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Priya Life Science Clinical trial register
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Trackers› Clinical trials› Toronto
Clinical trial register · Canada

Clinical Trials in Toronto, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Canada and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage โ€” all 6540 matching records held by the registry are in this view. Synced 26 Sep 2026, 19:55 UTC
6540
Studies in scope
all four open statuses
3515
Recruiting now
open to new participants
887
Lead sponsors
across recruiting studies
Top sites
Toronto 344 Vancouver 19 Montreal 19 London 14 Hamilton 14
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
University Health Network, Toronto344 Sunnybrook Health Sciences Centre137 AstraZeneca117 The Hospital for Sick Children80 Centre for Addiction and Mental Health71 Clear sponsor filter
Site location
Toronto344 Vancouver19 Montreal19 London14 Hamilton14
All 35 locations
Target enrolment
to

Trials with a site in Toronto

344 of 6540 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Canada
Start
Not yet open
Phase II Study of CAmizestrant in Resectable Endometrial Adenocarcinoma
NCT07840443Estrogen Receptor-positive, Early Stage Endometrial Cancer
DrugCamizestrant
University Health Network, Toronto
Phase 2
30
Vancouver, Kingston, Ottawa, Toronto, Montreal
2026-10-26
Not yet open
Functional Electrical Stimulation Plus High Intensity Interval Training at Home
NCT07773974Spinal Cord Injuries (SCI)
University Health Network, Toronto
Not applicable
24
Toronto
2026-10-01
Not yet open
Positioning in RT - Supine vs. Upright
NCT07765069Cancer
University Health Network, Toronto
Observational
105
Toronto
2026-10-01
Not yet open
Clinical Trial to Test Efficacy of Targeting Hypoxia Combined With ARSI After First-line ARSI Therapy for Castrate Resistant Prostate Cancer
NCT06836726Castration Resistant Prostate Cancer
DrugEvofosfamide
University Health Network, Toronto
Phase 2
35
Toronto
2026-10-01
Active, closed
Spinal Cord Stimulation for Refractory Pain Randomized Controlled Trial: the PAcStim RCT
NCT07468591Chronic Pain Syndrome
University Health Network, Toronto
Not applicable
90
Toronto
2026-09-17
Recruiting
Vagina-View Safety and Imaging Feasibility
NCT07818850Vaginal Cancer
University Health Network, Toronto
Not applicable
10
Toronto
2026-09-15
Not yet open
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled Trial
NCT07820033Advanced Cancer, Stage IV Solid Tumor Cancer, Stage IV Sarcoma of Bone, Stage IV Lymphoma
DrugPsilocybin
University Health Network, Toronto
Phase 2
46
Toronto
2026-09-14
Recruiting
Co-Adaptation of an Digital Pain Management Program for Canadian Veterans
NCT07818980Chronic Pain, Veterans
University Health Network, Toronto
Observational
22
Toronto
2026-09-14
Not yet open
Semaglutide for the Prevention Of Post-Transplant Diabetes Mellitus
NCT06913023Kidney Transplant Recipient
DrugsWegovy·Semaglutide
University Health Network, Toronto
Phase 2/3
37
Vancouver, Toronto
2026-09-05
Not yet open
68Ga-PSMA-11 PET/MRI for Selecting Men With Prostate Cancer for Focal Therapy
NCT07747493Prostate Cancer (Adenocarcinoma), Localized Prostate Cancer
DrugIlluccix
University Health Network, Toronto
Not applicable
8
Toronto
2026-09-01
Not yet open
ctDNA-Guided CURB for OPD mNSCLC on TKI (CURB-TKI)
NCT06813664Metastatic NSCLC - Non-Small Cell Lung Cancer, OligoProgressive Metastatic Disease
University Health Network, Toronto
Phase 2
60
Toronto
2026-09-01
Recruiting
Clear Me: Interception Trial to Detect and Clear Molecular Residual Disease in Patients With High-risk Melanoma
NCT06319196Cutaneous Melanoma, Melanoma Stage IV, Mucosal Melanoma
DrugsOpdualag·Nivolumab
University Health Network, Toronto
Phase 2
54
Toronto
2026-08-27
Recruiting
WomenFocused Education in CArdiac REhabilitation (WECARE) Pilot RCT
NCT07550036Cardiovascular Diseases, Heart Diseases, Health Knowledge, Attitudes, Practice, Behavior, Health
University Health Network, Toronto
Not applicable
50
Barrie, Toronto, Lรฉvis
2026-08-21
Not yet open
Reliability of Diaphragm Ultrasound: Intra- and Interrater Analysis
NCT07747532Diaphragm Issues
University Health Network, Toronto
Observational
58
Toronto
2026-08
Recruiting
Capecitabine in ER+/HER2-negative Breast Cancer
NCT07631052ER-positive, HER2-negative Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III
DrugCapecitabine
University Health Network, Toronto
Phase 2
15
Toronto
2026-07-29
Not yet open
Well-being Program for Caregivers of Patients With Advanced Cardiac and Pulmonary Disease
NCT07685912Caregiver, Cardiac Disease, Pulmonary Diseases
University Health Network, Toronto
Not applicable
80
Toronto
2026-07-15
Recruiting
PRT for Chronic Low Back Pain
NCT07696741Chronic Low Back Pain (CLBP), Nociplastic Pain
University Health Network, Toronto
Not applicable
30
Toronto
2026-07-15
Recruiting
Elective Adaptive Radiation With SBRT for Improved DurabilitY of Response
NCT06831032Prostate Adenocarcinoma, Iliac Nodal Disease, Para-aortic Lymph Node Metastasis, Para-aortic Nodal Disease
University Health Network, Toronto
Not applicable
26
Toronto
2026-07-07
Not yet open
Samuraciclib in Combination With Gemcitabine/Nab-Paclitaxel in Patients With Metastatic Basal-Like Pancreatic Cancer
NCT07665684Pancreas Ductal Adenocarcinoma, Pancreas Cancer, Metastatic, Pancreatic Adenocarcinoma Metastatic, Adenosquamous Carcinoma of the Pancreas
DrugsSamuraciclib·Gemcitabine-nab-paclitaxel
University Health Network, Toronto
Phase 1/2
67
Toronto
2026-07
Not yet open
Clinical Trial to Observe the Effects of Tamoxifen on Testosterone Recovery in Medically Castrated Prostate Cancer Patients
NCT07535905Hypogonadism, Prostate Cancer
DrugTamoxifen
University Health Network, Toronto
Phase 2
96
Toronto
2026-07
Recruiting
Contrast-enhanced CBCT With C-arm HyperSight Technology
NCT07648160Advanced Cancer
University Health Network, Toronto
Not applicable
20
Toronto
2026-06-24
Recruiting
Ted Rogers Understanding of Exacerbations in Heart Failure 2: Monitor
NCT07447908Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Patients, Cardiopulmonary Exercise Test
University Health Network, Toronto
Observational
360
Newmarket, Toronto
2026-06-16
Recruiting
Pneumonitis Prevention Protocol Using Pentoxifylline and ฮฑ-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation
NCT06634056Non-Small Cell Lung Cancer, Radiation Induced Lung Injury (RILI)
DrugPentoxifylline
University Health Network, Toronto
Phase 2
150
Toronto
2026-06-15
Recruiting
Shoulder RA Survey Study
NCT07641842Nerve Block
University Health Network, Toronto
Observational
140
Toronto
2026-06-05
Recruiting
Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy in Patients With Cancer-Related Celiac Pain
NCT07636382Advanced Cancer, Pancreatic Cancer
University Health Network, Toronto
Not applicable
5
Toronto
2026-06-04
Recruiting
Fecal Microbiota Transplantation in Patients Undergoing Chimeric Antigen Receptor T-cell Therapy and Allogeneic Stem Cell Transplant: A Pilot Study
NCT07509450Lymphoma Receiving CAR-T Therapy
University Health Network, Toronto
Not applicable
20
Toronto
2026-06-02
Recruiting
Heart Rate VAriability as a MaRker for tItrATing hIgh flOw Nasal Cannula Therapy
NCT07518862Respiratory Failure, Heart Rate Variability (HRV), High Flow Nasal Cannula
University Health Network, Toronto
Observational
20
Toronto
2026-05-26
Recruiting
Inhale and Exhale Breath Holds to Improve the Radiation Therapy Accuracy in People With Upper Abdominal Cancers
NCT07594691Abdominal Cancer
University Health Network, Toronto
Not applicable
15
Toronto
2026-05-25
Recruiting
Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition
NCT07468604Autonomic Dysfunction
University Health Network, Toronto
Phase 4
78
Toronto
2026-05-19
Recruiting
A Study of Standard Of Care Versus Radio Ablation in Early Stage HCC
NCT07628751Early Hepatocellular Carcinoma
University Health Network, Toronto
Not applicable
218
Toronto
2026-05-11
Recruiting
AI for Gastric POCUS ( Point-of-care Ultrasound)
NCT07580456Point-of-care Ultrasound
University Health Network, Toronto
Observational
30
Toronto
2026-05-05
Not yet open
Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas in Salvage Radiotherapy Using SBRT for Prostate Cancer to Reduce Treatment Toxicity
NCT07515651Prostate Cancer (Adenocarcinoma)
University Health Network, Toronto
Phase 2
50
Toronto
2026-05-01
Recruiting
A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)
