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Trackers› Clinical trials› Canada
Clinical trial register · Canada

Studies with a Canadian investigative site

Every study on the ClinicalTrials.gov registry that lists a site in Canada and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage โ€” all 6540 matching records held by the registry are in this view. Synced 26 Sep 2026, 19:55 UTC
6540
Studies in scope
all four open statuses
3515
Recruiting now
open to new participants
887
Lead sponsors
across recruiting studies
Top sites
Toronto 2809 Montreal 1902 Vancouver 1179 Calgary 1061 Edmonton 1017
Narrow the register
Recruitment status
Phase
Lead sponsor
University Health Network, Toronto349 University of British Columbia197 AstraZeneca190 University of Alberta180 University of Calgary149
Site location
Toronto2809 Montreal1902 Vancouver1179 Calgary1061 Edmonton1017
All 255 locations
Target enrolment
to

Trials in this register

6540 of 6540 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Canada
Start
Recruiting
Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
NCT04159103Propionic Acidemia
DrugMRNA-3927
ModernaTX, Inc.
Phase 1/2
77
Edmonton, Toronto
2021-04-15
Active, closed
Physiotherapy and Deep Brain Stimulation in Parkinson's Disease
NCT04953637Parkinson Disease
University of Toronto
Not applicable
60
Toronto
2021-04-15
Active, closed
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
NCT04736706Carcinoma, Renal Cell
DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,854
Calgary, Vancouver, Hamilton, Toronto, Quรฉbec
2021-04-14
Active, closed
Impellaยฎ-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
NCT04763200Left Ventricular Dysfunction, Coronary Artery Disease
Abiomed Inc.
Not applicable
1,252
Winnipeg, Toronto, Montreal
2021-04-13
Active, closed
Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)
NCT04603495Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
DrugsPelabresib·Ruxolitinib
Novartis Pharmaceuticals
Phase 3
430
Calgary, Edmonton, London, Toronto, Montreal
2021-04-09
Recruiting
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
NCT04655404High Grade Glioma, Diffuse Intrinsic Pontine Glioma
DrugLarotrectinib
Nationwide Children's Hospital
Phase EARLY_PHASE1
15
Toronto, Montreal
2021-04-08
Active, closed
Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)
NCT04662255Lymphoma, Mantle-Cell
DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib
Loxo Oncology, Inc.
Phase 3
500
Edmonton, Vancouver, Winnipeg
2021-04-08
Recruiting
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
NCT04728893Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia
DrugNemtabrutinib
Merck Sharp & Dohme LLC
Phase 2
490
Calgary, Ottawa, Toronto, Montreal
2021-04-05
Active, closed
Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
NCT04675294Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
DrugsEvorpacept·Pembrolizumab
ALX Oncology Inc.
