Respiratory support: Mechanical ventilation or extracorporeal life support
Study summary
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria (Cases):
* Receiving a respiratory support modality as a bridge to lung transplantation
* Formally listed for transplantation
Inclusion Criteria (Control Group 1):
\- Undergoing lung transplantation for either obstructive or restrictive lung disease
Inclusion Criteria (Control Group 2):
\- Undergoing elective thoracic surgery without any prior history of chronic pulmonary parenchymal disease
Exclusion Criteria (Cases and Controls):
* Previously diagnosed with neuromuscular disorder
* Received invasive mechanical ventilation for \>48 hours in the preceding four weeks
* Thoracic cage deformity
Primary outcome measure(s)
Difference in diaphragm thickness and thickening fraction in patients using MV and patients using ECLS — Change from baseline diaphragm thickness and thickening fraction at 7 days after lung transplant Diaphragm thickness and injury score will be tested for an interaction between the bridging modality (MV vs. ECLS) and the duration of exposure to the modality on the degree of diaphragm injury and atrophy
Trial sites (1)
Facility
City
Region
Status
Toronto General Hospital
Toronto
Canada
Recruiting
More University Health Network, Toronto trials in Canada
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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