TIPS in Patients With Decompensated Liver Cirrhosis

NCT04801290 · tracked via the Priya Life Science Germany tracker

Sponsor

Hannover Medical School

Phase

Observational

Started

2019-08-29

Last updated

2025-09-16

Condition(s) studied

Decompensated Liver Cirrhosis

Investigational drug(s) / intervention(s)

TIPS insertion

TIPS insertion: Patients are included in the registry if they receive a transjugular intrahepatic portosystemic shunt at Hannover Medical School and provide written informed consent.

Study summary

This is a single center patient registry of patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) at Hannover Medical School. By collecting and analyzing clinical data as well as blood samples, the overall aim is to optimize TIPS therapy (e.g. specify selection criteria).

Eligibility

Sex

ALL

Min age

18 Years

Max age

99 Years

Healthy volunteers

Inclusion Criteria: * Liver cirrhosis * Indication for TIPS insertion * Treatment at the Department of Gastroenterology, Hepatology and Endocrinology of Hannover Medical School * Informed consent Exclusion Criteria: * Pregnancy or Lactation * Age \<18 years * Lack of Informed consent * Symptomatic anemia with Hb \<7g/dl

Primary outcome measure(s)

Mortality — 1 year
Patients who die within 1 year
Occurrence of (Minimal) Hepatic Encephalopathy — 1 year
Using the Portosystemic encephalopathy (PSE) syndrome test, critical flicker frequency (CFF) and animal naming test (S-ANT)
Change in Nutritional Status — 1 year
Nutritional Status will be measured by hand grip strength (dynamometer) in kg
Change in Quality of Life — 1 year
Using the questionnaire short-form 36 (SF36) (Score range 0-100, higher scores correspond to better quality of life)

Trial sites (1)

Facility	City	Region	Status
Hannover Medical School	Hanover	Lower Saxony	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04801290 on ClinicalTrials.gov ↗ ← All trials in Germany