Phase 2
189
Hamilton, London, Ottawa, Toronto
2021-04-02
Active, closed
SMall Annuli Randomized To Evolutโ„ข or SAPIENโ„ข Trial
NCT04722250Symptomatic Aortic Stenosis, Aortic Valve Stenosis, Aortic Valve Replacement
Medtronic Cardiovascular
Not applicable
1,103
Vancouver, Victoria, Toronto, Montreal
2021-04-02
Recruiting
COVID-19 Vaccines Safety Tracking (CoVaST)
NCT04834869Adverse Reaction to Vaccine, COVID19 Vaccine
DrugsComirnaty·Efluelda (TIV-HD) and Spikevax
Masaryk University
Observational
30,000
Hamilton
2021-04-01
Active, closed
Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning Pathway
NCT04744298Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure, ARDS, Human
University of Calgary
Not applicable
19,916
Calgary, Edmonton, Fort McMurray, Grande Prairie, Lethbridge, Medicine Hat, Red Deer, St. Albert
2021-04-01
Active, closed
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
NCT04822181Non-alcoholic Steatohepatitis
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,205
Calgary, Vancouver, Halifax, Brampton, London, Toronto, Vaughan, Chicoutimi
2021-04-01
Recruiting
Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study
NCT06651580Chronic Pancreatitis, Exocrine Pancreas Carcinoma, Recurrent Acute Pancreatitis
M.D. Anderson Cancer Center
Observational
1,600
Toronto, Montreal
2021-04-01
Recruiting
Management of Type 1 Supracondylar Humeral Fractures
NCT04642807Elbow Fracture, Trauma
University of British Columbia
Not applicable
52
Vancouver
2021-04-01
Active, closed
Stepping-Up: Partnering With the Community to Prevent Early Mobility Decline
NCT04368949Mobility Limitation
McMaster University
Not applicable
249
Hamilton
2021-04-01
Recruiting
Virtual Reality and Field Training to Enhance Community Walking After Stroke
NCT04559373Stroke
McGill University
Not applicable
40
Laval, Quรฉbec
2021-04-01
Recruiting
BoStOn SCientific Rhythm MAnagemenT REgiStry
NCT04823663Cardiac Disease
Boston Scientific Corporation
Observational
12,500
Quรฉbec
2021-03-31
Recruiting
Alberta Back Care Pathway (ABCp)
NCT05452876Low Back Pain
University of Alberta
Phase 2
240
Edmonton
2021-03-31
Recruiting
Targeted Axillary Dissection (TAD) in Early-stage Node Positive Breast Cancer
NCT04671511Breast Cancer Female, Early-stage Breast Cancer, Lymph Node Metastases, Axillary Metastases
Jewish General Hospital
Not applicable
98
Montreal
2021-03-30
Recruiting
DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma
NCT04696029Medulloblastoma
DrugsDifluoromethylornithine·DFMO·Eflornithine
Giselle Sholler
Phase 2
118
Quรฉbec
2021-03-29
Recruiting
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature
NCT04674969Peripheral Vascular Diseases
Boston Scientific Corporation
Observational
5,000
Calgary, Sherbrooke
2021-03-29
Recruiting
Abatacept for the Treatment of Giant Cell Arteritis
NCT04474847Giant Cell Arteritis
DrugAbatacept
University of Pennsylvania
Phase 3
78
Vancouver, Hamilton, Toronto, Montreal
2021-03-29
Recruiting
A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes
NCT04786262Diabetes Mellitus, Type 1, Impaired Hypoglycemic Awareness, Severe Hypoglycemia
Vertex Pharmaceuticals Incorporated
Phase 3
57
Edmonton, Montreal, Toronto, Vancouver
2021-03-29
Active, closed
Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
NCT04586023Relapsing Multiple Sclerosis
DrugsFenebrutinib·Teriflunomide
Hoffmann-La Roche
Phase 3
751
Edmonton, Ottawa, Chicoutimi, Montreal, Quรฉbec
2021-03-24
Recruiting
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564Motor Function, Cognitive Function, Contrast Media
DrugsGadoterate meglumine·Gadobutrol
Guerbet
Phase 4
2,076
Burlington
2021-03-24
Recruiting
A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Children and Adolescent Participants With Moderate to Severe Plaque Psoriasis
NCT04772079Plaque Psoriasis
