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Trackers› Clinical trials› Pennsylvania
Clinical trial register · United States · industry-sponsored

Clinical Trials in Pennsylvania, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca33 Novartis Pharmaceuticals29 Merck Sharp & Dohme LLC20 Eli Lilly and Company18 Janssen Research & Development, LLC17
State
California5290 Florida4430 Illinois2481 Georgia2368 Arizona2238
All 51 states
Target enrolment
to

Trials with a site in Pennsylvania

1048 of 9118 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease
NCT03319485Parkinson Disease
InSightec
Not applicable
92
California, Florida, Maryland, Massachusetts, Minnesota, New York, Ohio, Pennsylvania
2018-02-09
Active, closed
Phase II Umbrella Study of Novel Anti-cancer Agents in Participants With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy
NCT03334617Non-Small Cell Lung Cancer
DrugsDanvatirsen·Vistusertib·Cediranib Maleate·Ceralasertib
AstraZeneca
Phase 2
528
California, District of Columbia, Illinois, Maryland, Massachusetts, Missouri, New York, Pennsylvania
2017-12-18
Active, closed
U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer
NCT03260491Non-Small Cell Lung Cancer (NSCLC)
DrugPatritumab deruxtecan
Daiichi Sankyo
Phase 1
312
California, Georgia, Massachusetts, Michigan, New York, Ohio, Pennsylvania, Tennessee
2017-10-30
Recruiting
Givinostat in Duchenne's Muscular Dystrophy Long-term Safety and Tolerability Study
NCT03373968Duchenne Muscular Dystrophy
DrugHydroxyurea
Italfarmaco
Phase 2/3
206
California, Connecticut, Florida, Georgia, Iowa, Missouri, Oregon, Pennsylvania
2017-10-24
Active, closed
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
NCT03211663Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Medacta USA
Observational
269
Florida, Kentucky, Montana, North Carolina, Pennsylvania
2017-10-09
Recruiting
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
NCT03175224Solid Tumors, Advanced Cancer, Renal Cancer, Gastric Cancer
DrugsBozitinib·Vebreltinib
Apollomics Inc.
Phase 2
497
California, Florida, Massachusetts, North Carolina, Pennsylvania, Wisconsin
2017-09-27
Active, closed
ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
NCT03130777Pulmonary Disease, Transcatheter Pulmonary Valve Replacement (TPVR), Tetralogy of Fallot, Congenital Heart Disease
Edwards Lifesciences
Not applicable
86
California, Colorado, Georgia, Missouri, New York, Ohio, Pennsylvania, Texas
2017-08-22
Active, closed
Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors
NCT03313778Solid Tumors
DrugsIntismeran autogene·Pembrolizumab
ModernaTX, Inc.
Phase 1
161
California, District of Columbia, Florida, Massachusetts, New York, Ohio, Pennsylvania, Texas
2017-08-14
Active, closed
Study Evaluating Safety and Efficacy of UCART123v1.2 in Patients With Relapsed/Refractory Acute Myeloid Leukemia
NCT03190278Relapsed/Refractory Acute Myeloid Leukemia
Cellectis S.A.
Phase 1
29
California, Florida, Illinois, Massachusetts, New York, Pennsylvania, Texas
2017-06-19
Active, closed
Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).
NCT03164616Non Small Cell Lung Cancer NSCLC
DrugsTremelimumab·Abraxane·Durvalumab·Pemetrexed
AstraZeneca
Phase 3
1,186
Arizona, California, Florida, Kentucky, Missouri, Ohio, Pennsylvania, Tennessee
2017-06-01
Recruiting
Initial Feasibility Study to Treat Borderline Resectable Pancreatic Cancer With a Planar LDR Source
NCT02843945Pancreatic Cancer
CivaTech Oncology
Phase 1/2
80
Florida, Illinois, Louisiana, Pennsylvania, Virginia
2017-05-31
Active, closed
Dose Escalation Study of Teclistamab, a Humanized BCMA*CD3 Bispecific Antibody, in Participants With Relapsed or Refractory Multiple Myeloma
NCT03145181Hematological Malignancies
DrugTeclistamab
Janssen Research & Development, LLC
Phase 1
302
California, Colorado, New York, North Carolina, Pennsylvania
2017-05-16
Active, closed
MAGE-A4ᶜ¹º³²T for Multi-Tumor
NCT03132922Urinary Bladder Cancer, Melanoma, Head and Neck Cancer, Ovarian Cancer
USWM CT, LLC
Phase 1
71
Florida, Missouri, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2017-05-15
Active, closed
Xeltis Bioabsorbable Pulmonary Valved Conduit Pivotal Study
NCT03022708Heart Defect, Congenital
Xeltis
Not applicable
6
California, Colorado, Florida, New York, Ohio, Pennsylvania, Texas
2017-05-08
Active, closed
A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma
NCT03075696Non-Hodgkin's Lymphoma
DrugsGlofitamab·Tocilizumab·Obinutuzumab
