MAMI Use of the Methoxyflurane as pain-killer in the prehospital management of Acute Myocardial Infarction

Condition studied

Acute Myocardial Infarction

Investigational medicinal product(s)

Eligibility

Primary endpoint

Proportion of patients achieving pain relief, i.e. pain intensity score on visual analogic scale (VAS) ≤ 3 at 30 minutes.

Endpoint detail

Pain relief: time before achieving pain relief, i.e. time between randomization and pain intensity score on VAS ≤ 3;, Pain relief: time to reach initial pain divided by two (initial VAS / 2), Impact of the treatments on cardiovascular system: heart rate, arterial blood pressure, pulse oximetry and ECG changes at hospital arrival, Tolerance of the treatments: respiratory depression: respiratory rate < 10 cycles per minutes, Tolerance of the treatments: sedation: Richmond Agitation - Sedation Scale (RASS) ≥ 2 or ≤ -2, Tolerance of the treatments: : dizziness, pruritus, nausea, vomiting, headache