical Trials in North Carolina, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9132 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 11 Oct 2026, 03:16 UTC
9132
Studies in scope
industry-sponsored, all four open statuses
4964
Recruiting now
open to new participants
2194
Lead sponsors
across recruiting studies
Top states
California 5299 Florida 4438 Illinois 2485 Georgia 2364 Arizona 2242
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AbbVie35 AstraZeneca32 Novartis Pharmaceuticals23 Janssen Research & Development, LLC22 Hoffmann-La Roche18
State
California5299 Florida4438 Illinois2485 Georgia2364 Arizona2242
All 51 states
Target enrolment
to

Trials with a site in North Carolina

1082 of 9132 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
Cartesian Therapeutics
Phase 2
30
California, Colorado, Florida, Georgia, Kansas, New York, North Carolina, Oregon
2019-12-04
Recruiting
Medtronic Cardiac Surgery PMCF Registry
NCT04073420Valve Disease, Heart
Medtronic Cardiac Surgery
Observational
2,700
Georgia, Michigan, New York, North Carolina, Ohio, Pennsylvania, Texas, Virginia
2019-12-02
Active, closed
Alnylam Pharmaceuticals
Phase 3
655
California, District of Columbia, Georgia, Illinois, Massachusetts, Minnesota, New York, North Carolina
2019-11-26
Active, closed
Regeneron Pharmaceuticals
Phase 2
515
Illinois, Iowa, Kentucky, Massachusetts, Minnesota, New Jersey, New York, North Carolina
2019-11-13
Active, closed
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors
NCT04082429Haemophilia A Without Inhibitors, Haemophilia B Without Inhibitors
DrugConcizumab
Novo Nordisk A/S
Phase 3
156
California, Georgia, Indiana, Iowa, Michigan, North Carolina, Pennsylvania, Tennessee
2019-11-13
Active, closed
AbbVie
Phase 1
85
California, Illinois, Kentucky, Michigan, Nebraska, North Carolina, Ohio, Pennsylvania
2019-11-08
Active, closed
AbbVie
Phase 1/2
218
California, Florida, Illinois, Massachusetts, Michigan, Minnesota, New York, North Carolina
2019-11-06
Active, closed
Boehringer Ingelheim
Phase 1
71
Massachusetts, North Carolina, Tennessee, Texas
2019-11-04
Active, closed
Bayer
Observational
371
Alabama, Arizona, California, Colorado, District of Columbia, Louisiana, Minnesota, North Carolina
2019-10-21
Active, closed
Novo Nordisk A/S
Phase 3
134
California, Georgia, Indiana, Missouri, North Carolina, Tennessee, Texas
2019-10-21
Active, closed
Biogen
Phase 3
152
California, North Carolina, Virginia
2019-10-18
Active, closed
Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer
NCT04050436Cutaneous Squamous Cell Carcinoma, Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
DrugsVusolimogene Oderparepvec·Cemiplimab
Replimune, Inc.
Phase 2
231
California, Colorado, Florida, Georgia, New Jersey, New York, North Carolina, Ohio
2019-10-08
Active, closed
Sequana Medical N.V.
Not applicable
110
Arizona, California, Massachusetts, Minnesota, North Carolina, Pennsylvania, South Carolina, South Dakota
2019-09-16
Active, closed
ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)
NCT04044859Endometrial Cancer, Esophageal Cancer, Esophagogastric Junction (EGJ), Gastric (Stomach) Cancer
USWM CT, LLC
Phase 1
120
Florida, Massachusetts, Missouri, New York, North Carolina, Oklahoma, Tennessee, Texas
2019-08-20
Recruiting
SUNOSI® (Solriamfetol) Pregnancy Registry
NCT06413420Narcolepsy, Obstructive Sleep Apnea, Pregnant Women and Their Offspring
DrugSolriamfetol
Axsome Therapeutics, Inc.
Observational
1,731
North Carolina
2019-07-31
Active, closed
Novartis Pharmaceuticals
Phase 3
254
Georgia, Massachusetts, North Carolina, Tennessee, Texas
2019-07-26
Active, closed
Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer
NCT04046445Colorectal Cancer, MSS, Stage IV Colon Cancer, Stage IV Rectal Cancer
DrugEzabenlimab
Amal Therapeutics
Phase 1
96
Arizona, California, Colorado, New York, North Carolina, Texas
2019-07-22
Active, closed
TARGET BP I Clinical Trial
NCT02910414Hypertension
DrugEthanol
Ablative Solutions, Inc.
