Clinical trial register · European Union · CTIS

Clinical Trials in France, 2026

The most recently authorised trials on the EU Clinical Trials Information System (CTIS), the single register for every trial run under the EU Clinical Trials Regulation (536/2014). CTIS holds a far larger historical archive than any one list can usefully show — this register states both numbers rather than picking one.

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Source: EMA Clinical Trials Information System (CTIS). Showing the 2557 most recently authorised of 12788 total CTIS records — a stated recency window, not the full historical archive. Synced 07 Nov 2026, 03:17 UTC

2557

Shown in this register

most recently authorised

12,788

Total on CTIS

full historical archive

789

Phase III

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Top member states

Spain 1074 France 933 Germany 893 Italy 777 Poland 614 Netherlands 544

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Trials with a site in France

Phase

Study

Lead sponsor

Area

Member states

Decision

Phase III

AFTER - Treatment of women with Acne vulgaris - Evaluation of the eFficacy of isoTretinoin low-dose vs spironolactonE in the attack phase and spiRonolactone in the maintenance phase: A 2-step randomized controlled trial

2025-520773-39-00acne in adult women

DrugsAdapalene·Tretinoin·Isotretinoin·Spironolactone

Assistance Publique Hopitaux De Paris

Skin and Connective Tissue Diseases

France

26/10/2026

Phase III

VISION - Non-Inferiority of videolaryngoscopy-assisted intubation without neuromuscular blockade versus with neuromuscular blockade on first-attempt intubation success free of major complications: a randomized clinical trial

2026-526824-29-00Adult patients requiring elective general anaesthesia with …

DrugAtracurium

Assistance Publique Hopitaux De Paris

Surgical Procedures, Operative

France

16/10/2026

Phase II

CombiMucor - Efficacy of combination therapy with isavuconazole and intermittent high doses liposomal amphotericin B for the treatment of mucormycosis

2025-521505-40-00Adults with mucormycosis

DrugAmphotericin B

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

09/10/2026

Phase III

COTRIM-HIGH - Efficacy of daily prophylaxis with Cotrimoxazole 800/160mg on the occurrence of bacterial infections at six months after renal transplantation

2026-526183-20-00bacterial infection, kidney transplant

DrugTrimethoprim-sulfamethoxazole

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

08/10/2026

Phase II

DIRECTION- Discontinuation versus continuation of riociguat monotherapy in chronic thromboembolic pulmonary hypertension successfully treated with balloon pulmonary angioplasty

2026-525351-81-00chronic thromboembolic pulmonary hypertension

DrugRiociguat

Assistance Publique Hopitaux De Paris

Cardiovascular Diseases

France

25/08/2026

Phase III

FOSFOLD - Fosfomycin trometamol compared with another active antibiotic relay therapy for the treatment of acute Escherichia coli pyelonephritis in elderly women: a randomized, multicenter, non-inferiority trial

2025-521663-13-00Women aged 75 years or older presenting with E. coli pyelon…

DrugsCefotaxime·Ertapenem·Aztreonam·Ceftazidime

Assistance Publique Hopitaux De Paris

Female Urogenital Diseases and Pregnancy Complications

France

21/08/2026

Phase II

TIPS : Immunomodulatory Treatment of Interstitial Lung Disease Associated with Surfactant related Gene Mutations

2026-525336-41-00Interstitial Lung Disease

DrugsAzithromycin·Hydroxychloroquine·Prednisolone·Prednisone

Assistance Publique Hopitaux De Paris

Respiratory Tract Diseases

France

14/08/2026

Phase II

SDH-FLUX - Development of a new biomarker for tumor development in patients with SDHx mutation by in vivo fluxomics

2023-506001-19-00paraganglioma or pheochromocytoma with surgical indication

Assistance Publique Hopitaux De Paris

Hormonal diseases

France

10/08/2026

Phase III

AVISO - Assessment of Flecainide versus Bisoprolol as First-Line Treatment for Premature Ventricular Contractions: a Multicenter Randomized Clinical Trial

2025-524584-20-00Premature ventricular contractions (PVC)