NCT07408063Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
DrugsGSK5764227·Dostarlimab
University Health Network, Toronto
Phase 2
30
Toronto
2026-04-27
Recruiting
Prospective Reduction Of Transplant Complications Through Enhanced Preservation Therapy to Prevent Primary Graft Dysfunction
NCT07230886Primary Graft Dysfunction
University Health Network, Toronto
Not applicable
50
Toronto
2026-04-17
Recruiting
Hypersight and Ethos In Pediatric Radiotherapy
NCT07528547Cancer
University Health Network, Toronto
Not applicable
20
Toronto
2026-04-14
Not yet open
A Lay Navigation Intervention for Patients With Lung Cancer
NCT07548788Lung Cancer Non-Small Cell Cancer (NSCLC), Lung Cancer Small Cell Lung Cancer (SCLC), Patient Navigation
University Health Network, Toronto
Not applicable
50
Toronto
2026-04-01
Recruiting
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
NCT07524114Breast Cancer, Lung Cancer, Melanoma, Gynecologic Cancer
University Health Network, Toronto
Observational
7,000
Toronto
2026-03-31
Not yet open
BOLD-100 Plus Doxorubicin in Advanced Soft Tissue Sarcomas
NCT07027423Sarcoma, Soft-tissue, Sarcoma, Sarcoma,Soft Tissue, Sarcomas
DrugBOLD-100
University Health Network, Toronto
Phase 1
32
Toronto
2026-03-30
Recruiting
Trial of a Virtual Exercise-based Rehabilitation Program to Treat Persistent Chemotherapy-Induced Peripheral Neuropathy (CIPN)
NCT07481149Chemotherapy-induced Peripheral Neuropathy (CIPN)
University Health Network, Toronto
Phase 3
240
Toronto
2026-03-30
Recruiting
STEP2 vs. Routine Early Palliative Care: Randomized Noninferiority Trial
NCT07446660Oncology
University Health Network, Toronto
Not applicable
652
Toronto
2026-03-23
Not yet open
Renal Ex Vivo SYN002 Perfusion to Eliminate CMV Transmission
NCT07488481Cytomegalovirus (CMV) Infection, Kidney Transplant Recipient
University Health Network, Toronto
Phase EARLY_PHASE1
12
Toronto
2026-03-16
By invitation
Digital Education in Colorectal Cancer Patients
NCT07686133Colorectal Cancer, Patient Satisfaction, Patient Engagement, Patient
University Health Network, Toronto
Not applicable
100
Toronto
2026-03-10
Not yet open
Trauma-Focused Managing Cancer And Living Meaningfully (CALM-TF) for Newly Diagnosed and Recurrent Ovarian Cancer
NCT07286162Ovarian Cancer (OvCa), Recurrent Ovarian Cancer
University Health Network, Toronto
Phase 3
300
Toronto
2026-03-01
Recruiting
Study of the Safety and Usefulness of Liposomal Curcumin in Multiple Myeloma
NCT07456605Multiple Myeloma Refractory, Multiple Myeloma in Relapse
University Health Network, Toronto
Phase 1
20
Toronto
2026-02-27
Recruiting
Efficacy of Biofeedback Training for Glaucoma
NCT07409077Glaucoma, Biofeedback Training
University Health Network, Toronto
Not applicable
70
Toronto
2026-02-10
Recruiting
Radiofrequency Ablation for Curative Treatment of Small Low-Risk Papillary Thyroid Cancer: Pilot Study
NCT07376837Thyroid Papillary Carcinoma
University Health Network, Toronto
Not applicable
30
Toronto
2026-02-05
Recruiting
Cannabinoids for Osteoarthritis Pain Effectiveness Trial
NCT06878417Osteoarthritis of Knee, Osteoarthritis Hip
University Health Network, Toronto
Not applicable
100
Toronto, Montreal
2026-01-29
Recruiting
Feasibility of a Cognitive Stepped Care Program for Adults With Brain Metastases
NCT07355348Brain Metastases, Brain Metastasis
University Health Network, Toronto
Not applicable
140
Toronto
2026-01-09
Recruiting
Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition
NCT06452095Long COVID, Post Acute Sequelae of COVID-19, Post-COVID-19 Condition
University Health Network, Toronto
Not applicable
120
Toronto
2026-01-01
Recruiting
Feasibility and Safety of a Combined Augmented Reality and Functional Electrical Stimulation System
NCT07299734Cervical Spinal Cord Injury
University Health Network, Toronto
Phase EARLY_PHASE1
7
Toronto
2026-01
Recruiting
Innovative Approaches to Enhance Balance and Neuroplasticity in Multiple Sclerosis
NCT07174973Multiple Sclerosis, Mobility Limitation, Balance; Distorted, Gait
University Health Network, Toronto
Not applicable
24
Toronto
2025-12-30
Recruiting
Combination Letermovir and Standard of Care Antiviral for Enhanced Antiviral Response in Cytomegalovirus Infection in Lung Transplant Recipients
NCT07235683CMV, Lung Transplant Recipient
DrugLetermovir
University Health Network, Toronto
Phase 4
40
Toronto
2025-12-24
Recruiting
Virtual Vs Telephone Education in Radiotherapy
NCT07255196Patient Education, Radiotherapy
University Health Network, Toronto
Not applicable
130
Toronto
2025-12-20
Recruiting
LIFUS For Neurological Disorders
NCT07417280Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
University Health Network, Toronto
Not applicable
50
Toronto
2025-12-02
Recruiting
Study to Assess the Safety and Effects of Porphysome Nanoparticles for Imaging in Gynaecological Cancers
NCT06977126Gynecological Cancers
University Health Network, Toronto
Phase 1
24
Toronto
2025-11-18
Recruiting
Lattice Radiation Therapy Versus Conventional Radiation Therapy for the Palliation of Large Tumors
NCT07444775Histopathologically or Cytologically Confirmed Solid Tumor Who Require Palliation Radiation Therapy to a Lesion โ‰ฅ5cm
University Health Network, Toronto
Phase 3
148
Toronto
2025-11-18
Recruiting
Pandemic Influenza Vaccine in Organ Transplantation (PIVOT Trial)
NCT07240558Influenza (Pandemic), Avian Influenza, Vaccination
DrugArepanrix
University Health Network, Toronto
Phase 3
120
Toronto
2025-11-03
Recruiting
Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer
NCT07348887Squamous Cell Cancer of Head and Neck (SCCHN)
University Health Network, Toronto
Not applicable
50
Toronto
2025-10-15
Recruiting
Combined Light, ExVivo, and Antivirals for Recipients of Lungs From HBV Donors
NCT07189377Hepatitis B Virus (HBV), Lung Transplant Recipient
DrugsHBIg·Entecavir
University Health Network, Toronto
Phase 4
20
Toronto
2025-09-24
Recruiting
A Trial of ABSK043, an Oral PD-L1 Inhibitor, in Patients With Angiogenic Sarcomas
NCT07014137Sarcoma
DrugABSK043
University Health Network, Toronto
Phase 2
20
Toronto
2025-09-09
Recruiting
Sentinel lympH Node Biopsy With Indocyanine Green in Breast Cancer After NEoadjuvant Chemotherapy (SHINE)
NCT06085274Breast Cancer
University Health Network, Toronto
Not applicable
100
Toronto
2025-09-03
Not yet open
Autologous Cold-stored Apheresis Platelets
NCT07064954Bleeding, Platelets, Cardiopulmonary Bypass, Cardiac Surgery
University Health Network, Toronto
Phase 2/3
100
Toronto
2025-09-01
Not yet open
Peri-procedural Management of Direct Oral Anticoagulants for Central VENOus Catheters in CAncer Patients With Venous Thromboembolism or Atrial Fibrillation Pilot Study
NCT06887270Anticoagulant-induced Bleeding, Direct Oral Anticoagulant, Cancer, Central Venous Catheter
University Health Network, Toronto
Not applicable
10
Toronto
2025-09
Recruiting
Study of How Safe and Effective Tarlatamab is in Brain Cancers
NCT06776250Astrocytic Tumor, Oligodendroglial Tumor
DrugTarlatamab
University Health Network, Toronto
Phase 2
44
Toronto
2025-08-18
Recruiting
Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation
NCT06384456Distal Radius Fractures
DrugTranexamic Acid
University Health Network, Toronto
Phase 4
90
Toronto
2025-08-13
Recruiting
Effect of Hi-OxSR for the Treatment of Post COVID Condition
NCT06928506Long COVID, Post COVID-19 Condition, Post Acute Sequelae of COVID-19
University Health Network, Toronto
Not applicable
120
Edmonton, Toronto, Sherbrooke
2025-08-01
Recruiting
Consolidative Use of Radiotherapy to Block Oligoprogression in Patients With Metastatic Melanoma
NCT07112170Metastatic Melanoma, OligoProgressive Metastatic Disease
University Health Network, Toronto
Not applicable
52
Toronto
2025-07-24
Recruiting
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Caregivers of Patients With Advanced Cancer
NCT07048743Caregiver Distress
DrugPsilocybin
University Health Network, Toronto
Phase 2
15
Toronto
2025-07-16
Recruiting
Stereotactic Body Radiotherapy or Standard of Care for Prostate Oligoprogressive Cancer
NCT06927635Castrate Resistance Prostate Cancer, OligoProgressive Metastatic Disease
University Health Network, Toronto
Phase 2
75
Toronto
2025-07-08
Not yet open
Time-effect of FEST+TST in the Upper-extremity Rehabilitation of Individuals with Traumatic SCI
NCT04910204Spinal Cord Injuries
University Health Network, Toronto
Not applicable
18
Toronto
2025-07
Recruiting
To Assess Safety of Mitapivat and Provide Proof of Concept of the Efficacy of the Drug in Patients With RBC Membranopathies or CDAII.
