Influence of Hypoxic Induced Factors in Patients With Hereditary Hemorrhagic Telangiectasia

Condition(s) studied

Investigational drug(s) / intervention(s)

hypoxic induced factors: hypoxic induced factors analyzed in blood sample

Study summary

Patients with hereditary hemorrhagic telangiectasia (HHT) suffer from an inherited disorder leading to systemic vascular malformations. Mutations in several genes of the transforming growth factor (TGF)-β superfamily pathway influence angiogenesis in patients with HHT. The genetic loss of ALK1 or ENG alone are not sufficient to induce AVMs; environmental insults that could trigger angiogenesis (e.g. wounding) are also needed. In this study it will be analyzed if hypoxic induced factors could have an influence on the disease HHT.

Eligibility

Primary outcome measure(s)

• Differences in hypoxic induced factors — 12 months
  Differences in hypoxic induced factors analyzed in blood samples from patients with HHT and healthy controls

Trial sites (1)

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