Phase 3
300
Alabama, Georgia, North Carolina, Texas
2019-07-22
Recruiting
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
NCT03947385Metastatic Uveal Melanoma, Cutaneous Melanoma, Colorectal Cancer, Other Solid Tumors
DrugsDarovasertib·Binimetinib·Crizotinib
IDEAYA Biosciences
Phase 1/2
336
California, Colorado, Iowa, Michigan, New York, North Carolina, Ohio, Pennsylvania
2019-06-28
Active, closed
AbbVie
Phase 1/2
220
California, Louisiana, Minnesota, Missouri, New York, North Carolina, Wisconsin
2019-06-24
Active, closed
Eisai Inc.
Phase 2
100
California, Colorado, Florida, Georgia, Michigan, New Jersey, North Carolina, Ohio
2019-05-31
Active, closed
AbbVie
Phase 1
150
Arkansas, California, Connecticut, Florida, Indiana, Missouri, North Carolina, Pennsylvania
2019-05-21
Recruiting
Treatment of Radiation and Cisplatin Induced Toxicities with Tempol
NCT03480971Mucositis, Nephrotoxicity, Ototoxicity
Matrix Biomed, Inc.
Phase 2
120
California, New York, North Carolina, Washington
2019-05-13
Active, closed
Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas
NCT03478462Pediatric Solid Tumor, Pediatric Lymphoma, Pediatric Brain Tumor, DIPG
DrugCLR 131
Cellectar Biosciences, Inc.
Phase 1
30
California, New York, North Carolina, Ohio, Texas, Wisconsin
2019-04-30
Active, closed
Cook MyoSite
Phase 3
96
Arizona, California, District of Columbia, Kansas, Michigan, New Mexico, New York, North Carolina
2019-04-23
Active, closed
AstraZeneca
Phase 3
810
California, District of Columbia, Florida, Kansas, Kentucky, Massachusetts, Missouri, North Carolina
2019-04-16
Active, closed
Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer
NCT03907852Mesothelioma, Mesothelioma, Malignant, Mesothelioma; Pleura, Mesotheliomas Pleural
DrugsIpilimumab·Fludarabine·Nivolumab·Cyclophosphamide
TCR2 Therapeutics
Phase 1/2
57
California, Florida, Illinois, Maryland, New York, North Carolina, Pennsylvania, Tennessee
2019-04-15
Recruiting
AstraZeneca
Phase 3
140
Alabama, Georgia, Maryland, Michigan, Missouri, New Jersey, New York, North Carolina
2019-04-02
Recruiting
Deep Brain Stimulation (DBS) Retrospective Outcomes Study
NCT03664609Parkinson Disease, Essential Tremor, Dystonia
Boston Scientific Corporation
Observational
5,000
Arizona, California, Florida, Idaho, New York, North Carolina, Pennsylvania, Washington
2019-03-12
Recruiting
Aptose Biosciences Inc.
Phase 1/2
240
Alabama, California, Connecticut, Florida, Georgia, Massachusetts, North Carolina, Ohio
2019-03-11
Active, closed
Hoffmann-La Roche
Phase 3
1,000
Colorado, Connecticut, Massachusetts, North Carolina, Pennsylvania, Texas
2019-02-28
Recruiting
Travere Therapeutics, Inc.
Phase 1/2
39
Colorado, Florida, Illinois, Indiana, Maine, Massachusetts, New York, North Carolina
2019-01-22
Active, closed
Hoffmann-La Roche
Phase 1/2
422
Alabama, California, Colorado, Florida, Michigan, New York, North Carolina, Pennsylvania
2018-09-25
Active, closed
A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors
NCT03611868Unresectable or Metastatic Melanoma or Advanced Solid Tumors, Melanoma, Uveal Melanoma, P53 Mutation
DrugPembrolizumab
Ascentage Pharma Group Inc.
Phase 1/2
230
Arizona, Arkansas, California, District of Columbia, Florida, Missouri, New York, North Carolina
2018-08-29
Active, closed
Neurotechnology Following Traumatic Brain Injury
NCT03649958Post-Concussion Symptoms, Insomnia, Pain, Chronic, Depressive Symptoms
Brain State Technologies, LLC
Not applicable
80
Maryland, North Carolina
2018-08-28
Active, closed
Venous Sinus Stenting With the River Stent in IIH
NCT03556085Idiopathic Intracranial Hypertension
Serenity Medical, Inc.
Not applicable
39
Florida, New York, North Carolina, Oregon
2018-08-24
By invitation
Advanced Materials Science in XLIF Study
NCT03649490Degenerative Disc Disease, Spondylolisthesis
NuVasive
Observational
300
Connecticut, Florida, Illinois, Kentucky, Maryland, Minnesota, Missouri, North Carolina
2018-08-19
Active, closed
Inovio Pharmaceuticals
Phase 1/2
52
California, Florida, Georgia, Massachusetts, Michigan, New Jersey, New York, North Carolina
2018-05-31
Active, closed
Hoffmann-La Roche
Phase 1/2
211
North Carolina
2018-05-08
Active, closed
MedImmune LLC
Phase 1
400
Michigan, New York, North Carolina, Rhode Island, Tennessee, Virginia
2018-04-24
Active, closed
Pyruvate Kinase Deficiency Global Longitudinal Registry
NCT03481738Pyruvate Kinase Deficiency
Agios Pharmaceuticals, Inc.