NCT07055243Anemia
DrugMitapivat
University Health Network, Toronto
Phase 2
9
Toronto
2025-06-26
Active, closed
Study of NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Pancreatic Cancer
NCT06783140Pancreatic Cancer, Advanced or Metastatic, BRCA1/2 Mutation, PALB2 Gene Mutation
DrugsNab-paclitaxel·Gemcitabine·Cisplatin
University Health Network, Toronto
Phase 2/3
10
Toronto
2025-06-10
Recruiting
A Study to Evaluate Zanubrutinib and Tislelizumab in Progressive Lymphoma Post CAR-T
NCT06167785Large B-cell Lymphoma
DrugsZanubrutinib·Tislelizumab
University Health Network, Toronto
Phase 2
76
Toronto
2025-06-04
Not yet open
Buccal Fat for Transoral Robotic Lateral Oropharyngectomy Defects to and Postoperative Pain
NCT06965738Tonsil Neoplasm, Oropharynx Neoplasm, Transoral Robotic Surgery
University Health Network, Toronto
Phase 2
40
Toronto
2025-06-01
Recruiting
Stimulating Postural Control to Augment Rehabilitation After Cerebral Stroke (SPARC): a Pilot Trial
NCT06987682Stroke
University Health Network, Toronto
Not applicable
16
Toronto
2025-05-21
Recruiting
Chemoimmunotherapy Followed by Surgery for Oligometastatic Esophagogastric Cancer: (TORO Protocol)
NCT06668454Esophageal Cancer, Gastric Cancer, Oligometastatic Disease
University Health Network, Toronto
Not applicable
72
Toronto
2025-05-09
Recruiting
Deep Brain Stimulation of the Pedunculopontine Nucleus for Alzheimer's Disease
NCT06936124Alzheimer Disease
University Health Network, Toronto
Not applicable
6
Toronto
2025-05
Recruiting
Micro-ultrasound-Guided Focal Laser Ablation for Intermediate-Risk Prostate Cancer: Safety & Effectiveness
NCT07339943Prostate Cancer (Adenocarcinoma), Low and Intermediate Risk Prostate Cancer
University Health Network, Toronto
Not applicable
7
Toronto
2025-04-30
Recruiting
PET/MR Scan With [68Ga]Ga-PentixaFor (CXCR4) vs Standard of Care (SOC) for Initial Staging and Follow up in Multiple Myeloma (MM)
NCT06871176Multiple Myeloma
Drug[68Ga]Ga-PentixaFor
University Health Network, Toronto
Not applicable
30
Toronto
2025-04-22
Recruiting
HN-BIO 02: A Phase II Randomized Study of the Effects of Delayed Elective Radiotherapy on Head and Neck MRI and Immune Response Biomarkers
NCT06487403Squamous Cell Carcinoma of Head and Neck
University Health Network, Toronto
Not applicable
40
Toronto
2025-04-17
Recruiting
EXtubation Related Complications - the EXTUBE Study (EXTUBE)
NCT06442930Extubation
University Health Network, Toronto
Observational
3,000
Surrey, Moncton, North York, Saint Catharines, Toronto, Montreal
2025-04-14
Recruiting
Using Tumor Models to Determine Treatments
NCT06813079Pancreatic Ductal Carcinoma, Advanced Cancer, Epithelial Tumor
DrugsNeratinib·Brigatinib·Cobimetinib·Ponatinib
University Health Network, Toronto
Phase 2
25
Toronto
2025-04-07
Recruiting
Dual PSMA and FDG PET Imaging for Patients With Advanced Prostate Cancer
NCT06335914Advanced Prostate Cancer
University Health Network, Toronto
Not applicable
30
Toronto
2025-04-03
Recruiting
Post-operative Intravenous Iron to Treat Iron-deficiency Anemia in Patients Undergoing Cardiac Surgery
NCT06287619Chronic Iron Deficiency Anaemia, Cardiac Surgery
University Health Network, Toronto
Phase 2
60
Kingston, Toronto
2025-04-03
Recruiting
A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment
NCT06453486Locally Advanced Pancreatic Adenocarcinoma
University Health Network, Toronto
Phase 2
43
Toronto, Montreal
2025-03-12
Recruiting
Emotion and Symptom-Focused Engagement (EASE) for Caregivers
NCT06367556Trauma and Stressor Related Disorders, Pediatric Cancer, Caregiver Burden
University Health Network, Toronto
Not applicable
306
Toronto
2025-02-14
Recruiting
VR&R: Providing Caregiver Respite by Managing BPSDs and Improving QoL in People with Dementia Using Immersive VR-Therapy
NCT05867641Dementia
University Health Network, Toronto
Not applicable
50
Oakville, Toronto, Montreal
2025-02-12
Recruiting
Is Adaptive SBRT for Prostate vs Image-guided Radiotherapy a True Evolution (ASPIRE)
NCT06825091Localized Prostate Cancer, Stereotactic Body Radiotherapy
University Health Network, Toronto
Phase 3
320
Toronto
2025-02-04
Not yet open
Effectiveness of AV-stimulation in Immersive VR to Improve Visual Perception and Driving Performance
NCT05703360Stroke, Visual Impairment, Low Vision, Virtual Reality
University Health Network, Toronto
Not applicable
30
Toronto
2025-02-01
Recruiting
BAL Fluid Biomarkers in Sarcoma
NCT06815666Soft Tissue Sarcoma (STS), Bronchoalveolar Lavage (BAL), Bronchoalveolar Lavage Fluid
University Health Network, Toronto
Phase 2
70
Toronto
2025-01-29
Recruiting
Feasibility Trial of Glofitamab in a Response Adapted Approach Incorporating Interim FDG PET and ctDNA to Optimize Primary Therapy of DLBCL (GRAIL)
NCT06050694Diffuse Large B Cell Lymphoma (DLBCL)
DrugGlofitamab
University Health Network, Toronto
Phase 2
40
Toronto, Montreal
2025-01-24
Not yet open
Preventing Delayed Graft Function in Kidney Transplant Patients
NCT06724211Kidney Transplant, Kidney Failure, Kidney Injury
University Health Network, Toronto
Not applicable
50
Toronto
2025-01-15
Not yet open
Point of Care Ultrasound in Pregnant Women (PoCUS-OB)
NCT06776237Obstructive Sleep Apnea (OSA)
University Health Network, Toronto
Observational
100
Toronto
2025-01-15
By invitation
EXercise Enhancement After RadioTherapy for Bone Metastases
NCT06470503Bone Metastases
University Health Network, Toronto
Not applicable
20
Toronto
2025-01-13
Recruiting
Improving Patient Sleep Prior to Elective Surgery
NCT06762639Surgery
University Health Network, Toronto
Not applicable
154
Toronto
2025-01-03
Recruiting
Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA
NCT05517434Osteoarthritis, Knee
University Health Network, Toronto
Phase 2/3
148
Toronto
2025-01-01
Recruiting
Dose Efficacy in Adhesive Capsulitis
NCT06848374Adhesive Capsulitis of the Shoulder
DrugMethylprednisolone
University Health Network, Toronto
Phase 3
40
Toronto
2024-12-20
Not yet open
Gemcitabine/Cisplatin/Nab-Paclitaxel and Rilvegostomig in Resectable iCCA
NCT06569225Cholangiocarcinoma Resectable
University Health Network, Toronto
Phase 2
40
Toronto
2024-12-15
Recruiting
Belimumab in Autoimmune Hepatitis
NCT06381453Autoimmune Hepatitis
DrugBelimumab
University Health Network, Toronto
Phase 2
48
Calgary, Vancouver, Hamilton, London, Toronto
2024-12-11
Recruiting
Radialis PET Imager for the Assessment of Neuritic Amyloid Plaque Burden
NCT06757569Cognitive Impairment
University Health Network, Toronto
Not applicable
160
Toronto
2024-12-06
Recruiting
Ultra-high Dose Radiation for Liver Metastasis Using MR-guided TReatment With Stereotactic Ablative Single-fraction
NCT06362395Liver Metastases
University Health Network, Toronto
Phase 3
114
Toronto
2024-12-05
Active, closed
Vitamin D Metabolites as Biomarkers for the Identification of Kidney Injury in Cardiac Surgery
NCT06688994Acute Kidney Injuries, Chronic Renal Diseases
University Health Network, Toronto
Observational
46
Toronto
2024-12-02
Recruiting
Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant
NCT06725121Hepatocellular Carcinoma (HCC), Macrovascular Invasion, Liver Transplant Surgery, Downstaging
DrugsAtezolizumab & Bevacizumab·Avastin·Tecentriq
University Health Network, Toronto
Phase 1/2
48
London, Toronto
2024-12
Recruiting
Comparing Moderately Ultra Hypofractionated Radiation Treatments for Prostate Cancer
NCT06409910Post-Operative Prostate Cancer
University Health Network, Toronto
Phase 2
204
London, Toronto
2024-11-26
Recruiting
Plan Development for Giving Teclistamab in the Outpatient Setting
NCT06251076Multiple Myeloma, Relapsed Cancer, Refractory Cancer
DrugsTeclistamab·Tocilizumab
University Health Network, Toronto
Phase 4
15
Toronto
2024-11-19
Recruiting
Evaluation of a Supportive Housing Program for Adults Who Are Unhoused and Have Complex Health Needs
NCT06723093Homeless Persons
University Health Network, Toronto
Not applicable
100
Toronto
2024-11-06
Active, closed
Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression
NCT06506019Bipolar Depression
DrugPsilocybin
University Health Network, Toronto
Phase 1
30
Toronto
2024-10-09
Active, closed
RSV Vaccine in Transplant Recipients
NCT06593210Vaccine Response Impaired, Respiratory Syncytial Virus Infections, Immune Suppression
DrugArexvy
University Health Network, Toronto
Phase 3
100
Toronto
2024-10-01
Recruiting
meChANisms and sAfety of SGLT2 Inhibition in peRitoneal dialYsis
NCT05715814Peritoneal Dialysis Complication, End Stage Kidney Disease, Sodium-glucose Co-transporter-2 Inhibitors, Kidney Dysfunction
DrugDapagliflozin
University Health Network, Toronto
Phase 3
20
Toronto
2024-09-01
Recruiting
Digital Peer Navigation for Adolescents and Young Adults With Cancer
NCT06193369Lymphoma, Breast Cancer, Testicular Cancer, Sarcoma
University Health Network, Toronto
Not applicable
138
Toronto
2024-08-27
Active, closed
Cognitive Health Awareness Program in Surgical Patients
NCT06540638Dementia, Cognitive
University Health Network, Toronto
Not applicable
164
Toronto
2024-08-12
Recruiting
Salvage MR-guided High-Dose-Rate Brachytherapy for Prostate Bed Recurrence After Radiotherapy in the PSMA PET Scan Era
NCT06508567Prostate Cancer Recurrent, Prostate Cancer
University Health Network, Toronto
Not applicable
20
Toronto
2024-08-08
Recruiting
Inspiratory Muscle Training in Lung Transplant Candidates
NCT06370832Inspiratory Muscle Training
University Health Network, Toronto
Not applicable
90
Edmonton, Vancouver, Toronto, Montreal
2024-08-06
Recruiting
COgnitive-somatoSensory-MOtor Training to Improve Arm and Hand Function After Stroke (iCOSMO)
NCT06498011Stroke, CVA, Cerebrovascular Accident
University Health Network, Toronto
Not applicable
40
Toronto
2024-08-01
Recruiting
Greater Occipital Nerve Block for Spontaneous Intracranial Hypotension
NCT06374524Spontaneous Intracranial Hypotension
University Health Network, Toronto
Observational
34
Toronto
2024-08-01
Recruiting
Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy
