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Clinical trial register · Italy

Colorectal Cancer Trials in Italy, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Italy and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6830 matching records held by the registry are in this view. Synced 26 Sep 2026, 19:52 UTC
6830
Studies in scope
all four open statuses
4109
Recruiting now
open to new participants
1019
Lead sponsors
across recruiting studies
Top sites
Milan 24 Naples 9 Roma 8 Rozzano 6 Pisa 6
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
Gruppo Oncologico del Nord-Ovest4 Fondazione Policlinico Universitario Agostino Gemelli IRCCS3 IRCCS Azienda Ospedaliero-Universitaria di Bologna2 Azienda USL Reggio Emilia - IRCCS2 Istituto Clinico Humanitas2
Site location
Milan24 Naples9 Roma8 Rozzano6 Pisa6
All 42 locations
Target enrolment
to

Colorectal Cancer trials in Italy

43 of 6830 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Italy
Start
Not yet open
Nutritional Supplementation to Improve Colorectal Cancer Surgery
NCT07599501Colorectal Cancer, Colorectal Surgery
Istituto Clinico Humanitas
Not applicable
190
Rozzano
2026-09-30
Not yet open
Implementation Of A Telesurgery Program At A Referral Center For Robotic Surgery
NCT07792109Prostate Cancer, Colorectal Cancer
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Not applicable
25
Roma, Rome
2026-08-20
Recruiting
[68Ga]BED003 PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications
NCT07702292Colorectal Cancer, Epithelial Ovarian Cancer, Gastric Cancer (GC), Pancreatic Ductal Adenocarcinoma (PDAC)
Blue Earth Diagnostics
Phase 2
71
Bergamo, Monza, Roma, Milan
2026-06-30
By invitation
SafeHeal Colovac Anastomosis Protection Device Evaluation Pivotal Study
NCT07116668Colorectal Cancer, Stoma - Ileostomy
SafeHeal Inc
Not applicable
108
Rozzano
2026-01-08
Recruiting
A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer
NCT06948448Colorectal Cancer
DrugsONO-4578·Opdivo·Leucovorin·Adrucil
Ono Pharmaceutical Co., Ltd.
Phase 2
144
Milan, Naples, Padova
2025-11-18
Recruiting
Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.
NCT07407465Colorectal Cancer, Colorectal Adenocarcinoma, Rectal Adenocarcinoma, Rectal Cancer, Adenocarcinoma
DrugsTrastuzumab deruxtecan·Capecitabine·Bevacizumab
Gruppo Oncologico del Nord-Ovest
Phase 2
42
Bari, Florence, Milan, Ravenna, Rozzano, Tricase, Modena, Roma
2025-10-20
Recruiting
MIMICC Study in Patients With Colorectal Cancer
NCT07494201Colorectal Cancer, Colon Cancer, Rectal Cancers
Fondazione del Piemonte per l'Oncologia
Not applicable
2,500
Candiolo
2025-09-15
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
NCT07023289Colorectal Cancer
DrugTelisotuzumab Adizutecan
AbbVie
Phase 2
140
Florence, Rozzano, Naples
2025-09-02
Recruiting
A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
NCT07169734Cervical Squamous Cell Carcinoma, Squamous Non-small-cell Lung Cancer, Colorectal Cancer, Intrahepatic Cholangiocarcinoma
Alentis Therapeutics AG
Phase 1/2
180
Milan, Ravenna, Rossano, Siena
2025-08-26
Recruiting
OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment (SPRINT)
NCT06462963Breast Cancer, Prostate Cancer, NSCLC, Colorectal Cancer
European Organisation for Research and Treatment of Cancer - EORTC
Not applicable
302
Florence, Milan, Negrar, Roma, Torino
2025-04-15
Recruiting
Role of Photon Counting CT in Detecting Liver Metastatis From Colorectal Cancer
NCT06753903Colorectal Cancer
IRCCS San Raffaele
Observational
100
Milan
2025-03-24
Recruiting
Microbiome-based Diagnostic Tool for the Screening of Colorectal Cancer (GUILTI)
NCT06738173Colorectal Cancer
Catholic University of the Sacred Heart
Observational
1,202
Rome
2025-02-07
Recruiting
Artificial Intelligence-based Screening Models for Prevention and Early Detection of Colorectal Cancer
NCT06799793Colorectal Cancer, Screening
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Not applicable
1,400
Bologna
2024-12-03
Recruiting
Microbiome Testing for the Screening of Colorectal Cancer
NCT06588166Colorectal Cancer
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Observational
1,006
Roma
2024-11-29
Recruiting
FOLFOXIRI Plus Bevacizumab With or Without Atezolizumab as 1st Line Treatment of pMMR and IS IC-High Metastatic Colorectal Cancer Patients.
