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Trackers› Clinical trials› Italy
Clinical trial register · Italy

Studies with an Italian investigative site

Every study on the ClinicalTrials.gov registry that lists a site in Italy and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6830 matching records held by the registry are in this view. Synced 26 Sep 2026, 19:52 UTC
6830
Studies in scope
all four open statuses
4109
Recruiting now
open to new participants
1019
Lead sponsors
across recruiting studies
Top sites
Milan 2849 Bologna 1313 Roma 1277 Naples 984 Rome 980
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Recruitment status
Phase
Lead sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS385 IRCCS Azienda Ospedaliero-Universitaria di Bologna308 AstraZeneca178 IRCCS San Raffaele162 Novartis Pharmaceuticals130
Site location
Milan2849 Bologna1313 Roma1277 Naples984 Rome980
All 483 locations
Target enrolment
to

Trials in this register

6830 of 6830 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Italy
Start
Recruiting
Dissecting the Molecular and Cellular Pathophysiology of Sarcopenic Obesity in the Elderly
NCT06320158Sarcopenic Obesity
IRCCS San Raffaele
Observational
1,108
Milan
2023-05-22
Recruiting
The Theranostic Value of STARD3 in Colorectal Cancer: The STAR Study
NCT06136949Colorectal Cancer
Centro di Riferimento Oncologico - Aviano
Observational
150
Aviano
2023-05-22
Recruiting
Human Leishmaniasis: Antigen Recognition Pattern and Study of New Potential Biomarkers
NCT06307171Leishmaniasis
IRCCS Sacro Cuore Don Calabria di Negrar
Not applicable
170
Negrar
2023-05-22
Recruiting
Trustworthy, Integrated Artificial Intelligence Tools for Predicting High-risk CORonary PlaqueS
NCT06410690Coronary Artery Disease, Coronary Computed Tomography Angiography
Centro Cardiologico Monzino
Observational
4,000
Milan
2023-05-22
Recruiting
Evaluation of Skin Health and QoL in Pts Receiving Anti-PD1/PDL1/CTLA4 or CDK Inhibitors.
NCT05878964Lung Cancer, Breast Cancer, Kidney Cancer, Bladder Cancer
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Observational
420
Roma
2023-05-22
Recruiting
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS
NCT06917924Amyotrophic Lateral Sclerosis (ALS)
A.O.U. Città della Salute e della Scienza
Observational
200
Milan, Naples, Torino
2023-05-20
Active, closed
Toward Molecular Profiling of Parkinson's Disease in Easily Accessible Biological Matrices
NCT07480187Parkinson Disease, Synucleinopathy, Alzheimer Disease
Azienda Ospedaliera di Perugia
Not applicable
340
Messina, Milan, Perugia
2023-05-20
Recruiting
A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]
NCT05895786Myositis
Pfizer
Phase 3
318
Rozzano, Roma, Catania, Milan
2023-05-20
Recruiting
Precision Diagnosis and Therapy for Rare Diseases by Interpreting Non-coding Genomes
NCT06775561Neuromuscular Diseases, Eye Diseases, Genetic Disease
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Observational
100
Bologna
2023-05-20
Active, closed
Vertebral Bone Marrow Clot for Spinal Surgery
NCT05947175Degenerative Spine Diseases
Istituto Ortopedico Rizzoli
Not applicable
96
Bologna
2023-05-19
Recruiting
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks
NCT06346418Beckwith-Wiedemann Syndrome
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Not applicable
208
Milan
2023-05-19
Recruiting
Biomarkers for Monitoring Dementia Progression
NCT06855368Alzheimer Disease
IRCCS San Raffaele Roma
Observational
300
Roma, Sassari
2023-05-18
Active, closed
A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer
NCT05908734Carcinoma, Non-Small-Cell Lung
DrugsCetrelimab·Amivantamab
Janssen Research & Development, LLC
Phase 1/2
71