Hoffmann-La Roche
Phase 1/2
940
Michigan, Missouri, New York, Pennsylvania, Washington
2017-02-21
Active, closed
The Medtronic Harmony™ Transcatheter Pulmonary Valve Clinical Study
NCT02979587Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
Medtronic Heart Valves
Not applicable
86
California, Connecticut, Minnesota, Ohio, Pennsylvania, Texas, Utah, Washington
2017-01
Active, closed
Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension
NCT02682511Scleroderma, Diffuse, Scleroderma, Systemic, Scleroderma, Limited, Sclerosis, Progressive Systemic
DrugIfetroban
Cumberland Pharmaceuticals
Phase 2
34
Arizona, California, Florida, Maryland, Massachusetts, Nebraska, New York, Pennsylvania
2017-01
Active, closed
An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis
NCT02808780Ulcerative Colitis
Janssen Biotech, Inc.
Observational
535
California, Florida, Georgia, Illinois, Ohio, Pennsylvania, Texas, Virginia
2016-12-16
Active, closed
Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:
NCT03100474Essential Tremor, Parkinson's Disease, Movement Disorders, Neuropathic Pain
InSightec
Observational
500
California, Maryland, Pennsylvania, Virginia, Washington
2016-12
Active, closed
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers
NCT02908906Neoplasms
DrugCetrelimab
Janssen Research & Development, LLC
Phase 1/2
234
Missouri, Pennsylvania
2016-11-21
Active, closed
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
NCT02803957Mitral Valve Insufficiency
NeoChord
Not applicable
585
California, District of Columbia, Georgia, Indiana, Maryland, Michigan, New York, Pennsylvania
2016-11-03
Active, closed
Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination in Adolescents and Children With Human Immunodeficiency Virus-1
NCT02881320HIV-1 Infection
DrugB/F/TAF
Gilead Sciences
Phase 2/3
177
District of Columbia, Florida, Georgia, Michigan, New York, North Carolina, Pennsylvania, Tennessee
2016-09-21
Active, closed
A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer
NCT02711553Biliary Tract Cancer, Metastatic Cancer, Advanced Cancer
DrugsRamucirumab·Gemcitabine·Cisplatin
Eli Lilly and Company
Phase 2
309
Arizona, California, District of Columbia, Florida, Michigan, Missouri, Pennsylvania, Tennessee
2016-05-19
Recruiting
Phase I/II/III Gene Transfer Clinical Trial of scAAV9.U1a.hSGSH
NCT02716246MPS IIIA, Sanfilippo Syndrome, Sanfilippo A, Mucopolysaccharidosis III
Ultragenyx Pharmaceutical Inc
Phase 2/3
36
Ohio, Pennsylvania
2016-04-25
Active, closed
A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.
NCT02734004Ovarian, Breast, SCLC, Gastric Cancers
DrugsAvastin·Olaparib·Durvalumab·Bevacizumab
AstraZeneca
Phase 1/2
264
Georgia, Maryland, Massachusetts, Michigan, Missouri, Ohio, Pennsylvania
2016-03-17
Active, closed
A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children
NCT02637687Solid Tumors Harboring NTRK Fusion
DrugLarotrectinib
Bayer
Phase 1/2
154
California, Florida, Massachusetts, New York, Ohio, Pennsylvania, Tennessee, Texas
2015-12-16
Active, closed
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
NCT02542293Non Small Cell Lung Carcinoma NSCLC
DrugsTremelimumab·Durvalumab·Pemetrexed·Gemcitabine
AstraZeneca
Phase 3
953
California, Kentucky, New Jersey, New Mexico, New York, Ohio, Pennsylvania, Texas
2015-11-03
Recruiting
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee
NCT02844751Osteoarthritis
DrugsPlatelet rich plasma (PRP)]·[StroMed
VivaTech International, Inc.
Phase 2
4,000
Pennsylvania
2015-07
Recruiting
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip
NCT02844764Osteoarthritis
DrugsPlatelet rich plasma (PRP)]·[StroMed
VivaTech International, Inc.
Phase 2
4,000
Pennsylvania
2015-07
Recruiting
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder
NCT02844738Osteoarthritis
DrugsPlatelet rich plasma (PRP)]·[StroMed
VivaTech International, Inc.
Phase 2
4,000
Pennsylvania
2015-07
Recruiting
Clinical Outcomes Study of the Nexel Total Elbow
NCT02469662Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis
Zimmer Biomet
Not applicable
134
Colorado, North Carolina, Pennsylvania, Tennessee
2015-06
Active, closed
Study of Safety and Efficacy of Ceritinib in Combination With Nivolumab in Patients With ALK-positive Non-small Cell Lung Cancer
NCT02393625ALK-positive NSCLC
DrugsCeritinib·Nivolumab
Novartis Pharmaceuticals
Phase 1
57
Arizona, Massachusetts, Pennsylvania
2015-05-27
Active, closed
