Ireland
--:--IST
Active, not recruiting Not applicable

Real-time Motion Management During Prostate and Lung Radiotherapy

NCT05844761 · tracked via the Priya Life Science Sweden tracker
Phase
Not applicable
Started
2023-05-01
Last updated
2026-07-28

Condition(s) studied

Cancer of LungLung MetastasisCancer of Prostate

Investigational drug(s) / intervention(s)

Triggered imaging on TrueBeam with margin reductionSynchrony MLC tracking on fiducials with margin reductionSynchrony MLC tracking and lung adaptive model with margin reduction

Triggered imaging on TrueBeam with margin reduction: At interim analysis the Planning target volume (PTV) will be reduced based on the accuracy of the TrueBeam triggered imaging motion management technique.

Synchrony MLC tracking on fiducials with margin reduction: At interim analysis the Planning target volume (PTV) will be reduced based on the accuracy of the Radixact Synchrony motion management technique.

Synchrony MLC tracking and lung adaptive model with margin reduction: At interim analysis the Planning target volume (PTV) will be reduced based on the accuracy of the Radixact Synchrony motion management technique for lung cancer.

Study summary

The goal of this interventional non-inferiority trial is to assess the accuracy of different real-time motion management radiotherapy techniques. The main question the study aims to answer are:

* What are the target margins for radiotherapy with motion management that are not inferior to target margin without motion management
* What are the dosimetric and geometrical accuracy to patient for the motion management techniques.

Participants will answer QoL questionary, and the accuracy of treatment will be assessed from treatment data.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: For prostate cancer patients: * Patients histologically proven prostate adenocarcinoma * Prostate specific antigen (PSA) obtained within three months prior to enrollment * Localised prostate cancer at any stage eligible for radiotherapy: i.e. any T- or Gleason stage, but no pelvic lymph nodes can be included within the target to be treated * Eastern Cooperative Oncology Group (ECOG) performance status 0-2 * Ability to understand and the willingness to sign a written informed consent document. * Hypofractionated radiation therapy (HYPO) fractionated patients with a prescribed dose of 42.7Gy in 7 fractions. * MRIOnly workflow meaning synthetic generated CT based on Magnetic resonance imaging (MRI) * Patients over 40 years old For lung cancer patients: * Lung cancer or localised metastatic disease from other cancer diagnoses, accepted for stereotactic radiotherapy to 45Gy in 3 fractions * Lesion distinguishable on Computer Tomography and where the majority of adjacent tissue is the lung. * Ability to understand and the willingness to sign a written informed consent document. * Is able to perform treatment simulation Exclusion Criteria: For prostate cancer patients: * Patient must have three gold fiducial markers inserted in the prostate * Patients with artificial Hip(s), lumbar spinal surgical rods or other large metallic pelvic implants * Patients with overlapping implanted gold fiducials in X-ray imaging * Unfeasible to track fiducials with kv imaging/existing online imaging systems For lung cancer patients: * Previous treatment with radiotherapy for lung cancer or lung metastasis * Idiopathic lung fibrosis

Primary outcome measure(s)

  • Dosemetric accuracy — At treatment completion, approximately 1-4 weeks
    Dose coverage defined as dose to 99% of clinical target volume (CTV) (D99%) to target including margin for other uncertainties.

Trial sites (1)

FacilityCityRegionStatus
Skåne University Hospital Lund Skåne County
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05844761 on ClinicalTrials.gov ↗ ← All trials in Sweden