NCT06733038Colorectal Cancer
Drugs5-FU·Leucovorin·Fluorouracil·Irinotecan
Gruppo Oncologico del Nord-Ovest
Phase 3
238
Brescia, Catania, Meldola, San Giovanni Rotondo, Florence, Tricase, Livorno, Lucca
2024-11-15
Active, closed
A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors
NCT06607185Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumor
Drugs5Fluorouracil·Leucovorin·Cetuximab·Irinotecan
Eli Lilly and Company
Phase 1
750
Verona
2024-10-21
Recruiting
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06586515Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer
DrugsLeucovorin·Adrucil·Cetuximab·Irinotecan
Eli Lilly and Company
Phase 1
630
Naples, Roma, Verona
2024-09-12
Active, closed
Phase II Study of ctDNA-guided Encorafenib Plus Cetuximab Retreatment in Patients BRAF V600E Mutated mCRC
NCT06578559Colorectal Cancer
DrugsEncorafenib·Cetuximab
Gruppo Oncologico del Nord-Ovest
Phase 2
16
Monserrato, Meldola, San Giovanni Rotondo, Tricase, Milan, Padova, Pisa, Prato
2024-07-23
Recruiting
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
NCT06428409Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer
DrugsLevoleucovorin·Sacituzumab tirumotecan·5-FU·Leucovorin
Merck Sharp & Dohme LLC
Phase 1/2
220
Milan, Roma
2024-06-20
Recruiting
Low and Intermediate Risk OliGometastatic ColoREctal CancEr PatieNts Treated with Stereotactic ABlative Radiotherapy
NCT06310564Colorectal Cancer
IRCCS Sacro Cuore Don Calabria di Negrar
Not applicable
204
Negrar
2024-03-18
Recruiting
Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection
NCT07450612Colorectal Cancer, Adenoma Colon, Adenoma Colon Polyp, Colon Adenoma
San Raffaele University
Observational
1,200
Milan
2024-01-01
Recruiting
A Comparative Study Between Early Onset Colorectal Cancer and Late Onset Colorectal Cancer Patients
NCT06326879Colorectal Cancer
Istituto Clinico Humanitas
Observational
340
Rozzano
2023-11-30
Recruiting
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
NCT06128551Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer, Pancreatic Ductal Adenocarcinoma
DrugsElironrasib·Cetuximab
Revolution Medicines, Inc.
Phase 1/2
534
Verona, Ancona, Aviano, Meldola, Milan, Naples, Orbassano, Ravenna
2023-11-14
Recruiting
Role of MRI in the Evaluation of Hepatic Metastases of Colorectal Cancer
NCT05950503Colorectal Cancer
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Observational
100
Roma
2023-07-10
Active, closed
First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer
NCT06398743Colorectal Cancer
Exact Sciences Corporation
Observational
416
Rozzano, Milan, Naples
2023-06-20
Recruiting
The Theranostic Value of STARD3 in Colorectal Cancer: The STAR Study
NCT06136949Colorectal Cancer
Centro di Riferimento Oncologico - Aviano
Observational
150
Aviano
2023-05-22
Recruiting
Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)
NCT05845450Colorectal Cancer, Resectable Colorectal Carcinoma
DrugsVorbipiprant·Balstilimab·Botensilimab·Sotorasib
Gruppo Oncologico del Nord-Ovest
Phase 2
197
Milan
2023-05-11
Recruiting
Early Onset Colorectal Cancer Detection
NCT06342401Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I
City of Hope Medical Center
Observational
400
Milan
2023-04-15
Recruiting
Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
NCT05732623Colorectal Cancer, Early Onset Colorectal Cancer, Diet Habit, Risk Reduction
San Raffaele University
Observational
2,300
Milan
2022-12-05
Recruiting
Microbiome, Immune-system and Tumor Interaction in Colorectal Cancer
NCT06331988Colorectal Cancer
European Institute of Oncology
Observational
320
Milan
2022-07-21
Recruiting
Recurrence Rate After Endoscopic Resection of , Laterally Spreading Tumor Granular Type (LST-G) of the Colon and Rectum: Endoscopic Mucosal Resection vs. Endoscopic Submucosal Dissection
NCT06815406Colorectal Cancer
Azienda USL Reggio Emilia - IRCCS
Not applicable
282
Bologna, Genova, Milan, Modena, Reggio Emilia
2021-11-18
Active, closed
Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).
NCT04895722Colorectal Cancer
DrugsPembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab·MK-4830·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 2
302
Milan, Naples, Padova
2021-06-25