Observational
500
Arizona, Arkansas, California, Georgia, Massachusetts, Michigan, North Carolina, Pennsylvania
2018-04-23
Active, closed
Janssen Research & Development, LLC
Phase 3
211
Kentucky, New Jersey, North Carolina
2018-04-17
Active, closed
Beacon Therapeutics
Phase 1/2
29
North Carolina, Ohio, Oregon, Texas
2018-04-16
By invitation
USWM CT, LLC
Phase 1
250
Georgia, Maryland, Michigan, Missouri, New York, North Carolina, Oregon, Pennsylvania
2018-04-09
Active, closed
Janssen Research & Development, LLC
Phase 1/2
125
Colorado, Kentucky, Maryland, New Jersey, New York, North Carolina, Ohio, Pennsylvania
2018-04-05
Active, closed
AbbVie
Phase 2
156
Colorado, Florida, Georgia, Illinois, Massachusetts, New Jersey, New York, North Carolina
2018-04-02
By invitation
Compliant Analysis of Patient Samples and Data
NCT04364503Pregnancy Related, Cancer, Infectious Disease
Sequenom, Inc.
Observational
2,000
California, Colorado, Illinois, New York, North Carolina
2018-03-17
Active, closed
PRospective Multiple Myeloma Impact Study
NCT02911571Multiple Myeloma
SkylineDx
Not applicable
250
District of Columbia, Georgia, New Jersey, New York, North Carolina, Wisconsin
2018-02-27
Active, closed
Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN
NCT03386513Blastic Plasmacytoid Dendritic Cell Neoplasm, Myeloproliferative Neoplasm
DrugIMGN632
AbbVie
Phase 1/2
179
Alabama, Arizona, California, Florida, Maryland, Massachusetts, New York, North Carolina
2018-01-02
Active, closed
Early Feasibility Study of the RelayBranch Thoracic Stent-Graft System
NCT03214601Thoracic Aorta Aneurysm, Aneurysm, Ruptured, Aortic Aneurysm
Bolton Medical
Not applicable
30
California, Florida, Georgia, Maryland, Massachusetts, Missouri, New York, North Carolina
2017-12-04
Active, closed
BeiGene
Phase 3
590
Georgia, Illinois, Massachusetts, Missouri, Nevada, New Jersey, New York, North Carolina
2017-10-31
Active, closed
Genzyme, a Sanofi Company
Phase 2
22
New York, North Carolina, Washington
2017-10-12
Active, closed
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
NCT03211663Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Medacta USA
Observational
269
Florida, Kentucky, Montana, North Carolina, Pennsylvania
2017-10-09
Recruiting
Apollomics Inc.
Phase 2
497
California, Florida, Massachusetts, North Carolina, Pennsylvania, Wisconsin
2017-09-27
Active, closed
Neonc Technologies, Inc.
Phase 1/2
49
California, Georgia, Louisiana, New Jersey, New York, North Carolina, Ohio, Texas
2017-08-01
Active, closed
A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)
NCT03162536Lymphoma, B-Cell, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia
DrugNemtabrutinib
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Phase 1/2
190
Arizona, California, Colorado, Michigan, Minnesota, North Carolina, Ohio, Tennessee
2017-06-26
Active, closed
Janssen Research & Development, LLC
Phase 1
302
California, Colorado, New York, North Carolina, Pennsylvania
2017-05-16
Active, closed
MAGE-A4ᶜ¹º³²T for Multi-Tumor
NCT03132922Urinary Bladder Cancer, Melanoma, Head and Neck Cancer, Ovarian Cancer
USWM CT, LLC
Phase 1
71
Florida, Missouri, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2017-05-15
Recruiting
Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only
NCT05619588Ankle Rheumatoid Arthritis, Arthritis of Ankle, Failure, Prosthesis
Exactech
Observational
370
Florida, North Carolina
2017-04-04
Active, closed
Prospective G7 Dual Mobility Total Hip PMCF
NCT03308929Clinical Outcomes, Functional Outcomes, Radiological Outcomes, Survivorship
Zimmer Biomet
Observational
250
New Jersey, New Mexico, North Carolina, Oregon, Virginia
2017-02-28
Active, closed
AbbVie
Phase 1
163
California, Illinois, Massachusetts, North Carolina, Tennessee, Texas, Virginia
2017-02-22
Active, closed
DBV Technologies
Phase 3
300
Arkansas, California, Colorado, Illinois, Maryland, Massachusetts, New York, North Carolina
2017-01-23
Active, closed
Trident II Tritanium Acetabular Shell Outcomes Study
NCT02999009Arthroplasty, Replacement, Hip
Stryker Orthopaedics
Not applicable
383
Arizona, Florida, Illinois, Louisiana, Michigan, New Jersey, New York, North Carolina
2017-01-20
Active, closed
Gilead Sciences
Phase 2/3
177
District of Columbia, Florida, Georgia, Michigan, New York, North Carolina, Pennsylvania, Tennessee
2016-09-21
Active, closed
DePuy Orthopaedics
Not applicable
540
Colorado, Florida, New Hampshire, New Jersey, New York, North Carolina, Tennessee, Texas
2016-09-01
By invitation
Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency
NCT02796937Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency
Grifols Therapeutics LLC
Phase 3
290
Arizona, Florida, North Carolina, Oregon, South Carolina, Texas
2016-07
Active, closed
DS-3201b in Participants With Lymphomas
NCT02732275Lymphoma, Malignant, Non-hodgkin Lymphoma
DrugValemetostat Tosylate
Daiichi Sankyo Co., Ltd.