Milan, Orbassano, Verona
2023-05-18
Active, closed
Functional Assessment Protocol for the Upper Limb for Pediatric Age
NCT06400667Upper Extremity, Child, Range of Motion, Articular
IRCCS Eugenio Medea
Not applicable
20
Bosisio Parini
2023-05-18
Active, closed
Gait Spine Functional Evaluation Protocol
NCT06400680Spine Disease, Gait
IRCCS Eugenio Medea
Not applicable
20
Bosisio Parini
2023-05-18
Active, closed
Advancing Early Bone Health: New Frontiers for Osteoporosis Prevention
NCT06750523Low-Risk Pregnant Women at Full-Term Gestation, Healthy Fetal Population, Healthy Neonatal Population
University of Parma
Not applicable
200
Messina, Parma
2023-05-17
By invitation
Evaluation of Lymph Node Analysis Using One Step Nucleic Acid Amplification (OSNA) in Patients With Lung Cancer Who Underwent Robotic Lung Resection, Comparison With Traditional Methods
NCT07301983Non Small Cell Lung Cancer
Azienda Ospedaliero, Universitaria Pisana
Observational
130
Pisa
2023-05-17
Recruiting
Concomitant Radiotherapy and New Drugs in Metastatic Breast Cancer
NCT07021911Breast Cancer, Radiotherapy; Complications
Fondazione Policlinico Universitario Campus Bio-Medico
Observational
300
Rome
2023-05-17
Recruiting
A Study to Learn More About the Study Medicine Called Inotuzumab Ozogamicin (InO) in Children (1 to <18 Years) With First Relapse ALL
NCT05748171ACUTE LYMPHOBLASTIC LEUKEMIA
DrugInotuzumab Ozogamicin
Pfizer
Phase 2
100
Naples, Genoa, Monza, Rome, Catania, Padova, Pavia, Torino
2023-05-17
Recruiting
Immunogenicity, Efficacy and Safety of Recombinant Herpes Zoster Vaccine in Frail Patients
NCT07321808Immunocompromised Patients
Fondazione IRCCS Policlinico San Matteo di Pavia
Observational
300
Pavia
2023-05-16
Active, closed
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
NCT05791201Type 1 Diabetes
Vertex Pharmaceuticals Incorporated
Phase 1/2
7
Milan
2023-05-16
Recruiting
Study of the Steroid Hormone Milieu in Obese Patients
NCT06341699Obesity, Morbid
Istituto Auxologico Italiano
Observational
180
Oggebbio
2023-05-16
Recruiting
A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
NCT05319730Esophageal Squamous Cell Carcinoma
DrugsMK-4830·Steroid mouthwash (dexamethasone·Acetaminophen·Sacituzumab tirumotecan
Merck Sharp & Dohme LLC
Phase 1/2
230
Meldola, Milan, Pisa, Padova
2023-05-16
Recruiting
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567Ulcerative Colitis, Crohn's Disease
DrugVedolizumab
Takeda
Phase 3
240
Naples, Bologna, Rome, Monza, Florence, Padova
2023-05-16
Recruiting
Effects of a Telerehabilitation Intervention in the Management of Complications After Breast Cancer Surgery
NCT06608446Breast Neoplasms
Fondazione Policlinico Universitario Campus Bio-Medico
Not applicable
155
Roma
2023-05-15
Recruiting
A Study to Evaluate the Efficacy and Safety of QMF149 (Indacaterol Acetate/Mometasone Furoate) Versus Budesonide in Children From 6 to Less Than 12 Years of Age With Asthma
NCT05562466Asthma
DrugBudesonide
Novartis Pharmaceuticals
Phase 3
200
Brescia, Catania, Florence, Pavia, Roma, Naples
2023-05-11
Recruiting
Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)
NCT05845450Colorectal Cancer, Resectable Colorectal Carcinoma
DrugsVorbipiprant·Balstilimab·Botensilimab·Sotorasib
Gruppo Oncologico del Nord-Ovest
Phase 2
197
Milan
2023-05-11
Recruiting
Safety and Feasibility of a Multidisciplinary Programme of Integrated Hospital-home Management With Early Discharge of Patients With Haematological Malignancies Undergoing High-dose Chemotherapy in Hospital
NCT06814405Haematological Malignancy
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Not applicable
100
Bologna
2023-05-11
Recruiting
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants
NCT05589714Inherited Retinal Degeneration, Retinitis Pigmentosa
Jaeb Center for Health Research
Observational
1,500
Brescia
2023-05-11
Recruiting
Autoimmune Dementia: Predictors of Neuronal Synaptic Antibodies in Patients With New-ONset Cognitive Impairment
NCT06321588Cognitive Impairment, Dementia
Azienda Usl di Bologna
Observational
300
Bologna, Milan
2023-05-10
Recruiting
Arterial Embolization for the Treatment of Bone Metastases: Prospective Observational Study
NCT06189079Bone Metastases
Istituto Ortopedico Rizzoli
Observational
60
Bologna
2023-05-10
Recruiting
Biochemical Profiling of Migraine Patients
NCT06549270Migraine Disorders, Chronic Migraine, Episodic Migraine
IRCCS National Neurological Institute "C. Mondino" Foundation
Observational
100
Pavia
2023-05-10
Recruiting
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
NCT05716100Focal Onset Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
360
Ancona, Bari
2023-05-09
Recruiting
Acoustic Analysis of VA Sounds
NCT05612022End Stage Renal Disease, Hemodialysis Access Failure
Mario Negri Institute for Pharmacological Research
Observational
44
Bergamo
2023-05-09
Active, closed
A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
NCT05789069Renal Cell Carcinoma, Melanoma, Non Small Cell Lung Cancer, Gastric Cancer
DrugTislelizumab
HiFiBiO Therapeutics
Phase 1
83
Naples, Rome, Verona
2023-05-09
Active, closed
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases
NCT05552469Myeloid Diseases
Novartis Pharmaceuticals
Phase 1
71
Brescia, Rozzano
2023-05-08
Active, closed
Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy
NCT05840211Locally Advanced or Unresectable Metastatic Breast Cancer, Stage IV Breast Cancer
DrugsSacituzumab Govitecan·Nab-paclitaxel·Capecitabine·Paclitaxel
Gilead Sciences
Phase 3
654
Ancona AN, Aviano, Bergamo, Bologna, Catania, Catanzaro, Genova GE, Milan
2023-05-08
Active, closed
Functional Coronary Angiography Guided Revascularization in STEMI
NCT05818475Myocardial Infarction
University Hospital of Ferrara
Not applicable
1,823
Bologna, Ferrara, Bolzano, Catanzaro, Cosenza, Baggiovara, Piacenza, Parma
2023-05-08
Recruiting
OPErA Orchestral Posture Egonomic Assessment
NCT06758349Abnormal Posture
Fondazione Don Carlo Gnocchi ETS
Observational
250
Milan
2023-05-05
Active, closed
Phase III Study of AK112 for NSCLC Patients
NCT06396065Non-Squamous Non-small Cell Lung Cancer
DrugsIvonescimab·Pemetrexed·Carboplatin
Summit Therapeutics
Phase 3
420
Milan, Parma, Roma, Rome
2023-05-04
Active, closed
Digital Twins for Model-driven Non-invasive Electrical Brain Stimulation
NCT06826261Alzheimer Disease
I.R.C.C.S. Fondazione Santa Lucia
Not applicable
30
Rome
2023-05-04
Active, closed
An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
NCT05876754Cholangiocarcinoma
DrugIvosidenib
Servier Affaires Médicales
Phase 3
299
Bologna, Florence, Milan, Naples, Reggio Emilia, Roma, Rozzano, San Giovanni Rotondo
2023-05-03
Recruiting
Functional Implications of Rare Gene Mutations in aHUS Open the Door to Personalized Therapy
NCT05805202Atypical Hemolytic Uremic Syndrome
Mario Negri Institute for Pharmacological Research
Not applicable
112
Ranica
2023-05-03
Active, closed
A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have
NCT05831176Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD), Eosinophilic Gastrointestinal Disease (EGID), Eosinophilic Gastroenteritis
DrugDupilumab
Regeneron Pharmaceuticals
Phase 2
22
Rozzano, Palermo, Bari, Milan, Pisa, Roma, Rome
2023-05-03
Active, closed
Ankura™ TAA Stent Graft System Post-Market Clinical Follow-up Study
NCT05639569Aneurysm Thoracic, Dissection of Thoracic Aorta
Lifetech Scientific (Shenzhen) Co., Ltd.