NCT06510868Myelodysplastic Syndrome, Acute Myeloid Leukemia
University Health Network, Toronto
Observational
45
Toronto
2024-08-01
Active, closed
Hypobaric L5-S1 Study
NCT06526156Anesthesia, Anesthesia, Local
DrugBupivacaine
University Health Network, Toronto
Observational
55
Toronto
2024-07-22
Recruiting
Diagnosis of Graft Pathology by TruGraf
NCT06557564Acute Graft Rejection
University Health Network, Toronto
Observational
471
Toronto
2024-07-20
Recruiting
Early Palliative Care for Patients With Multiple Myeloma and Aggressive Lymphoma
NCT06485076Multiple Myeloma in Relapse, Multiple Myeloma, Refractory, Multiple Myeloma Stage III, Multiple Myeloma Progression
University Health Network, Toronto
Not applicable
144
Toronto
2024-07-18
Active, closed
PASS Pain After Surgery
NCT06506110Analgesia
University Health Network, Toronto
Observational
7,000
Toronto
2024-07-11
Not yet open
Study of Radiation Therapy in Combination With Darolutamide + Degarelix in Intermediate Risk Prostate Cancer
NCT04176081Prostate Cancer
DrugsDegarelix·Darolutamide
University Health Network, Toronto
Phase 2
208
Toronto
2024-07-02
Active, closed
A Study to Test the Benefit of Vitamin B5 in Patients With Melanoma
NCT06377111Melanoma (Skin)
DrugsIpilimumab·Nivolumab
University Health Network, Toronto
Phase 1
12
Toronto
2024-06-24
Active, closed
Albumin Utilization in Adult Cardiac Surgical Patients : A Multicentre Prospective Cohort Study
NCT06395480Antithrombin III Levels, Albumin Levels
University Health Network, Toronto
Observational
104
Kingston, Toronto
2024-06-11
Recruiting
Feasibility of CALM in Patients With Ovarian Cancer
NCT06459271Patient Satisfaction, Ovarian Cancer
University Health Network, Toronto
Not applicable
50
Toronto
2024-06-10
Active, closed
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer
NCT06416085Advanced Cancer, Stage IV Solid Tumor Cancer, Stage IV Sarcoma of Bone, Stage IV Lymphoma
DrugPsilocybin
University Health Network, Toronto
Phase 2
15
Toronto
2024-06-06
Active, closed
Delayed Cold-Stored Platelets -PLTS-1
NCT06147531Platelets, Bleeding, Cardiopulmonary Bypass, Cardiac Surgery
University Health Network, Toronto
Phase 2
150
Kingston, Toronto
2024-06-05
Not yet open
Visual Telerehabilitation in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour
NCT06362434Hemianopsia
University Health Network, Toronto
Not applicable
50
Calgary, Vancouver, Toronto, Montreal, Quรฉbec
2024-06-01
Not yet open
Azoles Targeting Recurrent High Grade Gliomas
NCT03763396Brain Tumor, Recurrent, Cancer, Advanced, Glioma of Brain
DrugPosaconazole
University Health Network, Toronto
Phase EARLY_PHASE1
30
Toronto
2024-06-01
Active, closed
Albumin Utilization in Adult Cardiac Surgical Patients: Retrospective
NCT06322537Cardiovascular Surgical Procedures, Albumin
University Health Network, Toronto
Observational
505
New Westminster, Vancouver, Halifax, Hamilton, Kingston, London, Ottawa, Toronto
2024-05-23
Recruiting
A Pan-Canadian, Investigator Initiated Clinical Trial With Focal IRE Directed to Intermediate-Risk Prostate Cancer
NCT06451445Prostate Cancer
University Health Network, Toronto
Not applicable
100
Toronto
2024-05-16
Recruiting
M. Avium WGS During Mav-PD Treatment
NCT06266442Mycobacterium Avium, Mycobacterium Infections, Nontuberculous, Mycobacterium Infections, Nontuberculous Mycobacterial Lung Disease
University Health Network, Toronto
Observational
40
Toronto
2024-05-13
Not yet open
EASE-SOT Pilot Study
NCT06396702Transplant;Failure,Kidney, Transplant; Failure, Heart, Transplant; Failure, Liver, Transplant; Failure, Pancreas
University Health Network, Toronto
Not applicable
120
Toronto
2024-05
Active, closed
Exercise-based Rehabilitation to Treat Persistent Chemotherapy Induced Peripheral Neuropathy (CIPN)
NCT06405542Chemotherapy-induced Peripheral Neuropathy
University Health Network, Toronto
Phase 1
40
Toronto
2024-04-25
Recruiting
CfDNA in Hereditary And High-risk Malignancies 2
NCT06726642Hereditary Cancer Syndrome
University Health Network, Toronto
Observational
1,000
Vancouver, St. John's, Halifax, Toronto, Montreal
2024-04-19
Recruiting
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
NCT06123715Chronic Pain, Knee Pain Chronic, Post Operative Pain
DrugVitamin C
University Health Network, Toronto
Phase 2
400
Toronto
2024-04-16
Recruiting
Remote Monitoring of Patient Reported Outcomes to Improve the Efficacy of the Acute Phase Radiotherapy Review Process
NCT06274892Prostate Cancer, Breast Cancer
University Health Network, Toronto
Not applicable
124
Toronto
2024-04-09
Not yet open
Acellular Dermal Allograft for Chronic Diabetic Wounds
NCT06227520Wound Heal, Diabetic Foot Ulcer
University Health Network, Toronto
Not applicable
30
Toronto
2024-04-01
Active, closed
The Semaglutide Study
NCT06420739Fasting
University Health Network, Toronto
Observational
100
Toronto
2024-03-25
Active, closed
Phase 1 Study of RP-6306 With Carboplatin and Paclitaxel in TP53 Ovarian and Uterine Cancer
NCT06107868Recurrent Ovarian Cancer, Recurrent Uterine Cancer, Metastatic Cancer, Advanced Cancer
DrugsLunresertib·Paclitaxel·Carboplatin
University Health Network, Toronto
Phase 1
6
Toronto
2024-03-20
Recruiting
Vaccinal Effect of HBsAg Monoclonal Ab VIR-3434 in Chronic Hepatitis B Infection [VISION]
NCT06216470Hepatitis B, Chronic
DrugTobevibart
University Health Network, Toronto
Phase 2
15
Toronto
2024-03-13
Active, closed
Margin Intraoperative CT Feedback Feedback Study
NCT07242053Lung Cancer (Diagnosis)
University Health Network, Toronto
Not applicable
80
Toronto
2024-03-06
Recruiting
IVIM & OLINK in Sarcoma
NCT05950594Soft Tissue Sarcoma
University Health Network, Toronto
Phase 2
145
Toronto
2024-03-05
Recruiting
Emotion and Memory in Chronic Neuropathic Pain
NCT06518421Trigeminal Neuralgia, Facial Pain
University Health Network, Toronto
Observational
400
Toronto
2024-02-12
Active, closed
Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psilocybin
NCT06341426Major Depressive Disorder, Depression, Treatment-Resistant Depression, Mood Disorders
University Health Network, Toronto
Phase 2
92
Toronto
2024-02-05
Recruiting
Umbrella Study for Single Patient Treatments in Oncology
NCT06285500Advanced Cancer, Rare Diseases
University Health Network, Toronto
Observational
400
Toronto
2024-02-01
Recruiting
A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers
NCT06085781Squamous Cell Carcinoma of Head and Neck
University Health Network, Toronto
Not applicable
60
Toronto
2024-01-29
Recruiting
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial
NCT06480500Major Depressive Disorder, Suicide, Treatment Resistant Depression
DrugsMidazolam Hydrochloride·Ketamine Hydrochloride
University Health Network, Toronto
Phase 2
110
Toronto
2024-01-02
Recruiting
Feasibility of Reducing Respiratory Drive Using the Through-flow System
NCT05642832Respiratory Insufficiency, Diaphragm Injury, Lung Injury
University Health Network, Toronto
Not applicable
15
Toronto
2024-01-01
Recruiting
The HIMALAYAS Trial and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Study: A Multicentre Randomized Controlled Trial
NCT05023785Heart Failure, Cardiotoxicity, Cancer
University Health Network, Toronto
Not applicable
336
Toronto
2024-01-01
By invitation
Conversion of Maintenance Prograf to Envarsus in Liver Transplant Recipients
NCT05655273Liver Transplant Rejection, Immune System Suppression
DrugsEnvarsus·Prograf
University Health Network, Toronto
Phase 4
40
Toronto
2024-01-01
Recruiting
ODYSSEE Kidney Health Trial
NCT06274710Chronic Kidney Diseases
University Health Network, Toronto
Not applicable
344
Toronto
2023-12-13
Recruiting
Feasibility of Early Swallowing and Speech Intervention for Head and Neck Cancer Patients Treated SURGically
NCT06192771Dysphagia, Head and Neck Cancer
University Health Network, Toronto
Not applicable
40
Toronto
2023-12-01
Recruiting
Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)
NCT06142773Ventilation Therapy; Complications
University Health Network, Toronto
Not applicable
10
Toronto
2023-11-30
Recruiting
Durvalumab and Oleclumab in Resectable PDAC
NCT06060405Pancreatic Ductal Adenocarcinoma
DrugsOleclumab·Durvalumab
University Health Network, Toronto
Phase 2
22
Toronto
2023-11-29
Recruiting
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
NCT06529744Dementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia
University Health Network, Toronto
Observational
500
North York, Toronto
2023-11-11
Recruiting
Study of Venetoclax and Azacitidine in Advanced BCR-ABL Negative Myeloproliferative Neoplasms
NCT05074355Myeloproliferative Neoplasm
DrugsAzacitidine·Venetoclax
University Health Network, Toronto
Phase 2
40
Toronto
2023-11-08
Recruiting
Durvalumab and Tremelimumab in Resectable HCC
NCT05440864Hepatocellular Carcinoma
DrugsTremelimumab·Durvalumab
University Health Network, Toronto
Phase 2
28
Toronto
2023-10-26
Recruiting
The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients
NCT05938712Kidney Transplant Recipients
DrugsFarxiga·Ozempic·Semaglutide·Dapagliflozin
University Health Network, Toronto
Phase 2
20
Toronto
2023-10-24
Recruiting
MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach
NCT06050707Anal Squamous Cell Carcinoma
University Health Network, Toronto
Phase 2
80
Toronto, Montreal
2023-09-29
Recruiting
Positron Emission Mammography and Liquid Biopsy in Women With High-risk Breast Screenings
NCT06268405Breast Cancer
University Health Network, Toronto
Not applicable
100
Toronto
2023-09-21
Recruiting
CHARM-COPD Program of Care
NCT06253013Chronic Obstructive Pulmonary Disease
University Health Network, Toronto
Not applicable
100
Toronto
2023-09-15
Recruiting
Comparing Menghini-type Needle and Franseen-type Needle in EBUS-TBNA for Sarcoidosis
NCT06220526Suspected Sarcoidosis
University Health Network, Toronto
Not applicable
128
Toronto
2023-08-18
Active, closed
Study of Hydroxychloroquine With FOLFIRI and Bevacizumab in DTP-high Metastatic Colorectal Cancer
NCT05843188Metastatic Colorectal Cancer
