The overall objective of this project is to identify clinical and genetic risk factors for Atypical Femur Fractures (AFFs) in Anti-resorptive therapy (ART) users by conducting a case control study of 330 cases of AFFs and 660 controls without AFFs matched for age, sex, race and duration of ART.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* Cases: Have experienced a confirmed, documented Atypical femur fracture
* Controls: currently on anti-resorptive therapy, matches AFF case by age, race and length of ART use
Exclusion Criteria:
\-
Primary outcome measure(s)
Associations between AFF and clinical Risk Factor — baseline Associations between AFFs and clinical risk factors
Associations between AFF and common genetic variants — baseline Associations of common genetic variants among patients with AFFs
Validation of top genetic variants — baseline To validate the top few genetic variants identified in the above case-control study in a separate cohort of 100 cases and 100 controls.
Trial sites (3)
Facility
City
Region
Status
Adachi Medical Centre
Hamilton
Ontario
Bone Research & Education Centre
Oakville
Ontario
University Health Network, TGH
Toronto
Ontario
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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