DrugsBisoprolol·Flecainide

Assistance Publique Hopitaux De Paris

Cardiovascular Diseases

France

10/08/2026

Phase III

Topical Clobetasol Propionate for Inflammatory Hand osteoarthritis: A randomized trial versus placebo.(PROCLAME)

2025-520678-20-00Adult patients with symptomatic and inflammatory Hand osteo…

DrugClobetasol Propionate

Assistance Publique Hopitaux De Paris

Musculoskeletal Diseases

France

07/08/2026

Phase II

VIP-1 : Preclinical type 1 diabetes: the VIP-1 Study

2025-524318-27-00People with stage 1 or stage 2 T1D between the ages of 7 an…

DrugVerapamil

Assistance Publique Hopitaux De Paris

Immune System Diseases

France

05/08/2026

Phase III

RUBY study « Randomized controlled trial testing the efficacy of corticosteroid therapy versus placebo in fibrotic hypersensitivity pneumonitis.»

2025-521591-64-00Adult patients with a diagnosis of fibrotic Hypersensitivit…

Assistance Publique Hopitaux De Paris

Respiratory Tract Diseases

France

03/08/2026

Phase II

OBINUSS - Safety and efficacy of obinutuzumab in systemic sclerosis: a phase II, randomized, double-blinded versus placebo-controlled trial

2025-524003-68-00Patients with newly or active diffuse Systemic sclerosis at…

DrugObinutuzumab

Assistance Publique Hopitaux De Paris

Immune System Diseases

France

28/07/2026

Phase III

FOSFORMEN : Randomized, multicenter, non-inferiority trial comparing the efficacy of fosfomycin versus fluoroquinolones or cotrimoxazole as oral follow-up treatment in febrile urinary tract infections in men caused by susceptible enterobacteria

2026-525972-25-00Febrile male urinary tract infections caused by Escherichia…

DrugsFosfomycin·Ciprofloxacin·Levofloxacin

Assistance Publique Hopitaux De Paris

Male Urogenital Diseases

France

16/07/2026

Phase II

Obinutuzumab for systemic lupus erythematosus pure membranous nephropathy: a phase II trial (OBLUMEN)

2024-519985-35-00systemic lupus erythematosus pure membranous nephropathy

DrugObinutuzumab

Assistance Publique Hopitaux De Paris

Pathological Conditions, Signs and Symptoms

France

15/07/2026

Phase II

Shared decision-making in uncomplicated appendicitis: a pragmatic randomized trial comparing patient-driven choice (antibiotics only or appendectomy) with systematic appendectomy (FRENCH 47 — ALACARTE trial)

2025-520783-17-01Adult patients diagnosed with uncomplicated acute appendici…

Assistance Publique Hopitaux De Paris

Therapeutics

France

06/07/2026

Phase I

THERIPEX - A phase I/II open label non-randomized study, monocentric, single-arm, evaluating Safety and Efficacy of induced T-CD4 Treg by LV vector transduction expressing the FoxP3 cDNA in patients with IPEX syndrom

2025-523305-15-00Patients affected by IPEX syndrome, proven by molecular di…

Assistance Publique Hopitaux De Paris

Immune System Diseases

France

24/06/2026

Phase I/II

ACTIVATE - Phase 1 Clinical Trial evaluating the combination of Actinomycin D and venetoclax in patients with Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

2025-524728-22-01Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

Assistance Publique Hopitaux De Paris

Not possible to specify

France

10/06/2026

Phase IV

PREP-ANCA - Comparison of a strategy based on clinic-biological surveillance versus pre-emptive treatment with rituximab in the event of ANCA (anti-neutrophil cytoplasm antibodies) repositivation in patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)

2025-522049-23-00granulomatosis with polyangiitis and microscopic polyangiit…

DrugsPrednisone·Rituximab

Assistance Publique Hopitaux De Paris

Immune System Diseases

France

08/06/2026

Phase IV

ANTIMIDIS - Cefazolin mediastinal distribution using microdialysis

2025-521988-13-00Infection prophylaxis

DrugCefazolin

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

05/06/2026

Phase II

POMREP - Efficacy and safety of zoledronate versus placebo on pain at week 12 in pediatric patients with chronic recurrent multifocal osteomyelitis resistant to non-steroidal anti-inflammatory drug

2023-506420-93-00Chronic recurrent multifocal osteomyelitis (CRMO)

DrugZoledronic Acid

Assistance Publique Hopitaux De Paris

Musculoskeletal Diseases

France

26/05/2026

Phase III

Efficacy of Temocillin compared to standard of care in the Treatment of Neisseria gonorrhoeae Infections: A Multicenter Randomized Controlled Non-Inferiority Trial (TEMtoGo).

