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Clinical Trials in Egypt / NCT07675616
Recruiting Not applicable

Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia

NCT07675616 · tracked via the Priya Life Science Egypt tracker
Sponsor
Cairo University
Phase
Not applicable
Started
2026-05-16
Last updated
2026-06-30

Condition(s) studied

Hemodynamic EffectDexmedetomidineMagnesium SulphateLidocainePeribulbar BlockDacryocystorhinostomyGeneral Anesthesia

Investigational drug(s) / intervention(s)

Lidocaine + DexmedetomidineAll Lidocaine trials (57) →All Dexmedetomidine trials (137) →Lidocaine + Magnesium sulphateAll Lidocaine trials (57) →All Magnesium sulphate trials (3) →Lidocaine →

Lidocaine + Dexmedetomidine: Patients will receive 5 ml of lidocaine 2% + 50 µg dexmedetomidine, with a total volume of 7 ml.

Lidocaine + Magnesium sulphate: Patients will receive 5 ml of lidocaine 2% + 100 mg magnesium sulphate 10%, with a total volume of 7 ml.

Lidocaine: Patients will receive 7 ml of lidocaine 2% with no further additives.

Study summary

This study aims to compare the hemodynamic effect of dexmedetomidine and magnesium sulphate as an adjuvant to lidocaine in preemptive peribulbar block in patients undergoing Dacryocystorhinostomy (DCR) under general anaesthesia (GA) .

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥ 18 years. * Both sexes. * American Society of Anesthesiologists (ASA) physical status I or II. * Undergoing elective Dacryocystorhinostomy (DCR) surgery under general anesthesia. Exclusion Criteria: * Patients have local infection. * Allergic reaction or complications of the local anaesthesia (LA). * Coagulopathy defined as international normalized ratio (INR) \> 1.5, platelet count \< 100,000/mm³, or ongoing anticoagulant therapy not adequately discontinued. * Uncontrolled systemic disease, defined as poorly controlled hypertension \[systolic blood pressure (SBP) \> 160 mmHg\], uncontrolled diabetes mellitus (HbA1c \> 8.5%), unstable ischemic heart disease, or decompensated hepatic or renal disease. * Uncooperative patients.

Primary outcome measure(s)

  • Change in mean arterial blood pressure — Till the end of surgery (Up to 2 hours)
    The change in mean arterial blood pressure will be recorded at baseline, after induction of anesthesia, immediately before peribulbar block, after block administration, at skin incision, during osteotomy and lacrimal sac manipulation (oculocardiac reflexes-provoking steps), and every 5 minutes thereafter until the end of surgery.

Trial sites (1)

FacilityCityRegionStatus
Cairo University Cairo Egypt Recruiting

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Other trials for the same condition

Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries Recruiting
Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? Recruiting
Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy Recruiting
Virtual Reality Versus Intravenous Dexmedetomidine on Maternal Anxiety, Stress, Hemodynamics, and Neonatal Outcomes During Cesarean Section Recruiting
Intraperitoneal Dexmedetomidine Versus Magnesium as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07675616 on ClinicalTrials.gov ↗ ← All trials in Egypt