Observational
147
Turin
2023-05-03
Active, closed
Adjunctive Anti-seizure Medication (ASM) Real World Evidence (RWE) Study
NCT05867160Epilepsy
Aziende Chimiche Riunite Angelini Francesco S.p.A
Observational
300
Milan
2023-05-02
Recruiting
Mediterranean Diet on Pregnancy and Foetus Development
NCT05403632Pregnancy Outcomes, Fetal Development, Infant Development
Neuromed IRCCS
Observational
2,000
Agropoli
2023-05-01
Recruiting
Relationship Between Lifestyle Indicators and Cardiovascular Clinical Parameters
NCT06283069Cardiovascular Diseases, Lifestyle, Nutrition, Healthy, Physical Inactivity
Istituto Auxologico Italiano
Observational
100
Milan
2023-05-01
Recruiting
Fecal Microbiota Transplantation for the Prevention of Infectious Complications After Liver Transplantation
NCT06782880Fecal Microbiota Transplantation, Orthotopic Liver Transplantation, Multi-drug Resistant Bacteria
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Not applicable
144
Bologna
2023-05-01
Recruiting
Automated Fetal Cardiac Function in Babies Affected by Heart Diseases
NCT05698277Congenital Heart Defect, Cardiac Function
Anna Erenbourg
Observational
495
L’Aquila, Milan, Trieste
2023-05-01
Recruiting
Cisplatin, Nab-paclitaxel, Nivolumab With Radiotherapy After Resection of Non-Metastatic Muscle Invasive Bladder Cancer
NCT05203913Muscle-Invasive Bladder Carcinoma
DrugsAbraxane·CDDP·Opdivo·Nab-paclitaxel
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Phase 2
32
Roma
2023-05-01
Recruiting
Exploring Biomarkers in Hereditary Transthyretin Amyloidosis
NCT05929209Hereditary Transthyretin Amyloidosis
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Not applicable
80
Roma
2023-05-01
Recruiting
Exploring the Gut-Brain Axis in Ageing and Neurodegeneration
NCT05934188Healthy, Prodromal Alzheimer's Disease, Parkinson Disease, Multiple Sclerosis
IRCCS San Camillo, Venezia, Italy
Observational
200
Venice-Lido, Brescia, Venice
2023-05-01
Active, closed
TRanscatheter Aortic-Valve Implantation With or Without On-site Cardiac Surgery: the TRACS Trial
NCT05751577Aortic Stenosis, Severe
Azienda Usl di Bologna
Not applicable
657
Bologna, Arezzo, Asti, Biella, Ferrara, Forlì, Grosseto, Mirano
2023-05-01
Recruiting
Effectiveness and Safety of Bulevirtide (BLV) Therapy in Patients With Chronic Hepatitis Delta (CHD) in Italy (D-SHIELD)
NCT06122285Hepatitis D
DrugBulevirtide
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Observational
100
Milan
2023-05-01
Recruiting
Promoting Diagnosis and Management of AL in Italy (ProDigALIty)
NCT06383143AL Amyloidosis, Smoldering Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance
Fondazione IRCCS Policlinico San Matteo di Pavia
Observational
760
Bari, Catania, Pavia, Torino
2023-05-01
Recruiting
Multicentre Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy.