DrugsHydroxychloroquine·Leucovorin·Fluorouracil·Irinotecan
University Health Network, Toronto
Phase 2
155
Toronto
2023-08-09
Recruiting
Consolidative Prostate Radiotherapy in Metastatic Prostate Cancer
NCT05656794Prostate Metastases
University Health Network, Toronto
Phase 2
40
Toronto
2023-08-09
Active, closed
Towards Noninvasive DBS of the Basal Ganglia in Parkinson's Disease Using TUS
NCT06232629Parkinson Disease, Dystonia
University Health Network, Toronto
Not applicable
10
Toronto
2023-08-01
Recruiting
Toronto Western Hospital (TWH) Waste Audit
NCT06680284Audit of Medical Waste Disposal
University Health Network, Toronto
Observational
60
Toronto
2023-07-27
Recruiting
Study of TBI-2001(Autologous CD19 Specific Chimeric Antigen Receptor (CAR) Gene-transduced T Lymphocytes) for Relapsed or Refractory CD19+ B-cell Lymphoma, CLL/SLL
NCT05963217Relapsed or Refractory CD19+ B-cell Lymphoma, Relapsed or Refractory Chronic Lymphocytic Leukemia, Relapsed or Refractory Small Lymphocytic Lymphoma
DrugsFludarabine·Cyclophosphamide
University Health Network, Toronto
Phase 1
19
Toronto
2023-07-26
Recruiting
HN-QUEST: A Study of Head and Neck Imaging Biomarkers
NCT05919290Head and Neck Squamous Cell Carcinoma
University Health Network, Toronto
Not applicable
173
Toronto
2023-07-26
Active, closed
Comprehensive Health Assessment for my Cancer Treatment Plan
NCT05499975Cancer, Older Adults
University Health Network, Toronto
Not applicable
180
Toronto
2023-07-24
Recruiting
Optimizing lymphoDepletion to Improve Outcomes In Patients Receiving Cell Therapy With Yescarta
NCT05950802DLBCL - Diffuse Large B Cell Lymphoma
DrugCyclophosphamide
University Health Network, Toronto
Phase 1
40
Toronto
2023-07-14
Recruiting
Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC
NCT05414032Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)
DrugRilvegostomig
University Health Network, Toronto
Phase 2
102
Toronto
2023-07-12
Recruiting
Virtual Rehabilitation for Cancer Survivors
NCT05898789Breast Cancer, Stage 0, Colorectal Cancer Stage I, Head and Neck Cancer Stage I, Lymphoma
University Health Network, Toronto
Not applicable
388
Toronto
2023-07-07
Recruiting
Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)
NCT05592938Breast Cancer, Breast Cancer Recurrent
University Health Network, Toronto
Not applicable
171
Barrie, London, Oshawa, Toronto, Montreal
2023-06-27
Recruiting
At-home Breast Oncology Care Delivered With E-health Solutions
NCT05989477Patient Engagement, Patient Activation, Patient Reported Outcome Measures
University Health Network, Toronto
Not applicable
200
Toronto
2023-06-22
Active, closed
10ยฐC vs 4ยฐC Lung Preservation RCT
NCT05898776Lung Transplant, Organ Preservation
University Health Network, Toronto
Not applicable
317
Toronto, Montreal
2023-06-09
Recruiting
Duration of Androgen Receptor Pathway Inhibitor and ADT With Metastasis Directed Therapy in Oligometastatic Cancer of the Prostate (DIRECT)
NCT05404139Metastatic Prostate Cancer
DrugsAbiraterone·Atorvastatin
University Health Network, Toronto
Phase 2
352
Toronto
2023-05-24
Recruiting
TOward a comPrehensive Supportive Care Intervention for Older Men With Metastatic Prostate Cancer
NCT05582772Metastatic Prostate Cancer
University Health Network, Toronto
Not applicable
168
Toronto
2023-05-23
Recruiting
The Safety and Feasibility of Radiofrequency Ablation to Treat Low-risk Thyroid Cancer
NCT06929650Thyroid Nodule, Thyroid Cancer
University Health Network, Toronto
Not applicable
40
Toronto
2023-04-20
Active, closed
Symptom Management in Patients on Dialysis
NCT05515991End-stage Kidney Disease
University Health Network, Toronto
Not applicable
36
Brampton, Toronto
2023-04-19
Recruiting
PET-MRI Esophagus Feasibility Study
NCT05796102Esophagogastric Cancer
University Health Network, Toronto
Not applicable
15
Toronto
2023-03-28
Recruiting
End-on Versus Parallel Radiofrequency Lesioning for Neurotomy of the Cervical Medial Branch Nerves
NCT05818774Neck Pain, Zygapophyseal Joint Arthritis
University Health Network, Toronto
Not applicable
72
Toronto
2023-03-10
Active, closed
Province of Ontario Strategy for Personalized Management of Pancreatic Cancer Trial
NCT05927298Pancreas Cancer
University Health Network, Toronto
Observational
200
Toronto
2023-03-06
Recruiting
Cerebellar Deep Brain Stimulation for the Treatment of Ataxia
NCT07427563Ataxia, Gait
University Health Network, Toronto
Not applicable
12
Toronto
2023-03-02
Active, closed
MR-guided Tumour Boost
NCT05364229Prostate Cancer
University Health Network, Toronto
Not applicable
40
Toronto
2023-02-06
Recruiting
In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung
NCT05611034Lung Metastases, Colorectal Cancer Metastatic, Colorectal Cancer
DrugOxaliplatin
University Health Network, Toronto
Phase 1
10
Toronto
2023-02-06
Active, closed
The Use of Indocyanine Green to Visualize Blood Flow to the Gastrojejunostomy During Bariatric Surgery.
NCT06002906Ulcer, Gastric, Obesity, Morbid
DrugIndocyanine Green
University Health Network, Toronto
Phase 4
300
Toronto
2023-01-25
Recruiting
Intravenous vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients
NCT05425355Hip-fracture, Surgery
University Health Network, Toronto
Phase 4
42
Toronto
2023-01-23
Recruiting
The Lullaby Project as a Musical Intervention for Pregnant Individuals With Epilepsy
NCT05503290Epilepsy, Pregnancy Related
University Health Network, Toronto
Not applicable
30
Toronto
2023-01-23
Active, closed
Blood Salvage in Orthotopic Liver Transplantation With HCC
NCT05612477Hepatocellular Carcinoma, Surgery
University Health Network, Toronto
Not applicable
30
Toronto
2023-01-21
Recruiting
Comparing SBRT to CRT in Patients With Spinal Metastases
NCT05589701Spinal Metastases
University Health Network, Toronto
Observational
100
Toronto
2022-12-12
Recruiting
Kadcyla And Neratinib for Interception of HER2+ Breast Cancer With Molecular Residual Disease
NCT05388149Breast Cancer, HER2-positive Breast Cancer
DrugNeratinib
University Health Network, Toronto
Phase 2
15
Toronto
2022-12-06
Recruiting
Patient Reported Outcomes/Metrics Program Trial
NCT04983199Metastatic Cancer, Palliative
University Health Network, Toronto
Observational
100
Toronto
2022-11-24
By invitation
Reference Values for Videofluoroscopic Measures of Swallowing
NCT05497219Dysphagia, Oropharyngeal
University Health Network, Toronto
Not applicable
580
Hamilton, Toronto
2022-11-15
By invitation
Semaglutide vs Sitagliptin
NCT05195944Liver Transplant; Complications, Diabetes Mellitus, NASH - Nonalcoholic Steatohepatitis, NAFLD
DrugsSemaglutide treatment·Sitagliptin
University Health Network, Toronto
Phase 4
58
Toronto
2022-10-26
Active, closed
Evaluation of Nurse-led Integrated Care of Complex Patients Facilitated By Telemonitoring: The SMaRT Study
NCT05543720Heart Failure๏ผŒCongestive, Mental Health (Depression), Diabetes Mellitus, Chronic Obstructive Pulmonary Disease
University Health Network, Toronto
Not applicable
350
Brampton, Greater Sudbury, Markham, Toronto
2022-10-17
Recruiting
Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation After Spinal Cord Injury (ABT-TCSCS)
NCT06472986Spinal Cord Injuries, Spinal Cord Injury Cervical
University Health Network, Toronto
Not applicable
24
Toronto
2022-10-07
Active, closed
Circulating Tumor DNA Collection From Patients With High Grade Gliomas
NCT05925218High Grade Glioma
University Health Network, Toronto
Observational
70
Toronto
2022-09-02
Recruiting
Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas in Salvage Radiotherapy for Prostate Cancer
NCT05328505Prostate Cancer
University Health Network, Toronto
Not applicable
80
London, Toronto
2022-08-23
Recruiting
Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)
NCT05473689Spinal Cord Injuries, Spine Disease
University Health Network, Toronto
Not applicable
66
Toronto
2022-08-15
Recruiting
Clinical Outcomes of Pregnant Individuals With Epilepsy - Prospective Study
NCT05485649Epilepsy
University Health Network, Toronto
Observational
80
Toronto
2022-07-20
Recruiting
Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!)
NCT05196087Breast Cancer, Melanoma, Gastrointestinal Neuroendocrine Tumor
University Health Network, Toronto
Observational
500
Toronto
2022-07-20
Recruiting
Moderate Hypofractionated Boost to the Prostate With Pelvic RT in High Risk Prostate Cancer
NCT05313815Prostate Cancer
University Health Network, Toronto
Not applicable
100
Toronto
2022-07-18
Recruiting
A2 to O Lung Transplants
NCT05581745Lung Transplant, ABO Incompatibility
University Health Network, Toronto
Not applicable
10
Toronto
2022-07-14
Recruiting
Marathon of Hope Cancer Centres Network Study for Ontario (MOHCCN-O)
NCT05403177Breast Cancer, Colorectal Cancer, Pancreas Cancer, Kidney Cancer
University Health Network, Toronto
Observational
500
Kingston, Ottawa, Toronto
2022-06-23
Recruiting
Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches
NCT05306899Chronic Daily Headache
DrugKetamine
University Health Network, Toronto
Phase 3
56
Toronto
2022-06-01
Recruiting
Using ctDNA to Determine Therapies for Lung Cancer
NCT04966663Non Small Cell Lung Cancer, Complete Surgical Resection, Circulating Tumor DNA
DrugsParaplatin·Opdivo·Pemetrexed·Nivolumab
University Health Network, Toronto
Phase 2
66
Toronto
2022-03-28
Recruiting
R-RPLND as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma
NCT05345158Lymphadenopathy Retroperitoneal, Stage II Testicular Seminoma
University Health Network, Toronto
Not applicable
25
Toronto
2022-02-23
By invitation
Project Open - Use of Administrative Health Data to Increase Diabetic Retinopathy Screening
NCT05074342Diabetes, Diabetic Retinopathy
University Health Network, Toronto
Observational
2,000
Toronto
2022-02-01
Recruiting
Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility Study
NCT04962672Anesthesia, Brain Cancer, Survival
University Health Network, Toronto
Not applicable
40
Toronto
2022-01-01
Active, closed
A Randomized Phase II Study to Compare the Potential Long-Lasting Positive Effect of Decidual Stromal Cells to the Best Available Treatment in Graft Versus Host Disease