A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Previously Untreated Participants With EGFR Mutation-Positive Metastatic NSCLC (RELAY)
NCT02411448Metastatic Non-Small Cell Lung Cancer
DrugsGefitinib·Erlotinib·Ramucirumab·Osimertinib
Eli Lilly and Company
Phase 3
545
California, Colorado, Hawaii, Kansas, New York, North Carolina, Pennsylvania
2015-05-06
Active, closed
Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration
NCT02286089Age-Related Macular Degeneration
DrugOpRegen
Hoffmann-La Roche
Phase 1/2
24
California, Ohio, Pennsylvania
2015-04-01
Active, closed
Ascending Doses of Ceralasertib in Combination With Chemotherapy and/or Novel Anti Cancer Agents
NCT02264678Adv Solid Malig - H&N SCC, ATM Pro / Def NSCLC, Gastric, Breast and Ovarian Cancer
DrugsSaruparib·Olaparib·Durvalumab·Carboplatin
AstraZeneca
Phase 1
358
California, Massachusetts, New York, Pennsylvania
2014-10-31
Recruiting
Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer
NCT02174549Hepatocellular Carcinoma, Gastrointestinal Cancer Metastatic, Neuroendocrine Tumors
DrugTirapazamine
Teclison Ltd.
Phase 1/2
25
California, Pennsylvania
2014-09
Active, closed
AZD9291 in Combination With Ascending Doses of Novel Therapeutics
NCT02143466Advanced Non Small Cell Lung Cancer
DrugsSavolitinib·Selumetinib·Osimertinib·Durvalumab
AstraZeneca
Phase 1
344
Georgia, Massachusetts, New York, Pennsylvania, Tennessee
2014-08-05
Active, closed
Persona Total Knee Arthroplasty Outcomes Study
NCT02255383Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
737
Colorado, Illinois, Indiana, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2014-07
Active, closed
A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread
NCT02057133Breast Neoplasms
DrugsLoperamide·Samotolisib·Tamoxifen·Exemestane
Eli Lilly and Company
Phase 1
198
Arkansas, California, Massachusetts, Minnesota, New York, North Carolina, Oregon, Pennsylvania
2014-03-10
Active, closed
Zimmer Trabecular Metal Total Ankle PMCF
NCT02038140Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
Zimmer Biomet
Not applicable
120
California, Michigan, North Carolina, Pennsylvania
2014-03
Active, closed
Long-term Follow-up of Subjects With Transfusion-Dependent β-Thalassemia (TDT) Treated With Ex Vivo Gene Therapy
NCT02633943Transfusion-dependent Beta-Thalassemia
Genetix Biotherapeutics Inc.
Observational
66
California, Illinois, Maryland, New York, Pennsylvania, South Carolina
2014-01
Active, closed
Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
NCT01892722Multiple Sclerosis
DrugsAvonex·Fingolimod
Novartis Pharmaceuticals
Phase 3
240
Alabama, California, Florida, Massachusetts, Michigan, New Jersey, Pennsylvania, Utah
2013-07-26
Active, closed
Survivorship of Attune Primary Total Knee Prosthesis
NCT01754363Noninflammatory Degenerative Joint Disease
DePuy International
Not applicable
1,542
Arizona, California, Florida, Indiana, Iowa, Ohio, Pennsylvania, Texas
2013-02-01
Active, closed
Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis
NCT00999609Inherited Retinal Dystrophy Due to RPE65 Mutations, Leber Congenital Amaurosis
DrugVoretigene neparvovec-rzyl
Spark Therapeutics, Inc.
Phase 3
31
Iowa, Pennsylvania
2012-10
Active, closed
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
NCT01480440Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Ununited Humeral Head Fracture
Zimmer Biomet
Observational
200
California, Kentucky, New Jersey, Pennsylvania
2011-01
Active, closed
Phase 1 Follow-on Study of AAV2-hRPE65v2 Vector in Subjects With Leber Congenital Amaurosis (LCA) 2
NCT01208389Leber Congenital Amaurosis
DrugVoretigene neparvovec-rzyl
Spark Therapeutics, Inc.
Phase 1/2
12
Pennsylvania
2010-11
By invitation
Zyprexa® Relprevv™ Patient Care Program
NCT01088386Schizophrenia
Eli Lilly and Company
Observational
4,000
Pennsylvania
2010-03-03
Active, closed
10 Year Registry of Children (Ages 2-17 Years) With Eczema That Have Used Pimecrolimus
NCT00568997Atopic Dermatitis
DrugsElidel·Pimecrolimus
Bausch Health Americas, Inc.
Observational
8,000
Pennsylvania
2005-06-27
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/pennsylvania?page=3

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,048 of those studies with a site in Pennsylvania.

How many clinical trials are recruiting in Pennsylvania?

580 of the 1,048 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 37 have not yet opened recruitment, 392 are active but closed to new participants, and 39 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.