DrugDeucravacitinib
Bristol-Myers Squibb
Phase 3
153
Calgary, Edmonton, Hamilton, Markham, Toronto
2021-03-23
Recruiting
Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
NCT05058612Vasoplegia
DrugMidodrine
University of Alberta
Phase 4
870
Edmonton
2021-03-22
Active, closed
INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders
NCT04455841Anemia, Post-essential Thrombocythemia Myelofibrosis, Post-polycythemia Vera Myelofibrosis
DrugsINCB000928·Ruxolitinib
Incyte Corporation
Phase 1/2
84
Toronto, Montreal
2021-03-19
Active, closed
Study of Niacin in Glioblastoma
NCT04677049Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
DrugNiacin
AHS Cancer Control Alberta
Phase 1/2
59
Calgary
2021-03-18
By invitation
Motivational Interviewing in Hearing Aid Users
NCT04673565Hearing Loss, Motivation, Hearing Disability, Hearing Disorders and Deafness
University of British Columbia
Not applicable
180
Vancouver
2021-03-16
Recruiting
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
NCT07717437Liver Cancer, Liver Metastases
Maastricht University Medical Center
Observational
350
Hamilton, Ottawa, Montreal
2021-03-16
Active, closed
Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease
NCT04639050Alzheimers Disease
DrugTrontinemab
Hoffmann-La Roche
Phase 1/2
241
Richmond, Toronto
2021-03-15
Recruiting
Adaptation and Pilot Testing of Web and Mobile Interface for the ATTACHโ„ข Intervention
NCT04857775Depression, Addiction, Domestic Violence, Poverty
University of Calgary
Not applicable
100
Calgary
2021-03-15
Active, closed
First-in-Human Study of TSHA-101 Gene Therapy for Treatment of Infantile Onset GM2 Gangliosidosis
NCT04798235Infantile GM2 Gangliosidosis (Disorder)
Dr. Anupam Sehgal
Phase 1/2
3
Kingston
2021-03-12
Active, closed
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
NCT04591392Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities
atHeart Medical
Not applicable
250
Toronto
2021-03-12
Active, closed
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis
NCT04562389Myelofibrosis
DrugsSelinexor·Ruxolitinib
Karyopharm Therapeutics Inc
Phase 3
353
Edmonton, Oshawa, Montreal
2021-03-11
Active, closed
Investigating Bone Cement With or Without Inossiaยฎ Cement Softener for Vertebral Compression Fractures
NCT05676320Vertebral Compression Fracture
Inossia AB
Not applicable
203
Calgary
2021-03-11
Recruiting
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
NCT04686305Locally Advanced or Metastatic Non-Small Cell Lung Cancer
DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Durvalumab
AstraZeneca
Phase 1
304
Winnipeg, London, Montreal
2021-03-09
Active, closed
Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT04666038Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsIdelalisib·Truxima·Pirtobrutinib·Bendamustine
Loxo Oncology, Inc.
Phase 3
238
Winnipeg, Halifax, Newmarket, Toronto
2021-03-09
Active, closed
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III
BioNTech SE
Phase 2
327
Ottawa, Toronto
2021-03-08
Active, closed
Modulating Cerebellar Activity With Low-intensity Focused Ultrasound Stimulation for Primary Orthostatic Tremor
NCT05547620Orthostatic Tremor
University Health Network, Toronto
Not applicable
15
Toronto
2021-03-08
Active, closed
Tele-rehabilitation Group Program for Urinary Incontinence in Older Women
NCT05182632Urinary Incontinence, Urinary Stress Incontinence
Universitรฉ de Montrรฉal
Not applicable
32
Montreal
2021-03-06
Active, closed
Dual Tracer (68Ga-DOTATATE and 18F-FDG) PET Imaging in G2 & G3 Gastroenteropancreatic Neuroendocrine Tumors
NCT04804371Neuroendocrine Tumors
University Health Network, Toronto
Not applicable
40
Toronto
2021-03-04
Active, closed
TH1902 in Patients With Advanced Solid Tumors
NCT04706962Solid Tumor, TNBC - Triple-Negative Breast Cancer, Hormone Receptor-positive Breast Cancer, Epithelial Ovarian Cancer