NCT05132166Graft Vs Host Disease
University Health Network, Toronto
Phase 2
50
Toronto
2021-12-22
Recruiting
Study of Pembrolizumab With Bendamustine in Hodgkin Lymphoma
NCT04510636Classical Hodgkin Lymphoma, Relapsed Cancer, Refractory Cancer
DrugsBendamustine·Keytruda·Pembrolizumab
University Health Network, Toronto
Phase 2
40
Toronto
2021-12-20
Recruiting
StereoTactic Ablative RadioTherapy of Cardiac Arrhythmias
NCT04843683Cardiac Arrhythmia
University Health Network, Toronto
Not applicable
60
Toronto
2021-12-14
Recruiting
Biofeedback Training for Hemianopia
NCT06995313Hemianopia, Brain Injuries
University Health Network, Toronto
Not applicable
70
Toronto
2021-12-08
Recruiting
Biofeedback for Hemianopia Vision Rehabilitation
NCT05397873Hemianopsia, Homonymous, Brain Injury, Stroke, Brain Tumor
University Health Network, Toronto
Not applicable
32
Toronto
2021-12-01
Recruiting
Evaluating the Effectiveness of the Nurse Ned Clinic
NCT05033301Prostate Cancer
University Health Network, Toronto
Not applicable
600
Toronto
2021-11-15
Recruiting
Hypopharynx ICG to Reduce the Fistula Rate in Patients Undergoing Salvage Laryngectomy
NCT05350540Surgery Site Fistula
University Health Network, Toronto
Phase 2
70
Toronto
2021-11-11
Active, closed
COVID-19 Burnout Study
NCT04594278Stress
University Health Network, Toronto
Not applicable
43
Toronto
2021-11-01
Recruiting
Digital Technology for Sleep and Homelessness
NCT06620601Sleep Apnea, Sleep Disorder, Sleep Deprivation, Sleep Disturbance
University Health Network, Toronto
Not applicable
100
Toronto
2021-10-20
Active, closed
Phase II RCT of an Internet-adaptation of Managing Cancer and Living Meaningfully (iCALM)
NCT04757155Advanced Cancer
University Health Network, Toronto
Not applicable
50
Toronto
2021-10-13
Recruiting
Brain Imaging Biomarkers in Patients With Brain Metastasis
NCT04197297Brain Metastases, Adult
University Health Network, Toronto
Phase 2
90
Toronto
2021-10-05
Active, closed
Myocardial Injury and Outcomes Following COVID-19 Vaccination (MYOVAX Study)
NCT04967807Myocardial Injury, Myocarditis, COVID-19 Vaccination, SARS-CoV-2
University Health Network, Toronto
Not applicable
57
Toronto
2021-08-05
Recruiting
Using ctDNA to Detect Minimal Residual Disease After Lung Cancer Resection
NCT05254782Non Small Cell Lung Cancer
University Health Network, Toronto
Observational
360
Toronto
2021-07-06
Recruiting
MCID and PASS for Acute Pain and Quality of Recovery After Orthopedic Surgery
NCT04811209Pain Management
University Health Network, Toronto
Observational
300
Toronto
2021-06-21
Recruiting
Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI
NCT04856059Fabry Disease
University Health Network, Toronto
Not applicable
300
Toronto
2021-06-15
Active, closed
BRAINFUL (BRAIN Tumor Focused Ultrasound-enabled Liquid Biopsy) Trial
NCT04940507Brain Neoplasms, Liquid Biopsy
University Health Network, Toronto
Not applicable
50
Toronto
2021-06-10
Active, closed
An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)
NCT04563338Hepatocellular Carcinoma, Non-small Cell Lung Cancer Metastatic, Liver Metastases
DrugsAvastin·Tecentriq·Atezolizumab·Bevacizumab
University Health Network, Toronto
Phase 2
36
Toronto
2021-06-04
Recruiting
PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation
NCT04901884Pulmonary Hypertension
University Health Network, Toronto
Not applicable
40
Toronto
2021-06-01
Active, closed
Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity
NCT04923659Low Intensity Focussed Ultrasound
DrugsNimodipine·Nimotop·Dextromethorphan·Lorazepam
University Health Network, Toronto
Phase EARLY_PHASE1
20
Toronto
2021-05-25
Active, closed
FAZA PET/MRI Pancreas
NCT04395469Pancreatic Adenocarcinoma Non-resectable, Locally Advanced Pancreatic Adenocarcinoma, Unresectable Pancreatic Cancer
Drug18F-FAZA
University Health Network, Toronto
Not applicable
20
Toronto
2021-05-18
Recruiting
Bariatric Surgery for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer of the Endometrium
NCT04008563Endometrial Cancer, Atypical Hyperplasia, Bariatric Surgery Candidate
University Health Network, Toronto
Not applicable
36
Toronto
2021-05-14
Active, closed
Modulating Cerebellar Activity With Low-intensity Focused Ultrasound Stimulation for Primary Orthostatic Tremor
NCT05547620Orthostatic Tremor
University Health Network, Toronto
Not applicable
15
Toronto
2021-03-08
Active, closed
Dual Tracer (68Ga-DOTATATE and 18F-FDG) PET Imaging in G2 & G3 Gastroenteropancreatic Neuroendocrine Tumors
NCT04804371Neuroendocrine Tumors
University Health Network, Toronto
Not applicable
40
Toronto
2021-03-04
Active, closed
Acalabrutinib With R-CHOP in Previously Untreated Mantle Cell Lymphoma
NCT04566887Mantle Cell Lymphoma
DrugAcalabrutinib
University Health Network, Toronto
Phase 2
105
Vancouver, Halifax, Toronto, Quรฉbec
2021-03-01
Active, closed
Implementation and Evaluation of a Stepped-Care Mental Health Treatment Program for Patients With Chronic Pain
NCT04885192Chronic Pain
University Health Network, Toronto
Observational
70
Toronto
2021-03-01
Recruiting
Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)
NCT04574960Bladder Cancer, Bladder Urothelial Carcinoma
DrugsParaplatin·Gemcitabine·Cisplatin·Carboplatin
University Health Network, Toronto
Phase 3
14
Ottawa, Toronto
2021-02-08
Active, closed
Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer
NCT04624477Papillary Thyroid Cancer, Papillary Thyroid Carcinoma, Papillary Microcarcinoma of the Thyroid
University Health Network, Toronto
Observational
450
Calgary, Vancouver, Halifax, Hamilton, London, Toronto, Montreal, Quรฉbec
2021-02-03
Active, closed
Accelerating Lung Cancer Diagnosis Through Liquid Biopsy
NCT04863924Non-small Cell Lung Cancer
University Health Network, Toronto
Observational
170
Toronto
2021-01-14
Recruiting
LANDscape MApping of Epitopes and T Cell Receptors for Selected Cancers
NCT04665388Solid Tumor
University Health Network, Toronto
Observational
105
Toronto
2020-11-30
Active, closed
Real-time Detection of ctDNA and/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma
NCT04599309Cancer, Head and Neck Squamous Cell Carcinoma, Head and Neck Cancer
University Health Network, Toronto
Observational
35
Toronto
2020-10-15
Recruiting
Talazoparib and Thoracic RT for ES-SCLC
NCT04170946Lung Cancer, Small-Cell Lung Cancer
University Health Network, Toronto
Phase 1
24
Toronto
2020-10-05
Recruiting
Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure
NCT04524585Respiratory Insufficiency, Neuromuscular Blockade, Mechanical Ventilation
DrugCisatracurium
University Health Network, Toronto
Not applicable
23
Toronto
2020-10-01
Active, closed
FLT-PET / MRI Brain Mets
NCT04244019Brain Metastases, Radionecrosis
University Health Network, Toronto
Observational
30
Toronto
2020-10-01
Recruiting
FAZA PETMRI Gastro-Oesophageal Study
NCT04560036Metastasized Gastro-Oesophageal Cancer
University Health Network, Toronto
Not applicable
40
Toronto
2020-09-15
Recruiting
Inspiratory Work of Breathing Before and After Extubation
NCT07017608Lung Transplant; Complications, Ventilator-Induced Lung Injury, Ventilator Associated Pneumonia
University Health Network, Toronto
Observational
67
Toronto
2020-09-01
Recruiting
Immune Resistance Interrogation Study
NCT04243720Cancer, Solid Tumor, Metastatic Cancer, Immune Resistance
University Health Network, Toronto
Observational
100
Toronto
2020-08-26
Active, closed
GATA6 Expression as a Predictor of Response to Peri-Operative Chemotherapy in Resectable Pancreatic Adenocarcinoma
NCT04472910Resectable Pancreatic Cancer
DrugModified FOLFORINOX
University Health Network, Toronto
Not applicable
84
Vancouver, Kingston, London, Ottawa, Toronto, Montreal
2020-08-21
Active, closed
The Person-centered Evolution of Radiotherapy Services in Ontario Study
NCT04507568Breast Cancer, Quality of Life
University Health Network, Toronto
Not applicable
109
Toronto
2020-08-13
Recruiting
Cabozantinib to Treat Recurrent Liver Cancer Post Transplant
NCT04204850Hepatocellular Carcinoma, Recurrent Cancer, Liver Transplant
DrugCabozantinib
University Health Network, Toronto
Phase 2
20
Toronto
2020-08-07
Active, closed
Study of Stem Cell Transplant vs. Non-Transplant Therapies in High-Risk Myelofibrosis
NCT04217356Myelofibrosis, High-Risk Cancer, Bone Marrow Cancer
DrugsJakavi·Hydroxyurea·Ruxolitinib
University Health Network, Toronto
Observational
90
Calgary, Edmonton, Vancouver, Halifax, Toronto
2020-08-05
By invitation
Ex-Vivo COF Study for Lung Cancer Observation
NCT04534413Lung Cancer
University Health Network, Toronto
Observational
50
Toronto
2020-08-05
Recruiting
Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)
NCT04526093Pain, Sleep, Anxiety, Depression
University Health Network, Toronto
Observational
1,000
Toronto
2020-07-15
Active, closed
The Canadian COVID-19 Prospective Cohort Study
NCT05125510Covid19
University Health Network, Toronto
Observational
2,176
Calgary, Vancouver, Winnipeg, Etobicoke, Hamilton, Ottawa, Toronto, Montreal
2020-06-17
Not yet open
Canadian Adult Congenital Heart Disease Intervention Registry
NCT04288596Atrial Septal Defect, Patent Foramen Ovale, Tetralogy of Fallot, Fontan
University Health Network, Toronto
Observational
9,000
Toronto
2020-04-01
Recruiting
Effect of Erector Spinae (ESP) Block on Opioid Reduction and Enhanced Recovery After Posterior Cervical Spine Surgery
NCT04646707Postoperative, Pain
University Health Network, Toronto
Not applicable
52
Toronto
2020-02-17
Recruiting
FIGO 2018 Stage IB2 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery
NCT04016389Cervical Cancer
DrugsPaclitaxel·Cisplatin·Carboplatin
University Health Network, Toronto
Not applicable
31
Toronto, Quรฉbec
2020-02-11
Active, closed
Study of Olaparib and Durvalumab in IDH-Mutated Solid Tumors
NCT03991832Glioma, Cholangiocarcinoma, Solid Tumor, IDH Mutation
DrugsOlaparib·Durvalumab
University Health Network, Toronto
Phase 2
58
Toronto
2019-12-31
By invitation
