Gfree - For Improved Blood Sugar and Reduced Inflammation.

Condition(s) studied

Investigational drug(s) / intervention(s)

gluten-free: see info in arm description

probiotic: see info in arm description

gluten: see info in arm description

Study summary

The goal of this clinical trial is to reduce inflammation and improve glycemic control in healthy volunteers, parents, as well as children, adolescents and adults with or without diabetes. The main questions it aims to answer are: • does a reduction wheat gluten improve glycemic control and/or inflammatory biomarkers • does a reduction in certain amino acids (which is most common in wheat gluten) improve glycemic control and/or inflammatory biomarkers • can we identify individuals with an inflammatory response, which leads to poor glycemic control. Participants will eat gluten-free products as well as similar products containing gluten. They will also eat gluten together with probiotics to see if an effect of gluten can be reduced. Researchers will compare everyone with themselves (cross-over design) and if possible individuals with and without diabetes.

Eligibility

Primary outcome measure(s)

• Stabilizing of blood sugar levels — 0 days to 4 weeks
  Continuous glucose monitoring (CGM) data will be analysed together with activity level data, lower glucose peaks after a meal, adjusted for activity level.
• Amino acid metabolism — 0 days to 4 weeks
  Lowering of the aminoacid proline

Trial sites (2)

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