Theratechnologies
Phase 1
70
Montreal
2021-03-04
Recruiting
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
NCT04710576Chronic Graft-versus-host-disease
DrugAxatilimab
Syndax Pharmaceuticals
Phase 2
296
Vancouver, Toronto, Montreal
2021-03-04
Active, closed
OptiMized REsistaNt Starch in Inflammatory Bowel Disease: The MEND Trial
NCT04520594Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
Children's Hospital of Eastern Ontario
Not applicable
100
Ottawa
2021-03-03
Recruiting
Anti-CD19, Dual Co-stimulatory (4-1BB, CD3ฮถ) Chimeric Antigen Receptor T-cells in Patients With Relapsed/Refractory Aggressive Lymphoma or Acute Lymphoblastic Leukemia (ALL)
NCT03938987Relapsed Non Hodgkin Lymphoma, Relapsed Adult ALL, Relapsed Pediatric ALL
University of Alberta
Phase 1/2
63
Calgary, Edmonton
2021-03-03
Recruiting
Trial of Combined Radiotherapy and Vertebroplasty for Patients With Painful Metastatic Spinal Lesions
NCT04242589Spinal Metastases
AHS Cancer Control Alberta
Phase 2
64
Edmonton
2021-03-03
Recruiting
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
NCT04269902Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsObinutuzumab·Venetoclax
National Cancer Institute (NCI)
Phase 3
247
Vancouver, Winnipeg, Saint John, Halifax, Oshawa, Ottawa, Montreal, Regina
2021-03-02
Active, closed
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial
NCT04457596Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma
DrugsTucatinib·Trastuzumab emtansine
Alliance for Clinical Trials in Oncology
Phase 3
1,056
Vancouver, Saint John, London, Oshawa, Toronto, Quรฉbec, Regina, Saskatoon
2021-03-02
Active, closed
Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia
NCT04624906Waldenstrom Macroglobulinemia
DrugsAcalabrutinib·Bendamustine·Rituximab
Sunnybrook Health Sciences Centre
Phase 2
63
Calgary, Edmonton, Vancouver, Halifax, Hamilton, Ottawa, Toronto, Laval
2021-03-02
Recruiting
Diet Intervention Treatment for Active Ulcerative Colitis
NCT04121806Colitis, Ulcerative
Mount Sinai Hospital, Canada
Not applicable
20
Toronto
2021-03-01
Active, closed
Focused Suicide Prevention Strategy for Youth Presenting to the Emergency Department With Suicide Related Behaviour
NCT06225661Suicide, Suicide Prevention, Suicidal Ideation, Self-Injurious Behavior
The Hospital for Sick Children
Not applicable
330
Calgary, Hamilton, Mississauga, Toronto
2021-03-01
Active, closed
Acalabrutinib With R-CHOP in Previously Untreated Mantle Cell Lymphoma
NCT04566887Mantle Cell Lymphoma
DrugAcalabrutinib
University Health Network, Toronto
Phase 2
105
Vancouver, Halifax, Toronto, Quรฉbec
2021-03-01
Active, closed
Implementation and Evaluation of a Stepped-Care Mental Health Treatment Program for Patients With Chronic Pain
NCT04885192Chronic Pain
University Health Network, Toronto
Observational
70
Toronto
2021-03-01
Recruiting
Pancreatic Adenocarcinoma Neoadjuvant Chemotherapy Before Surgery
NCT04452461Pancreatic Adenocarcinoma
DrugsGemcitabine-nab-paclitaxel·MFOLFIRINOX·5-FU·Leucovorin
Hamilton Health Sciences Corporation
Phase 2
30
Hamilton
2021-03-01
By invitation
Tobacco-Concurrent Addictions in At-Risk Youth in Ottawa
NCT04812613Tobacco Use, Substance Use, Cannabis Use
Ottawa Hospital Research Institute
Observational
520
Ottawa
2021-03-01
Recruiting
Fluid Intake After Hemodialysis
NCT04721652Chronic Kidney Disease Requiring Chronic Dialysis, Interdialytic Weight Gain
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Observational
20
London
2021-02-25
Active, closed
Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment
NCT04647526Metastatic Castration-Resistant Prostate Cancer
DrugsAbiraterone·Enzalutamide
POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company
Phase 3
455
Vancouver, Halifax, London, Toronto, Montreal, Quรฉbec