Liver Transplant for Stable, Advanced Intrahepatic Cholangiocarcinoma
NCT04195503Cholangiocarcinoma, Intrahepatic
University Health Network, Toronto
Not applicable
10
Toronto
2019-12-10
Active, closed
Magnetic Resonance-Guided Adaptive Radiotherapy (MRgART) Using an Integrated Magnetic Resonance Linear Accelerator (MRL)
NCT04135794Cancer
University Health Network, Toronto
Observational
377
Toronto
2019-12-09
Recruiting
Molecular Characteristics of Gastroesophageal Adenocarcinoma (MOCHA): A Prospective Feasibility Study
NCT04219137Esophagogastric Adenocarcinoma
University Health Network, Toronto
Observational
120
Toronto
2019-11-14
Recruiting
Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI
NCT04007380Spinal Cord Injuries, Sleep Apnea
University Health Network, Toronto
Not applicable
24
Toronto
2019-09-27
Active, closed
Study of Binimetinib in Combination With Pembrolizumab in Advanced Non-Small Cell Lung Cancer
NCT03991819Non-small Cell Carcinoma
DrugsBinimetinib·Keytruda·Pembrolizumab
University Health Network, Toronto
Phase 1
40
Calgary, Toronto, Regina, Saskatoon
2019-09-20
Active, closed
The Role of Stereo-tActic BoDy RadIotherApy iN Oligo-Progressive MalignanT Disease
NCT04122469Malignancy, Breast Cancer Metastatic, Genito-urinary
University Health Network, Toronto
Not applicable
130
Toronto
2019-09-11
Active, closed
Prospective Analysis of Intestinal Microbiome and Autoimmune Panels as Predictors of Toxicity in ImmunOncology Patients
NCT04107311Solid Tumor
University Health Network, Toronto
Observational
120
Toronto
2019-09-05
Active, closed
A Feasibility Study Evaluating Surgery for Mesothelioma After Radiation Therapy Using Extensive Pleural Resection
NCT04028570Mesothelioma; Lung
University Health Network, Toronto
Not applicable
15
Toronto
2019-09-05
Recruiting
FAZA PET/MRI in CLI Patients Pre and Post Revascularization
NCT04054609Critical Limb Ischemia
University Health Network, Toronto
Not applicable
40
Toronto
2019-08-31
Active, closed
Binimetinib and Encorafenib for the Treatment of Advanced Solid Tumors With Non-V600E BRAF Mutations
NCT03839342Solid Tumor
DrugsBinimetinib·Encorafenib
University Health Network, Toronto
Phase 2
26
Toronto
2019-06-07
Recruiting
Mechanisms and Outcome-Prognostication for Paresthesia-based and -Free Spinal Cord Stimulation
NCT03852381Neuropathic Pain, Chronic Pain
University Health Network, Toronto
Not applicable
90
Toronto
2019-05-16
Recruiting
FDG-PET and Circulating HPV in Patients With Cervical Cancer Treated With Definitive Chemoradiation (II)
NCT03853915Cervical Cancer
University Health Network, Toronto
Not applicable
64
Toronto
2019-04-23
Active, closed
Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid Tumors
NCT03851614Mismatch Repair Proficient Colorectal Cancer, Pancreatic Adenocarcinoma, Leiomyosarcoma
DrugsCediranib Maleate·Olaparib·Durvalumab
University Health Network, Toronto
Phase 2
90
Toronto
2019-04-08
Recruiting
Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
NCT03667027Diaphragm Injury, Respiratory Failure, Mechanical Ventilation Complication
University Health Network, Toronto
Observational
40
Toronto
2019-04-01
Recruiting
Opioid Use Post-Discharge After Ambulatory Distal Arm Surgery
NCT04044820Opioid Use
University Health Network, Toronto
Not applicable
292
Toronto
2019-03-04
Active, closed
High Resolution Ultrasound in Pancreatic Ductal Adenocarcinoma
NCT03820661Pancreatic Ductal Adenocarcinoma
University Health Network, Toronto
Not applicable
30
Toronto
2019-02-01
Active, closed
Identification of Patients With Age-Related Clonal Hematopoiesis (ARCH) Among Cancer Survivors
NCT03878407Cancer
University Health Network, Toronto
Observational
2,400
Toronto
2019-01-18
Recruiting
Circulating Tumor DNA in Soft Tissue Sarcoma
NCT03818412Soft Tissue Sarcoma
University Health Network, Toronto
Not applicable
40
Toronto
2019-01-17
Active, closed
Feasibility Study of MET-4: Evaluating Fecal Microbiome Effects in Immunotherapy Patients
NCT03686202All Solid Tumors
University Health Network, Toronto
Phase 2/3
65
Toronto
2018-11-30
Active, closed
Effects of Telemonitoring on the Outcome of Heart Failure Patients After an Incidence of Acute Decompensation
NCT03358303Heart Failure
University Health Network, Toronto
Not applicable
90
North York, Toronto
2018-11-16
Active, closed
Multi-Omic Assessment of Squamous Cell Cancers Receiving Systemic Therapy
NCT03712566Cancer, Esophagus Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck, Anal Canal Squamous Cell Carcinoma
University Health Network, Toronto
Observational
39
Toronto
2018-11-06
Recruiting
SABR for Renal Tumors
NCT03747133Renal Tumor
University Health Network, Toronto
Not applicable
90
Toronto
2018-11-01
Recruiting
Reducing Opioid Use for Chronic Pain Patients Following Surgery
NCT03675386Chronic Pain, Opioid Use, Postoperative Pain, Opioid Dependence
University Health Network, Toronto
Not applicable
210
Toronto
2018-10-15
Active, closed
Palliative Thoracic ImmunoRT
NCT03705806Lung Cancer, Nonsmall Cell, Lung Cancer
University Health Network, Toronto
Observational
12
Toronto
2018-10-03
Active, closed
Integrative Sequencing In Germline and Hereditary Tumours
NCT03857594Hereditary Cancer Syndrome, High-Risk, Mutation, Germline Mutation
University Health Network, Toronto
Observational
10
Toronto
2018-10-02
Active, closed
CBF and NCF Changes With Brain Radiation
NCT03606421Neurocognitive Dysfunction, Brain Metastases
University Health Network, Toronto
Observational
110
Toronto
2018-10-01
Active, closed
A Study of Avelumab in Penile Cancer Who Are Unfit for or Have Progressed After Platinum-Based Chemotherapy
NCT03391479Penile Cancer, Advanced Cancer, Metastatic Cancer
DrugAvelumab
University Health Network, Toronto
Phase 2
25
Toronto
2018-08-15
Recruiting
MR Guidance for Liver and Pancreas
NCT03582189Magnetic Resonance Imaging
University Health Network, Toronto
Observational
30
Toronto
2018-07-11
Active, closed
Cell-free DNA in Hereditary And High-Risk Malignancies 1
NCT04261972Hereditary Cancer Syndrome
University Health Network, Toronto
Observational
1,416
Vancouver, St. John's, Halifax, Toronto, Montreal
2018-07-01
Active, closed
Personalizing Osteoporosis Care: Clinical & Genetic Risk Factors for AFFs
NCT04110795Atypical Femur Fracture
University Health Network, Toronto
Observational
1,200
Hamilton, Oakville, Toronto
2018-06-25
Recruiting
MRI Guided Focal Laser Ablation of Prostate Cancer
NCT03650595Prostate Cancer, Low and Intermediate Risk Prostate Cancer
University Health Network, Toronto
Not applicable
102
Toronto
2018-03-29
Active, closed
FAZA PET/MRI Sarcoma
NCT03418818Sarcoma
Drugs18F-FAZA·Pimonidazole
University Health Network, Toronto
Not applicable
70
Toronto
2018-03-27
Active, closed
Phase 2 Study of Pembrolizumab, DPX-Survivac Vaccine and Cyclophosphamide in Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer
NCT03029403Advanced Cancer, Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
DrugsDPX-Survivac·Procytox·Keytruda·Cyclophosphamide
University Health Network, Toronto
Phase 2
47
Toronto
2018-02-12
Recruiting
Study Looking at Biomarkers in Ovarian Cancer
NCT03419689Gynecologic Cancer
University Health Network, Toronto
Not applicable
510
Barrie, Hamilton, Kingston, London, Ottawa, Toronto
2018-01-08
Recruiting
Study of Biomarkers in Gynecological Cancers
NCT03420118Gynecologic Cancer
University Health Network, Toronto
Not applicable
1,000
Toronto
2017-12-21
Active, closed
WATChmAN Virtual Testicular Cancer Clinic
NCT03360994Testicular Cancer
University Health Network, Toronto
Not applicable
144
Toronto
2017-12-15
Active, closed
Study of Niraparib and TSR-042 in Recurrent Endometrial Cancer
NCT03016338Endometrial Cancer
DrugsNiraparib·Dostarlimab
University Health Network, Toronto
Phase 2
51
Calgary, Hamilton, Kingston, London, Toronto, Montreal
2017-11-06
Active, closed
Lung Transplant HCV, Pilot Study
NCT03112044Lung Transplant Infection, Hepatitis C
DrugSofosbuvir-Velpatasvir
University Health Network, Toronto
Phase EARLY_PHASE1
26
Toronto
2017-09-19
Active, closed
Comprehensive Genomic Profiling of Colorectal Cancer Patients With Isolated Liver Metastases to Understand Response & Resistance to Cancer Therapy
NCT03364621Colorectal Cancer, Colorectal Cancer Metastatic, Hepatic Metastases
University Health Network, Toronto
Observational
17
Vancouver, Toronto
2017-08-29
Recruiting
Improving Quality of Life for Patients With Breast Cancer Invading the Chest Wall: A Prospective Registry For Patients Undergoing Full Thickness Chest Wall Resection
NCT03265379Breast Cancer
University Health Network, Toronto
Observational
104
Toronto
2017-08-22
Recruiting
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
NCT03702309Cancer, Breast Cancer, Lung Cancer, Colon Cancer
University Health Network, Toronto
Observational
2,500
Toronto
2017-08-03
Recruiting
3T MRI in Patients With Deep Brain Stimulation (DBS)
NCT03153670Neuro-Degenerative Disease
University Health Network, Toronto
Not applicable
250
Toronto
2017-06-01
Active, closed
Mindfulness Based Eating Awareness Training for Bariatric Surgery Patients
NCT03488966Obesity, Morbid, Eating Disorder Symptom
University Health Network, Toronto
Not applicable
85
Toronto
2017-03-20
Recruiting
Effects of Compression Stockings in Asthma Symptoms at Night
NCT03303586Asthma
University Health Network, Toronto
Not applicable
40
Toronto
2017-02-21
Active, closed
HDR Focal: Feasibility Study
NCT02918253Prostate Cancer
University Health Network, Toronto
Not applicable
60
Toronto
2016-10-14
Active, closed
Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors
NCT02869217NY-ESO-1 Expressing Solid Tumors in HLA-A2 Positive Patients, Synovial Sarcoma, Melanoma, Esophageal Cancer
DrugsTBI-1301·Fludarabine·Cyclophosphamide
University Health Network, Toronto
Phase 1
22
Toronto
2016-09
Recruiting
Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases
NCT02864485Colorectal Cancer, Liver Metastases
University Health Network, Toronto
Not applicable
20