2025-524475-23-00Neisseria gonorrhoeae Infections

DrugCeftriaxone

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

18/05/2026

Phase III

IMMUNOTIME « EVALUATION OF THE EFFECT OF TIME OF ADMINISTRATION ON THE ACTIVITY ON FIRST LINE OF PEMBROLIZUMAB IN ASSOCIATION WITH CARBOPLATIN PEMETREXED IN METASTATIC NON-SQUAMOUS LUNG CANCER. A RANDOMISED MULTICENTER PHASE III TRIAL»

2025-521891-78-00Adult patients with stage IV non squamous non-small cell lu…

DrugsPemetrexed·Carboplatin·Pembrolizumab

Assistance Publique Hopitaux De Paris

Neoplasms

France

12/05/2026

Phase III

MAINRITSys : Rituximab vs placebo for maintenance in systemic sclerosis – interstitial lung disease

2025-521331-36-00Patient with stabilized SSc-ILD (as defined by a decline of…

DrugRituximab

Assistance Publique Hopitaux De Paris

Skin and Connective Tissue Diseases

France

11/05/2026

Phase III

ANTIPROM - Comparison of two prophylactic antibiotic regimens in case of preterm prelabor rupture of membranes before 34 weeks of gestation: a randomized controlled trial

2025-520842-31-00Population of study participants Pregnant women with PPROM …

DrugsCeftriaxone·Azithromycin·Amoxicillin

Assistance Publique Hopitaux De Paris

Female Urogenital Diseases and Pregnancy Complications

France

28/04/2026

Phase II

Electrophysiological analysis of Gamma-Hydroxybutyrate-induced sleep in intensive care patients: A Pilot Double-Blind Randomized Controlled Trial.(GAMMA-SLEEP)

2025-521967-11-00The study population includes adult ICU patients with a hos…

DrugNaCl

Assistance Publique Hopitaux De Paris

Mental Disorders

France

28/04/2026

Phase III

KARMA - INtenSive care TreAtmeNT with adjuvant KetAmine and Recovery after Mechanical ventilAtion: a multicenter doubleblind randomized controlled trial

2025-523149-80-00Adult patients admitted to the ICU and receiving unplanned …

Assistance Publique Hopitaux De Paris

Respiratory Tract Diseases

France

20/04/2026

Phase III

PREV-CART - A multicentric phase III randomized clinical trial open-label, comparing immunoglobulin replacement therapy (IgRT) and antibiotic prophylaxis (AP) in patients treated by CD19-targeted Chimeric Antigen Receptor (CAR)T Cells for a B cell acute lymphoblastic leukemia or a B cell lymphoma

2025-521571-30-00Young Adults and adults with R/R B-cell acute lymphoblastic…

DrugsImmunoglobulins·Levofloxacin·Azithromycin·Amoxicillin

Assistance Publique Hopitaux De Paris

Hemic and Lymphatic Diseases

France

13/04/2026

Phase II

A Phase 2, single arm Multicenter, Study testing Mezigdomide, Carfilzomib, and Dexamethasone (480Kd) in Participants with Relapsed or Refractory Multiple Myeloma (RRMM). (MEZI-KD)

2025-521090-14-00Patients with relapsed/refractory symptomatic multiple myel…

DrugsMezigdomide·Carfilzomib·Dexamethasone

Assistance Publique Hopitaux De Paris

Hemic and Lymphatic Diseases

France

08/04/2026

Phase III

“Intravenous Thrombolysis With Tenecteplase Plus Thrombectomy Versus Thrombectomy Alone In Patients With A Large Ischemic Stroke: A Multicentre Randomized Controlled Trial” THE IVT ALL IN TRIAL