NCT04662723Glomerulonephritis, Immunoglobulin A Nephropathy
DrugsRamipril·Canagliflozin·Losartan·Prednisolone
Fondazione Schena
Phase 4
878
Bari
2023-05-01
Recruiting
Fundus Camera Module for Early Detection of Alzheimer's Disease
NCT06841848Alzheimer Disease
I.R.C.C.S. Fondazione Santa Lucia
Observational
80
Rome
2023-05-01
Active, closed
Relationship Between Thoracic Hyperkyphosis and Fall Risk in Women with Fragility Vertebral Fractures
NCT06842758Osteoporosis, Hyperkyphosis, Vertebral Body Fracture
University of Palermo
Observational
40
Palermo
2023-05-01
Recruiting
Tissue Study on the Chronic Active Humoral Rejection (cAMR) Population of Kidney Transplantation
NCT06794970Kidney Transplant
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Observational
50
Bologna
2023-05-01
Recruiting
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
NCT05711394Episodic Migraine
DrugAtogepant
AbbVie
Phase 3
450
Milan, Rome, Palermo
2023-05-01
Recruiting
Predicting clinicAL outcoMes During First-line CDK4/6 Inhibitors Plus Endocrine Therapy in Patients With Advanced Hormone REceptor-poSitive HER2-negative Breast Cancer: the Retrospective-prospective Multicenter Italian PALMARES-2 Study
NCT06805812Breast Adenocarcinoma, Breast Cancer Stage IV, Breast Cancer, Metastatic, Breast Carcinoma
DrugsRibociclib·Abemaciclib·Palbociclib
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Observational
3,500
Aviano, Brescia, Catania, Como, Cremona, Florence, Genova, Meldola
2023-05-01
Recruiting
Transfemoral Transcatheter Aortic Valve Implementation at Hospital Without On-site Cardiac Surgery: Early Clinical Outcome in Patients With Prohibitive Surgical Risk.
NCT05886517Aortic Stenosis
AUSL Romagna Rimini
Not applicable
200
Acquaviva delle Fonti, Forlì, Ravenna
2023-05-01
Not yet open
Suture of the Ovary After Enucleation of Ovarian Endometrioma
NCT03788720Endometrioma
Università degli Studi dell'Insubria
Not applicable
100
Varese
2023-05
Not yet open
RCT KS-SA Versur KS-BA in Diabetic Patients
NCT05847907Dental Implant, Diabetes
Università degli Studi di Sassari
Not applicable
50
Rome
2023-04-30
Recruiting
Platform of Randomized Adaptive Clinical Trials in Critical Illness
NCT05440851Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
University Health Network, Toronto
Not applicable
6,250
Legnano, Milan
2023-04-30
By invitation
MODELING OBSESSIVE COMPULSIVE DISORDER AND EXPLORING TREATMENT RESPONSE USING INNOVATIVE THERAPIES AND STEM CELLS
NCT07488663Obsessive - Compulsive Disorder
ASST Fatebenefratelli Sacco
Not applicable
60
Milan
2023-04-30
Active, closed
AI for Lung Cancer Risk Definition in Computed Tomography Screening Programs
NCT06320184Lung Cancer, Blood Biomarkers
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Observational
650
Milan
2023-04-30
Recruiting
AP Metabolism Transcriptomics
NCT06814314Neurodevelopmental Disorders, Irritability
IRCCS Eugenio Medea
Observational
100
Bosisio Parini
2023-04-30
Active, closed
Comparison of Different Rehabilitation Protocols in Parkinson's Disease With Postural Instability and Gait Disorders
NCT05799690Parkinson Disease
Prof. Massimo Filippi
Not applicable
80
Milan, Verona
2023-04-30
Recruiting
The Safe-line Technique as Additional Attempt to Mitigate Spinal Cord Ischemia After Endovascular Exclusion of TAAA
NCT05758844Thoracoabdominal Aortic Aneurysm
University Hospital Padova
Observational
100
Padova
2023-04-30
Recruiting
AIRFRAME: Artificial Intelligence for Recognition of Fetal bRain AnoMaliEs at Second Trimester Fetal Brain Scan
NCT06675266Fetal Anomalies, Brain Malformation
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Observational
10,000
Rome
2023-04-30
Active, closed
To Evaluate Long- Term Safety and Efficacy of Luspatercept
NCT06875219Thalassemia Major
DrugLuspatercept
Fondazione per la Ricerca sulle Anemie ed Emoglobinopatie in Italia
Observational
350
Cagliari
2023-04-30
Active, closed
Brain Connectivity Analysis
NCT06823102Neural Injury
IRCCS San Raffaele Roma
Not applicable
75
Rome
2023-04-28
Recruiting
Diagnostic Value of Next-Generation Sequencing Analysis in Biliary Tract Tumours
NCT06729944Hepatectomy, NGS, Stenosis of Bile Duct
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Not applicable
50
Bologna
2023-04-27
Recruiting
OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial
NCT05587894COVID-19, Immunodeficiency
DrugsNirmatrevlir/ritonavir·Veklury·Remdesivir
ANRS, Emerging Infectious Diseases
Phase 2
256
Verona
2023-04-27
Active, closed
Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)
NCT05804045Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath
DrugPimicotinib
Abbisko Therapeutics Co, Ltd
Phase 3
94
Bologna, Milan, Prato
2023-04-27
Active, closed
FOLFIRINOX Versus OncoSil™ in Addition to FOLFIRINOX in Patients With Locally Advanced Pancreatic Adenocarcinoma
NCT05466799Locally Advanced Pancreatic Cancer
OncoSil Medical Limited
Phase 2
88
Rome, Verona
2023-04-26
Active, closed
ROLL Versus Magnetic Seed for Preoperative Localization of Non-palpable Breast Lesion: Comparison Between Techniques.
