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Clinical Trials in Egypt / NCT07108764
Recruiting Not applicable

Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries

NCT07108764 · tracked via the Priya Life Science Egypt tracker
Sponsor
Tanta University
Phase
Not applicable
Started
2025-04-17
Last updated
2025-08-07

Condition(s) studied

Intraoperative InfusionLidocaineDexmedetomidineCerebral Oxygen SaturationPostoperative DeliriumElderly PatientsAbdominal Surgeries

Investigational drug(s) / intervention(s)

Lidocaine →Dexmedetomidine →

Lidocaine: Patients will receive an IV bolus (50 ml) of lidocaine (1mg/kg) diluted with saline over 10 min before induction of anesthesia. This will be followed by intraoperative lidocaine infusion in a dose of 1.5mg /kg/hr till the end of surgery.

Dexmedetomidine: Patients will receive an IV bolus (50 ml) of dexmedetomidine in dose 0.5 μg/kg over 10 min before induction of anesthesia. This will be followed by intraoperative dexmedetomidine infusion in a dose of 0.3 μg/kg/hr till the end of surgery.

Study summary

This study aims to compare the effect of intraoperative infusion of either lidocaine or dexmedetomidine on the incidence of postoperative delirium (POD) in elderly patients undergoing major surgeries. It also aims to evaluate the impact of both medications on intraoperative regional cerebral oxygen saturation (rSO₂).

Eligibility

Sex
ALL
Min age
65 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥ 65years old. * Both sexes. * Physical status classification of II - III according to the American Society of Anesthesiologists (ASA). * Undergo elective non-cardiac surgeries. Exclusion Criteria: * History of mental illness, neurological illness, or scoring less than 8 using the abbreviated mental test (AMT) before operation. * Severe hearing or visual impairment that may interfere with communication. * Severe renal or hepatic dysfunction. * Patients on central nervous system (CNS) medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants). * Contraindications to lidocaine or dexmedetomidine \[e.g., allergy, severe bradycardia, atrioventricular (AV) block\].

Primary outcome measure(s)

  • Incidence of postoperative delirium — Three days after surgery
    Incidence of postoperative delirium (POD) will be recorded.

Trial sites (1)

FacilityCityRegionStatus
Tanta University Tanta El-Gharbia Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07108764 on ClinicalTrials.gov ↗ ← All trials in Egypt