2024-520414-21-00Adult patients with a LVOS with large core within 9 hours o…

DrugTenecteplase

Assistance Publique Hopitaux De Paris

Nervous System Diseases

France

12/03/2026

Phase III

CANDISHORT : A randomized study of a short duration therapy for candidemia

2024-514244-81-00Uncomplicated candidemia

DrugsCaspofungin·Voriconazole·Fluconazole

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

06/03/2026

Phase III

APICALE - Cervical facet injection of corticosteroids for the management of cervicobrachialgia : protocol for a randomized pilot study

2024-511790-30-00Cervicobrachial Neuralgia

DrugsNaCl·Dexamethasone

Assistance Publique Hopitaux De Paris

Nervous System Diseases

France

06/03/2026

Phase III

CUSHMAH - Benefit of steroidogenesis inhibitors in Mild Cushing syndrome (Mild Autonomous Cortisol Secretion): a randomized trial in patients with Primary Bilateral Macronodular Adrenocortical Hyperplasia

2023-507010-27-00Primary Bilateral Macronodular Adrenal Hyperplasia causing …

Assistance Publique Hopitaux De Paris

Nutritional and Metabolic Diseases

France

05/03/2026

Phase III

TIC-TAC-SAM « Comparison of two strategies of etoposide initiation in severe sporadic hemophagocytic lymphohistiocytosis in intensive care: a randomized trial »

2024-511807-41-01Hemophagocytic lymphohistiocytosis (HLH)

DrugsEtoposide·Dexamethasone

Assistance Publique Hopitaux De Paris

Pathological Conditions, Signs and Symptoms

France

27/02/2026

Phase II

STARS - Prospective, bayesian, randomized, controlled, open-label, parallel-group, phase II interventional study evaluating efficacy and safety of secukinumab versus standard of care in active severe Takayasu patients

2024-516215-24-00TAkayasu ARteritiS

Assistance Publique Hopitaux De Paris

Immune System Diseases

France

26/02/2026

Phase III

Sustained-release oral morphine to alleviate persistent dyspnea in patients with chronic respiratory insufficiency due to amyotrophic lateral sclerosis outside the administration of ventilatory assistance: prospective multicenter randomized, placebo-controlled study, parallel arms. (OPIDYS-ALS).

2025-522546-52-00patients with chronic respiratory insufficiency due to amyo…

DrugMorphine

Assistance Publique Hopitaux De Paris

Respiratory Tract Diseases

France

13/02/2026

Phase III

Evaluation of the efficacy of corticosteroids in septic arthritis in adults: Randomized double-blind controlled trial [CORSAR]

2025-522193-37-00Septic arthritis

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

10/02/2026

Phase III

MAMI Use of the Methoxyflurane as pain-killer in the prehospital management of Acute Myocardial Infarction

2025-523349-86-00Acute Myocardial Infarction

DrugsMethoxyflurane·Morphine

Assistance Publique Hopitaux De Paris

Cardiovascular Diseases

France

02/02/2026

Phase I/II

DREPAMIR - A Phase 1/2 Open Label Cohort Comparative Study Evaluating the Efficacy and the safety of Gene Therapy of the Sickle Cell Disease by Transplantation of an Autologous CD34+ enriched cell fraction that contains autologous CD34+ cells transduced ex vivo by the bifunctional βAS3m/miR7m lentiviral vector expressing the βAS3m and a micro-RNA (miRNA) targeting specifically the endogenous βS-globin mRNA in Patients with Sickle Cell Disease (SCD)

2025-521257-17-00SCD severe patients

Assistance Publique Hopitaux De Paris

Hemic and Lymphatic Diseases

France

16/01/2026

Phase III

Fecal microbiota transplantation for primary sclerosing cholangitis - randomized study versus sham transplantation (FMT-SCLER).