Phase 1
100
California, Connecticut, Georgia, Massachusetts, New Jersey, New York, North Carolina, Ohio
2016-03-31
Active, closed
Pentax Medical
Not applicable
150
California, Florida, Illinois, Maryland, Minnesota, New York, North Carolina, Ohio
2016-03
Active, closed
MedImmune LLC
Phase 2
433
Arizona, California, Connecticut, Florida, Indiana, Massachusetts, New York, North Carolina
2015-10-19
Recruiting
Karyopharm Therapeutics Inc
Phase 1/2
300
Arizona, California, Colorado, Massachusetts, Nebraska, New Jersey, New York, North Carolina
2015-10
Active, closed
JOURNEY™ II CR Total Knee System
NCT02440672Osteoarthritis, Knee
Smith & Nephew, Inc.
Observational
170
Arizona, Illinois, Maryland, New York, North Carolina, Ohio
2015-09
Recruiting
Clinical Outcomes Study of the Nexel Total Elbow
NCT02469662Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis
Zimmer Biomet
Not applicable
134
Colorado, North Carolina, Pennsylvania, Tennessee
2015-06
Active, closed
Eli Lilly and Company
Phase 3
545
California, Colorado, Hawaii, Kansas, New York, North Carolina, Pennsylvania
2015-05-06
Recruiting
Kaneka Medical America LLC
Not applicable
35
California, Delaware, Florida, Michigan, Minnesota, New York, North Carolina, Ohio
2015-05-03
Active, closed
Persona Total Knee Arthroplasty Outcomes Study
NCT02255383Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
737
Colorado, Illinois, Indiana, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2014-07
Active, closed
Eli Lilly and Company
Phase 1
198
Arkansas, California, Massachusetts, Minnesota, New York, North Carolina, Oregon, Pennsylvania
2014-03-10
Active, closed
Zimmer Trabecular Metal Total Ankle PMCF
NCT02038140Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
Zimmer Biomet
Not applicable
120
California, Michigan, North Carolina, Pennsylvania
2014-03
Recruiting
Observational Pharmaco-Epidemiology Research & Analysis
NCT03813862Chronic Disease, HIV/AIDS, Liver Diseases, Inflammatory Bowel Diseases
Epividian
Observational
2,000,000
North Carolina
2013-12-01
Active, closed
AstraZeneca
Phase 3
510
Colorado, Florida, Georgia, Illinois, Louisiana, Massachusetts, New York, North Carolina
2013-09-25
Recruiting
Atypical Hemolytic-Uremic Syndrome (aHUS) Registry
NCT01522183Atypical Hemolytic-Uremic Syndrome
Alexion Pharmaceuticals, Inc.
Observational
3,000
Colorado, District of Columbia, Florida, Georgia, Illinois, Massachusetts, Missouri, North Carolina
2013-03-18
Recruiting
BioCytics, Inc.
Observational
1,500
North Carolina
2007-11
Recruiting
Exactech Shoulder Post Market Clinical Follow-up Study
NCT05603728Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy
Exactech
Observational
20,000
California, Colorado, Florida, Georgia, Illinois, Michigan, New York, North Carolina
2007-07-19
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Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 12 October 2026. https://priyalifescience.com/clinical-trials-usa/state/north-carolina?page=3

Query this register directly
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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,132 studies in total at the last sync on 11 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,082 of those studies with a site in North Carolina.

How many clinical trials are recruiting in North Carolina?

595 of the 1,082 studies on this page are recruiting new participants as of the 11 Oct 2026, 03:16 UTC sync. A further 28 have not yet opened recruitment, 411 are active but closed to new participants, and 48 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.