2021-02-25
Active, closed
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
NCT04717414Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis
DrugLuspatercept
Celgene
Phase 3
313
Calgary, Edmonton, Vancouver, London, Toronto, Montreal, Sherbrooke
2021-02-25
Active, closed
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
NCT04586231Carcinoma, Renal Cell
DrugsBelzutifan·Cabozantinib·Lenvatinib
Merck Sharp & Dohme LLC
Phase 3
747
Calgary, Edmonton, Vancouver, Moncton, Hamilton, Kingston, Ottawa, Toronto
2021-02-25
Active, closed
Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
NCT04699188KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal, Cancer of Lung
DrugsTNO155·JDQ443·Tislelizumab
Novartis Pharmaceuticals
Phase 1/2
344
Montreal
2021-02-24
By invitation
Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository
NCT05100420Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Cardiomyopathies
Montreal Heart Institute
Observational
2,000
Edmonton, Vancouver, Victoria, Halifax, Hamilton, London, Ottawa, Montreal
2021-02-23
Active, closed
Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms
NCT04279847Myelofibrosis, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome, Myeloproliferative Neoplasm
DrugRuxolitinib
Incyte Corporation
Phase 1
140
Toronto, Montreal, Vancouver
2021-02-23
Active, closed
Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A
NCT04644575Hemophilia A
DrugEfanesoctocog alfa
Bioverativ, a Sanofi company
Phase 3
261
Hamilton, Ottawa, Toronto
2021-02-23
Recruiting
Single-Sided Deafness and Asymmetric Hearing Loss
NCT04506853Hearing Loss, Unilateral, Hearing Loss, Sensorineural
Med-El Corporation
Not applicable
65
Toronto
2021-02-22
Recruiting
Strength After Elbow Fractures in the Elderly
NCT05135949Fracture;Elbow
Fraser Orthopaedic Research Society
Observational
50
New Westminster
2021-02-22
Recruiting
Longitudinal Study Examining At-Home tDCS
NCT04524338Alzheimer Disease
Lady Davis Institute
Not applicable
20
Montreal
2021-02-22
Active, closed
Firehawk Rapamycin Target Eluting Coronary Stent North American Trial
NCT04562532Coronary Artery Disease
Shanghai MicroPort Medical (Group) Co., Ltd.
Not applicable
1,720
Calgary, Winnipeg, Newmarket, Quรฉbec, Montreal, Sherbrooke
2021-02-17
Active, closed
A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma
NCT04576117Recurrent Low Grade Astrocytoma, Recurrent WHO Grade 2 Glioma, Refractory Low Grade Astrocytoma, Refractory Low Grade Glioma
DrugsVinblastine Sulfate·Selumetinib
National Cancer Institute (NCI)
Phase 3
300
Edmonton, Vancouver, Winnipeg, Halifax, Ottawa, Toronto, Montreal, Sherbrooke
2021-02-16
Recruiting
Learning Study: Improving Vision in Adults With Macular Degeneration
NCT04762368Macular Degeneration
University of Waterloo
Not applicable
30
Waterloo
2021-02-13
Active, closed
A Natural History Study to TRACK Brain and Spinal Cord Changes in Individuals with Friedreich Ataxia (TRACK-FA)
NCT04349514Friedreich Ataxia
Monash University
Observational
300
Montreal
2021-02-10
Active, closed
Hypofractionated LocoRegional Radiotherapy in Breast Cancer
NCT04228991Breast Neoplasms, Radiotherapy, Lymphedema
Ontario Clinical Oncology Group (OCOG)
Phase 3
588
Calgary, Edmonton, Kelowna, Prince George, Vancouver, Victoria, Greater Sudbury, Hamilton
2021-02-10
Recruiting
Statins for Venous Event Reduction in Patients With Venous Thromboembolism
NCT04319627Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome
DrugsRosuvastatin Calcium·Rosuvastatin
Ottawa Hospital Research Institute
Phase 3
2,700
Calgary, Halifax, Hamilton, Ottawa, St. Catharines, Toronto, Montreal, Quรฉbec
2021-02-10
Active, closed
Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML)
NCT04657081Acute Myeloid Leukemia
DrugsDecitabine·Venetoclax
Taiho Oncology, Inc.
