Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints

NCT06370312 · tracked via the Priya Life Science Sweden tracker

Sponsor

Region Skane

Phase

Observational

Started

2024-05-01

Last updated

2025-06-25

Condition(s) studied

Osteoarthritis ThumbOsteoarthritis, KneeMetabolic Disease

Investigational drug(s) / intervention(s)

Trapeziectomy

Trapeziectomy: Patients scheduled for trapeziectomy due to thumb basal joint osteoarthritis are invited to participate. Synovial fluid is aspirated before the joint is opened. Bone and cartilage are collected. Blood samples are obtained preop. Patients are measured with grip strength, pinch strength, range of thumb motion, body mass index, central obesity and blood pressure.

Study summary

The study project aims at examining molecular markers in synovial fluid, bone and articular cartilage from osteoarthritic thumb basal joints. The degradation of extracellular matrix (ECM) proteins in thumb basal joints will be evaluated in association to the metabolic profile of the patient, but we also aim to compare the ECM degradation and inflammatory profiles with articular cartilage degradation ECM profile from knee joints with osteoarthritis. A third aim is to evaluate associations between patient-reported hand function, pain, strength and range of thumb motion to analyses of synovial fluid.

Eligibility

Sex

ALL

Min age

25 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Men and women age ≥ 25 years * Radiologically confirmed and symptomatic thumb basal joint osteoarthritis (OA) planned for trapeziectomy Exclusion Criteria: * Previous surgery to the affected thumb basal joint * Post-traumatic thumb basal joint OA * Rheumatoid arthritis or other chronic inflammatory arthritis, history of psoriasis affecting joints, gout or pseudogout * Ongoing infection in the hand or wrist * Inability to co-operate with the follow-up protocol or to assimilate information about the study protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction) * Systemic or intra-articular glucocorticoids or intraarticular platelet-rich plasma or hyaluronic acid injections in the affected joint within 3 months prior to enrollment

Primary outcome measure(s)

Serum cholesterol levels — Serum cholesterol levels are drawn at baseline (i.e. the day of surgery)
Blood samples are drawn from the patients and analysed according to Swedish laboratory standards

Trial sites (2)

Facility	City	Region	Status
Department of Hand Surgery, Skane University Hospital	Malmö	Skåne County	Not Yet Recruiting
Aleris Specialistläkare Hyllie	Malmö	Skåne County	Recruiting

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Other trials for the same condition

The Halland Osteoarthritis Cohort Active, not recruiting

Digitalization of Osteoarthritis Care Active, not recruiting

Patients' Perceptions of Assessment and Treatment of Knee Osteoarthritis in Primary Care Active, not recruiting

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Gfree - For Improved Blood Sugar and Reduced Inflammation. Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06370312 on ClinicalTrials.gov ↗ ← All trials in Sweden