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Trackers› Clinical trials› Heart Failure
Clinical trial register · Italy

Heart Failure Trials in Italy, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Italy and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6788 matching records held by the registry are in this view. Synced 13 Nov 2026, 03:19 UTC
6788
Studies in scope
all four open statuses
4077
Recruiting now
open to new participants
1016
Lead sponsors
across recruiting studies
Top sites
Milan 29 Naples 12 Bergamo 11 Roma 10 Brescia 9
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
Abbott Medical Devices4 Niguarda Hospital3 Medtronic3 IRCCS Azienda Ospedaliero-Universitaria di Bologna2 Boehringer Ingelheim2 Fondazione Policlinico Universitario Agostino Gemelli IRCCS2 Colorado Prevention Center2 IRCCS Policlinico S. Donato2 University of Salerno2 Centro Cardiologico Monzino2 Fondazione Don Carlo Gnocchi ETS2 IRCCS San Raffaele Roma1 Radboud University Medical Center1 Universitat Internacional de Catalunya1 Fatebenefratelli Hospital1 Cytokinetics1 Boston Scientific Corporation1 University of Padova1 Fondazione Toscana Gabriele Monasterio1 Heart Care Foundation1 Fondazione IRCCS Policlinico San Matteo di Pavia1 AstraZeneca1 Cardiac Dimensions, Inc.1 Impulse Dynamics1 Zoll Medical Corporation1 Show all 50
Site location
Milan29 Naples12 Bergamo11 Roma10 Brescia9 Bologna9 Rome7 Florence7 Pavia6 Ancona5 Udine4 Pisa4 Genova4 San Donato Milanese4 Bari4 Ferrara4 Cona3 Turin3 Monza3 Cotignola3 Foggia3 Rozzano3 Lecce3 Taranto3 Verona2 Show all 69
All 69 locations
Target enrolment
to