Phase 1/2
101
Calgary, Edmonton, Ottawa, Montreal
2021-02-09
Recruiting
Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)
NCT04574960Bladder Cancer, Bladder Urothelial Carcinoma
DrugsParaplatin·Gemcitabine·Cisplatin·Carboplatin
University Health Network, Toronto
Phase 3
14
Ottawa, Toronto
2021-02-08
Active, closed
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors
NCT04431726Severe Hemophilia A
DrugEmicizumab
Hoffmann-La Roche
Phase 3
55
Ottawa, Toronto
2021-02-04
Active, closed
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
NCT05388708Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
University of Michigan
Observational
550
Edmonton, Toronto
2021-02-04
Recruiting
Hypofractionated External-beam RadiOtherapy for Intact Cervical Cancer (HEROICC-Trial): A Feasibility Study
NCT04583254Cervical Cancer
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Phase 2
48
Kelowna, London, Toronto
2021-02-04
Active, closed
Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer
NCT04624477Papillary Thyroid Cancer, Papillary Thyroid Carcinoma, Papillary Microcarcinoma of the Thyroid
University Health Network, Toronto
Observational
450
Calgary, Vancouver, Halifax, Hamilton, London, Toronto, Montreal, Quรฉbec
2021-02-03
Recruiting
Surveillance of Complex Renal Cysts - The SOCRATIC Study
NCT04558593Complex Renal Cyst
Universitรฉ de Sherbrooke
Observational
330
Calgary, Edmonton, Vancouver, Winnipeg, Halifax, Hamilton, Ottawa, Thunder Bay
2021-02-02
Active, closed
Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation
NCT04755283Atrial Fibrillation (AF), Stroke
DrugsAbelacimab·Rivaroxaban
Anthos Therapeutics, Inc.
Phase 2
1,287
Cambridge, Greater Sudbury, Oshawa, Greenfield Park, Montreal
2021-02-02
Active, closed
MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb
NCT04649359Multiple Myeloma
DrugElranatamab
Pfizer
Phase 2
187
Montreal
2021-02-02
Recruiting
Institut de Recherche Cliniques de Montreal (IRCM) Post-COVID-19 (IPCO) Research Clinic
NCT04736732Covid19, Long COVID
Emilia Falcone, MD
Observational
650
Montreal
2021-02-01
Recruiting
Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer.
NCT03061435Vulvar Cancer, Cervical Cancer, Vulvar Dysplasia, Cervical Dysplasia
Dr. Danielle Vicus
Not applicable
110
Toronto
2021-02-01
Recruiting
The Parkwood Pacing and Planningโ„ข App
NCT03957343Acquired Brain Injury
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Not applicable
200
London
2021-02-01
Active, closed
[68Ga]Ga-PSMA-11 PET/CT in the Assessment of High Risk and Recurrent Prostate Cancer
NCT04484701Prostatic Neoplasm, Prostatic Cancer
Drug68Ga-PSMA-11
British Columbia Cancer Agency
Observational
1,574
Vancouver
2021-02-01
Recruiting
Crossover Study of Propranolol vs Ivabradine in POTS
NCT04186286Postural Tachycardia Syndrome
DrugPropranolol
University of Calgary
Phase 2
20
Calgary
2021-02-01
Recruiting
Nabilone for Agitation Blinded Intervention Trial
NCT04516057Alzheimer Disease, Agitation
DrugNabilone
Sunnybrook Health Sciences Centre
Phase 3
112
Calgary, London, Toronto, Whitby
2021-02-01
Recruiting
Brain Imaging Study on Biomarkers for Fibromyalgia
NCT03910010Fibromyalgia
Nova Scotia Health Authority
Not applicable
35
Halifax
2021-02-01
Recruiting
Dissecting Host-microbiome Modifiers of Type 2 Diabetes Risk
NCT04579900Type 2 Diabetes
Laval University
Not applicable
40
Quรฉbec
2021-02-01
Active, closed
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
NCT04624659Sickle Cell Disease
DrugEtavopivat
Forma Therapeutics, Inc.