NCT05942092Breast Cancer
Istituti Clinici Scientifici Maugeri SpA
Observational
1,400
Pavia
2023-04-26
By invitation
An Open-label Study of XEN1101 in Epilepsy
NCT05718817Focal Epilepsy, Tonic-Clonic Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
880
Bologna, Chieti, Pisa, Roma
2023-04-25
Active, closed
Ultimaster Nagomi™ Sirolimus Eluting Coronary Stent System in Complex PCI Patients
NCT05705973Cardiovascular Disease, Coronary Artery Occlusion, Ischemic Heart Disease
Terumo Europe N.V.
Observational
3,000
Milan
2023-04-25
Active, closed
Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer
NCT05775159Hepatocellular Carcinoma, Biliary Tract Cancer
DrugsVolrustomig·Rilvegostomig·Lenvatinib·Gemcitabine
AstraZeneca
Phase 2
294
Florence, Milan, Naples, Rozzano
2023-04-24
Active, closed
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
NCT05624749Systemic Lupus Erythematosus
DrugIanalumab
Novartis Pharmaceuticals
Phase 3
288
Ancona, Cona, Padova, Pisa, Roma, Torino
2023-04-21
Recruiting
The Unmet Needs of Cancer Survivors in Ausl IRCCS Reggio Emilia
NCT06236373Cancer, Breast Cancer, Prostate Cancer, Thyroid Cancer
University of Modena and Reggio Emilia
Observational
45
Reggio Emilia
2023-04-20
Recruiting
Axitinib Intensification Plus Nivolumab or Nivolumab Alone After Nivolumab Plus Ipilimumab in mRCC Patients
NCT05817903Metastatic Renal Cell Carcinoma
DrugsAxitinib·Nivolumab
Consorzio Oncotech
Phase 2
118
Brescia, Candiolo, Catania, Cremona, Florence, Genova, Milan, Modena
2023-04-18
Active, closed
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
NCT05611931Endometrial Cancer
DrugSelinexor
Karyopharm Therapeutics Inc
Phase 3
257
Bologna, Brescia, Meldola, Milan, Monza, Naples, Padova, Pisa
2023-04-18
Recruiting
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
NCT05786924Non-small Cell Lung Cancer, Histiocytic Neoplasm, Histiocytosis, BRAF Gene Mutation
DrugsPanitumumab·Folfiri·Cetuximab·Nab-paclitaxel
Institut de Recherches Internationales Servier
Phase 1/2
554
Milan, Rome, Rozzano
2023-04-18
Recruiting
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
NCT05768139Breast Cancer, Solid Tumors, Adult
DrugsTersolisib·Imlunestrant·Tamoxifen·Exemestane
Eli Lilly and Company
Phase 1/2
880
Alessandria, Brescia, Milan, Monza, Pisa, Ravenna, Roma, Verona
2023-04-17
Active, closed
Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab
NCT05626855Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type 2, SMA
DrugApitegromab
Scholar Rock, Inc.
