Risk Prediction Model for Cerebrovascular Events in Carotid Artery Stenosis

Condition(s) studied

Investigational drug(s) / intervention(s)

Plasma: Plasma levels of metabolites and some proteins will be further determined

carotid high-resolution magnetic resonance imaging: Define plaque composition and morphological characteristics

Study summary

Atherosclerotic carotid artery stenosis is a major cause of stroke, and early identification of high-risk patients combined with surgical intervention can significantly reduce stroke risk. Currently, stroke risk assessment in patients with carotid artery stenosis primarily relies on imaging indicators such as plaque morphology, composition, and degree of stenosis, with less emphasis on indicators directly related to inflammation, hemodynamics, and plaque instability. Certain circulating metabolites are closely linked to plaque progression and are direct risk factors for stroke. However, there is a lack of stroke risk prediction models for patients with carotid stenosis that incorporate these indicators, and the ability to identify high-risk patients needs improvement.

This study proposes using deep learning technology to integrate multidimensional data from plaque imaging, fluid dynamics, circulating metabolomics, and proteomics to construct an accurate prediction model for cerebrovascular events in patients with carotid artery stenosis. Additionally, it aims to explore markers of plaque instability characteristics based on plaque pathology. The study is expected to provide a basis for identifying high-risk patients with carotid artery stenosis, thereby laying the foundation for reducing stroke risk and improving long-term patient outcomes.

Eligibility

Primary outcome measure(s)

• Number of Patients with Cerebrovascular Events — Within six months from the date of consultation
  Patients will be categorized as having a cerebrovascular event if they meet one of the following indicators: i. cerebral infarction in the middle cerebral artery territory on the side of carotid stenosis; ii. transient ischemic attack symptoms (including motor and sensory) in the hemisphere on the side of stenosis; and iii. transient amaurosis on the side of stenosis.

Trial sites (1)

More Beijing Tiantan Hospital trials in China

Other trials for the same condition