Heart Failure trials in Italy

65 of 6788 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Italy
Start
Not yet open
Metabolic Changes in Heart Failure Patients Treated With Vericiguat
NCT07901270Heart Failure, Worsening Heart Failure, Heart Failure With Reduced Ejection Fraction
DrugVericiguat
University of Salerno
Observational
30
Potenza
2026-11-01
Recruiting
Niguarda Hospital
Not applicable
60
Milan
2026-10-30
Not yet open
Zoll Medical Corporation
Not applicable
800
Roma
2026-10-01
Not yet open
KardioVis S.r.l.
Not applicable
120
Modena
2026-09
Not yet open
University Medical Center Groningen
Not applicable
292
Florence, Lavagna, Milan, Nola, Reggio Emilia, Roma, Tricase
2026-07
Active, closed
Monitoring of the Sympathetic/Vagal Balance Through Multiparametric Analysis of Heart Rate Variability (HRV)
NCT07471802Diabete Type 2, Heart Failure, Kidney Disease, Chronic, Cardiorenal Syndrome
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Observational
150
Roma
2026-05-20
Recruiting
Novo Nordisk A/S
Phase 3
5,610
Chieti, Cosenza, Naples, Bentivoglio, Bologna, Ferrara, Reggio Emilia, Udine
2026-05-11
Recruiting
Università Vita-Salute San Raffaele
Observational
300
Bergamo, Milan
2026-05-08
Recruiting
Transcultural Digital Solutions in Phase III Cardiac Rehabilitation
NCT07252856Heart Failure, Myocardial Infarction
Fondazione Don Carlo Gnocchi ETS
Not applicable
306
Castellanza, Lumezzane, Milan
2026-04-20
Recruiting
Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap?
NCT07295522Heart Failure, Acute Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF)
DrugGDMT
IRCCS Policlinico S. Donato
Phase 4
368
San Donato Milanese, Ancona, Cecina, Ferrara, Florence, Milan, Pisa, Ravenna
2026-03-31
Not yet open
Universitat Internacional de Catalunya
Observational
90
Brescia
2026-03
Recruiting
Istituti Clinici Scientifici Maugeri SpA
Observational
419
Bari, Milan, Pavia, Torino, Veruno
2026-01-08
Not yet open
RAPIDE: The Feasibility of a Hybrid Care Model
NCT06735404Diabetes Type 2, Heart Failure
Radboud University Medical Center
Not applicable
180
Verona
2026-01
Not yet open
Leonardo Calò, MD
Not applicable
194
Rome
2025-10-30
Recruiting
Left Bundle Branch Area Pacing (LBBAP) PMCF Study
NCT07217392Bradycardia, Right Ventricular Pacing, Heart Failure, Atrial Fibrillation (AF)
Abbott Medical Devices
Not applicable
200
Cona
2025-07-24
Recruiting
University of Padova
Observational
100
Mercogliano, Brescia, Rho, Monza, Naples, Ragusa, Cotignola, Sassari
2025-06-20
Recruiting
University of Salerno
Observational
205
Salerno
2025-06-10
Recruiting
Boehringer Ingelheim
Phase 3
4,200
Bergamo, Naples, Pavia, Pisa, Roma, Rozzano
2025-05-20
Recruiting
Fondazione Don Carlo Gnocchi ETS
Observational
1,600
Milan
2025-05-01
Active, closed
ASCEND CSP IDE Study
NCT06830746Heart Failure, Ventricular Arrythmia
Abbott Medical Devices
Not applicable
414
Taranto, Milan
2025-04-11
Recruiting
AstraZeneca
Phase 3
11,300
Alessandria, Bari, Bergamo, Brescia, Chiavari, Cona, Foggia, Milan
2025-03-14
Recruiting
FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Observational
300
Bergamo
2025-03-10
Recruiting
Genetic and Immunity in Heart Failure
NCT06758128Heart Failure
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Observational
215
San Giovanni Rotondo, Rome
2025-02-04
Recruiting
Impulse Dynamics
Observational
200
Rome, Naples
2025-02-01
Recruiting
LMU Klinikum
Observational
2,000
Bolzano
2025-02-01
Recruiting
Centro Cardiologico Monzino
Not applicable
110
Milan
2025-01-28
Recruiting
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Observational
400
Bergamo, Bologna, Genova, Milan, Padova, Palermo, Pavia, Roma
2025-01-10
Recruiting
Cytokinetics
Phase 3
1,800
Brescia, Rimini, Arzignano, Bergamo, Milan, Sesto San Giovanni, Perugia, Cona
2024-12-19
Recruiting
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NCT06526195Heart Failure, Heart Diseases, Cardiovascular Diseases, Pulmonary Hypertension
Abbott Medical Devices
Not applicable
850
Turin
2024-12-13
Recruiting
Drug Management in Heart Failure
NCT06915584Heart Failure
IRCCS San Raffaele Roma
Observational
450
Rome
2024-11-30
Recruiting
EVOLVING AZIMUTH IN MUSA CONTEXT
NCT07022067Heart Failure, Blood Pressure, Weight Change, Telemonitoring
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Not applicable
184
Milan
2024-10-02
Recruiting
University Hospital, Geneva
Not applicable
220
Bologna
2024-10-01
Recruiting
Colorado Prevention Center
Phase 3
2,600
Brescia, Germaneto
2024-08-20
Recruiting
Boehringer Ingelheim
Phase 3
6,712
Bergamo, Foggia, Genova, Naples, Pavia, Roma, Rozzano
2024-06-17
Recruiting
Abbott Medical Devices
Observational
50
San Donato Milanese
2024-05-15
Not yet open
TRAnscutaneous vaGUS Nerve Stimulation in Patients With Chronic Heart Failure
NCT06355388Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Midrange Ejection Fraction
Fondazione Toscana Gabriele Monasterio
Not applicable
24
Pisa
2024-05-01
Recruiting
Integrated Approach in Frail Older People with Atrial Fibrillation
NCT06775028Atrial Fibrillation (AF), Hypertension, Coronary Arterial Disease (CAD), Heart Failure
Heart Care Foundation
Not applicable
1,250
Caserta, Florence, Genova, Grosseto, Monza, Milan, Piacenza, Gubbio
2024-04-11
Recruiting
InnovHeart
Not applicable
30
Milan
2024-04-04
Recruiting
Colorado Prevention Center
Phase 3
5,200
Bergamo, Catanzaro, Genova, Varese, Ancona, Brescia
2024-01-17
Active, closed