2023-505469-95-00Primary Sclerosing Cholangitis

Assistance Publique Hopitaux De Paris

Nutritional and Metabolic Diseases

France

02/12/2025

Phase III

RASBU-SEPSIS Study: Effects of rasburicase on renal function during sepsis – a randomized, placebo-controlled, double-blind trial

2023-508071-36-00Patients hospitalised in intensive care, diagnosed with sep…

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

24/11/2025

Phase II

BOOSTERS - BiOlogics in FOlliculitis decalvanS : an adaptaTivE tRial reSearch

2024-514848-88-00Folliculitis decalvans

DrugsUstekinumab·Baricitinib·Adalimumab

Assistance Publique Hopitaux De Paris

Therapeutics

France

24/11/2025

Phase II

PALETTE - Adaptive platform trial for personalisation of sepsis treatment in children and adults: a multi-national, treatable traits-guided, adaptive, exploratory, bayesian basket trial

2025-521371-31-00Sepsis

Assistance Publique Hopitaux De Paris

Virus Diseases

France

24/11/2025

Phase II

ALaDIN - Use of low doses of interleukin-2 in autism spectrum disorders

2025-522841-23-00Autism Spectrum disorder ASD

Assistance Publique Hopitaux De Paris

Mental Disorders

France

17/11/2025

Phase III

LEISURE : Lenalidomide vs methotrexate in difficult-to-treat cutaneous lupus erythematosus (LEISURE trial): An assessor-blinded randomized clinical trial

2024-520089-70-00Cutaneous lupus erythematosus

Assistance Publique Hopitaux De Paris

Skin and Connective Tissue Diseases

France

14/11/2025

Phase II

BASECOVID - Bevacizumab in post-acute sequelae of COVID-19 : Efficacy and Safety (Pilot Study)

2024-520308-24-00Adult patients with persistent dyspnea more than 3 months a…

DrugBevacizumab

Assistance Publique Hopitaux De Paris

Virus Diseases

France

24/10/2025

Phase III

SERORL Effect of aspirin and folic acid for sudden sensorineural hearing loss

2024-513710-35-00Patients presenting to ENT emergencies with a unilateral su…

Assistance Publique Hopitaux De Paris

Otorhinolaryngologic Diseases

France

17/10/2025

Phase II

CBD-SIB - Efficacy of cannabidiol in the management of Self-Injurious Behavior in children and adolescents with severe neurodevelopmental disorders

2025-521161-27-00Children and adolescents with severe neurodevelopmental dis…

DrugCannabidiol

Assistance Publique Hopitaux De Paris

Behavior and Behavior Mechanisms

France

07/10/2025

Phase IV

TIME-TO-LIA : Optimal Duration of Antibiotic Therapy in Drained Pyogenic Liver Abscess: 3 weeks versus 6 weeks, a non-inferiority trial

2025-520940-14-00Pyogenic liver abscess

DrugsDaptomycin·Colistin·Imipenem·Amikacin

Assistance Publique Hopitaux De Paris

Bacterial Infections and Mycoses

France

06/10/2025

Cite this view

Priya Life Science (2026). EU Clinical Trials Register (CTIS), filtered. Derived from the EMA Clinical Trials Information System. Retrieved 7 November 2026. https://priyalifescience.com/clinical-trials-europe/country/france

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About this register

This register is built from the EU Clinical Trials Information System (CTIS), run by the European Medicines Agency: the single register for every trial authorised under the EU Clinical Trials Regulation (536/2014). CTIS held 12,788 trial records at the last sync on 07 Nov 2026, 03:17 UTC; this register shows the 2,557 most recently authorised of them, a stated recency window rather than the full archive. The list can be downloaded as CSV or JSON.

This page shows the 49 of those trials with a site in France that also match the filters currently applied.

How many recently authorised EU trials have a site in France?

49 of the 2,557 most recently authorised trials in this register list a site in France and match the filters applied; 26 of them are Phase III. Trials are counted by authorisation on CTIS, not by recruitment status, which CTIS does not publish in the same form as ClinicalTrials.gov.

Summary by phase

Trials by phase (France), 49 trials
Phase	Trials	Share
Phase III	26	53.1%
Phase II	17	34.7%
Phase IV	3	6.1%
Phase I/II	2	4.1%
Phase I	1	2%

Most active sponsors

Lead sponsors with the most trials (France)
Lead sponsor	Trials
Assistance Publique Hopitaux De Paris	49

Listing here is informational and not medical advice; eligibility is determined by each study team. Looking for Irish sites? See the Ireland, UK or USA registers. For approved medicines, see the EMA Approvals Tracker.