Phase 3
238
Genova, Messina, Milan, Roma
2023-04-17
Active, closed
A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy
NCT05707377Primary Membranous Nephropathy
DrugsTacrolimus·Zanubrutinib
BeOne Medicines
Phase 2/3
178
Pavia
2023-04-17
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NCT04124120Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting
Weill Medical College of Cornell University
Not applicable
2,300
Bari, Bergamo, Brescia, Cotignola, Florence, Roma, Torino
2023-04-17
Recruiting
Use of 'Mechanical Power' as a Predictor of Increased Serum and Pulmonary Proinflammatory Cytokine Concentrations in Patients With Acute Hypoxemic Respiratory Failure: A Prospective Observational Study
NCT06425354Mechanical Power
University of Roma La Sapienza
Observational
150
Roma
2023-04-15
Recruiting
Early Onset Colorectal Cancer Detection
NCT06342401Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I
City of Hope Medical Center
Observational
400
Milan
2023-04-15
Recruiting
Advanced Proton Therapy Approaches: a Multicenter High-quality Data Registry
NCT05860361Cancer
European Institute of Oncology
Observational
2,000
Milan
2023-04-14
Active, closed
A Two-part Study to Investigate the Effects in Adults of Two Doses of Golexanolone in Patients With Primary Biliary Cholangitis (PBC) With Fatigue and Cognitive Dysfunction
NCT07304843Primary Biliary Cholangitis (PBC)
Umecrine Cognition AB
Phase 1/2
84
Milan, Padova, Palermo, Roma, Rozzano, Udine
2023-04-14
Active, closed
A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer
NCT05645692Urothelial Cancer
DrugsTobemstomig·Tiragolumab·Atezolizumab
Hoffmann-La Roche
Phase 2
204
Bari, Naples, Bologna, Meldola, Rome, Milan, Terni, Padova
2023-04-13
Recruiting
Study of the Prevalence of Osteo-metabolic Complications in Patients With Thyroid Cancer
NCT06627998Cancer of Thyroid, Vertebral Fracture, Osteoporosis
IRCCS San Raffaele
Observational
82
Milan
2023-04-12
Active, closed
TrEatment Approach in the Multimodal Era Registry
NCT05629052Chronic Thromboembolic Pulmonary Hypertension, CTEPH
International CTEPH Association
Observational
1,000
Bologna
2023-04-12
Recruiting
The Potential Role of Compounds Derived From Ultra-processed Foods in Pathogenesis of Eosinophilic Esophagitis
NCT06093204Esophagitis, Eosinophilic
Federico II University
Observational
100
Naples
2023-04-12
Recruiting
Robotic Hemi-Prostatectomy With Urethral Preservation in Low and Intermediate Risk Monolateral Prostate Cancer
NCT05832736Prostate Cancer
Fondazione del Piemonte per l'Oncologia
Not applicable
36
Candiolo
2023-04-12
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Priya Life Science (2026). Clinical trial register: studies with an Italian investigative site. Derived from ClinicalTrials.gov. Retrieved 28 September 2026. https://priyalifescience.com/clinical-trials-italy?page=44

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Italy and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,830 studies in total at the last sync on 26 Sep 2026, 19:52 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

How many clinical trials are recruiting in Italy?

4,109 of the 6,830 studies in this register are recruiting new participants as of the 26 Sep 2026, 19:52 UTC sync. A further 587 have not yet opened recruitment, 1,928 are active but closed to new participants, and 206 are enrolling by invitation only. Eligibility for any study is decided by its study team.

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Browse trials by condition

Breast Cancer (164) Heart Failure (67) Parkinson Disease (66) Multiple Sclerosis (57) Multiple Myeloma (57) Prostate Cancer (57) Stroke (55) Ovarian Cancer (54) Obesity (48) Colorectal Cancer (43) Coronary Artery Disease (42) Non-Small Cell Lung Cancer (40) Non-small Cell Lung Cancer (39) Carcinoma, Non-Small-Cell Lung (36) Ulcerative Colitis (36)
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Browse trials by site location

Milan (2849) Bologna (1313) Roma (1277) Naples (984) Rome (980) Florence (787) Pavia (566) Brescia (526) Padova (495) Genova (482) Rozzano (473) Bari (439) Pisa (393) Bergamo (373) Meldola (356)
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.