Microvascular Dysfunction Assessment to Predict Left Ventricular Reverse Remodeling
NCT06356727Heart Failure, Left Ventricular Dysfunction, Idiopathic Dilated Cardiomyopathy
Azienda Ospedaliera Universitaria Integrata Verona
Not applicable
200
Ferrara, Conegliano, Novara, Milan, Roma, Rome, Torino, Verona
2024-01-03
Recruiting
Multicenter Evaluation of Patients Using LATITUDE Monitoring System
NCT06311149Cardiovascular Diseases, Arrhythmias, Cardiac, Heart Failure, Sudden Cardiac Death
University Hospital of Ferrara
Observational
20,000
Ferrara, Naples, Roma
2023-12-01
Recruiting
CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine
NCT06158698Cardiomyopathies, Myocarditis, Inflammatory Cardiomyopathy, Heart Failure
DrugColchicine
Niguarda Hospital
Phase 3
80
Naples, Bologna, Trieste, Udine, Rome, Milan, Turin, Ancona
2023-11-14
Active, closed
Bristol-Myers Squibb
Phase 2
227
Naples, San Donato Milanese, Pisa, Bergamo
2023-11-07
Recruiting
Electronic Register on Advanced Heart Failure and Transplantation di Cuore
NCT06773611Heart Failure, Heart Transplantation
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Observational
10,000
Bologna
2023-09-04
Recruiting
Merck Sharp & Dohme LLC
Phase 2/3
342
Genoa, Milan, Turin, Rome, Florence, Padova
2023-05-31
Active, closed
Primary Care-Hospital Embedding: a Prospective, Multicentric, Observational Study
NCT05723185Heart Failure, Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, Pneumonia
Rovere Querini Patrizia
Observational
246
Milan
2023-02-13
Recruiting
Alleviant ALLAY-HF Study
NCT05685303Heart Failure
Alleviant Medical, Inc.
Not applicable
700
Rozzano, Milan
2023-01-10
Recruiting
Fondazione IRCCS Policlinico San Matteo di Pavia
Observational
101
Pavia
2022-11-22
Recruiting
Azienda Ospedaliero-Universitaria Careggi
Not applicable
60
Florence
2022-02-07
Recruiting
Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging
NCT05081115Coronary Artery Disease, Heart Failure, Hypertrophic Cardiomyopathy, Congenital Heart Disease
Fatebenefratelli Hospital
Observational
10,000
Benevento
2021-04-01
Recruiting
Centro Cardiologico Monzino
Observational
10,000
Milan, Ancona, Bari, Bergamo, Brescia, Foggia, Naples, Palermo
2021-02-10
Active, closed
Assessment of the Axone Micro Quadripolar Lead for Enhanced Cardiac Resynchronization Therapy
NCT04463641Heart Failure, Cardiac Resynchronization Therapy
MicroPort CRM
Not applicable
92
Brescia, Naples
2020-12-03
Recruiting
Occlutech International AB
Observational
150
Florence, Milan
2020-10-28
Active, closed
Medtronic
Observational
2,200
Bologna, Cosenza, Lecce, Milan, Taranto, Udine
2020-08-01
Recruiting
Niguarda Hospital
Observational
26
Milan
2020-06-30
Active, closed
Ancora Heart, Inc.
Not applicable
132
Milan, Cotignola
2019-01-15
Active, closed
Vectorious Medical Technologies Ltd.
Not applicable
45
Florence
2019-01-08
Active, closed
Biotronik SE & Co. KG
Observational
3,030
Milan, Roma
2018-05-14
Active, closed
EBR Systems, Inc.
Not applicable
300
Bologna, Monza
2018-01-17
Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NCT03142152Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases
Cardiac Dimensions, Inc.
Not applicable
300
Naples, Roma
2018-01-01
Active, closed
Medtronic
Observational
1,092
Bologna, Castrovillari, Lecce, Milan, Taranto, Udine
2017-08-21
Recruiting
CVRx, Inc.
Observational
500
Campobasso
2016-12-13
Recruiting
Heart Failure and Aortic Stenosis Transcriptome
NCT03268135Heart Failure, Aortic Stenosis
IRCCS Policlinico S. Donato
Observational
500
San Donato Milanese, Milan
2016-05-30
Active, closed
Neural Cardiac Therapy for Heart Failure Study (NECTAR-HF)
NCT01385176Heart Failure, Congestive Heart Failure
Boston Scientific Corporation
Not applicable
118
Milan, Naples, Pavia
2011-09-21
Recruiting
Medtronic
Observational
20,000
Ancona, Bari, Bergamo, Bologna, Brescia, Castrovillari, Cotignola, Lecce
1983-01
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with an Italian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 13 November 2026. https://priyalifescience.com/clinical-trials-italy/condition/heart-failure

Query this register directly
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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Italy and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,788 studies in total at the last sync on 13 Nov 2026, 03:19 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 65 of those studies listing the condition Heart Failure.

How many Heart Failure trials are recruiting in Italy?

44 of the 65 studies on this page are recruiting new participants as of the 13 Nov 2026, 03:19 UTC sync. A further 8 have not yet opened recruitment, 13 are active but closed to new participants, and 0 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Heart Failure), 65 studies
PhaseStudiesRecruitingShare
Observational292244.6%
Not applicable251238.5%
Phase 38812.3%
Phase 2101.5%
Phase 2/3111.5%
Phase 4111.5%

Most active sponsors

Lead sponsors with the most studies (Heart Failure)
Lead sponsorStudiesRecruiting
Abbott Medical Devices43
Medtronic31
Niguarda Hospital33
Boehringer Ingelheim22
Centro Cardiologico Monzino22
Colorado Prevention Center22
Fondazione Don Carlo Gnocchi ETS22
Fondazione Policlinico Universitario Agostino Gemelli IRCCS21
IRCCS Azienda Ospedaliero-Universitaria di Bologna22
IRCCS Policlinico S. Donato22
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.