Phase 3
450
Vancouver, Toronto, Montreal
2021-01-29
Active, closed
A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
NCT04711252ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Anastrozole·Palbociclib
AstraZeneca
Phase 3
1,370
Edmonton, Vancouver, Kitchener, London, Toronto, Montreal
2021-01-28
Active, closed
Community-based Cognitive Remediation and tDCS to Enhance Seniors' Function and Mental Health
NCT04648371Mental Health Disorder, Aging
Centre for Addiction and Mental Health
Not applicable
18
Toronto
2021-01-27
Active, closed
Fulvestrant and Ipatasertib for Advanced HER-2 Negative and Estrogen Receptor Positive (ER+) Breast Cancer Following Progression on First Line CDK 4/6 Inhibitor and Aromatase Inhibitor
NCT04650581Breast Cancer
DrugsIpatasertib·Fulvestrant
Canadian Cancer Trials Group
Phase 3
250
Kelowna, Surrey, Vancouver, Saint John, Halifax, Barrie, Brampton, Hamilton
2021-01-27
Active, closed
Exercise & Brain Energetics in PD
NCT04426786Parkinson Disease
Pacific Parkinson's Research Centre
Not applicable
40
Vancouver
2021-01-26
Recruiting
Breakthrough CMV Lung Transplant -Multicentre
NCT04439916Cytomegalovirus Infections
University of Alberta
Observational
40
Edmonton
2021-01-25
Active, closed
Microneedling for Burn Hypertrophic Scars
NCT05423613Burn Scar
Centre hospitalier de l'Universitรฉ de Montrรฉal (CHUM)
Not applicable
36
Montreal
2021-01-22
Active, closed
Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial
NCT04513717Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
DrugsBuserelin·Histrelin·Flutamide·Degarelix
NRG Oncology
Phase 3
2,753
Calgary, Ottawa, Toronto, Montreal, Quรฉbec, Sherbrooke, Regina, Saskatoon
2021-01-21
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Canadian investigative site. Derived from ClinicalTrials.gov. Retrieved 26 September 2026. https://priyalifescience.com/clinical-trials-canada?page=51

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Canada and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,540 studies in total at the last sync on 26 Sep 2026, 19:55 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

How many clinical trials are recruiting in Canada?

3,515 of the 6,540 studies in this register are recruiting new participants as of the 26 Sep 2026, 19:55 UTC sync. A further 629 have not yet opened recruitment, 2,212 are active but closed to new participants, and 184 are enrolling by invitation only. Eligibility for any study is decided by its study team.

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Browse trials by condition

Breast Cancer (136) Prostate Cancer (110) Cancer (75) Obesity (64) Multiple Myeloma (63) Stroke (57) Heart Failure (56) Ulcerative Colitis (43) Non-small Cell Lung Cancer (39) Type 2 Diabetes (39) Non-Small Cell Lung Cancer (38) Atrial Fibrillation (38) Healthy (36) Anxiety (35) Asthma (35)
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Browse trials by site location

Toronto (2809) Montreal (1902) Vancouver (1179) Calgary (1061) Edmonton (1017) Ottawa (872) London (871) Hamilton (809) Quรฉbec (678) Halifax (533) Winnipeg (455) Sherbrooke (265) Kingston (256) Kelowna (172) Brampton (147)
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.