The possibility of body donation in hereditary hemorrhagic telangiectasia (HHT) means that human tissue samples with and without vascular malformations can be analyzed. The aim is to gain insights into the disease mechanism.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* positiv genetic testing for HHT and/ or at least three fulfilled Curacao Criteria
* older than 18 years
Exclusion Criteria:
* missing inclusion criteria
Primary outcome measure(s)
Differences in immune and endothelial cells in tissue with and without telangiectasia in HHT — after the patients who gave informed consent died their body will be donated to the Institute of Anatomy of the University Hospital Essen, samples will be taken until the body is cremated (regularly within 12 months) Analysis of the differences in tissue with and without telangiectasia in HHT, e.g. immunfluorescence staining of tissue / bone with endoglin-/ alk 1- antibodies and quantitative analysis of endoglin/ alk1 lacking cells such as immune cells or endothelial cells
Trial sites (1)
Facility
City
Region
Status
Institut für Anatomie und Klinik für HNO-Heilkunde, Universitätsklinik Essen
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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