Toronto
2016-08-03
Recruiting
Ontario-wide Cancer TArgeted Nucleic Acid Evaluation
NCT02906943Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma
University Health Network, Toronto
Observational
10,000
Hamilton, Kingston, London, Ottawa, Toronto
2016-08
Active, closed
A Study of Olaparib Prior to Surgery and Chemotherapy in Ovarian, Primary Peritoneal, and Fallopian Tube Cancer
NCT02489006Ovarian Cancer, Fallopian Tube Cancer, Neoadjuvant Treatment, Debulking Surgical Procedures
DrugOlaparib
University Health Network, Toronto
Phase 2
71
Calgary, Ottawa, Toronto, Montreal
2016-07-19
Active, closed
Lu-DOTATATE Treatment in Patients With 68Ga-DOTATATE Somatostatin Receptor Positive Neuroendocrine Tumors
NCT02743741Neuroendocrine Tumors
DrugLutathera
University Health Network, Toronto
Not applicable
195
Hamilton, London, Toronto
2016-07-15
Active, closed
Deciding on Active Surveillance or Surgery for Primary Management of Low Risk Papillary Thyroid Cancer
NCT03271892Thyroid Cancer Stage I
University Health Network, Toronto
Observational
200
Toronto
2016-05-11
Active, closed
Study of the Effects of Pembrolizumab in Patients With Advanced Solid Tumors
NCT02644369Squamous Cell Cancer of Head and Neck, Triple Negative Breast Cancer, Epithelial Ovarian Cancer, Malignant Melanoma
DrugPembrolizumab
University Health Network, Toronto
Phase 2
100
Toronto
2016-03-21
Active, closed
Receiving Radiation Therapy in the MRgRT Research Facility
NCT02701712Solid Tumors and Metastatic Lesions
University Health Network, Toronto
Not applicable
150
Toronto
2016-02
Recruiting
In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma
NCT02811523Bone Sarcoma, Soft Tissue Sarcoma, Pulmonary Metastases
DrugDoxorubicin
University Health Network, Toronto
Phase 1
17
Toronto
2016-02
Recruiting
Personalized Patient Derived Xenograft (pPDX) Modeling to Test Drug Response in Matching Host
NCT02732860Colorectal Neoplasms, Colorectal Cancer, Breast Cancer, Breast Neoplasms
University Health Network, Toronto
Observational
120
Toronto
2015-12
Active, closed
A Study of (Interleukin-12) IL-12 in Patients With Acute Myelogenous Leukemia (AML)
NCT02483312Acute Myeloid Leukemia
DrugEdodekin alfa
University Health Network, Toronto
Phase 1
9
Toronto
2015-09
Recruiting
Diagnosing Frontotemporal Lobar Degeneration
NCT02964637Corticobasal Syndrome, Progressive Supranuclear Palsy, Behavioral Variant Frontotemporal Dementia, Semantic Dementia
University Health Network, Toronto
Observational
100
Toronto
2015-08
Active, closed
Nasopharyngeal Carcinoma Post IMRT
NCT02597426Nasopharyngeal Carcinoma
University Health Network, Toronto
Observational
108
Toronto
2015-06
Recruiting
Tissue Collection Protocol for Gastroesophageal Cancers
NCT02495337Esophageal Cancer
University Health Network, Toronto
Observational
100
Toronto
2015-05
Recruiting
Myeloproliferative Neoplasms (MPNs) Patient Registry
NCT02760238Primary Myelofibrosis, Polycythemia Vera, Essential Thrombocythemia, Mastocytosis
University Health Network, Toronto
Observational
5,000
Toronto
2015-04
Active, closed
"Re-Stimulated" TILs And IL-2 Therapy for Platinum Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
NCT01883297Recurrent, Platinum-resistant, High Grade Serous Ovarian Cancer, Fallopian Tube Cancer
DrugsProcytox·Autologous Tumor Infiltrating Lymphocytes·Aldesleukin·Cyclophosphamide
University Health Network, Toronto
Phase 1
3
Toronto
2015-01
Active, closed
18F-Fluoroazomycin Arabinoside (18F-FAZA) in Lung Cancer
NCT02701699Lung Cancer
University Health Network, Toronto
Not applicable
36
Toronto
2014-12
Active, closed
A Study of Different Dosing Schedules of Selumetinib With Cisplatin/Gemcitabine (CIS/GEM) Versus CIS/GEM Alone in Biliary Cancer
NCT02151084Biliary Tract Carcinoma, Gallbladder Carcinoma
DrugsSelumetinib·Gemcitabine·Cisplatin
University Health Network, Toronto
Phase 2
57
Toronto
2014-11
Recruiting
Head and Neck Squamous Cell Carcinoma (HNSCC)PET-CT Pilot Study
NCT02678884Head and Neck Squamous Cell Carcinoma
University Health Network, Toronto
Not applicable
20
Toronto
2014-10
Active, closed
Disease Status in Primary Sclerosing Cholangitis by Elastography
NCT02446665Primary Sclerosing Cholangitis, Elastography, Hepatic Fibrosis, Magnetic Resonance Imaging
University Health Network, Toronto
Not applicable
82
Toronto
2014-10
Active, closed
Prostate Hypoxia - TIC
NCT02095249Prostate Cancer
DrugPimonidazole
University Health Network, Toronto
Not applicable
39
Toronto
2014-09
Recruiting
Genomic Investigation of Unusual Responders
NCT03740503Cancer, Breast Cancer, Non-small Cell Lung Cancer, Colorectal Cancer
University Health Network, Toronto
Observational
100
Toronto
2013-11-01
Active, closed
Evaluation of Myocardial Changes During BReast Adenocarcinoma Therapy to Detect Cardiotoxicity Earlier With MRI
NCT02306538Breast Neoplasms
University Health Network, Toronto
Observational
180
Toronto
2013-10
Recruiting
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients With Non-small Cell Lung Cancer Pursuing Stereotactic Body Radiotherapy (SBRT)
NCT01786590Lung Cancer
University Health Network, Toronto
Not applicable
150
Toronto
2013-02
Active, closed
Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain
NCT04798573Chronic Pain, Surgery
University Health Network, Toronto
Observational
10,000
Toronto
2012-08-03
Active, closed
Evaluation of IVA (SE Femur Scans) to Identify Incomplete AFFs
NCT01747304Atypical Femur Fracture
University Health Network, Toronto
Observational
285
Toronto
2012-07
Active, closed
Integrated Molecular Profiling in Advanced Cancers Trial
NCT01505400Breast Cancer, Non-small Cell Lung Cancer, Colorectal Cancer, Genitourinary Cancer
University Health Network, Toronto
Observational
3,026
Toronto
2012-02
Recruiting
Feasibility of Evaluating Gene Alteration Analysis Using Samples Obtained by EBUS-TBNA in Patients With Lung Cancer
NCT01487603Lung Cancer
University Health Network, Toronto
Observational
400
Toronto
2011-10
Recruiting
Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study
NCT03218332Chronic Traumatic Encephalopathy
University Health Network, Toronto
Observational
150
Toronto
2011-07-04
Active, closed
Cervix Hypoxia FAZA
NCT01549730Cervix Cancer
University Health Network, Toronto
Not applicable
30
Toronto
2011-05
Recruiting
Atypical Fracture Cohort Study
NCT01747291Atypical Femur Fracture, Atypical Subtrochanteric Fracture, Osteoporosis With AFf
University Health Network, Toronto
Observational
300
Hamilton, Toronto
2009-06
Recruiting
High-Dose-Rate Brachytherapy
NCT00913939Patients With Prostate Cancer
University Health Network, Toronto
Not applicable
500
Toronto
2009-05
Active, closed
Femoral Bone Metastases
NCT01428895Cancer, Metastatic Malignant Neoplasm to Femur, Risk of Fracture
University Health Network, Toronto
Not applicable
180
Toronto
2009-03
Active, closed
Teriparatide (PTH) and Bone Strength in Postmenopausal Women
NCT01155245Osteoporosis
University Health Network, Toronto
Observational
60
Toronto
2008-06
Active, closed
Intra-Pelvic Organ Motion for Cervix Cancer Patient Using Imaging
NCT00957450Cervix Cancer
University Health Network, Toronto
Observational
12
Toronto
2008-02
Active, closed
Randomized Controlled Trial of Early Palliative Care for Patients With Advanced Cancer
NCT01248624Cancer
University Health Network, Toronto
Not applicable
461
Toronto
2006-12
Active, closed
Advanced Imaging for Radiotherapy Treatment Planning and Guidance for Low-Intermediate Risk Prostate Cancer (Margin)
NCT00890006Low or Intermediate Risk Prostate Cancer
University Health Network, Toronto
Not applicable
99
Toronto
2006-09
Active, closed
Predictive Assays In Cervix Cancer
NCT01181375Cervical Cancer
University Health Network, Toronto
Not applicable
500
Toronto
2006-08-01
Recruiting
Stereotactic Radiotherapy (SBRT) of Lung Metastasis
NCT01803542Non-small Cell Lung Cancer, Metastasis From Other Cancers
University Health Network, Toronto
Phase 2
200
Toronto
2006-03
Recruiting
Registry for Patients Receiving Intravenous Nutrition at Home
NCT02299466Parenteral Nutrition, Home
University Health Network, Toronto
Observational
1,000
Calgary, Edmonton, Vancouver, Winnipeg, Hamilton, Toronto, Montreal, Quรฉbec
2005-12
Active, closed
Low-Dose CT - Stage I Testicular Cancer
NCT03142802Testicular Cancer
University Health Network, Toronto
Not applicable
251
Toronto
2005-09-16
Active, closed
Effects of Teriparatide (PTH) on Bone in Men and Women With Osteoporosis
NCT01155232Osteoporosis
DrugTeriparatide
University Health Network, Toronto
Observational
100
Toronto
2004-11
Active, closed
Cervix: Hypoxia, Interstitial Fluid Pressure and GSH Levels
NCT00188539Cervix Neoplasms
University Health Network, Toronto
Phase 2
346
Toronto
1995-12
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Canadian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 30 September 2026. https://priyalifescience.com/clinical-trials-canada/city/toronto

Query this register directly
GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Canada and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,540 studies in total at the last sync on 26 Sep 2026, 19:55 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 344 of those studies with a site in Toronto that also match the filters currently applied.

How many clinical trials are recruiting in Toronto?

202 of the 344 studies on this page are recruiting new participants as of the 26 Sep 2026, 19:55 UTC sync. A further 31 have not yet opened recruitment, 103 are active but closed to new participants, and 8 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Toronto), 344 studies
PhaseStudiesRecruitingShare
Not applicable1529944.2%
Observational824223.8%
Phase 2623618%
Phase 11674.7%
Phase 31193.2%
Phase 4962.6%
Phase 2/3511.5%
Phase EARLY_PHASE1511.5%
Phase 1/2210.6%

Most active sponsors

Lead sponsors with the most studies (Toronto)
Lead sponsorStudiesRecruiting
University Health Network, Toronto344202
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.