Active, closed
Study in mCRC Patients RAS/BRAF wt Tissue and RAS Mutated LIquid BIopsy to Compare FOLFIRI Plus CetuxiMAb or BevacizumaB
NCT04776655Colorectal Cancer, Metastatic Colorectal Cancer, RAS Mutation
DrugsCalcium levofolinate·Erbitux·Avastin·5-FU
Azienda USL Reggio Emilia - IRCCS
Phase 3
280
Coppito, Guastalla, Reggio Emilia, Mirano
2021-04-30
Recruiting
Liver Transplantation for Non-Resectable Colorectal Liver Metastasis
NCT05185245Liver Metastasis Colon Cancer, Colorectal Cancer
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Not applicable
20
Bologna
2021-04-01
Recruiting
A Retrospective Protocol Empowering Precision Research in Colorectal Cancer (ALFAOMEGA-RETRÒ)
NCT05101382Colorectal Cancer
IFOM ETS - The AIRC Institute of Molecular Oncology
Observational
500
Genova, Milan, Padua, Pisa, Candiolo, Orbassano, Torino
2020-10-28
Active, closed
Retrospective Study on the Use of Immunotherapy in Patients With MSI-H Metastatic Colorectal Cancer
NCT04612309Colorectal Cancer
Gruppo Oncologico Italiano di Ricerca Clinica
Observational
100
Carpi
2020-10-28
Recruiting
BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours
NCT04421820Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma
DrugBOLD-100
Bold Therapeutics, Inc.
Phase 1/2
220
Milan, Naples, Pisa
2020-08-28
Active, closed
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
NCT04449874Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors
DrugsDivarasib·Erlotinib·Inavolisib·Cetuximab
Genentech, Inc.
Phase 1
498
Meldola, Milan, Rozzano (MI), Pisa
2020-07-29
Recruiting
Early Detection of Advanced Adenomas and Colorectal Cancer
NCT06342440Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
City of Hope Medical Center
Observational
2,000
Milan
2020-03-15
Recruiting
ALFAOMEGA Master Observational Trial
NCT04120935Colorectal Cancer
IFOM ETS - The AIRC Institute of Molecular Oncology
Observational
3,000
Biella, Milan, Padova, Perugia, Pisa, Ravenna, Candiolo, Orbassano
2019-10-15
Recruiting
Study of Folfiri/Cetuximab in FcGammaRIIIa V/V Stage IV Colorectal Cancer Patients
NCT03874026Colorectal Cancer, ADCC
National Cancer Institute, Naples
Phase 2
34
Naples
2019-09-05
Recruiting
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
NCT03526835Advanced/Metastatic Solid Tumors, Colorectal Cancer, Gastric Cancer, Gastroesophageal-junction Cancer
Merus B.V.
Phase 1/2
560
Milan
2018-05-02
Active, closed
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
NCT02568267Breast Cancer, Cholangiocarcinoma, Colorectal Cancer, Head and Neck Neoplasms
DrugEntrectinib
Hoffmann-La Roche
Phase 2
534
Naples, Rome, Milan, Pisa, Perugia, Padova
2015-11-19
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with an Italian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 26 September 2026. https://priyalifescience.com/clinical-trials-italy/condition/colorectal-cancer

Query this register directly
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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Italy and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,830 studies in total at the last sync on 26 Sep 2026, 19:52 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 43 of those studies listing the condition Colorectal Cancer.

How many Colorectal Cancer trials are recruiting in Italy?

32 of the 43 studies on this page are recruiting new participants as of the 26 Sep 2026, 19:52 UTC sync. A further 2 have not yet opened recruitment, 8 are active but closed to new participants, and 1 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Colorectal Cancer), 43 studies
PhaseStudiesRecruitingShare
Observational151334.9%
Not applicable9620.9%
Phase 29620.9%
Phase 1/25511.6%
Phase 1317%
Phase 3214.7%

Most active sponsors

Lead sponsors with the most studies (Colorectal Cancer)
Lead sponsorStudiesRecruiting
Gruppo Oncologico del Nord-Ovest43
Fondazione Policlinico Universitario Agostino Gemelli IRCCS32
Azienda USL Reggio Emilia - IRCCS21
City of Hope Medical Center22
Eli Lilly and Company21
IFOM ETS - The AIRC Institute of Molecular Oncology22
IRCCS Azienda Ospedaliero-Universitaria di Bologna22
Istituto Clinico Humanitas21
Merck Sharp & Dohme LLC21
San Raffaele University22
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.