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Clinical Trials in Egypt / NCT07693621
Recruiting Not applicable

Intraperitoneal Dexmedetomidine Versus Magnesium as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy

NCT07693621 · tracked via the Priya Life Science Egypt tracker
Sponsor
Alexandria University
Phase
Not applicable
Started
2026-05-03
Last updated
2026-07-09

Condition(s) studied

DexmedetomidineMagnesium SulfateLaparoscopic Cholecystectomy

Investigational drug(s) / intervention(s)

Bupivacaine 100 mg + dexmedetomidine 1 µg/kgBupivacaine 100 mg + magnesium sulphate 50 mg/kg

Bupivacaine 100 mg + dexmedetomidine 1 µg/kg: 20 ml bupivacaine + 1 µg/kg dexmedetomidine . The total volume will be adjusted to 50 mL with saline.

Bupivacaine 100 mg + magnesium sulphate 50 mg/kg: 20 ml bupivacaine + 50 mg/kg magnesium sulphate . The total volume will be adjusted to 50 mL with saline.

Study summary

Although both dexmedetomidine and magnesium sulphate have been individually evaluated as adjuvants to local anesthetics, direct comparisons between the two agents in intraperitoneal instillation during laparoscopic cholecystectomy remain limited. Understanding their relative efficacy and safety could provide valuable guidance for optimizing perioperative analgesia in these patients.

Eligibility

Sex
ALL
Min age
18 Years
Max age
60 Years
Healthy volunteers
No
Inclusion Criteria: * Patients aged 18-60 years * ASA physical status I-II * scheduled for elective laparoscopic cholecystectomy under general anesthesia. Exclusion Criteria: * Known hypersensitivity to study drugs * history of cardiac arrhythmias or conduction abnormalities * severe hepatic/renal impairment * chronic opioid or analgesic use * pregnancy * conversion to open surgery * drain insertion.

Primary outcome measure(s)

  • Postoperative pain scores (VAS) — postoperative day 1
    at rest , at movement
  • Quality of recovery — postoperative day 1
    QoR-15 questionnaire

Trial sites (1)

FacilityCityRegionStatus
Alexandria University Alexandria Egypt Recruiting

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Other trials for the same condition

Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries Recruiting
Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia Recruiting
Erector Spina Plane Block Versus Modified Thoracoabdominal Nerve Block After Laparoscopic Cholecystectomy Recruiting
Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? Recruiting
Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07693621 on ClinicalTrials.gov ↗ ← All trials in Egypt