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Clinical Trials in China / NCT06138340
Recruiting Observational

The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma

NCT06138340 · tracked via the Priya Life Science China tracker
Sponsor
Beijing Tiantan Hospital
Phase
Observational
Started
2023-08-31
Last updated
2025-02-14

Condition(s) studied

Brain Network ConnectivityPostoperative DeliriumDexmedetomidinePropofol

Investigational drug(s) / intervention(s)

Dexmedetomidine →Propofol →Remimazolam Injection →

Dexmedetomidine: Participants will be sedated and maintained by dexmedetomidine during the surgery.

Propofol: Participants will be sedated and maintained by propofol during the surgery.

Remimazolam Injection: Participants will be sedated and maintained by remimazolam during the surgery.

Study summary

Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Diagnosed as unilateral supratentorial glioma by MRI * Selective operation * Age over 18 years old * ASA I-II * Right handedness Exclusion Criteria: * History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs * History of intracranial surgery * Drug and/or alcohol abuse * History of dementia or mental illness * Pregnant or lactating women * Contraindications for MRI * Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block * Severe hepatic or renal dysfunction

Primary outcome measure(s)

  • The alterations of brain network connectivity. — Before sedation, 30 minutes after sedation，and 30 minutes after surgery.
    fMRI and DTI will be used to detect brain network connectivity.

Trial sites (1)

FacilityCityRegionStatus
Beijing Tian Tan Hospital, Capital Medical University Beijing Beijing Municipality Recruiting

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Other trials for the same condition

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Remimazolam Besylate in Sedation of Postcardioperative Patients Recruiting
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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06138340 on ClinicalTrials.gov ↗ ← All trials in China